TissGeneSummary for ICAM5 |
Gene summary |
Basic gene information | Gene symbol | ICAM5 |
Gene name | intercellular adhesion molecule 5, telencephalin | |
Synonyms | TLCN|TLN | |
Cytomap | UCSC genome browser: 19p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_003259.3, | |
Description | ICAM-5intercellular adhesion molecule 5telencephalin | |
Modification date | 20141207 | |
dbXrefs | MIM : 601852 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105376 | ||
HPRD : 03509 | ||
Vega : OTTHUMG00000180406 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ICAM5 | |
BioGPS: 7087 | ||
Pathway | NCI Pathway Interaction Database: ICAM5 | |
KEGG: ICAM5 | ||
REACTOME: ICAM5 | ||
Pathway Commons: ICAM5 | ||
Context | iHOP: ICAM5 | |
ligand binding site mutation search in PubMed: ICAM5 | ||
UCL Cancer Institute: ICAM5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of ICAM5 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ICAM5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.215611006 | 3.325671791 | -2.110060784 | 2.72E-10 | 9.86E-10 |
BRCA | -2.282805763 | -0.511383834 | -1.77142193 | 7.53E-15 | 3.86E-14 |
KIRC | -2.933042752 | -1.791067752 | -1.141975 | 8.92E-09 | 2.72E-08 |
HNSC | 1.025118941 | -1.387236873 | 2.412355814 | 4.55E-13 | 1.93E-11 |
LUAD | 1.610308877 | 3.469719221 | -1.859410345 | 1.67E-12 | 1.27E-11 |
THCA | 3.393450986 | -0.52671342 | 3.920164407 | 2.47E-20 | 1.05E-18 |
KICH | 0.744613359 | -0.721926641 | 1.46654 | 0.00596 | 0.011275399 |
STAD | -0.846847266 | -1.857519141 | 1.010671875 | 0.00173 | 0.008173887 |
KIRP | -2.559675391 | -1.410444141 | -1.14923125 | 4.76E-05 | 0.00017495 |
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TissGene-miRNA for ICAM5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ICAM5 |
TissGeneSNV for ICAM5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A348T | COAD | 2 |
p.N649S | PAAD | 1 |
p.A887T | COAD | 1 |
p.G435E | STAD | 1 |
p.E432* | BLCA | 1 |
p.Q369* | HNSC | 1 |
p.P666Q | SKCM | 1 |
p.Q109E | LGG | 1 |
p.A647T | STAD | 1 |
p.Y263C | UCEC | 1 |
p.T678M | STAD | 1 |
p.E553K | HNSC | 1 |
p.G757R | LUAD | 1 |
p.R175Q | BLCA | 1 |
p.R61W | BLCA | 1 |
p.S579R | LUSC | 1 |
p.S216L | COAD | 1 |
p.G741C | HNSC | 1 |
p.S258L | HNSC | 1 |
p.A720G | LUAD | 1 |
p.G538E | LUAD | 1 |
p.A453S | SARC | 1 |
p.D388N | STAD | 1 |
p.R551C | STAD | 1 |
p.D475V | STAD | 1 |
p.A752V | READ | 1 |
p.P332H | LUAD | 1 |
p.R166L | STAD | 1 |
p.W584R | LIHC | 1 |
p.D384H | LUAD | 1 |
p.D191N | SKCM | 1 |
p.R73Q | ESCA | 1 |
p.S560F | HNSC | 1 |
p.E537K | SKCM | 1 |
p.V659I | STAD | 1 |
p.N375D | KIRP | 1 |
p.A400T | READ | 1 |
p.C673* | BLCA | 1 |
p.C645R | ESCA | 1 |
p.W584C | BLCA | 1 |
p.E63Q | LUSC | 1 |
p.G694S | LIHC | 1 |
p.D626N | SKCM | 1 |
p.R558L | LIHC | 1 |
p.R695C | SKCM | 1 |
p.L153F | PAAD | 1 |
p.A43V | STAD | 1 |
p.E423Q | LUAD | 1 |
p.D669N | SKCM | 1 |
p.V515L | OV | 1 |
p.E597G | STAD | 1 |
p.A292T | STAD | 1 |
p.G193A | BLCA | 1 |
p.R111H | COAD | 1 |
p.R445C | STAD | 1 |
p.E336K | BLCA | 1 |
p.R403C | SKCM | 1 |
p.L26F | ESCA | 1 |
p.P228S | SKCM | 1 |
p.A832S | LIHC | 1 |
p.T672I | LGG | 1 |
p.E423K | LUSC | 1 |
p.G786E | OV | 1 |
p.R704W | LUAD | 1 |
p.T657I | HNSC | 1 |
p.T428M | LUAD | 1 |
p.A288T | UCEC | 1 |
p.R177Q | BLCA | 1 |
p.A151V | BLCA | 1 |
p.A662V | STAD | 1 |
p.A234V | COAD | 1 |
p.E537A | PRAD | 1 |
p.V301I | COAD | 1 |
p.R714L | LUAD | 1 |
p.G763E | LUAD | 1 |
p.F382L | LUSC | 1 |
p.C302Y | ESCA | 1 |
p.G356E | SKCM | 1 |
p.D447H | BLCA | 1 |
p.A516V | COAD | 1 |
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TissGeneCNV for ICAM5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ICAM5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ICAM5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ICAM5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ICAM5 |
TissGeneDrug for ICAM5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ICAM5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 2 | CTD_human |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree,CTD_human |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0010606 | Adenoid Cystic Carcinoma | 1 | BeFree |
umls:C0018671 | Head and Neck Neoplasms | 1 | BeFree |
umls:C0019196 | Hepatitis C | 1 | GAD |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | GAD |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree,GAD |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C3875321 | Inflammatory dermatosis | 1 | GWASCAT |