TissGeneSummary for SYT5 |
Gene summary |
Basic gene information | Gene symbol | SYT5 |
Gene name | synaptotagmin V | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19q13.42|11p | |
Type of gene | protein-coding | |
RefGenes | NM_001297774.1, NM_003180.2, | |
Description | synaptotagmin 5synaptotagmin-5sytV | |
Modification date | 20141207 | |
dbXrefs | MIM : 600782 | |
HGNC : HGNC | ||
HPRD : 02870 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SYT5 | |
BioGPS: 6861 | ||
Pathway | NCI Pathway Interaction Database: SYT5 | |
KEGG: SYT5 | ||
REACTOME: SYT5 | ||
Pathway Commons: SYT5 | ||
Context | iHOP: SYT5 | |
ligand binding site mutation search in PubMed: SYT5 | ||
UCL Cancer Institute: SYT5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGPAAD | |
Reference showing the relevant tissue of SYT5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SYT5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -1.838248501 | 0.726574576 | -2.564823077 | 1.31E-12 | 3.38E-11 |
LUSC | -0.542647596 | -2.606965243 | 2.064317647 | 6.44E-09 | 2.07E-08 |
BRCA | -1.750206935 | -3.041334128 | 1.291127193 | 3.10E-10 | 1.17E-09 |
HNSC | -0.595301631 | -2.045783027 | 1.450481395 | 0.000143 | 0.000610531 |
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TissGene-miRNA for SYT5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SYT5 |
TissGeneSNV for SYT5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G187W | LIHC | 1 |
p.G134A | BLCA | 1 |
p.L283M | LUAD | 1 |
p.R58Q | ESCA | 1 |
p.G286C | UCEC | 1 |
p.K268T | STAD | 1 |
p.A178T | PAAD | 1 |
p.R58Q | PAAD | 1 |
p.P53L | HNSC | 1 |
p.F179L | STAD | 1 |
p.H24Y | BRCA | 1 |
p.P222T | LUAD | 1 |
p.T168M | BRCA | 1 |
p.E161K | SKCM | 1 |
p.L77R | COAD | 1 |
p.P304L | SKCM | 1 |
p.L37M | BLCA | 1 |
p.R166Q | STAD | 1 |
p.E175K | SKCM | 1 |
p.P146L | SKCM | 1 |
p.V36M | PAAD | 1 |
p.R203C | BLCA | 1 |
p.S39* | CESC | 1 |
p.K267E | HNSC | 1 |
p.R291W | UCEC | 1 |
p.L130V | STAD | 1 |
p.A309T | KIRP | 1 |
p.R159W | BLCA | 1 |
p.I243M | BLCA | 1 |
p.S246F | LUSC | 1 |
p.F310L | LUSC | 1 |
p.S77* | BLCA | 1 |
p.D199N | UCEC | 1 |
p.E43K | SKCM | 1 |
p.P96L | SKCM | 1 |
p.R56Q | LUAD | 1 |
p.F312L | BLCA | 1 |
p.V314M | LGG | 1 |
p.P171R | LIHC | 1 |
p.G287D | GBM | 1 |
p.D18Y | LUAD | 1 |
p.F173L | LUAD | 1 |
p.R149W | HNSC | 1 |
p.T168M | READ | 1 |
p.F177L | COAD | 1 |
p.R63L | BLCA | 1 |
p.I82T | LIHC | 1 |
p.R157Q | PAAD | 1 |
p.D270N | LGG | 1 |
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TissGeneCNV for SYT5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SYT5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SYT5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SYT5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SYT5 |
TissGeneDrug for SYT5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SYT5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |