TissGeneSummary for DAGLA |
Gene summary |
Basic gene information | Gene symbol | DAGLA |
Gene name | diacylglycerol lipase, alpha | |
Synonyms | C11orf11|DAGL(ALPHA)|DAGLALPHA|NSDDR | |
Cytomap | UCSC genome browser: 11q12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_006133.2, | |
Description | DGL-alphaneural stem cell-derived dendrite regulatorsn1-specific diacylglycerol lipase alpha | |
Modification date | 20141207 | |
dbXrefs | MIM : 614015 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134780 | ||
HPRD : 07092 | ||
Vega : OTTHUMG00000168160 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DAGLA | |
BioGPS: 747 | ||
Pathway | NCI Pathway Interaction Database: DAGLA | |
KEGG: DAGLA | ||
REACTOME: DAGLA | ||
Pathway Commons: DAGLA | ||
Context | iHOP: DAGLA | |
ligand binding site mutation search in PubMed: DAGLA | ||
UCL Cancer Institute: DAGLA | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGPAAD | |
Reference showing the relevant tissue of DAGLA | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0019369 | arachidonic acid metabolic process | 14610053 | GO:0042136 | neurotransmitter biosynthetic process | 14610053 | GO:0046340 | diacylglycerol catabolic process | 14610053 | GO:0019369 | arachidonic acid metabolic process | 14610053 | GO:0042136 | neurotransmitter biosynthetic process | 14610053 | GO:0046340 | diacylglycerol catabolic process | 14610053 |
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TissGeneExp for DAGLA |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.648038105 | 1.320673895 | -1.968712 | 1.96E-06 | 7.05E-06 |
HNSC | -0.615078943 | 0.841565243 | -1.456644186 | 5.15E-07 | 4.23E-06 |
LUSC | 0.048114993 | 1.172156169 | -1.124041176 | 9.52E-10 | 3.26E-09 |
LIHC | -0.085564105 | -1.317496105 | 1.231932 | 5.97E-05 | 0.000216656 |
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TissGene-miRNA for DAGLA |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DAGLA |
TissGeneSNV for DAGLA |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S836L | SKCM | 2 |
p.R8Q | BLCA | 2 |
p.P700S | SKCM | 2 |
p.L988V | DLBC | 2 |
p.P490S | SKCM | 1 |
p.L492F | STAD | 1 |
p.L466V | LGG | 1 |
p.R91L | LUAD | 1 |
p.Y123H | PAAD | 1 |
p.R227Q | STAD | 1 |
p.A376V | STAD | 1 |
p.M447I | ESCA | 1 |
p.P870L | STAD | 1 |
p.V608M | CESC | 1 |
p.D717A | OV | 1 |
p.C293Y | LUSC | 1 |
p.R288H | PAAD | 1 |
p.S791C | SKCM | 1 |
p.Q752H | STAD | 1 |
p.G799A | OV | 1 |
p.T192S | LUAD | 1 |
p.R185S | ESCA | 1 |
p.R178W | ESCA | 1 |
p.G458C | LUAD | 1 |
p.L577M | KIRP | 1 |
p.P601Q | SKCM | 1 |
p.A452S | LUSC | 1 |
p.P418L | SKCM | 1 |
p.R311W | STAD | 1 |
p.T1004K | LIHC | 1 |
p.E415V | HNSC | 1 |
p.R227Q | DLBC | 1 |
p.A672T | PAAD | 1 |
p.L263F | LUAD | 1 |
p.R178W | STAD | 1 |
p.R185H | UCEC | 1 |
p.E664K | STAD | 1 |
p.R356L | LUAD | 1 |
p.R547* | HNSC | 1 |
p.R869W | KICH | 1 |
p.E664K | BLCA | 1 |
p.I151V | UCEC | 1 |
p.V448I | SKCM | 1 |
p.S1009N | GBM | 1 |
p.S675F | LUAD | 1 |
p.S52F | SKCM | 1 |
p.L841P | LUAD | 1 |
p.V394M | COAD | 1 |
p.I113T | LGG | 1 |
p.R892S | THYM | 1 |
p.S905L | HNSC | 1 |
p.G189S | ESCA | 1 |
p.E415Q | CESC | 1 |
p.L278F | COAD | 1 |
p.R175H | UCEC | 1 |
p.A253T | COAD | 1 |
p.E878K | SKCM | 1 |
p.R740Q | HNSC | 1 |
p.A253T | LUAD | 1 |
p.R10C | STAD | 1 |
p.G84C | ESCA | 1 |
p.V865I | STAD | 1 |
p.G1028E | STAD | 1 |
p.A219T | PRAD | 1 |
p.F916L | STAD | 1 |
p.L481F | HNSC | 1 |
p.I555T | THYM | 1 |
p.R486H | LGG | 1 |
p.Q95P | BLCA | 1 |
p.P47L | THYM | 1 |
p.A112V | SKCM | 1 |
p.L136F | SKCM | 1 |
p.R740W | PRAD | 1 |
p.R773Q | BRCA | 1 |
p.P527L | SKCM | 1 |
p.T580M | LGG | 1 |
p.P527S | SKCM | 1 |
p.R547Q | PRAD | 1 |
p.R246W | UCEC | 1 |
p.L417P | ESCA | 1 |
p.T207M | STAD | 1 |
p.R183L | UCEC | 1 |
p.P973S | SKCM | 1 |
p.R162H | SKCM | 1 |
p.R244W | SKCM | 1 |
p.E830K | SKCM | 1 |
p.R455Q | COAD | 1 |
p.D235N | UCEC | 1 |
p.R398W | SKCM | 1 |
p.G658R | SKCM | 1 |
p.R91C | SKCM | 1 |
p.P1005H | UCEC | 1 |
p.G460R | STAD | 1 |
p.R804W | STAD | 1 |
p.V117A | STAD | 1 |
p.I71V | UCEC | 1 |
p.R719C | UCEC | 1 |
p.H612P | PAAD | 1 |
p.R869P | LUSC | 1 |
p.R332G | LIHC | 1 |
p.R82H | STAD | 1 |
p.E224K | SKCM | 1 |
p.V38M | HNSC | 1 |
p.D844N | BLCA | 1 |
p.R486H | STAD | 1 |
p.F495L | SARC | 1 |
p.R416C | PAAD | 1 |
p.A353V | ESCA | 1 |
p.R961C | SKCM | 1 |
p.R804W | THCA | 1 |
p.V448A | BRCA | 1 |
p.R795H | BLCA | 1 |
p.F921I | LIHC | 1 |
p.D753H | LUAD | 1 |
p.E781D | LUAD | 1 |
p.T491N | LUAD | 1 |
p.E257K | KIRC | 1 |
p.A475T | STAD | 1 |
p.L933V | LIHC | 1 |
p.P270S | STAD | 1 |
p.H810Q | SKCM | 1 |
p.E217K | HNSC | 1 |
p.S725G | STAD | 1 |
p.A112V | SARC | 1 |
p.A351P | ESCA | 1 |
p.A508V | UCEC | 1 |
p.D209E | UCEC | 1 |
p.H48Y | LGG | 1 |
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TissGeneCNV for DAGLA |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DAGLA |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB409589 | DAGLA-DAGLA | chr11:61513568 | chr11:61514292 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-OL-A66I-01A | DAGLA-C11orf66 | CDS-5UTR | Chr11:61487722 | Chr11:61249254 |
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TissGeneNet for DAGLA |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DAGLA |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DAGLA |
TissGeneDrug for DAGLA |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DAGLA |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 1 | BeFree |