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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for UMOD
check button Gene summary
Basic gene informationGene symbolUMOD
Gene nameuromodulin
SynonymsADMCKD2|FJHN|HNFJ|HNFJ1|MCKD2|THGP|THP
CytomapUCSC genome browser: 16p12.3
Type of geneprotein-coding
RefGenesNM_001008389.2,
NM_001278614.1,NM_003361.3,
DescriptionTamm-Horsfall urinary glycoproteinuromucoid
Modification date20141219
dbXrefs MIM : 191845
HGNC : HGNC
Ensembl : ENSG00000169344
HPRD : 11771
Vega : OTTHUMG00000131488
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UMOD
BioGPS: 7369
PathwayNCI Pathway Interaction Database: UMOD
KEGG: UMOD
REACTOME: UMOD
Pathway Commons: UMOD
ContextiHOP: UMOD
ligand binding site mutation search in PubMed: UMOD
UCL Cancer Institute: UMOD
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of UMODIntegrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection. J Am Soc Nephrol. 2010 Apr;21(4):646-53. (pmid:20150539)
go to article
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules20798515
GO:0007159leukocyte cell-cell adhesion20798515
GO:1990266neutrophil migration20798515
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules20798515
GO:0007159leukocyte cell-cell adhesion20798515
GO:1990266neutrophil migration20798515


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TissGeneExp for UMOD

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRP1.99155313114.72282813-12.7312751.48E-338.30E-31
KICH-0.15900611914.81658988-14.9755964.48E-282.47E-25
KIRC1.25122743614.39036077-13.139133331.40E-491.13E-47


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TissGene-miRNA for UMOD

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for UMOD
TissGeneSNV for UMOD

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S360FSKCM2
p.A400VUCEC1
p.L94MLUAD1
p.P105SSKCM1
p.P466TLUAD1
p.N600ILUAD1
p.R449KSKCM1
p.Q20*HNSC1
p.L670VLUAD1
p.Q557*SKCM1
p.R459WSTAD1
p.D177GESCA1
p.N371KGBM1
p.F581LSKCM1
p.D144GESCA1
p.D388NUVM1
p.K610RHNSC1
p.R482KSKCM1
p.E430GHNSC1
p.S619RBRCA1
p.S513FHNSC1
p.L382MUCEC1
p.G452RCOAD1
p.D229NESCA1
p.E48QBLCA1
p.V477MLUAD1
p.P499TLUAD1
p.D376YBRCA1
p.R531*BLCA1
p.D355NREAD1
p.R418QPAAD1
p.D338YLUAD1
p.Y286*LUAD1
p.N633DHNSC1
p.D196NESCA1
p.D259GUCEC1
p.G484VLUAD1
p.R415CUCEC1
p.S509FSKCM1
p.P474TLUAD1
p.M442TKIRC1
p.S480FHNSC1
p.T394MSTAD1
p.S39AKIRC1
p.D355NUVM1
p.S618NUCEC1
p.T394MPAAD1
p.A23VUCEC1
p.C69XESCA1
p.P441TLUAD1
p.K577RHNSC1
p.S327FSKCM1
p.E575*LUAD1
p.V625FLUSC1
p.L349MUCEC1
p.L344PUCEC1
p.A433VUCEC1
p.G546CHNSC1
p.T40SCOAD1
p.A556GOV1
p.V80FLUAD1
p.G191ASARC1
p.A299DLUAD1
p.Y507SUCS1
p.V64MUCEC1
p.N257KLUSC1
p.R492QLUAD1
p.A438VCOAD1
p.L634FLUAD1
p.T357SLUSC1
p.G579CHNSC1
p.E54KSKCM1
p.C102*ESCA1
p.R385QPAAD1
p.P636LLUSC1
p.E129KKICH1
p.R587WSKCM1
p.L429MCOAD1
p.A471TPAAD1
p.G451VLUAD1
p.C539YBLCA1
p.E96KKICH1
p.R415CESCA1
p.R554WSKCM1
p.S33FSKCM1
p.V375LLUAD1
p.D353NSKCM1
p.V47FLUAD1
p.P466SSKCM1
p.R492WLUAD1
p.A260VSTAD1
p.Y319*LUAD1
p.T437NESCA1
p.R459WUCEC1
p.V357ISTAD1
p.R459WLUAD1
p.L406FCOAD1
p.L377PUCEC1
p.C96SLUAD1
p.N633ILUAD1
p.V276MLUAD1
p.D292NSKCM1
p.P543TBLCA1
p.T62ICOAD1
p.Y540SUCS1
p.V12ASKCM1
p.G344CLUAD1
p.T427_spliceGBM1
p.A438TPAAD1
p.P428LSKCM1
p.T234MCOAD1
p.P461LSKCM1
p.E87KSKCM1
p.R385QUCEC1
p.V510MLUAD1
p.N600DHNSC1
p.V47IESCA1
p.P499SSKCM1
p.C65FLUAD1
p.E337DSKCM1


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TissGeneCNV for UMOD

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for UMOD

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for UMOD

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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COAD (tumor)COAD (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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HNSC (tumor)HNSC (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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KICH (tumor)KICH (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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KIRC (tumor)KIRC (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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KIRP (tumor)KIRP (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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LIHC (tumor)LIHC (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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LUAD (tumor)LUAD (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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LUSC (tumor)LUSC (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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PRAD (tumor)PRAD (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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STAD (tumor)STAD (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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THCA (tumor)THCA (normal)
UMOD, LTA, IL1B, MMP8, CD83 (tumor)UMOD, LTA, IL1B, MMP8, CD83 (normal)
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TissGeneProg for UMOD

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for UMOD
TissGeneDrug for UMOD

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for UMOD

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0268113Familial juvenile gout38BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT
umls:C0022658Kidney Diseases25BeFree,CTD_human,GAD,LHGDN
umls:C1561643Chronic Kidney Diseases22BeFree,GWASCAT
umls:C0022661Kidney Failure, Chronic17BeFree,GAD
umls:C0035078Kidney Failure16BeFree
umls:C0740394Hyperuricemia14BeFree,LHGDN
umls:C1868139Medullary cystic kidney disease 113BeFree,MGD
umls:C0403447Chronic Kidney Insufficiency11BeFree,GAD
umls:C0020538Hypertensive disease10BeFree,CTD_human,GAD,GWASCAT
umls:C2316810Chronic kidney disease stage 59BeFree
umls:C0687120Nephronophthisis8BeFree
umls:C1859040Medullary Cystic Kidney Disease Type 28BeFree,CLINVAR,CTD_human,MGD,UNIPROT
umls:C0022650Kidney Calculi6BeFree,GAD
umls:C0235419Hyperuricemic nephropathy5BeFree
umls:C1565489Renal Insufficiency5BeFree
umls:C1691228Cystic Kidney Diseases4LHGDN
umls:C0003469Anxiety Disorders3BeFree
umls:C0011847Diabetes3BeFree
umls:C0011849Diabetes Mellitus3BeFree
umls:C0027707Nephritis, Interstitial3BeFree
umls:C0041349Nephritis, Tubulointerstitial3BeFree
umls:C0042029Urinary tract infection3BeFree
umls:C0010709Cyst2BeFree
umls:C0011881Diabetic Nephropathy2BeFree,GAD
umls:C0020258Hydrocephalus, Normal Pressure2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C1833683NEPHROLITHIASIS, CALCIUM OXALATE2BeFree
umls:C2919861Medullary cystic kidney disease type 12BeFree
umls:C2939174Medullary cystic disease2BeFree
umls:C0001925Albuminuria1GAD
umls:C0002986Fabry Disease1LHGDN
umls:C0003850Arteriosclerosis1BeFree
umls:C0003868Arthritis, Gouty1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree,GAD
umls:C0018099Gout1GAD
umls:C0019693HIV Infections1BeFree
umls:C0029456Osteoporosis1GAD
umls:C0041107Trisomy1BeFree
umls:C0042075Urologic Diseases1GAD
umls:C0043167Pertussis1LHGDN
umls:C0085548Autosomal Recessive Polycystic Kidney Disease1BeFree
umls:C0085580Essential Hypertension1BeFree
umls:C0221248Tophus1BeFree
umls:C0238304Chronic interstitial nephritis1BeFree
umls:C0282488Interstitial Cystitis1LHGDN
umls:C0403553Renal dysplasia and retinal aplasia (disorder)1BeFree
umls:C0431716Nephronophthisis - medullary cystic disease1BeFree
umls:C1561535Creatinine finding1GAD
umls:C1835934Glomerulocystic Kidney Disease with Hyperuricemia and Isosthenuria1CLINVAR,CTD_human,UNIPROT
umls:C1855681Nephronophthisis, familial juvenile1BeFree
umls:C36653822,8-Dihydroxyadenine Urolithiasis1BeFree