 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for CUBN |
 Gene summary |
| Basic gene information | Gene symbol | CUBN |
| Gene name | cubilin (intrinsic factor-cobalamin receptor) | |
| Synonyms | IFCR|MGA1|gp280 | |
| Cytomap | UCSC genome browser: 10p12.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001081.3, | |
| Description | 460 kDa receptorcubilincubilin precursor variant 1cubilin precursor variant 2intestinal intrinsic factor receptorintrinsic factor-vitamin B12 receptor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602997 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000107611 | ||
| HPRD : 04296 | ||
| Vega : OTTHUMG00000017741 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CUBN | |
| BioGPS: 8029 | ||
| Pathway | NCI Pathway Interaction Database: CUBN | |
| KEGG: CUBN | ||
| REACTOME: CUBN | ||
| Pathway Commons: CUBN | ||
| Context | iHOP: CUBN | |
| ligand binding site mutation search in PubMed: CUBN | ||
| UCL Cancer Institute: CUBN | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of CUBN | ||
| Description by TissGene annotations | Risk TissGene in OS Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for CUBN |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -1.111422422 | -2.222516422 | 1.111094 | 1.72E-06 | 8.70E-06 |
| LUSC | -0.782210736 | 0.750826519 | -1.533037255 | 1.04E-13 | 5.38E-13 |
| KICH | -0.381078422 | 5.638105578 | -6.019184 | 3.55E-12 | 3.71E-11 |
| BRCA | -0.027209755 | 1.804137613 | -1.831347368 | 4.71E-38 | 1.19E-36 |
| KIRP | 4.545132953 | 7.700311078 | -3.155178125 | 8.78E-05 | 0.000304718 |
| Top |
| TissGene-miRNA for CUBN |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for CUBN |
| TissGeneSNV for CUBN |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R1249C | SKCM | 3 |
| p.P833S | SKCM | 2 |
| p.H3438Y | SKCM | 2 |
| p.A3402V | PAAD | 2 |
| p.I2816M | KIRP | 2 |
| p.R3148Q | STAD | 2 |
| p.S331F | SKCM | 2 |
| p.G596C | LUAD | 2 |
| p.S212F | SKCM | 2 |
| p.E1115K | SKCM | 2 |
| p.G2219C | LUAD | 1 |
| p.P1529L | SKCM | 1 |
| p.H3400Q | LUAD | 1 |
| p.E1204K | SKCM | 1 |
| p.L3206V | HNSC | 1 |
| p.R2476W | BRCA | 1 |
| p.R1921L | HNSC | 1 |
| p.P833S | LUSC | 1 |
| p.Q852H | COAD | 1 |
| p.I398L | LIHC | 1 |
| p.G2170V | ESCA | 1 |
| p.H3400Q | OV | 1 |
| p.D2941N | BLCA | 1 |
| p.L724F | HNSC | 1 |
| p.L120I | HNSC | 1 |
| p.P3012Q | LUAD | 1 |
| p.A3360S | LUAD | 1 |
| p.S153F | SKCM | 1 |
| p.S2776Y | SARC | 1 |
| p.Y206* | LUSC | 1 |
| p.R2750G | LUAD | 1 |
| p.N1855D | BLCA | 1 |
| p.G1801E | SKCM | 1 |
