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| TissGeneSummary for TG |
 Gene summary |
| Basic gene information | Gene symbol | TG |
| Gene name | thyroglobulin | |
| Synonyms | AITD3|TGN | |
| Cytomap | UCSC genome browser: 8q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003235.4, | |
| Description | - | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 188450 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000042832 | ||
| HPRD : 01782 | ||
| Vega : OTTHUMG00000164649 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TG | |
| BioGPS: 7038 | ||
| Pathway | NCI Pathway Interaction Database: TG | |
| KEGG: TG | ||
| REACTOME: TG | ||
| Pathway Commons: TG | ||
| Context | iHOP: TG | |
| ligand binding site mutation search in PubMed: TG | ||
| UCL Cancer Institute: TG | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
| Reference showing the relevant tissue of TG | ||
| Description by TissGene annotations | Unique usage of specific isoform Cancer gene Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS Fused withTSGene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for TG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 1.246601982 | -2.480063403 | 3.726665385 | 6.69E-10 | 7.67E-09 |
| KICH | 3.027803366 | 0.217831366 | 2.809972 | 6.03E-06 | 1.99E-05 |
| THCA | 13.52198601 | 15.62148771 | -2.099501695 | 1.09E-14 | 1.31E-13 |
| KIRC | -0.593039578 | 0.607521533 | -1.200561111 | 5.04E-06 | 1.21E-05 |
| LUSC | -0.00329734 | -1.884926751 | 1.881629412 | 3.86E-07 | 1.01E-06 |
| Top |
| TissGene-miRNA for TG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for TG |
| TissGeneSNV for TG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R2177C | SKCM | 2 |
| p.G264C | LUAD | 2 |
| p.R1646Q | SKCM | 2 |
| p.S2565F | SKCM | 2 |
| p.R169C | SKCM | 2 |
| p.S2511Y | UCEC | 2 |
| p.R995C | SKCM | 2 |
| p.R1398C | STAD | 2 |
| p.D2595G | LGG | 2 |
| p.S69F | SKCM | 2 |
| p.G2372* | UCEC | 1 |
| p.S2089P | KIRP | 1 |
| p.E2240Q | CESC | 1 |
| p.E244K | SKCM | 1 |
| p.E2739K | LUAD | 1 |
| p.E1797D | LGG | 1 |
| p.C297Y | SKCM | 1 |
| p.G264S | LUAD | 1 |
| p.S2425I | LUAD | 1 |
| p.L565V | LUSC | 1 |
| p.S2272F | LUAD | 1 |
| p.D2687E | LUSC | 1 |
| p.E576D | LUAD | 1 |
| p.R2371* | ESCA | 1 |
| p.N65T | STAD | 1 |
| p.P922T | LUSC | 1 |
| p.K546N | ESCA | 1 |
| p.M2034I | LUAD | 1 |
| p.R1009S | PRAD | 1 |
| p.T114S | STAD | 1 |
| p.K1953N | STAD | 1 |
| p.A2293T | BRCA | 1 |
| p.R1009H | COAD | 1 |
| p.A1531V | THYM | 1 |
| p.R810T | LUSC | 1 |
| p.D27N | SKCM | 1 |
| p.R1009C | STAD | 1 |
| p.L819I | LUAD | 1 |
| p.S882F | SKCM | 1 |
