TissGeneSummary for BTC |
Gene summary |
Basic gene information | Gene symbol | BTC |
Gene name | betacellulin | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001729.2, | |
Description | probetacellulin | |
Modification date | 20141207 | |
dbXrefs | MIM : 600345 | |
HGNC : HGNC | ||
HPRD : 02643 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BTC | |
BioGPS: 685 | ||
Pathway | NCI Pathway Interaction Database: BTC | |
KEGG: BTC | ||
REACTOME: BTC | ||
Pathway Commons: BTC | ||
Context | iHOP: BTC | |
ligand binding site mutation search in PubMed: BTC | ||
UCL Cancer Institute: BTC | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonKidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADKIRC,KIRP,KICH | |
Reference showing the relevant tissue of BTC | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for BTC |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 1.588450082 | 2.718700082 | -1.13025 | 1.68E-05 | 7.32E-05 |
STAD | 1.441156332 | 3.283028207 | -1.841871875 | 1.75E-07 | 4.23E-06 |
HNSC | -1.132842941 | 1.054450082 | -2.187293023 | 2.78E-08 | 2.98E-07 |
KIRP | 0.827393832 | 2.079425082 | -1.25203125 | 4.28E-07 | 2.35E-06 |
LUSC | -0.009787173 | 1.885010866 | -1.894798039 | 5.25E-10 | 1.85E-09 |
KIRC | 0.205812582 | 2.372758415 | -2.166945833 | 8.97E-25 | 1.05E-23 |
ESCA | 0.681650082 | 2.359313718 | -1.677663636 | 0.00699 | 0.049826154 |
BLCA | 0.728692187 | 1.835260608 | -1.106568421 | 0.00988 | 0.044751772 |
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TissGene-miRNA for BTC |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for BTC |
TissGeneSNV for BTC |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E105D | CESC | 1 |
p.E157K | BLCA | 1 |
p.C7G | PRAD | 1 |
p.E156D | SKCM | 1 |
p.R149H | SKCM | 1 |
p.G101R | SKCM | 1 |
p.R62L | SKCM | 1 |
p.K61Q | LUAD | 1 |
p.P49S | SKCM | 1 |
p.E40* | KIRC | 1 |
p.T160N | LGG | 1 |
p.G47X | STAD | 1 |
p.R62Q | BRCA | 1 |
p.R68M | STAD | 1 |
p.R62W | UCEC | 1 |
p.Q118H | HNSC | 1 |
p.E174Q | LUAD | 1 |
p.P144L | SKCM | 1 |
p.E40X | KIRC | 1 |
p.C7G | READ | 1 |
p.G47* | STAD | 1 |
p.I25S | KIRP | 1 |
p.E174K | HNSC | 1 |
p.P70S | UCEC | 1 |
p.C7G | BRCA | 1 |
p.E156K | SKCM | 1 |
p.P167S | SKCM | 1 |
p.R113S | HNSC | 1 |
p.L112I | LUSC | 1 |
p.E159K | SKCM | 1 |
p.L124M | COAD | 1 |
p.R149C | SKCM | 1 |
p.R149C | COAD | 1 |
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TissGeneCNV for BTC |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for BTC |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI758136 | BTC-SPIN1 | chr4:75719896 | chr9:91083284 |
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TissGeneNet for BTC |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for BTC |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for BTC |
TissGeneDrug for BTC |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for BTC |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | BeFree,GAD |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0011847 | Diabetes | 2 | BeFree |
umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree,GAD,LHGDN |
umls:C0020456 | Hyperglycemia | 2 | BeFree |
umls:C0021670 | insulinoma | 2 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029882 | Otitis Media | 1 | RGD |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0162568 | Erythropoietic Protoporphyria | 1 | CTD_human |
umls:C0334463 | Malignant Fibrous Histiocytoma | 1 | LHGDN |
umls:C0858252 | Breast adenocarcinoma | 1 | BeFree |
umls:C1176475 | Ductal Carcinoma | 1 | LHGDN |
umls:C1260325 | Dendritic Cell Sarcoma, Follicular | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
umls:C2239176 | Liver carcinoma | 1 | BeFree |