| p.H954N | LUAD | 1 |
| p.N50T | ESCA | 1 |
| p.G415V | THCA | 1 |
| p.S153F | SARC | 1 |
| p.P2255S | SKCM | 1 |
| p.S2528N | LUSC | 1 |
| p.F2630C | SKCM | 1 |
| p.T791I | PAAD | 1 |
| p.P1975S | BRCA | 1 |
| p.G613E | UCS | 1 |
| p.P2243L | READ | 1 |
| p.E2566K | PAAD | 1 |
| p.S623C | LUAD | 1 |
| p.S2182* | BLCA | 1 |
| p.I17V | ESCA | 1 |
| p.G2205R | LUSC | 1 |
| p.V3423I | LGG | 1 |
| p.T2031M | UCEC | 1 |
| p.I1918M | KIRC | 1 |
| p.V3373A | ESCA | 1 |
| p.R2266X | READ | 1 |
| p.C210R | KIRP | 1 |
| p.N562D | LIHC | 1 |
| p.K645N | BLCA | 1 |
| p.S560T | LIHC | 1 |
| p.D3061N | BLCA | 1 |
| p.E1206Q | BRCA | 1 |
| p.T893S | LUAD | 1 |
| p.R2100T | CESC | 1 |
| p.V322I | STAD | 1 |
| p.R1275Q | KIRC | 1 |
| p.L349I | OV | 1 |
| p.T3150S | ACC | 1 |
| p.F417C | STAD | 1 |
| p.G2150E | SKCM | 1 |
| p.L120V | HNSC | 1 |
| p.A1587S | HNSC | 1 |
| p.S2091G | LUAD | 1 |
| p.R2100S | LUSC | 1 |
| p.Y1222C | LUSC | 1 |
| p.V322I | BLCA | 1 |
| p.E3207* | LUAD | 1 |
| p.R2517T | BLCA | 1 |
| p.P470S | LUAD | 1 |
| p.D2284N | CESC | 1 |
| p.C1278W | HNSC | 1 |
| p.F3236L | BLCA | 1 |
| p.S2163T | LUSC | 1 |
| p.S570F | HNSC | 1 |
| p.E3538K | ESCA | 1 |
| p.R520W | PRAD | 1 |
| p.P2503L | LUAD | 1 |
| p.E934* | UCEC | 1 |
| p.G633V | LUAD | 1 |
| p.D3082H | BLCA | 1 |
| p.A1962V | PRAD | 1 |
| p.P1656R | HNSC | 1 |
| p.R3498H | HNSC | 1 |
| p.E3443K | UCEC | 1 |
| p.T1313A | BLCA | 1 |
| p.L724V | STAD | 1 |
| p.S704L | HNSC | 1 |
| p.E2135K | BRCA | 1 |
| p.R3117H | READ | 1 |
| p.H752L | HNSC | 1 |
| p.G1928D | SARC | 1 |
| p.Q3338P | UCS | 1 |
| p.P389T | COAD | 1 |
| p.A1224S | SKCM | 1 |
| p.P2738S | HNSC | 1 |
| p.P2954H | SKCM | 1 |
| p.T2501M | UCEC | 1 |
| p.P2243L | BLCA | 1 |
| p.H2810Y | SKCM | 1 |
| p.G1840D | PAAD | 1 |
| p.G1852A | LUSC | 1 |
| p.S1815F | SKCM | 1 |
| p.F1407L | LUSC | 1 |
| p.P1413Q | HNSC | 1 |
| p.D2041E | SKCM | 1 |
| p.L2153F | COAD | 1 |
| p.Q3155R | BLCA | 1 |
| p.G207R | LUSC | 1 |
| p.R1810Q | COAD | 1 |
| p.T859S | LUAD | 1 |
| p.S2119F | BLCA | 1 |
| p.R1576S | THYM | 1 |
| p.N2514K | COAD | 1 |
| p.L700V | STAD | 1 |
| p.R2488M | LUSC | 1 |
| p.E820D | LIHC | 1 |
| p.F3168L | UCEC | 1 |
| p.D2144H | BLCA | 1 |
| p.Q756R | UCS | 1 |
| p.D641E | LUSC | 1 |
| p.S551C | BRCA | 1 |
| p.G342C | PRAD | 1 |
| p.I17M | LUAD | 1 |
| p.M234I | LIHC | 1 |
| p.E3265G | LUAD | 1 |
| p.T1713M | STAD | 1 |
| p.Y3336* | PRAD | 1 |
| p.R2030Q | LIHC | 1 |
| p.Y2112C | STAD | 1 |
| p.G892C | SKCM | 1 |
| p.N3348I | BRCA | 1 |
| p.V3070I | STAD | 1 |