| p.G1539E | SKCM | 1 |
| p.V1391M | SKCM | 1 |
| p.R2489H | CESC | 1 |
| p.V1618M | LGG | 1 |
| p.P2686H | ACC | 1 |
| p.V845I | STAD | 1 |
| p.A2560V | STAD | 1 |
| p.R2555C | THYM | 1 |
| p.D517N | BLCA | 1 |
| p.Q1796K | UCEC | 1 |
| p.E1054D | READ | 1 |
| p.R350Q | LUAD | 1 |
| p.E1770G | STAD | 1 |
| p.T2273S | SKCM | 1 |
| p.E2753K | CESC | 1 |
| p.A402S | STAD | 1 |
| p.M2444T | HNSC | 1 |
| p.V598G | OV | 1 |
| p.V629A | STAD | 1 |
| p.P2475S | SKCM | 1 |
| p.Q1741H | BRCA | 1 |
| p.L81P | LUAD | 1 |
| p.R2379C | DLBC | 1 |
| p.L93M | COAD | 1 |
| p.R1998* | BRCA | 1 |
| p.F377V | STAD | 1 |
| p.P1755S | UCS | 1 |
| p.R2691H | KICH | 1 |
| p.T1781S | LGG | 1 |
| p.Q1682H | STAD | 1 |
| p.R1093I | READ | 1 |
| p.Q1404H | CESC | 1 |
| p.C1126F | LUAD | 1 |
| p.S2757T | LUAD | 1 |
| p.A286T | STAD | 1 |
| p.M1I | GBM | 1 |
| p.Q1863H | LUAD | 1 |
| p.I2107S | LGG | 1 |
| p.P215S | UCEC | 1 |
| p.S1024L | SKCM | 1 |
| p.T199I | SKCM | 1 |
| p.R1283Q | STAD | 1 |
| p.V2472M | COAD | 1 |
| p.G2253V | LUSC | 1 |
| p.R2707* | UCEC | 1 |
| p.D1628Y | BRCA | 1 |
| p.G2375E | SKCM | 1 |
| p.E1572Q | LUAD | 1 |
| p.A1502T | ESCA | 1 |
| p.S1177F | SKCM | 1 |
| p.G1650E | SKCM | 1 |
| p.S1370L | SKCM | 1 |
| p.Q1698P | UCEC | 1 |
| p.D766N | BLCA | 1 |
| p.Q2033K | LUAD | 1 |
| p.A1531G | LIHC | 1 |
| p.L1678F | LUSC | 1 |
| p.S1713L | LUAD | 1 |
| p.S2652L | UCEC | 1 |
| p.P33L | GBM | 1 |
| p.F580V | STAD | 1 |
| p.R296Q | SKCM | 1 |
| p.Q503H | LUAD | 1 |
| p.P449S | SKCM | 1 |
| p.D590N | BLCA | 1 |
| p.D1959Y | UCEC | 1 |
| p.V2152L | LUSC | 1 |
| p.V2152M | PAAD | 1 |
| p.N198S | STAD | 1 |
| p.V2556I | LUAD | 1 |
| p.L2081M | BLCA | 1 |
| p.L803V | LUAD | 1 |
| p.I1708V | DLBC | 1 |
| p.C662Y | BRCA | 1 |
| p.R32C | SKCM | 1 |
| p.P2377S | SKCM | 1 |
| p.V49M | GBM | 1 |
| p.E1561K | OV | 1 |
| p.S1139L | BRCA | 1 |
| p.P656L | SKCM | 1 |
| p.L568I | STAD | 1 |
| p.G2313R | SKCM | 1 |
| p.V804A | LUAD | 1 |
| p.G512A | READ | 1 |
| p.V684F | LUAD | 1 |
| p.R152H | PAAD | 1 |
| p.E576K | SKCM | 1 |
| p.E2195D | ESCA | 1 |
| p.F8S | SKCM | 1 |
| p.R68S | HNSC | 1 |
| p.V2608I | HNSC | 1 |
| p.T349A | STAD | 1 |
| p.R2177C | BLCA | 1 |
| p.R2185W | PRAD | 1 |
| p.V208F | LUAD | 1 |
| p.P922S | HNSC | 1 |
| p.M190I | HNSC | 1 |
| p.G56S | BLCA | 1 |
| p.A1020T | PRAD | 1 |
| p.Q1297* | LUAD | 1 |
| p.L802M | STAD | 1 |
| p.R2455C | SKCM | 1 |
| p.G2633R | HNSC | 1 |
| p.E1133G | LUAD | 1 |
| p.E2427D | STAD | 1 |
| p.N792D | UCEC | 1 |
| p.D2730G | ACC | 1 |
| p.T1201M | ACC | 1 |
| p.Q1334* | SKCM | 1 |
| p.C1565S | LIHC | 1 |
| p.R1435M | STAD | 1 |
| p.P335L | SKCM | 1 |
| p.D1582N | UCEC | 1 |
| p.K1534E | THCA | 1 |
| p.A744V | STAD | 1 |
| p.R350Q | READ | 1 |
| p.P464Q | DLBC | 1 |
| p.Q1095X | LIHC | 1 |
| p.F497V | ESCA | 1 |
| p.A2384T | PRAD | 1 |
| p.F2287L | UCS | 1 |
| p.E1324V | LUAD | 1 |
| p.S1011F | LUAD | 1 |
| p.S111N | STAD | 1 |
| p.R2676W | BRCA | 1 |
| p.K1461R | STAD | 1 |
| p.Q432H | UCEC | 1 |
| p.T1432N | HNSC | 1 |
| p.R1388S | STAD | 1 |
| p.S373Y | LUAD | 1 |
| p.C1919Y | PRAD | 1 |
| p.E555K | THCA | 1 |
| p.D628N | SKCM | 1 |
| p.Y1965N | LUAD | 1 |
| p.S407F | LUAD | 1 |
| p.P1575A | SKCM | 1 |
| p.E2641D | LUAD | 1 |
| p.Q1277* | CESC | 1 |
| p.E955V | LIHC | 1 |
| p.E2741K | BLCA | 1 |
| p.S887G | LUAD | 1 |
| p.L2470R | SKCM | 1 |
| p.R2707* | SKCM | 1 |
| p.K1153N | BRCA | 1 |
| p.G2388R | LUSC | 1 |
| p.A2493G | LUSC | 1 |
| p.Q1698X | SKCM | 1 |
| p.R445* | LUAD | 1 |
| p.G989W | LUAD | 1 |
| p.E2503D | STAD | 1 |
| p.Q482L | ESCA | 1 |
| p.G87E | READ | 1 |
| p.G874D | ACC | 1 |
| p.L2249F | PRAD | 1 |
| p.E1797* | STAD | 1 |
| p.K539N | CESC | 1 |
| p.S823T | LUAD | 1 |
| p.C1249F | BRCA | 1 |
| p.E1854* | UCEC | 1 |
| p.E576Q | CESC | 1 |
| p.Q2512* | SKCM | 1 |
| p.W1368X | SKCM | 1 |
| p.A1502V | UCEC | 1 |
| p.K465N | UCEC | 1 |
| p.L958P | UCEC | 1 |
| p.D527Y | READ | 1 |
| p.A1107V | OV | 1 |
| p.R68G | LUAD | 1 |
| p.R1661C | BLCA | 1 |
| p.G1045R | BRCA | 1 |
| p.Q99K | LUAD | 1 |
| p.R1661S | ESCA | 1 |
| p.T411M | READ | 1 |
| p.E2623K | SKCM | 1 |
| p.Q385L | LUAD | 1 |
| p.R1691C | KICH | 1 |
| p.A584S | KIRP | 1 |
| p.D2001N | LUAD | 1 |
| p.T2746M | SKCM | 1 |
| p.L250S | SKCM | 1 |
| p.D2551G | LIHC | 1 |
| p.Q1454H | LIHC | 1 |
| p.L1717V | BLCA | 1 |
| p.G1520D | SKCM | 1 |
| p.G2372E | SKCM | 1 |
| p.P1475H | UCEC | 1 |
| p.S1857F | SKCM | 1 |
| p.C140G | THCA | 1 |
| p.P685S | LUAD | 1 |
| p.A997V | STAD | 1 |
| p.D1562Y | LUAD | 1 |
| p.Q2094K | STAD | 1 |
| p.R162S | LUAD | 1 |
| p.G2010A | BLCA | 1 |
| p.R1967C | UCEC | 1 |
| p.T1076S | UCEC | 1 |
| p.G2509W | LUAD | 1 |
| p.G2041* | STAD | 1 |
| p.A185V | UCEC | 1 |
| p.K1153N | BLCA | 1 |
| p.R2455L | THYM | 1 |
| p.S1222L | COAD | 1 |
| p.G1456V | SKCM | 1 |
| p.R1270C | STAD | 1 |
| p.S1024L | BLCA | 1 |
| p.A2399P | LUAD | 1 |
| p.P535S | SKCM | 1 |
| p.S2575F | SKCM | 1 |
| p.E2742K | SKCM | 1 |
| p.G1123D | STAD | 1 |
| p.S373F | BRCA | 1 |
| p.S1656N | LUAD | 1 |
| p.R1328H | UCEC | 1 |
| p.F205S | CESC | 1 |
| p.D1729A | DLBC | 1 |
| p.P191S | THYM | 1 |
| p.S2763T | LIHC | 1 |
| p.L1262F | BLCA | 1 |
| p.S2575C | ESCA | 1 |
| p.E2037K | LUAD | 1 |
| p.D527N | UCEC | 1 |
| p.P977L | ESCA | 1 |
| p.P575S | LUSC | 1 |
| p.A2713G | LGG | 1 |
| p.V1618M | LUAD | 1 |
| p.G264A | LUAD | 1 |
| p.V1511A | OV | 1 |
| p.D2687H | LUSC | 1 |
| p.P2491L | SKCM | 1 |
| p.L104F | OV | 1 |
| p.V2472M | LGG | 1 |
| p.P1074L | STAD | 1 |
| p.Q37H | LUAD | 1 |
| p.E2427K | SKCM | 1 |
| p.P2638T | THYM | 1 |
| p.E1611K | SKCM | 1 |
| p.S1343F | SKCM | 1 |
| p.R1361H | UCEC | 1 |
| p.L953V | STAD | 1 |
| p.P1345T | UCEC | 1 |
| p.R2532Q | COAD | 1 |
| p.C2154S | LUAD | 1 |
| p.D2318N | SKCM | 1 |
| p.G2341R | ESCA | 1 |
| p.D831Y | READ | 1 |
| p.A537V | COAD | 1 |
| p.N700S | STAD | 1 |
| p.Q2227K | LUAD | 1 |
| p.E1609K | KIRP | 1 |
| p.L595F | LIHC | 1 |
| p.Q502X | LIHC | 1 |
| p.Q2512X | SKCM | 1 |
| p.E2744K | SKCM | 1 |
| p.A1585D | LIHC | 1 |
| p.A327S | LUSC | 1 |
| p.E627D | LGG | 1 |
| p.S1591F | SKCM | 1 |
| p.C636F | COAD | 1 |
| p.V1319I | SKCM | 1 |
| p.P118S | STAD | 1 |
| p.W788C | STAD | 1 |
| p.A2125V | SKCM | 1 |
| p.G174W | CHOL | 1 |
| p.A1504D | STAD | 1 |
| p.S2546Y | UCEC | 1 |
| p.R2371Q | BLCA | 1 |
| p.R2371X | ESCA | 1 |
| p.G2352V | HNSC | 1 |
| p.R2408Q | SKCM | 1 |
| p.G2313V | COAD | 1 |
| p.P1944S | UCEC | 1 |
| p.C1306S | THCA | 1 |
| p.R2386H | UCEC | 1 |
| p.R2386C | SKCM | 1 |
| p.A686S | HNSC | 1 |
| p.E1518K | SKCM | 1 |
| p.D1729N | UCEC | 1 |
| p.D1382Y | UCEC | 1 |
| p.R666T | ESCA | 1 |
| p.L2745F | OV | 1 |
| p.R1829W | SKCM | 1 |
| p.L862F | SKCM | 1 |
| p.S1990Y | COAD | 1 |
| p.M1833I | LUAD | 1 |
| p.G242E | SKCM | 1 |
| p.L876I | COAD | 1 |
| p.G512R | SKCM | 1 |
| p.H892R | BLCA | 1 |
| p.D2586N | SKCM | 1 |
| p.Q1185R | COAD | 1 |
| p.A1585V | LIHC | 1 |
| p.G2748A | HNSC | 1 |
| p.C92F | LUAD | 1 |
| p.E360K | CESC | 1 |
| p.Y1819C | THYM | 1 |
| p.Q1243R | STAD | 1 |
| p.D2514N | SKCM | 1 |
| p.S530Y | UCEC | 1 |
| p.D2514N | STAD | 1 |
| p.S1591Y | LUAD | 1 |
| p.R88Q | STAD | 1 |
| p.S1154N | LUAD | 1 |
| p.R1371W | PAAD | 1 |
| p.E2695D | BLCA | 1 |
| p.F1480L | LUAD | 1 |
| p.G624R | OV | 1 |
| p.Q1246P | THCA | 1 |
| p.E2739Q | BLCA | 1 |
| p.P2260L | LUAD | 1 |
| p.F509S | LUAD | 1 |
| p.C1490G | KIRP | 1 |
| p.S2546F | SKCM | 1 |
| p.P317T | ESCA | 1 |
| p.Y2540* | LUAD | 1 |
| p.P1237H | STAD | 1 |
| p.P1039S | UCS | 1 |
| p.R931H | ESCA | 1 |
| p.G2348R | SARC | 1 |
| p.G1696S | LUAD | 1 |
| p.H2182N | HNSC | 1 |
| p.C164G | THCA | 1 |
| p.S1235L | SKCM | 1 |
| p.V1742A | LIHC | 1 |
| p.P1707H | LUAD | 1 |
| p.P1947S | UCEC | 1 |
| p.W2251C | STAD | 1 |
| p.T621M | UCEC | 1 |
| p.Q1788K | LUSC | 1 |
| p.Q225P | LIHC | 1 |
| p.P978S | LUAD | 1 |
| p.L467V | BRCA | 1 |
| p.A2747T | SKCM | 1 |
| p.A365V | LUAD | 1 |
| p.G513E | SKCM | 1 |
| p.L1521Q | PRAD | 1 |
| p.A2599V | STAD | 1 |
| p.P677S | SKCM | 1 |
| p.P1213S | UCEC | 1 |
| p.S1977F | SKCM | 1 |
| p.L522F | SKCM | 1 |
| p.R2044H | READ | 1 |
| p.V2292M | HNSC | 1 |
| p.N1636S | STAD | 1 |
| p.S1307N | SKCM | 1 |
| p.P834L | HNSC | 1 |
| p.R2185Q | COAD | 1 |
| p.H2477Y | SKCM | 1 |
| p.S269F | SKCM | 1 |
| p.R1423H | HNSC | 1 |
| p.S1141C | LUAD | 1 |
| p.E1622K | SKCM | 1 |
| p.W2501R | COAD | 1 |
| p.P2686S | STAD | 1 |
| p.A1044T | UCEC | 1 |
| p.L2506M | LUAD | 1 |
| p.P915S | STAD | 1 |
| p.G679V | LUAD | 1 |
| p.D1795Y | STAD | 1 |
| p.P1804L | SKCM | 1 |
| p.K2720R | STAD | 1 |
| p.C2005* | LUAD | 1 |
| p.R2386H | LUAD | 1 |
| p.P2705R | LGG | 1 |
| p.W1368* | SKCM | 1 |
| p.S1088I | BLCA | 1 |
| p.L2462F | GBM | 1 |
| p.A1907T | COAD | 1 |
| p.L2284I | UCEC | 1 |
| p.E230Q | BLCA | 1 |
| p.Q1863K | HNSC | 1 |
| p.G2341S | LUAD | 1 |
| p.S2099F | SKCM | 1 |
| p.R2336Q | KIRC | 1 |
| p.G334V | LUAD | 1 |
| p.D2553E | BLCA | 1 |
| p.I204V | ESCA | 1 |
| p.L1152P | OV | 1 |
| p.P1098Q | KIRC | 1 |
| p.K2698N | LUAD | 1 |
| p.W1437* | OV | 1 |
| p.G691E | SKCM | 1 |
| p.R1952W | COAD | 1 |
| p.D66N | SKCM | 1 |
| p.S2665P | SKCM | 1 |
| p.Q1899* | LUAD | 1 |
| p.G634R | UCEC | 1 |
| p.S1614N | LUAD | 1 |
| p.R1952W | STAD | 1 |
| p.G1164V | LIHC | 1 |
| p.N545S | LUSC | 1 |
| p.P424L | BLCA | 1 |
| p.F1338L | UCEC | 1 |
| p.S2675L | HNSC | 1 |
| p.I1909T | PAAD | 1 |
| p.P2289L | SKCM | 1 |
| p.D1672N | BLCA | 1 |
| p.R668C | STAD | 1 |
| p.M203I | SKCM | 1 |
| p.P2668S | SKCM | 1 |
| p.R445* | STAD | 1 |
| p.R152H | STAD | 1 |
| p.R1646* | BRCA | 1 |
| p.A327V | UCEC | 1 |
| p.H236R | STAD | 1 |
| p.P919S | SKCM | 1 |
| p.P1969S | UCEC | 1 |
| p.V2472L | DLBC | 1 |
| p.S2757R | UCEC | 1 |
| p.Q743H | LUSC | 1 |
| p.R2378W | STAD | 1 |
| p.G954E | STAD | 1 |
| p.C1760W | STAD | 1 |
| p.R1979K | SKCM | 1 |
| p.G1195R | STAD | 1 |
| p.A2417T | GBM | 1 |
| p.Q1698* | SKCM | 1 |
| p.G852E | SKCM | 1 |
| p.F577L | LIHC | 1 |
| p.T1421I | UCEC | 1 |
| p.A744V | UCEC | 1 |
| p.E256K | SKCM | 1 |
| p.D2714Y | LUAD | 1 |
| p.F1417V | STAD | 1 |
| p.F2123L | UCEC | 1 |
| p.E2449X | READ | 1 |
| p.G1539V | HNSC | 1 |
| p.V1600M | COAD | 1 |
| p.G1496D | UCEC | 1 |
| p.V602E | LUAD | 1 |
| p.C1440R | UCEC | 1 |
| p.G2341V | OV | 1 |
| p.S924T | STAD | 1 |
| p.E859D | UCEC | 1 |
| p.G474R | BLCA | 1 |
| p.R2371* | OV | 1 |
| p.R1730C | STAD | 1 |
| p.A2068G | LUAD | 1 |
| p.K1101E | LGG | 1 |
| p.E600K | SKCM | 1 |
| p.L1410I | ESCA | 1 |
| p.Q1515L | ESCA | 1 |
| p.S2258I | UCEC | 1 |
| p.E360* | HNSC | 1 |
