TissGeneSummary for FAM57A |
Gene summary |
Basic gene information | Gene symbol | FAM57A |
Gene name | family with sequence similarity 57, member A | |
Synonyms | CT120 | |
Cytomap | UCSC genome browser: 17p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_024792.1, | |
Description | membrane protein expressed in epithelial-like lung adenocarcinomaprotein FAM57A | |
Modification date | 20141207 | |
dbXrefs | MIM : 611627 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167695 | ||
HPRD : 13096 | ||
Vega : OTTHUMG00000177491 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM57A | |
BioGPS: 79850 | ||
Pathway | NCI Pathway Interaction Database: FAM57A | |
KEGG: FAM57A | ||
REACTOME: FAM57A | ||
Pathway Commons: FAM57A | ||
Context | iHOP: FAM57A | |
ligand binding site mutation search in PubMed: FAM57A | ||
UCL Cancer Institute: FAM57A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMSTAD | |
Reference showing the relevant tissue of FAM57A | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM57A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 1.282213864 | 0.179006172 | 1.103207692 | 1.67E-06 | 8.97E-06 |
KIRC | 0.95074677 | -0.647068508 | 1.597815278 | 1.74E-23 | 1.82E-22 |
LUSC | 1.808182718 | 0.414300365 | 1.393882353 | 2.78E-13 | 1.37E-12 |
KIRP | 0.13113045 | -0.907391425 | 1.038521875 | 8.99E-05 | 0.000310086 |
KICH | -1.410457675 | -0.404017675 | -1.00644 | 4.88E-05 | 0.000136146 |
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TissGene-miRNA for FAM57A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM57A |
TissGeneSNV for FAM57A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R104C | PRAD | 1 |
p.H123Q | UCEC | 1 |
p.L195F | BRCA | 1 |
p.A253V | SKCM | 1 |
p.R104C | READ | 1 |
p.G181E | LIHC | 1 |
p.R242K | SKCM | 1 |
p.L119V | BLCA | 1 |
p.C97S | LUAD | 1 |
p.S107P | PRAD | 1 |
p.R139W | BLCA | 1 |
p.R111* | LUSC | 1 |
p.R139L | KIRP | 1 |
p.P133S | LGG | 1 |
p.P197H | PRAD | 1 |
p.M84I | BLCA | 1 |
p.A125V | UCEC | 1 |
p.T157A | UCEC | 1 |
p.L108I | PRAD | 1 |
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TissGeneCNV for FAM57A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM57A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA977293 | PPIF-FAM57A | chr10:81115090 | chr17:645099 | |
Chimerdb3.0 | ChiTaRs | NA | BG111497 | FAM57A-FAM57A | chr17:645071 | chr17:645043 |
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TissGeneNet for FAM57A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM57A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM57A |
TissGeneDrug for FAM57A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM57A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |