TissGeneSummary for AGBL2 |
Gene summary |
Basic gene information | Gene symbol | AGBL2 |
Gene name | ATP/GTP binding protein-like 2 | |
Synonyms | CCP2 | |
Cytomap | UCSC genome browser: 11p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_024783.3, | |
Description | cytoplasmic carboxypeptidase 2cytosolic carboxypeptidase 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000165923 | ||
HPRD : 08039 | ||
Vega : OTTHUMG00000165368 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AGBL2 | |
BioGPS: 79841 | ||
Pathway | NCI Pathway Interaction Database: AGBL2 | |
KEGG: AGBL2 | ||
REACTOME: AGBL2 | ||
Pathway Commons: AGBL2 | ||
Context | iHOP: AGBL2 | |
ligand binding site mutation search in PubMed: AGBL2 | ||
UCL Cancer Institute: AGBL2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of AGBL2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for AGBL2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.185755694 | -0.263903694 | -1.921852 | 1.26E-11 | 1.18E-10 |
STAD | -1.149087694 | -2.200462694 | 1.051375 | 0.000733 | 0.004162922 |
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TissGene-miRNA for AGBL2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AGBL2 |
TissGeneSNV for AGBL2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P463H | MESO | 1 |
p.P414L | SKCM | 1 |
p.C420F | LUSC | 1 |
p.R159C | STAD | 1 |
p.K652R | UCEC | 1 |
p.V156E | LUAD | 1 |
p.R879G | STAD | 1 |
p.H645Q | BLCA | 1 |
p.S831L | HNSC | 1 |
p.G223R | SKCM | 1 |
p.E800D | READ | 1 |
p.C855* | HNSC | 1 |
p.I80M | ESCA | 1 |
p.R576S | OV | 1 |
p.G223E | SKCM | 1 |
p.L457F | LUSC | 1 |
p.M336T | UCEC | 1 |
p.L149I | BLCA | 1 |
p.L552M | UCEC | 1 |
p.N432T | KIRP | 1 |
p.Y901H | LUAD | 1 |
p.D230Y | PAAD | 1 |
p.T378M | LUAD | 1 |
p.M671I | COAD | 1 |
p.R685* | STAD | 1 |
p.L728V | HNSC | 1 |
p.A411P | ACC | 1 |
p.R308C | SKCM | 1 |
p.G655S | SKCM | 1 |
p.R512W | UCEC | 1 |
p.K858N | OV | 1 |
p.P175S | UCEC | 1 |
p.H558Y | SKCM | 1 |
p.Q89K | CHOL | 1 |
p.M21I | BRCA | 1 |
p.T321I | SKCM | 1 |
p.Q404L | HNSC | 1 |
p.E547K | HNSC | 1 |
p.C571F | LUAD | 1 |
p.M770R | STAD | 1 |
p.I492V | UCEC | 1 |
p.N768H | STAD | 1 |
p.D386N | LUAD | 1 |
p.P793Q | ESCA | 1 |
p.L662I | CHOL | 1 |
p.K361R | STAD | 1 |
p.A891V | PAAD | 1 |
p.I169V | LGG | 1 |
p.T43M | HNSC | 1 |
p.G335W | HNSC | 1 |
p.W353X | PCPG | 1 |
p.P52H | PAAD | 1 |
p.V508A | UCEC | 1 |
p.G210E | SKCM | 1 |
p.A888V | STAD | 1 |
p.E649K | SKCM | 1 |
p.P199L | SKCM | 1 |
p.E800D | COAD | 1 |
p.K63R | LGG | 1 |
p.G468C | STAD | 1 |
p.E74* | UCEC | 1 |
p.R349H | COAD | 1 |
p.Q802H | BRCA | 1 |
p.W353* | PCPG | 1 |
p.F20C | PAAD | 1 |
p.R48Q | SKCM | 1 |
p.A593V | LGG | 1 |
p.D778Y | LUAD | 1 |
p.V334L | STAD | 1 |
p.E203Q | HNSC | 1 |
p.L66F | BRCA | 1 |
p.T43M | STAD | 1 |
p.V225I | BLCA | 1 |
p.K49E | UCEC | 1 |
p.E235Q | BLCA | 1 |
p.P442S | SKCM | 1 |
p.G622V | LUSC | 1 |
p.L701X | READ | 1 |
p.E155K | LUSC | 1 |
p.D315E | UCEC | 1 |
p.I322V | STAD | 1 |
p.R512Q | COAD | 1 |
p.A4S | STAD | 1 |
p.G727S | SKCM | 1 |
p.L651M | UCEC | 1 |
p.P384S | SKCM | 1 |
p.Q675E | HNSC | 1 |
p.D402Y | LAML | 1 |
p.T401I | BLCA | 1 |
p.G249R | SKCM | 1 |
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TissGeneCNV for AGBL2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AGBL2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BX113229 | AGBL2-C6orf10 | chr11:47736750 | chr6:3608270 |
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TissGeneNet for AGBL2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AGBL2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AGBL2 |
TissGeneDrug for AGBL2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AGBL2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003873 | Rheumatoid Arthritis | 6 | BeFree |
umls:C0003864 | Arthritis | 2 | BeFree |
umls:C0238462 | Medullary carcinoma of thyroid | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0025007 | Measles | 1 | BeFree |
umls:C0035435 | Rheumatism | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |