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| TissGeneSummary for TYRP1 |
 Gene summary |
| Basic gene information | Gene symbol | TYRP1 |
| Gene name | tyrosinase-related protein 1 | |
| Synonyms | CAS2|CATB|GP75|OCA3|TRP|TRP1|TYRP|b-PROTEIN | |
| Cytomap | UCSC genome browser: 9p23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000550.2, | |
| Description | 5,6-dihydroxyindole-2-carboxylic acid oxidaseDHICA oxidasecatalase Bglycoprotein 75melanoma antigen gp75 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 115501 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000107165 | ||
| HPRD : 00283 | ||
| Vega : OTTHUMG00000021034 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TYRP1 | |
| BioGPS: 7306 | ||
| Pathway | NCI Pathway Interaction Database: TYRP1 | |
| KEGG: TYRP1 | ||
| REACTOME: TYRP1 | ||
| Pathway Commons: TYRP1 | ||
| Context | iHOP: TYRP1 | |
| ligand binding site mutation search in PubMed: TYRP1 | ||
| UCL Cancer Institute: TYRP1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMUVM | |
| Reference showing the relevant tissue of TYRP1 | ||
| Description by TissGene annotations | Protective TissGene in RFS Cancer gene Have significant anti-correlated miRNA TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TYRP1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.935640831 | 3.132291812 | -2.19665098 | 1.59E-11 | 6.49E-11 |
| LUAD | 0.959833495 | 2.964619702 | -2.004786207 | 7.94E-11 | 4.80E-10 |
| BRCA | -0.991339251 | -2.407462058 | 1.416122807 | 6.88E-10 | 2.48E-09 |
| KICH | -2.154751953 | 4.896080047 | -7.050832 | 2.08E-21 | 1.91E-19 |
| KIRC | -2.496469953 | 4.51581338 | -7.012283333 | 1.27E-52 | 1.58E-50 |
| KIRP | -1.913401203 | 4.606742547 | -6.52014375 | 1.37E-23 | 1.28E-21 |
| STAD | 2.005001922 | 0.758198797 | 1.246803125 | 0.00731 | 0.026602249 |
| LIHC | -1.358403953 | -2.808523953 | 1.45012 | 0.00024 | 0.000758236 |
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| TissGene-miRNA for TYRP1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-382-3p | MIMAT0022697 | 0.02 | -0.32 | 56 |
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| TissGeneMut for TYRP1 |
| TissGeneSNV for TYRP1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R87W | STAD | 2 |
| p.G254W | PRAD | 1 |
| p.F105L | READ | 1 |
| p.V189F | COAD | 1 |
| p.R55H | OV | 1 |
| p.D397Y | HNSC | 1 |
| p.P395Q | KIRP | 1 |
| p.N385D | LUAD | 1 |
| p.A523T | UCEC | 1 |
| p.H377N | SKCM | 1 |
| p.L265F | PAAD | 1 |
| p.E465K | LUSC | 1 |
| p.N175I | SKCM | 1 |
| p.E338K | SKCM | 1 |
| p.I466T | SKCM | 1 |
| p.L158F | STAD | 1 |
| p.G300* | UCEC | 1 |
| p.L376I | SARC | 1 |
| p.T450A | KIRC | 1 |
| p.W286* | BRCA | 1 |
| p.P398L | HNSC | 1 |
| p.G10C | COAD | 1 |
| p.R502C | READ | 1 |
| p.R73Q | COAD | 1 |
| p.T253R | UCEC | 1 |
| p.A430V | UCEC | 1 |
| p.L379F | ESCA | 1 |
| p.E140D | SKCM | 1 |
| p.R130M | LUAD | 1 |
| p.G388W | LUAD | 1 |
| p.S292F | SKCM | 1 |
| p.R146Q | CESC | 1 |
| p.E428K | HNSC | 1 |
| p.V333I | LGG | 1 |
| p.L246I | ESCA | 1 |
| p.P346H | UCEC | 1 |
| p.K152R | SKCM | 1 |
| p.G171E | KICH | 1 |
| p.P115A | KIRP | 1 |
| p.G103C | LUAD | 1 |
| p.D370G | ACC | 1 |
| p.Q467K | UCEC | 1 |
| p.L6H | STAD | 1 |
| p.I432V | LGG | 1 |
| p.Y296D | SKCM | 1 |
| p.V89D | DLBC | 1 |
| p.R55H | STAD | 1 |
| p.S137N | SKCM | 1 |
| p.R374X | READ | 1 |
| p.D308V | BLCA | 1 |
| p.T69A | UCEC | 1 |
| p.V203L | BRCA | 1 |
| p.A486T | COAD | 1 |
| p.G461* | LUAD | 1 |
| p.G209C | LUSC | 1 |
| p.T176M | THCA | 1 |
| p.V339I | BRCA | 1 |
| Top |
| TissGeneCNV for TYRP1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for TYRP1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0D0-01A | RALGPS1-TYRP1 | CDS-5UTR | Chr9:129728230 | Chr9:12693912 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0SX-01A | C9orf150-TYRP1 | CDS-5UTR | Chr9:12776026 | Chr9:12693912 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-OL-A5RY-01A | ACO1-TYRP1 | 5UTR-5UTR | Chr9:32384733 | Chr9:12693912 |
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| TissGeneNet for TYRP1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (tumor) | TYRP1, GIPC1, CTNNB1, MITF, TYR, OTX1 (normal) |
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| TissGeneProg for TYRP1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for TYRP1 |
| TissGeneDrug for TYRP1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TYRP1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025202 | melanoma | 37 | BeFree,GAD,LHGDN |
| umls:C0078918 | Albinism, Oculocutaneous | 19 | BeFree,GAD,LHGDN |
| umls:C0001916 | Albinism | 7 | BeFree |
| umls:C0026010 | Microphthalmos | 5 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 5 | BeFree,GAD |
| umls:C0042900 | Vitiligo | 5 | BeFree |
| umls:C0078917 | Albinism, Ocular | 5 | BeFree,LHGDN |
| umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 5 | BeFree |
| umls:C2931599 | Oculocutaneous albinism type 3 | 5 | BeFree,CTD_human,ORPHANET |
| umls:C0162835 | Hypopigmentation disorder | 4 | BeFree |
| umls:C0342683 | ALBINISM, OCULOCUTANEOUS, TYPE III | 4 | BeFree,ORPHANET,UNIPROT |
| umls:C0023264 | Leigh Disease | 3 | BeFree |
| umls:C0151779 | Cutaneous Melanoma | 3 | BeFree |
| umls:C0004096 | Asthma | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0007117 | Basal cell carcinoma | 2 | GAD |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,GAD |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
| umls:C0008354 | Cholera | 2 | BeFree |
| umls:C0017601 | Glaucoma | 2 | BeFree |
| umls:C0017668 | Focal glomerulosclerosis | 2 | BeFree |
| umls:C0020597 | Hypobetalipoproteinemias | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | BeFree |
| umls:C0022680 | Polycystic Kidney Diseases | 2 | BeFree |
| umls:C0035304 | Retinal Degeneration | 2 | BeFree |
| umls:C0037286 | Skin Neoplasms | 2 | GAD |
| umls:C0079504 | Hermanski-Pudlak Syndrome | 2 | BeFree |
| umls:C0085413 | Polycystic Kidney, Autosomal Dominant | 2 | BeFree |
| umls:C0153687 | Secondary malignant neoplasm of skin | 2 | BeFree |
| umls:C0162670 | Mitochondrial Myopathies | 2 | BeFree |
| umls:C0206735 | Melanoma, Amelanotic | 2 | BeFree,LHGDN |
| umls:C0220633 | Uveal melanoma | 2 | BeFree |
| umls:C0238286 | Mucolipidosis Type IV | 2 | BeFree |
| umls:C0242994 | Hantavirus Infections | 2 | BeFree |
| umls:C0268495 | Oculocutaneous albinism type 2 | 2 | BeFree |
| umls:C0268497 | Brown oculocutaneous albinism | 2 | BeFree |
| umls:C0278883 | Metastatic melanoma | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1402294 | Primary Lesion | 2 | BeFree |
| umls:C1519680 | Tumor Immunity | 2 | BeFree |
| umls:C1720983 | Channelopathies | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | CTD_human |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0004565 | Melanoma, B16 | 1 | BeFree |
| umls:C0005694 | Bladder neck obstruction | 1 | BeFree |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007965 | Chediak-Higashi Syndrome | 1 | BeFree |
| umls:C0010200 | Coughing | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0022078 | Iris Diseases | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | CTD_human |
| umls:C0026269 | Mitral Valve Stenosis | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0028043 | Nicotine Dependence | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0033375 | Prolactinoma | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0035369 | Retroviridae Infections | 1 | BeFree |
| umls:C0036651 | Senile lentigo | 1 | BeFree |
| umls:C0040147 | Thyroiditis | 1 | BeFree |
| umls:C0087012 | Ataxia, Spinocerebellar | 1 | BeFree |
| umls:C0149931 | Migraine Disorders | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0205711 | Pelizaeus-Merzbacher Disease | 1 | BeFree |
| umls:C0268731 | Renal glomerular disease | 1 | BeFree |
| umls:C0272138 | Erythroblastosis | 1 | BeFree |
| umls:C0282488 | Interstitial Cystitis | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0338480 | Common Migraine | 1 | BeFree |
| umls:C0342158 | Hypothyroidism, Autoimmune | 1 | BeFree |
| umls:C0496836 | Malignant tumor of eye | 1 | BeFree |
| umls:C0549567 | Pigmentation Disorders | 1 | BeFree |
| umls:C0600040 | Chronic interstitial cystitis | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0728936 | Disorder of circulatory system | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1285162 | Degenerative disorder | 1 | BeFree |
| umls:C1334170 | indolent lymphoma | 1 | BeFree |
| umls:C1511291 | Breast Cancer Model | 1 | BeFree |
| umls:C1846058 | Lubs X-linked mental retardation syndrome | 1 | BeFree |
| umls:C1876214 | ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT | 1 | BeFree |
| umls:C2677086 | Skin/Hair/Eye Pigmentation, Variation In, 11 | 0 | CLINVAR |
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