| p.G1548W | SKCM | 1 |
| p.Q329H | THCA | 1 |
| p.Q743X | THYM | 1 |
| p.N1365D | STAD | 1 |
| p.R1160S | LUAD | 1 |
| p.F1104L | HNSC | 1 |
| p.D1401Y | COAD | 1 |
| Top |
| TissGeneCNV for TG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG992510 | TG-TG | chr8:134108578 | chr8:134125797 | |
| Chimerdb3.0 | ChiTaRs | NA | BF828012 | TG-TG | chr8:134011421 | chr8:134010799 | |
| Chimerdb3.0 | ChiTaRs | NA | BF061174 | TG-TG | chr8:134147143 | chr8:134146934 | |
| Chimerdb3.0 | ChiTaRs | NA | BI002383 | TG-SDHAF1 | chr8:133953700 | chr19:36486834 | |
| Chimerdb3.0 | ChiTaRs | NA | BF810597 | TG-ITGAX | chr8:134054834 | chr16:31384629 | |
| Chimerdb3.0 | ChiTaRs | NA | CR986635 | TG-USP19 | chr8:134087166 | chr3:49146115 | |
| Chimerdb3.0 | ChiTaRs | NA | BF740490 | TG-GPRC5A | chr8:134101880 | chr12:13064166 | |
| Chimerdb3.0 | ChiTaRs | NA | AU141421 | ANP32B-TG | chr9:100771382 | chr8:133961126 | |
| Chimerdb3.0 | ChiTaRs | NA | BG999952 | TG-FNBP1 | chr8:133918554 | chr9:132803598 | |
| Chimerdb3.0 | ChiTaRs | NA | BI003062 | TG-CTNNB1 | chr8:133907588 | chr3:41279542 | |
| Chimerdb3.0 | ChiTaRs | NA | BI005429 | TG-PFKP | chr8:134144076 | chr10:3149421 | |
| Chimerdb3.0 | ChiTaRs | NA | BF839733 | TG-TNRC6A | chr8:134026049 | chr16:24831244 | |
| Chimerdb3.0 | ChiTaRs | NA | BI002377 | SDHAF1-TG | chr19:36487009 | chr8:133945842 | |
| Chimerdb3.0 | ChiTaRs | NA | BG992571 | HIRA-TG | chr22:19418480 | chr8:134144161 | |
| Chimerdb3.0 | ChiTaRs | NA | AU141950 | MALAT1-TG | chr11:65272022 | chr8:133978890 | |
| Chimerdb3.0 | ChiTaRs | NA | BG993810 | NOL3-TG | chr16:67209572 | chr8:134128898 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A1F0-01A | AGAP3-TG | In-Frame | chr7:150813938 | chr8:133948000 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-78-7153-01A | FAM49B-TG | 5'UTR-CDS | chr8:131028615 | chr8:134107287 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-21-5783-01A | SAMD12-TG | Out-of-Frame | chr8:119592953 | chr8:133925291 |
| Top |
| TissGeneNet for TG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (tumor) | TG, HSP90B1, CTSL1, APCS, NKX2-1, HSPA5, CANX, CTSD, P4HB, LRP2, ASGR1 (normal) |
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| Top |
| TissGeneProg for TG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for TG |
| TissGeneDrug for TG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for TG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010308 | Congenital Hypothyroidism | 57 | BeFree,LHGDN |
| umls:C0342200 | Endemic Cretinism | 56 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 53 | BeFree,GAD |
| umls:C0018021 | Goiter | 43 | BeFree,CTD_human,LHGDN |
| umls:C0020676 | Hypothyroidism | 38 | BeFree,GAD,LHGDN,RGD |
| umls:C0007115 | Malignant neoplasm of thyroid | 34 | BeFree |
| umls:C0349476 | Congenital goiter | 30 | BeFree |
| umls:C0018213 | Graves Disease | 29 | BeFree,GAD,GWASCAT,LHGDN |
| umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 26 | BeFree |
| umls:C0677607 | Hashimoto Disease | 24 | BeFree,GAD,RGD |
| umls:C0040128 | Thyroid Diseases | 23 | BeFree,GAD,LHGDN |
| umls:C0178468 | Autoimmune thyroid disease | 18 | BeFree,GAD |
| umls:C0027627 | Neoplasm Metastasis | 16 | BeFree |
| umls:C0040147 | Thyroiditis | 15 | BeFree |
| umls:C0920350 | Autoimmune thyroiditis | 14 | BeFree,CTD_human,GAD |
| umls:C0040136 | Thyroid Neoplasm | 11 | BeFree,LHGDN |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 8 | BeFree |
| umls:C0018022 | Endemic goiter | 7 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 7 | BeFree |
| umls:C1321809 | HYPOTHYROIDISM, GOITROUS | 7 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 6 | BeFree |
| umls:C0001430 | Adenoma | 5 | BeFree |
| umls:C0342194 | Thyroid Dyshormonogenesis 3 | 5 | CLINVAR,CTD_human,MGD,UNIPROT |
| umls:C0019348 | Herpes Simplex Infections | 4 | BeFree |
| umls:C0020550 | Hyperthyroidism | 4 | BeFree |
| umls:C0023530 | Leukopenia | 4 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 3 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 3 | BeFree |
| umls:C0018023 | Nodular Goiter | 3 | BeFree |
| umls:C0205696 | Anaplastic carcinoma | 3 | BeFree |
| umls:C0205698 | Undifferentiated carcinoma | 3 | BeFree |
| umls:C0238461 | Anaplastic thyroid carcinoma | 3 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 3 | BeFree |
| umls:C0311361 | Adenomatous goiter | 3 | BeFree |
| umls:C0342208 | Multinodular goiter | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree,LHGDN |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
| umls:C0013336 | Dwarfism | 2 | BeFree,CTD_human |
| umls:C0023003 | Langer-Giedion Syndrome | 2 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 2 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
| umls:C0040137 | Thyroid Nodule | 2 | BeFree |
| umls:C0040156 | Thyrotoxicosis | 2 | BeFree |
| umls:C0206682 | Follicular thyroid carcinoma | 2 | BeFree |
| umls:C0266283 | Ectopic thyroid tissue (disorder) | 2 | BeFree |
| umls:C0271790 | Subclinical hypothyroidism | 2 | BeFree |
| umls:C0271791 | Severe hypothyroidism | 2 | BeFree |
| umls:C0271826 | Iodide transport defect | 2 | BeFree |
| umls:C0271829 | Pendred's syndrome | 2 | BeFree |
| umls:C0302859 | Euthyroid Goiter | 2 | BeFree |
| umls:C0339143 | Thyroid associated opthalmopathies | 2 | BeFree |
| umls:C0521158 | Recurrent tumor | 2 | BeFree |
| umls:C0854467 | Myelosuppression | 2 | BeFree |
| umls:C0920420 | cancer recurrence | 2 | BeFree |
| umls:C1096666 | Thyroid cancer metastatic | 2 | BeFree |
| umls:C1262091 | Lymphocytic infiltration | 2 | BeFree |
| umls:C1318500 | Non-toxic nodular goiter | 2 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | BeFree |
| umls:C0007384 | Cataplexy | 1 | BeFree |
| umls:C0007570 | Celiac Disease | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0013080 | Down Syndrome | 1 | BeFree |
| umls:C0015397 | Disorder of eye | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0024131 | Lupus Vulgaris | 1 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 1 | BeFree |
| umls:C0024312 | Lymphopenia | 1 | BeFree |
| umls:C0025322 | Premature Menopause | 1 | BeFree |
| umls:C0029182 | orbit (eye disorders) | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0035920 | Rubella | 1 | BeFree |
| umls:C0038478 | Struma Ovarii | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042900 | Vitiligo | 1 | GWASCAT |
| umls:C0085215 | Ovarian Failure, Premature | 1 | BeFree,GAD |
| umls:C0151468 | Thyroid Gland Follicular Adenoma | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0156841 | Thyroid dysfunction, postpartum | 1 | BeFree |
| umls:C0221777 | Nontoxic goiter | 1 | BeFree |
| umls:C0242520 | Chronic thyroiditis | 1 | BeFree |
| umls:C0266617 | Congenital anomaly of face | 1 | BeFree |
| umls:C0278861 | Recurrent Thyroid Carcinoma | 1 | BeFree |
| umls:C0333516 | Tumor necrosis | 1 | BeFree |
| umls:C0342158 | Hypothyroidism, Autoimmune | 1 | BeFree |
| umls:C0342162 | Compensated hypothyroidism | 1 | BeFree |
| umls:C0342199 | Iodine deficiency syndrome | 1 | BeFree |
| umls:C0346182 | Immature teratoma of ovary | 1 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C1266050 | Poorly Differentiated Thyroid Carcinoma | 1 | BeFree |
| umls:C1290884 | Inflammatory disorder | 1 | BeFree |
| umls:C1336748 | Thyroid Angiosarcoma | 1 | BeFree |
| umls:C1839141 | Thyroxine-Binding Globulin Deficiency | 1 | BeFree |
| umls:C1855794 | Bamforth syndrome | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
| umls:C3711378 | Inherited Thyroxine-Binding Globulin Deficiency | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
| umls:C1842444 | AUTOIMMUNE THYROID DISEASE, SUSCEPTIBILITY TO, 3 (finding) | 0 | CLINVAR |
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