| p.L553F | SKCM | 1 |
| p.D2745H | LUSC | 1 |
| p.P1182R | BLCA | 1 |
| p.S3496F | HNSC | 1 |
| p.D2733N | LGG | 1 |
| p.T940S | LUAD | 1 |
| p.Y3336X | PRAD | 1 |
| p.F905C | UCEC | 1 |
| p.D1898G | UCEC | 1 |
| p.E323G | READ | 1 |
| p.L277V | ESCA | 1 |
| p.P3343L | PAAD | 1 |
| p.S1736L | LUAD | 1 |
| p.H402L | LIHC | 1 |
| p.T2007M | PRAD | 1 |
| p.Q2125* | SKCM | 1 |
| p.N1071Y | BLCA | 1 |
| p.S2078N | LUAD | 1 |
| p.R2595I | UCEC | 1 |
| p.P321H | LUAD | 1 |
| p.S2971F | SKCM | 1 |
| p.L1692F | SKCM | 1 |
| p.A1156D | ACC | 1 |
| p.S317F | SKCM | 1 |
| p.T327S | STAD | 1 |
| p.E3077K | UCEC | 1 |
| p.P2469S | SARC | 1 |
| p.Q674L | HNSC | 1 |
| p.G1252R | SKCM | 1 |
| p.G1725A | LGG | 1 |
| p.S479L | BLCA | 1 |
| p.R843S | UCEC | 1 |
| p.G933R | SKCM | 1 |
| p.L2046V | STAD | 1 |
| p.R2030Q | COAD | 1 |
| p.E975K | UCEC | 1 |
| p.R2283W | COAD | 1 |
| p.S1822F | SKCM | 1 |
| p.T2425A | HNSC | 1 |
| p.N3396K | OV | 1 |
| p.S108I | KIRP | 1 |
| p.V2901D | BLCA | 1 |
| p.V3478D | LUAD | 1 |
| p.R1775W | UCEC | 1 |
| p.D2265Y | COAD | 1 |
| p.A3545P | HNSC | 1 |
| p.W960X | SKCM | 1 |
| p.S2303N | UCEC | 1 |
| p.Q1585K | UCEC | 1 |
| p.C392F | LUSC | 1 |
| p.R3382I | PAAD | 1 |
| p.S275C | BLCA | 1 |
| p.R2258H | HNSC | 1 |
| p.P2165L | UCEC | 1 |
| p.D1964N | SKCM | 1 |
| p.R2476Q | STAD | 1 |
| p.N2274Y | LUAD | 1 |
| p.G1968D | STAD | 1 |
| p.S2767L | SKCM | 1 |
| p.M3368I | SKCM | 1 |
| p.M2449I | LUSC | 1 |
| p.A2245T | ESCA | 1 |
| p.V322I | UCEC | 1 |
| p.I2694V | KIRP | 1 |
| p.D3311H | HNSC | 1 |
| p.N1319D | GBM | 1 |
| p.G1352E | HNSC | 1 |
| p.G1726D | STAD | 1 |
| p.Q2778* | LUAD | 1 |
| p.V427A | ACC | 1 |
| p.H2352Y | HNSC | 1 |
| p.Q31H | BLCA | 1 |
| p.P2575A | LUAD | 1 |
| p.R1693X | STAD | 1 |
| p.D1149Y | UCEC | 1 |
| p.T1507A | COAD | 1 |
| p.W3143* | BLCA | 1 |
| p.H1860D | BLCA | 1 |
| p.G3101D | UCEC | 1 |
| p.S198I | UCEC | 1 |
| p.R1345W | STAD | 1 |
| p.P3477T | LUAD | 1 |
| p.T193A | UCEC | 1 |
| p.S3578R | LIHC | 1 |
| p.S865R | STAD | 1 |
| p.P3244S | SKCM | 1 |
| p.D1029N | LUAD | 1 |
| p.H2966N | ACC | 1 |
| p.L969P | KIRC | 1 |
| p.Q586R | LGG | 1 |
| p.E431K | SKCM | 1 |
| p.S559R | THYM | 1 |
| p.A2877D | THYM | 1 |
| p.P337A | BLCA | 1 |
| p.Y1567H | STAD | 1 |
| p.G838E | SKCM | 1 |
| p.R235* | LUAD | 1 |
| p.S1839G | LUAD | 1 |
| p.S540P | BLCA | 1 |
| p.F3028L | STAD | 1 |
| p.T1730M | ESCA | 1 |
| p.Q814* | BLCA | 1 |
| p.K1144R | LUAD | 1 |
| p.E928* | BLCA | 1 |
| p.C409Y | UCEC | 1 |
| p.L856I | CHOL | 1 |
| p.V3596M | COAD | 1 |
| p.F664L | LIHC | 1 |
