TissGeneSummary for CCDC15 |
Gene summary |
Basic gene information | Gene symbol | CCDC15 |
Gene name | coiled-coil domain containing 15 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_025004.2, | |
Description | coiled-coil domain-containing protein 15 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000149548 | ||
HPRD : 07820 | ||
Vega : OTTHUMG00000165940 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC15 | |
BioGPS: 80071 | ||
Pathway | NCI Pathway Interaction Database: CCDC15 | |
KEGG: CCDC15 | ||
REACTOME: CCDC15 | ||
Pathway Commons: CCDC15 | ||
Context | iHOP: CCDC15 | |
ligand binding site mutation search in PubMed: CCDC15 | ||
UCL Cancer Institute: CCDC15 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTExHPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC15 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC15 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.492444142 | -0.706206838 | 1.19865098 | 6.55E-15 | 3.98E-14 |
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TissGene-miRNA for CCDC15 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC15 |
TissGeneSNV for CCDC15 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H458P | THCA | 3 |
p.H458P | LUAD | 3 |
p.H458P | LGG | 2 |
p.R786T | ESCA | 1 |
p.G155V | THYM | 1 |
p.V433I | STAD | 1 |
p.K796Q | UCEC | 1 |
p.D334G | PRAD | 1 |
p.Q477H | COAD | 1 |
p.Q604H | LUAD | 1 |
p.R203K | ESCA | 1 |
p.Q347H | LUAD | 1 |
p.D584E | LUAD | 1 |
p.R183Q | STAD | 1 |
p.Q507H | HNSC | 1 |
p.R687I | CHOL | 1 |
p.S439N | UCEC | 1 |
p.E873D | STAD | 1 |
p.V433A | UCEC | 1 |
p.M782V | LUSC | 1 |
p.V369A | SKCM | 1 |
p.D584N | SARC | 1 |
p.Q855X | COAD | 1 |
p.E67V | STAD | 1 |
p.A79T | LUSC | 1 |
p.S264L | BRCA | 1 |
p.Q707* | OV | 1 |
p.E797* | UCEC | 1 |
p.E68X | READ | 1 |
p.L861R | UCEC | 1 |
p.R209T | BLCA | 1 |
p.Q707K | ESCA | 1 |
p.K178N | PAAD | 1 |
p.K634T | STAD | 1 |
p.Y661C | BLCA | 1 |
p.K8N | UCS | 1 |
p.D766Y | LUAD | 1 |
p.R794M | PAAD | 1 |
p.Q677* | HNSC | 1 |
p.L616F | UCEC | 1 |
p.K70M | LUAD | 1 |
p.Q558* | PRAD | 1 |
p.Q620E | LUAD | 1 |
p.R11Q | COAD | 1 |
p.N930Y | KIRC | 1 |
p.A44T | STAD | 1 |
p.N941D | UCS | 1 |
p.N12H | UCEC | 1 |
p.D359Y | LUSC | 1 |
p.Q498E | HNSC | 1 |
p.G228R | KIRP | 1 |
p.Q811H | LUSC | 1 |
p.R452K | PAAD | 1 |
p.P148S | KIRC | 1 |
p.K194R | STAD | 1 |
p.N930D | UCS | 1 |
p.K436E | LUSC | 1 |
p.R11Q | READ | 1 |
p.M365I | UCEC | 1 |
p.R7Q | READ | 1 |
p.R215S | THYM | 1 |
p.D655Y | COAD | 1 |
p.G529D | COAD | 1 |
p.K112T | UCEC | 1 |
p.K357T | DLBC | 1 |
p.M177I | CESC | 1 |
p.H458P | PRAD | 1 |
p.S265Y | UCEC | 1 |
p.H458P | CESC | 1 |
p.E399* | LUAD | 1 |
p.K192* | HNSC | 1 |
p.S439I | THYM | 1 |
p.A241T | THYM | 1 |
p.R819K | STAD | 1 |
p.L917P | GBM | 1 |
p.Q319K | STAD | 1 |
p.L207F | SKCM | 1 |
p.R606Q | KIRC | 1 |
p.R11Q | UCEC | 1 |
p.R868* | UCEC | 1 |
p.D649N | LIHC | 1 |
p.S265F | ESCA | 1 |
p.E164K | UCEC | 1 |
p.R868L | SKCM | 1 |
p.E364Q | BLCA | 1 |
p.E797Q | BLCA | 1 |
p.Q361* | LUAD | 1 |
p.R851T | HNSC | 1 |
p.M248I | LUAD | 1 |
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TissGeneCNV for CCDC15 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC15 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CCDC15 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC15 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC15 |
TissGeneDrug for CCDC15 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC15 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |