TissGeneSummary for CRISP2 |
Gene summary |
Basic gene information | Gene symbol | CRISP2 |
Gene name | cysteine-rich secretory protein 2 | |
Synonyms | CRISP-2|CT36|GAPDL5|TPX1|TSP1 | |
Cytomap | UCSC genome browser: 6p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001142407.2, NM_001142408.2,NM_001142417.2,NM_001142435.2,NM_001261822.1, NM_003296.3, | |
Description | cancer/testis antigen 36glyceraldehyde-3-phosphate dehydrogenase-like 5testis specific protein 1 (probe H4-1 p3-1)testis-specific protein TPX-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 187430 | |
HGNC : HGNC | ||
Ensembl : ENSG00000124490 | ||
HPRD : 01758 | ||
Vega : OTTHUMG00000014822 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CRISP2 | |
BioGPS: 7180 | ||
Pathway | NCI Pathway Interaction Database: CRISP2 | |
KEGG: CRISP2 | ||
REACTOME: CRISP2 | ||
Pathway Commons: CRISP2 | ||
Context | iHOP: CRISP2 | |
ligand binding site mutation search in PubMed: CRISP2 | ||
UCL Cancer Institute: CRISP2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CRISP2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CRISP2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.347071563 | 0.297376437 | -2.644448 | 1.31E-08 | 6.81E-08 |
KIRC | -2.416705119 | 0.539601826 | -2.956306944 | 3.19E-31 | 6.74E-30 |
HNSC | -2.243557703 | 0.480581832 | -2.724139535 | 2.19E-08 | 2.43E-07 |
LUSC | -1.188672112 | 0.921980829 | -2.110652941 | 8.79E-07 | 2.22E-06 |
KIRP | -2.283921438 | 0.650397312 | -2.93431875 | 6.07E-14 | 1.26E-12 |
PRAD | -0.236657255 | 1.388575437 | -1.625232692 | 6.92E-05 | 0.000301707 |
LUAD | -0.667651287 | 0.927203885 | -1.594855172 | 7.55E-05 | 0.000194875 |
Top |
TissGene-miRNA for CRISP2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CRISP2 |
TissGeneSNV for CRISP2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E230K | SKCM | 4 |
p.D84N | SKCM | 3 |
p.S216F | SKCM | 2 |
p.L98F | SKCM | 2 |
p.S108Y | LUAD | 2 |
p.G21E | SKCM | 2 |
p.S204I | LUSC | 1 |
p.K22* | SKCM | 1 |
p.Y164D | CESC | 1 |
p.L210I | UCEC | 1 |
p.W63X | STAD | 1 |
p.E117K | COAD | 1 |
p.R88H | LUAD | 1 |
p.G135E | SKCM | 1 |
p.D120N | SKCM | 1 |
p.L210I | ACC | 1 |
p.D116E | LUAD | 1 |
p.G191R | SKCM | 1 |
p.R88H | BLCA | 1 |
p.Q168H | LUSC | 1 |
p.S144L | SKCM | 1 |
p.A234D | COAD | 1 |
p.T181A | CESC | 1 |
p.R88S | LUAD | 1 |
p.R73T | HNSC | 1 |
p.N131S | DLBC | 1 |
p.Y165C | LUAD | 1 |
p.E226* | LUAD | 1 |
p.Y165N | THCA | 1 |
p.E20D | SKCM | 1 |
p.K22X | SKCM | 1 |
p.L119Q | SKCM | 1 |
p.S212R | HNSC | 1 |
p.V122L | PRAD | 1 |
p.S113R | OV | 1 |
p.T11S | LUAD | 1 |
p.E66D | LUAD | 1 |
p.W63* | STAD | 1 |
p.E86Q | LUAD | 1 |
p.W142C | HNSC | 1 |
p.M61_splice | LUSC | 1 |
p.G186E | SKCM | 1 |
p.G124S | SKCM | 1 |
p.G191S | UCEC | 1 |
p.T79A | KIRC | 1 |
p.A19V | COAD | 1 |
p.P15Q | LUAD | 1 |
p.P54L | KIRP | 1 |
p.A19P | LUAD | 1 |
p.E46K | SKCM | 1 |
p.P5L | LUSC | 1 |
p.P171S | SKCM | 1 |
p.P15T | LUAD | 1 |
p.C236F | LUAD | 1 |
Top |
TissGeneCNV for CRISP2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CRISP2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CRISP2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CRISP2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CRISP2 |
TissGeneDrug for CRISP2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CRISP2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 5 | BeFree |
umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
umls:C0028754 | Obesity | 3 | BeFree |
umls:C0699790 | Colon Carcinoma | 3 | BeFree |
umls:C1519670 | Tumor Angiogenesis | 3 | BeFree |
umls:C0001430 | Adenoma | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0017601 | Glaucoma | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0018801 | Heart failure | 2 | BeFree |
umls:C0018802 | Congestive heart failure | 2 | BeFree |
umls:C0021364 | Male infertility | 2 | BeFree,GAD |
umls:C0022116 | Ischemia | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 2 | BeFree |
umls:C0003857 | Congenital arteriovenous malformation | 1 | BeFree |
umls:C0003864 | Arthritis | 1 | BeFree |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0011644 | Scleroderma | 1 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0017075 | Ganglioneuroma | 1 | BeFree |
umls:C0018889 | Helminthiasis | 1 | BeFree |
umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
umls:C0023652 | Lichen Sclerosus et Atrophicus | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0028945 | oligodendroglioma | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0029928 | Ovarian Diseases | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0034155 | Purpura, Thrombotic Thrombocytopenic | 1 | BeFree |
umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0156259 | Hypertrophy of kidney | 1 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
umls:C0238190 | Inclusion Body Myositis (disorder) | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C0278883 | Metastatic melanoma | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0334590 | Anaplastic Oligodendroglioma | 1 | BeFree |
umls:C0595936 | Aqueous Humor Disorders | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
umls:C0751713 | Inclusion Body Myopathy, Sporadic | 1 | BeFree |
umls:C0812413 | Malignant Pleural Mesothelioma | 1 | BeFree |
umls:C1318485 | Liver regeneration disorder | 1 | BeFree |
umls:C1335110 | Oligodendroglial Neoplasm | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1510885 | Angiogenic Switch | 1 | BeFree |
umls:C1704436 | Peripheral Arterial Diseases | 1 | BeFree |
umls:C2584778 | Thrombotic thrombocytopenic purpura, acquired | 1 | BeFree |