| p.R3212T | BRCA | 1 |
| p.H948Y | SKCM | 1 |
| p.I1856V | LUSC | 1 |
| p.H752D | SKCM | 1 |
| p.L660H | SKCM | 1 |
| p.P612S | UCEC | 1 |
| p.Y1185C | COAD | 1 |
| p.Q2385* | HNSC | 1 |
| p.S3349L | SKCM | 1 |
| p.D3275G | UCEC | 1 |
| p.V3070F | HNSC | 1 |
| p.K510_splice | OV | 1 |
| p.R122I | COAD | 1 |
| p.S3579F | HNSC | 1 |
| p.E938* | LUAD | 1 |
| p.H2616Y | SKCM | 1 |
| p.V3565I | PRAD | 1 |
| p.N1495T | ESCA | 1 |
| p.L1220F | LIHC | 1 |
| p.I3190M | STAD | 1 |
| p.E2524D | BLCA | 1 |
| p.R3397* | LIHC | 1 |
| p.S2294F | SARC | 1 |
| p.W2120C | LUAD | 1 |
| p.R264I | LUAD | 1 |
| p.T46I | UCEC | 1 |
| p.T2815A | STAD | 1 |
| p.F1514S | ACC | 1 |
| p.C360R | KIRC | 1 |
| p.E3002G | COAD | 1 |
| p.S2529N | ACC | 1 |
| p.T1931A | LUSC | 1 |
| p.G2309E | BLCA | 1 |
| p.T1046R | KIRP | 1 |
| p.G1725R | LUAD | 1 |
| p.P2168S | COAD | 1 |
| p.S1518I | LUSC | 1 |
| p.G2150V | LUSC | 1 |
| p.L3473V | BLCA | 1 |
| p.G2093S | STAD | 1 |
| p.Y1641H | STAD | 1 |
| p.T1014K | LUSC | 1 |
| p.P1474H | COAD | 1 |
| p.P849L | HNSC | 1 |
| p.Q86* | LUAD | 1 |
| p.V3013F | UCEC | 1 |
| p.R224G | SKCM | 1 |
| p.T634I | LUAD | 1 |
| p.Q209* | LUSC | 1 |
| p.E2396D | CESC | 1 |
| p.D1242N | SKCM | 1 |
| p.D3560N | UCEC | 1 |
| p.Q2903P | COAD | 1 |
| p.F668L | UCEC | 1 |
| p.A3140P | KIRC | 1 |
| p.W3187* | SKCM | 1 |
| p.R2317L | LUSC | 1 |
| p.F2851V | COAD | 1 |
| p.S3506L | LUSC | 1 |
| p.P1702S | SKCM | 1 |
| p.S1334Y | SKCM | 1 |
| p.A1087V | UCEC | 1 |
| p.S3127I | LUAD | 1 |
| p.D1209Y | UCEC | 1 |
| p.G415D | GBM | 1 |
| p.R3613H | LUAD | 1 |
| p.K2683R | ESCA | 1 |
| p.P328S | SKCM | 1 |
| p.S1012F | BLCA | 1 |
| p.A1733T | CHOL | 1 |
| p.S603Y | UCEC | 1 |
| p.D760N | CESC | 1 |
| p.S1723N | READ | 1 |
| p.D3057N | SKCM | 1 |
| p.H696R | BLCA | 1 |
| p.F1990Y | SKCM | 1 |
| p.D1630N | LUAD | 1 |
| p.Q2861* | STAD | 1 |
| p.L1030H | BLCA | 1 |
| p.T3422I | DLBC | 1 |
| p.Q1476X | CHOL | 1 |
| p.R3407G | SKCM | 1 |
| p.E1279K | BLCA | 1 |
| p.S1917G | LIHC | 1 |
| p.M194T | KIRC | 1 |
| p.V135G | SKCM | 1 |
| p.R2674C | COAD | 1 |
| p.L2184V | CESC | 1 |
| p.R1487X | SKCM | 1 |
| p.S1459P | LIHC | 1 |
| p.R769* | UCEC | 1 |
| p.A1690V | STAD | 1 |
| p.R2072S | ESCA | 1 |
| p.H3438N | LGG | 1 |
| p.S1043N | BLCA | 1 |
| p.S600F | COAD | 1 |
| p.Q1515L | LUAD | 1 |
| p.A2086V | STAD | 1 |
| p.Q2125X | SKCM | 1 |
| p.V2949D | LUAD | 1 |
| p.H919Q | HNSC | 1 |
| p.G300E | SKCM | 1 |
| p.P2651H | PAAD | 1 |
| p.A1886S | LUSC | 1 |
| p.V1762G | STAD | 1 |
| p.P1358T | STAD | 1 |
| p.G2642E | PRAD | 1 |
| p.L856I | COAD | 1 |
| p.R1487* | SKCM | 1 |
| p.E530K | READ | 1 |
| p.P2141L | LUSC | 1 |
| p.R769Q | READ | 1 |
| p.Q693H | KIRP | 1 |
| p.S3579T | LUSC | 1 |
| p.R2315T | ESCA | 1 |
| p.G1968D | SKCM | 1 |
| p.P293L | SKCM | 1 |
| p.D363E | LIHC | 1 |
| p.E2391Q | HNSC | 1 |
| p.R1541Q | COAD | 1 |
| p.P2937T | LUSC | 1 |
| p.A1653V | HNSC | 1 |
| p.G3039C | STAD | 1 |
| p.Y3223H | COAD | 1 |
| p.L855I | UCEC | 1 |
| p.P3464A | LUAD | 1 |
| p.F1064V | BLCA | 1 |
| p.R3613S | LUAD | 1 |
| p.K133Q | SKCM | 1 |
| p.L2633F | SKCM | 1 |
| p.Q2861X | STAD | 1 |
| p.H227N | LIHC | 1 |
| p.R1677C | UCEC | 1 |
| p.D363E | KIRC | 1 |
| p.M194V | KIRP | 1 |
| p.P1245H | HNSC | 1 |
| p.P1656A | HNSC | 1 |
| p.W1960* | LUAD | 1 |
| p.M524I | LUSC | 1 |
| p.C3470Y | GBM | 1 |
| p.P3087L | SKCM | 1 |
| p.D1689Y | UCEC | 1 |
| p.E1900D | ESCA | 1 |
| p.R828C | HNSC | 1 |
| p.T3321N | UCEC | 1 |
| p.V3186A | STAD | 1 |
| p.S2387F | CESC | 1 |
| p.R2591K | UCEC | 1 |
| p.R3148W | STAD | 1 |
| p.S2774L | SKCM | 1 |
| p.G2856S | LUAD | 1 |
| p.E2450K | BLCA | 1 |
| p.P3012L | KIRP | 1 |
| p.V492A | STAD | 1 |
| p.G1892S | UCEC | 1 |
| p.E1115K | LUSC | 1 |
| p.I306M | LIHC | 1 |
| p.R1693* | STAD | 1 |
| p.K3490N | COAD | 1 |
| p.R1695H | LUAD | 1 |
| p.Q1464R | STAD | 1 |
| p.N2824S | KIRP | 1 |
| p.D646V | ACC | 1 |
| p.K3181N | LUSC | 1 |
| p.G250E | SKCM | 1 |
| p.G2540E | LUAD | 1 |
| p.Q852H | STAD | 1 |
| p.F1123L | UCEC | 1 |
| p.W10C | BLCA | 1 |
| p.P1605R | HNSC | 1 |
| p.P321L | SKCM | 1 |
| p.R1541L | LUSC | 1 |
| p.V2569M | ESCA | 1 |
| p.E2486K | LGG | 1 |
| p.S477P | UCEC | 1 |
| p.P2471R | LIHC | 1 |
| p.R64I | BLCA | 1 |
| p.D3180Y | BLCA | 1 |
| p.L3440R | PAAD | 1 |
| p.R1613Q | BLCA | 1 |
| p.F2686V | BLCA | 1 |
| p.E2600K | UCEC | 1 |
| p.N3430S | LIHC | 1 |
| p.S1015I | LGG | 1 |
| p.G2792R | LUAD | 1 |
| p.G1295W | UVM | 1 |
| p.S1404I | LUSC | 1 |
| p.L2166V | SKCM | 1 |
| p.R3117H | STAD | 1 |
| p.R1377H | STAD | 1 |
| p.R1911T | OV | 1 |
| p.R1715T | BLCA | 1 |
| p.F2362S | LUAD | 1 |
| p.C616Y | UCEC | 1 |
| p.M2543I | CESC | 1 |
| p.S453C | LUSC | 1 |
| p.G3588V | COAD | 1 |
| p.G3520C | UCEC | 1 |
| p.D538Y | UCEC | 1 |
| p.S1254C | OV | 1 |
| p.H2224N | COAD | 1 |
| p.D3413A | PAAD | 1 |
| p.Q128L | HNSC | 1 |
| p.I1540N | ESCA | 1 |
| p.D1998H | SARC | 1 |
| p.Q1383* | SKCM | 1 |
| p.G3471R | HNSC | 1 |
| p.R574K | HNSC | 1 |
| p.R3519S | KIRP | 1 |
| p.I3257V | STAD | 1 |
| p.Q742L | HNSC | 1 |
| p.K3141I | LUAD | 1 |
| p.Q814E | CESC | 1 |
| p.P1297L | BLCA | 1 |
