TissGeneSummary for TCP11 |
Gene summary |
Basic gene information | Gene symbol | TCP11 |
Gene name | t-complex 11, testis-specific | |
Synonyms | D6S230E|FPPR | |
Cytomap | UCSC genome browser: 6p21.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001093728.2, NM_001261817.1,NM_001261818.1,NM_001261819.1,NM_001261820.1, NM_001261821.1,NM_018679.5, | |
Description | T-complex protein 11 homologfertilization-promoting peptide receptort-complex 11 (a murine tcp homolog)t-complex 11 homolog | |
Modification date | 20141207 | |
dbXrefs | MIM : 186982 | |
HGNC : HGNC | ||
Ensembl : ENSG00000124678 | ||
HPRD : 01749 | ||
Vega : OTTHUMG00000014560 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TCP11 | |
BioGPS: 6954 | ||
Pathway | NCI Pathway Interaction Database: TCP11 | |
KEGG: TCP11 | ||
REACTOME: TCP11 | ||
Pathway Commons: TCP11 | ||
Context | iHOP: TCP11 | |
ligand binding site mutation search in PubMed: TCP11 | ||
UCL Cancer Institute: TCP11 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TCP11 | Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. Tohoku J Exp Med. 2011 Jun;224(2):111-7. (pmid:21597245) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TCP11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.692500871 | 0.477821351 | -1.170322222 | 7.90E-10 | 2.60E-09 |
COAD | -0.684218606 | -1.873476299 | 1.189257692 | 0.00454 | 0.011027871 |
KICH | -0.70300476 | 0.36940324 | -1.072408 | 0.00499 | 0.00948918 |
KIRP | -0.60402101 | 0.618819615 | -1.222840625 | 3.80E-05 | 0.00014223 |
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TissGene-miRNA for TCP11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TCP11 |
TissGeneSNV for TCP11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E228K | SKCM | 2 |
p.E233K | SKCM | 2 |
p.V345F | OV | 1 |
p.L231M | UCEC | 1 |
p.M212I | SKCM | 1 |
p.P287S | SKCM | 1 |
p.A2T | THYM | 1 |
p.G409D | SKCM | 1 |
p.S499F | SKCM | 1 |
p.E514K | SKCM | 1 |
p.P26T | SKCM | 1 |
p.M303V | KIRP | 1 |
p.R188Q | SKCM | 1 |
p.R373H | HNSC | 1 |
p.D154E | THYM | 1 |
p.R144H | COAD | 1 |
p.L294F | SKCM | 1 |
p.R214Q | LUAD | 1 |
p.S504F | SKCM | 1 |
p.K337N | COAD | 1 |
p.Q456X | KIRC | 1 |
p.T82I | UCEC | 1 |
p.R183Q | SKCM | 1 |
p.N477S | SKCM | 1 |
p.P23L | LUSC | 1 |
p.P15T | ESCA | 1 |
p.N433K | THYM | 1 |
p.N482S | SKCM | 1 |
p.E472X | COAD | 1 |
p.G404D | SKCM | 1 |
p.E67K | SKCM | 1 |
p.H164L | LUSC | 1 |
p.R141C | ESCA | 1 |
p.P323S | SKCM | 1 |
p.A166V | STAD | 1 |
p.Q142E | LUAD | 1 |
p.P493L | SKCM | 1 |
p.L299F | SKCM | 1 |
p.E245* | HNSC | 1 |
p.P488L | SKCM | 1 |
p.T501P | OV | 1 |
p.L246F | PRAD | 1 |
p.S420Y | UCEC | 1 |
p.R214Q | PAAD | 1 |
p.E510* | LUAD | 1 |
p.E245K | HNSC | 1 |
p.L157F | LUAD | 1 |
p.Q250K | LUAD | 1 |
p.R188* | UCEC | 1 |
p.P282S | SKCM | 1 |
p.N221S | OV | 1 |
p.T199M | COAD | 1 |
p.K337N | UCEC | 1 |
p.E324D | CESC | 1 |
p.E509K | SKCM | 1 |
p.L459I | BRCA | 1 |
p.P186Q | LUSC | 1 |
p.L309F | SKCM | 1 |
p.A292S | KIRC | 1 |
p.P289S | STAD | 1 |
p.A285T | STAD | 1 |
p.I236V | LIHC | 1 |
p.P54L | SKCM | 1 |
p.V452G | STAD | 1 |
p.E129* | UCEC | 1 |
p.Q488K | KIRC | 1 |
p.L314F | SKCM | 1 |
p.M217I | SKCM | 1 |
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TissGeneCNV for TCP11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TCP11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | UCS | TCGA-N5-A4RU-01A | NUDT3-TCP11 | Out-of-Frame | chr6:34360040 | chr6:35096959 |
Chimerdb3.0 | FusionScan | UCS | TCGA-N5-A4RU-01A | NUDT3-TCP11 | In-Frame | chr6:34360040 | chr6:35090114 |
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TissGeneNet for TCP11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TCP11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TCP11 |
TissGeneDrug for TCP11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TCP11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |