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| TissGeneSummary for WNT3 |
 Gene summary |
| Basic gene information | Gene symbol | WNT3 |
| Gene name | wingless-type MMTV integration site family, member 3 | |
| Synonyms | INT4 | |
| Cytomap | UCSC genome browser: 17q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_030753.4, | |
| Description | WNT-3 proto-oncogene proteinproto-oncogene Int-4 homologproto-oncogene Wnt-3 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 165330 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000108379 | ||
| HPRD : 01318 | ||
| Vega : OTTHUMG00000178076 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WNT3 | |
| BioGPS: 7473 | ||
| Pathway | NCI Pathway Interaction Database: WNT3 | |
| KEGG: WNT3 | ||
| REACTOME: WNT3 | ||
| Pathway Commons: WNT3 | ||
| Context | iHOP: WNT3 | |
| ligand binding site mutation search in PubMed: WNT3 | ||
| UCL Cancer Institute: WNT3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMSTAD | |
| Reference showing the relevant tissue of WNT3 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0060070 | canonical Wnt signaling pathway | 10557084 | GO:0060070 | canonical Wnt signaling pathway | 10557084 |
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| TissGeneExp for WNT3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -1.468022353 | -3.579222353 | 2.1112 | 5.14E-11 | 7.93E-10 |
| THCA | -0.466370658 | -1.716975743 | 1.250605085 | 5.22E-09 | 2.70E-08 |
| BLCA | -1.116340774 | -3.42946709 | 2.313126316 | 6.53E-07 | 2.38E-05 |
| LUAD | -0.219855111 | -1.927429249 | 1.707574138 | 2.21E-15 | 2.35E-14 |
| LUSC | -0.783948823 | -1.799695882 | 1.015747059 | 6.06E-06 | 1.41E-05 |
| KICH | -3.229324353 | -1.521480353 | -1.707844 | 0.000926 | 0.002016704 |
| ESCA | -1.254426898 | -3.343872353 | 2.089445455 | 1.70E-05 | 0.001157788 |
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| TissGene-miRNA for WNT3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for WNT3 |
| TissGeneSNV for WNT3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E271K | SKCM | 2 |
| p.P70L | SKCM | 1 |
| p.R85Q | HNSC | 1 |
| p.D236G | COAD | 1 |
| p.A223V | STAD | 1 |
| p.R195H | KICH | 1 |
| p.I94L | SKCM | 1 |
| p.W222* | ACC | 1 |
| p.R298Q | STAD | 1 |
| p.S184L | PCPG | 1 |
| p.H171N | SKCM | 1 |
| p.E171K | SKCM | 1 |
| p.A337P | STAD | 1 |
| p.E177K | COAD | 1 |
| p.N61D | GBM | 1 |
| p.E285K | UCEC | 1 |
| p.C337R | STAD | 1 |
| p.R176H | STAD | 1 |
| p.D96N | SKCM | 1 |
| p.D297N | SKCM | 1 |
| p.G231D | SKCM | 1 |
| p.A271T | SKCM | 1 |
| p.G254V | MESO | 1 |
| p.A261P | HNSC | 1 |
| p.R347C | SKCM | 1 |
| p.R57H | STAD | 1 |
| p.H94Y | SKCM | 1 |
| p.G32D | UCEC | 1 |
| p.L5M | LUSC | 1 |
| p.G294S | SKCM | 1 |
| p.L6F | UCEC | 1 |
| p.A162V | STAD | 1 |
| p.G39C | ESCA | 1 |
| p.R162L | STAD | 1 |
| p.R253* | BLCA | 1 |
| p.L31V | LUSC | 1 |
| p.G210W | ACC | 1 |
| p.G318D | HNSC | 1 |
| p.P49S | SKCM | 1 |
| p.H305Y | SKCM | 1 |
| p.A182V | SKCM | 1 |
| p.Q39X | ESCA | 1 |
| p.A70V | SKCM | 1 |
| p.E2Q | HNSC | 1 |
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| TissGeneCNV for WNT3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for WNT3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for WNT3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| COAD (tumor) | COAD (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| KICH (tumor) | KICH (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| STAD (tumor) | STAD (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| THCA (tumor) | THCA (normal) |
| WNT3, FZD1, FZD7 (tumor) | WNT3, FZD1, FZD7 (normal) |
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| TissGeneProg for WNT3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for WNT3 |
| TissGeneDrug for WNT3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for WNT3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0041296 | Tuberculosis | 7 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 6 | BeFree |
| umls:C0008924 | Cleft Lip | 3 | GAD |
| umls:C0008925 | Cleft Palate | 3 | GAD |
| umls:C0030567 | Parkinson Disease | 3 | GAD,GWASCAT |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0023343 | Leprosy | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree,LHGDN |
| umls:C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 2 | BeFree,CTD_human,LHGDN |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C2931216 | Tetra-amelia autosomal recessive | 2 | BeFree,CTD_human |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0002871 | Anemia | 1 | BeFree |
| umls:C0005689 | Bladder Exstrophy | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007570 | Celiac Disease | 1 | GAD,GWASCAT |
| umls:C0011351 | Dental Enamel Hypoplasia | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0032231 | Pleurisy | 1 | BeFree |
| umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
| umls:C0037116 | Silicosis | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
| umls:C0038868 | Progressive supranuclear palsy | 1 | GAD |
| umls:C0041326 | Pleural Tuberculosis | 1 | BeFree |
| umls:C0151699 | Intracranial Hemorrhages | 1 | GAD |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0497354 | Pleurisy with pleural effusion | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
| umls:C1838703 | Bladder Exstrophy and Epispadias Complex | 0 | CLINVAR |
| umls:C2931218 | Tetraamelia multiple malformations | 0 | ORPHANET |
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