TissGeneSummary for C6 |
Gene summary |
Basic gene information | Gene symbol | C6 |
Gene name | complement component 6 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 5p13 | |
Type of gene | protein-coding | |
RefGenes | NM_000065.3, NM_001115131.2, | |
Description | complement component C6 | |
Modification date | 20141221 | |
dbXrefs | MIM : 217050 | |
HGNC : HGNC | ||
Ensembl : ENSG00000039537 | ||
HPRD : 01956 | ||
Vega : OTTHUMG00000094781 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C6 | |
BioGPS: 729 | ||
Pathway | NCI Pathway Interaction Database: C6 | |
KEGG: C6 | ||
REACTOME: C6 | ||
Pathway Commons: C6 | ||
Context | iHOP: C6 | |
ligand binding site mutation search in PubMed: C6 | ||
UCL Cancer Institute: C6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of C6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BLCA | -3.694431857 | -1.020579225 | -2.673852632 | 2.77E-06 | 7.39E-05 |
PRAD | -2.753249671 | -1.571111209 | -1.182138462 | 8.90E-06 | 5.04E-05 |
HNSC | -3.259640547 | -0.245756826 | -3.013883721 | 2.29E-10 | 4.33E-09 |
LUSC | -2.269773653 | 2.510130269 | -4.779903922 | 2.96E-21 | 4.11E-20 |
LIHC | 7.609701406 | 10.07293941 | -2.463238 | 1.92E-12 | 3.58E-11 |
BRCA | -1.026939752 | 1.931898845 | -2.958838596 | 2.64E-16 | 1.49E-15 |
THCA | -3.102892696 | 0.285144593 | -3.388037288 | 1.53E-23 | 1.30E-21 |
LUAD | -0.46140418 | 2.598504441 | -3.059908621 | 1.95E-10 | 1.12E-09 |
ESCA | -2.425208412 | 1.676218861 | -4.101427273 | 0.00105 | 0.015163636 |
COAD | -2.491999671 | -0.529541978 | -1.962457692 | 3.62E-05 | 0.000146336 |
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TissGene-miRNA for C6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C6 |
TissGeneSNV for C6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R145C | SKCM | 6 |
p.E871K | SKCM | 4 |
p.S836F | SKCM | 4 |
p.E170K | SKCM | 3 |
p.R356Q | SKCM | 3 |
p.S853L | SKCM | 3 |
p.E265K | SKCM | 3 |
p.S584L | UCEC | 2 |
p.S671L | SKCM | 2 |
p.R587Q | SKCM | 2 |
p.W32X | SKCM | 2 |
p.W32* | SKCM | 2 |
p.Q887E | SKCM | 2 |
p.P89L | SKCM | 2 |
p.D257N | SKCM | 2 |
p.S584L | SKCM | 2 |
p.R182Q | SKCM | 2 |
p.G42R | SKCM | 2 |
p.P592S | SKCM | 2 |
p.E58K | SKCM | 2 |
p.K817T | STAD | 2 |
p.G892R | SKCM | 2 |
p.S432L | SKCM | 2 |
p.E478K | SKCM | 2 |
p.Q719* | SKCM | 2 |
p.R289K | SKCM | 2 |
p.R587Q | READ | 1 |
p.R145P | LUSC | 1 |
p.E844D | LUAD | 1 |
p.S742T | OV | 1 |
p.V208I | SKCM | 1 |
p.F254L | UCEC | 1 |
p.N388T | ESCA | 1 |
p.P636L | HNSC | 1 |
p.G781R | HNSC | 1 |
p.D689H | BLCA | 1 |
p.P282L | SKCM | 1 |
p.D248Y | LUSC | 1 |
p.K18N | LUAD | 1 |
p.R723K | SKCM | 1 |
p.R205I | LUAD | 1 |
p.A119T | HNSC | 1 |
p.G846D | CESC | 1 |
p.Q694L | ESCA | 1 |
p.E385K | SKCM | 1 |
p.L345M | BLCA | 1 |
p.R531Q | SKCM | 1 |
p.L345V | LUSC | 1 |
p.L353S | STAD | 1 |
p.E538K | HNSC | 1 |
p.E265X | COAD | 1 |
p.G735S | HNSC | 1 |
p.N343I | SKCM | 1 |
p.S260Y | UCEC | 1 |
p.P527T | LUSC | 1 |
p.A815S | LUAD | 1 |
p.Y230S | KIRC | 1 |
p.R48G | HNSC | 1 |
p.E394K | SKCM | 1 |
p.H364N | LUAD | 1 |
p.S573F | SKCM | 1 |
p.W845* | SARC | 1 |
p.L261I | THYM | 1 |
p.R150G | BLCA | 1 |
p.R104I | BRCA | 1 |
p.S556Y | LUAD | 1 |
p.L7F | LGG | 1 |
p.G549S | SKCM | 1 |
p.S370F | SKCM | 1 |
p.R445* | SKCM | 1 |
p.K817R | OV | 1 |
p.L353F | SKCM | 1 |
p.E384A | KIRP | 1 |
p.G149S | KIRC | 1 |
p.V416M | PAAD | 1 |
p.G901E | SKCM | 1 |
p.M320T | UCEC | 1 |
p.Q63H | PRAD | 1 |
p.W29* | SKCM | 1 |
p.V374L | LUAD | 1 |
p.R849K | SKCM | 1 |
p.N855D | LGG | 1 |
p.A2T | COAD | 1 |
p.E242Q | LUAD | 1 |
p.K763E | SARC | 1 |
p.E729K | PRAD | 1 |
p.R407C | CESC | 1 |
p.K219E | LUSC | 1 |
p.G372E | SKCM | 1 |
p.D558N | BRCA | 1 |
p.C39Y | LUSC | 1 |
p.Q777H | BLCA | 1 |
p.K582R | HNSC | 1 |
p.K328* | CESC | 1 |
p.V239G | PAAD | 1 |
p.R445X | READ | 1 |
p.E925K | SKCM | 1 |
p.D53Y | KIRP | 1 |
p.G748R | LUSC | 1 |
p.C420* | LUSC | 1 |
p.S290I | LUSC | 1 |
p.C919* | LUSC | 1 |
p.W870X | SKCM | 1 |
p.Y581C | READ | 1 |
p.C146S | HNSC | 1 |
p.S561F | SKCM | 1 |
p.P186L | SKCM | 1 |
p.E588* | UCEC | 1 |
p.N296I | SKCM | 1 |
p.Y56* | LUAD | 1 |
p.P649S | HNSC | 1 |
p.N893I | SKCM | 1 |
p.A456S | THYM | 1 |
p.D376N | SKCM | 1 |
p.P532S | STAD | 1 |
p.Y868* | LUAD | 1 |
p.S878F | SKCM | 1 |
p.E762K | SKCM | 1 |
p.G863A | BLCA | 1 |
p.G114R | SKCM | 1 |
p.E136* | LUAD | 1 |
p.M193I | PRAD | 1 |
p.S794N | SKCM | 1 |
p.R495K | SKCM | 1 |
p.G840S | OV | 1 |
p.K330N | HNSC | 1 |
p.V664G | SKCM | 1 |
p.G536R | SKCM | 1 |
p.C526* | LUAD | 1 |
p.T674N | LUSC | 1 |
p.N350T | UCEC | 1 |
p.A500E | STAD | 1 |
p.P204S | SKCM | 1 |
p.E513* | HNSC | 1 |
p.S758C | SKCM | 1 |
p.R4C | STAD | 1 |
p.S440F | UCEC | 1 |
p.P480S | SKCM | 1 |
p.T674I | SKCM | 1 |
p.D558Y | PAAD | 1 |
p.L635F | SKCM | 1 |
p.D249N | LUAD | 1 |
p.S856N | SKCM | 1 |
p.P649L | SKCM | 1 |
p.G88E | CESC | 1 |
p.F124Y | KIRP | 1 |
p.G915R | SKCM | 1 |
p.L884F | ACC | 1 |
p.S45N | STAD | 1 |
p.R145H | HNSC | 1 |
p.H47Q | THCA | 1 |
p.R289K | STAD | 1 |
p.E136* | HNSC | 1 |
p.R587* | LGG | 1 |
p.G452E | DLBC | 1 |
p.R508S | LUSC | 1 |
p.R108H | DLBC | 1 |
p.D839N | SKCM | 1 |
p.G930E | SKCM | 1 |
p.G840D | SKCM | 1 |
p.R606X | PRAD | 1 |
p.P204L | UCEC | 1 |
p.T576P | OV | 1 |
p.P95T | LUSC | 1 |
p.R600C | READ | 1 |
p.R145C | COAD | 1 |
p.R171S | SARC | 1 |
p.P188L | SKCM | 1 |
p.T363A | PAAD | 1 |
p.L386Q | KIRP | 1 |
p.V337D | HNSC | 1 |
p.R606* | PRAD | 1 |
p.N162H | COAD | 1 |
p.D809N | SKCM | 1 |
p.T327M | COAD | 1 |
p.G566R | UCEC | 1 |
p.E466K | SKCM | 1 |
p.G262E | SKCM | 1 |
p.A396S | SARC | 1 |
p.P346L | SKCM | 1 |
p.T226K | LUSC | 1 |
p.E913* | UCEC | 1 |
p.G915X | SKCM | 1 |
p.R445X | SKCM | 1 |
p.V51L | COAD | 1 |
p.R77K | LUAD | 1 |
p.W29X | SKCM | 1 |
p.L534I | LUAD | 1 |
p.G915E | SKCM | 1 |
p.G42E | SKCM | 1 |
p.W472L | PRAD | 1 |
p.L540R | LUAD | 1 |
p.P498S | SKCM | 1 |
p.S272* | UCEC | 1 |
p.G174W | LUAD | 1 |
p.K706N | ESCA | 1 |
p.P520S | BLCA | 1 |
p.R504W | PRAD | 1 |
p.G840D | PAAD | 1 |
p.P126A | SKCM | 1 |
p.I152V | GBM | 1 |
p.S311Y | UCEC | 1 |
p.N893K | LUAD | 1 |
p.D869Y | LUAD | 1 |
p.G690E | SKCM | 1 |
p.R587L | HNSC | 1 |
p.E588Q | KIRC | 1 |
p.D210H | BLCA | 1 |
p.R596Q | SKCM | 1 |
p.D626N | SKCM | 1 |
p.P489H | HNSC | 1 |
p.E762K | COAD | 1 |
p.G915* | SKCM | 1 |
p.C888* | LUSC | 1 |
p.I926M | HNSC | 1 |
p.P79L | SKCM | 1 |
p.S260Y | READ | 1 |
p.D696G | DLBC | 1 |
p.P929S | SKCM | 1 |
p.L775Q | LUAD | 1 |
p.E242Q | ESCA | 1 |
p.V243_splice | LUSC | 1 |
p.Q49E | HNSC | 1 |
p.C880S | HNSC | 1 |
p.E848Q | BLCA | 1 |
p.E711K | SKCM | 1 |
p.E458K | SKCM | 1 |
p.K67N | BRCA | 1 |
p.G930R | LUAD | 1 |
p.Q76* | UCEC | 1 |
p.C140X | ESCA | 1 |
p.K923Q | LUAD | 1 |
p.T252R | LUSC | 1 |
p.Q719X | SKCM | 1 |
p.F60I | STAD | 1 |
p.T702M | COAD | 1 |
p.K817T | COAD | 1 |
p.E913K | SKCM | 1 |
p.K477R | STAD | 1 |
p.R508S | ESCA | 1 |
p.R918I | READ | 1 |
p.G892E | SKCM | 1 |
p.G452R | SKCM | 1 |
p.D248N | SKCM | 1 |
p.W751X | SKCM | 1 |
p.R356Q | UCEC | 1 |
p.M630I | SKCM | 1 |
p.S449N | SKCM | 1 |
p.N296K | SKCM | 1 |
p.R77K | SKCM | 1 |
p.D626Y | COAD | 1 |
p.E242_splice | LUSC | 1 |
p.E790D | SKCM | 1 |
p.D558E | SKCM | 1 |
p.R841H | UCEC | 1 |
p.P186T | THYM | 1 |
p.D809N | STAD | 1 |
p.W870* | SKCM | 1 |
p.R596* | BRCA | 1 |
p.P525S | SKCM | 1 |
p.C919F | LUAD | 1 |
p.D359H | CESC | 1 |
p.S383G | SKCM | 1 |
p.H198Y | SKCM | 1 |
p.R587* | HNSC | 1 |
p.E161K | SKCM | 1 |
p.M900I | SKCM | 1 |
p.K503T | UCEC | 1 |
p.R841H | BRCA | 1 |
p.E486D | HNSC | 1 |
p.G546S | SKCM | 1 |
p.D376N | BLCA | 1 |
p.G276R | SKCM | 1 |
p.W751* | SKCM | 1 |
p.T226K | ESCA | 1 |
p.S470F | SKCM | 1 |
p.L209F | SKCM | 1 |
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TissGeneCNV for C6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE764210 | C6-HUWE1 | chr5:41153974 | chrX:53621462 | |
Chimerdb3.0 | ChiTaRs | NA | BE388029 | C6-MRPL14 | chr5:41154083 | chr6:44081594 |
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TissGeneNet for C6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C6 |
TissGeneDrug for C6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006663 | Calcinosis | 1 | CTD_human |
umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | RGD |
umls:C0017658 | Glomerulonephritis | 1 | RGD |
umls:C0018824 | Heart valve disease | 1 | CTD_human |
umls:C0022661 | Kidney Failure, Chronic | 1 | RGD |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
umls:C0024535 | Malaria, Falciparum | 1 | GAD |
umls:C0033687 | Proteinuria | 1 | RGD |
umls:C0242383 | Age related macular degeneration | 1 | GAD |
umls:C0243026 | Sepsis | 1 | RGD |
umls:C0752087 | Myasthenia Gravis, Autoimmune, Experimental | 1 | RGD |
umls:C2676232 | Complement Component 6 Deficiency | 1 | BeFree,CLINVAR,CTD_human |
umls:C3714514 | Infection | 1 | LHGDN |
umls:C2676233 | C6 Deficiency, Subtotal | 0 | CLINVAR |