| p.E975Q | CESC | 1 |
| p.R2476W | KIRP | 1 |
| p.A1920V | BRCA | 1 |
| p.P3087S | SKCM | 1 |
| p.S1710I | UCEC | 1 |
| p.I2759T | STAD | 1 |
| p.R1541W | STAD | 1 |
| p.W1868* | CESC | 1 |
| p.A1501V | STAD | 1 |
| p.R3397X | LIHC | 1 |
| p.R651X | COAD | 1 |
| p.Y1811H | UCEC | 1 |
| p.A1578S | LUAD | 1 |
| p.Q1789L | LUSC | 1 |
| p.F832Y | HNSC | 1 |
| p.W960* | SKCM | 1 |
| p.G1995C | LUAD | 1 |
| p.D1967N | BLCA | 1 |
| p.I2984V | COAD | 1 |
| p.H2668Q | HNSC | 1 |
| p.V835M | UCEC | 1 |
| p.T773I | SKCM | 1 |
| p.R1487Q | UCEC | 1 |
| p.K134N | COAD | 1 |
| p.S880Y | LUAD | 1 |
| p.F2073Y | ESCA | 1 |
| p.R2636* | SKCM | 1 |
| p.G359D | LGG | 1 |
| p.D2417E | LGG | 1 |
| p.I100V | LIHC | 1 |
| p.F2195Y | LIHC | 1 |
| p.L2967F | LUAD | 1 |
| p.V3193L | LUSC | 1 |
| p.R1081K | LGG | 1 |
| p.P722S | BRCA | 1 |
| p.P1408T | BLCA | 1 |
| p.P1010L | STAD | 1 |
| p.Q185H | HNSC | 1 |
| p.V735I | LIHC | 1 |
| p.G3101S | SKCM | 1 |
| p.S3304F | SKCM | 1 |
| p.L1683F | ESCA | 1 |
| p.C2363F | LUAD | 1 |
| p.S865G | LIHC | 1 |
| p.G2752C | COAD | 1 |
| p.R2081S | ACC | 1 |
| p.S2459F | SKCM | 1 |
| p.D3451N | SKCM | 1 |
| p.D1149G | LUAD | 1 |
| p.G3027E | SKCM | 1 |
| p.E29Q | UCEC | 1 |
| p.R1775W | PRAD | 1 |
| p.S3081T | BLCA | 1 |
| p.S600C | BLCA | 1 |
| p.G329R | LUSC | 1 |
| p.R1775L | LUAD | 1 |
| p.Y1186* | LUAD | 1 |
| p.T2730I | BRCA | 1 |
| p.V2532I | UCEC | 1 |
| p.S3509C | LUSC | 1 |
| p.S3124N | OV | 1 |
| p.A2500D | LUAD | 1 |
| p.T731N | KIRC | 1 |
| p.T3422I | COAD | 1 |
| p.P3475S | COAD | 1 |
| p.S2663Y | READ | 1 |
| p.C3064Y | LUSC | 1 |
| p.E839D | HNSC | 1 |
| p.R43Q | PAAD | 1 |
| p.E1584D | COAD | 1 |
| p.T859I | LIHC | 1 |
| p.F2382L | STAD | 1 |
| p.R1541W | BRCA | 1 |
| p.C1444F | LUAD | 1 |
| p.A3577T | GBM | 1 |
| p.P2141S | SKCM | 1 |
| p.D3082Y | READ | 1 |
| p.V874I | LIHC | 1 |
| p.E824* | BLCA | 1 |
| p.N2045T | ESCA | 1 |
| p.G2557V | BLCA | 1 |
| p.G2060R | LIHC | 1 |
| p.G290E | LUSC | 1 |
| p.R2317* | SKCM | 1 |
| p.C2831Y | KICH | 1 |
| p.S3175L | BLCA | 1 |
| p.A249T | UCEC | 1 |
| p.V3373A | UCS | 1 |
| p.E820A | STAD | 1 |
| p.N2506I | LUSC | 1 |
| p.K1196Q | STAD | 1 |
| p.R769Q | HNSC | 1 |
| p.M1183I | HNSC | 1 |
| p.E308K | BLCA | 1 |
| p.K3116M | STAD | 1 |
| p.L1036F | BLCA | 1 |
| p.G1295R | LUAD | 1 |
| p.R3618Q | THYM | 1 |
| p.A1501V | CESC | 1 |
| p.R1695H | THCA | 1 |
| p.T959I | BRCA | 1 |
| Top |
| TissGeneCNV for CUBN |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for CUBN |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI039276 | FLNA-CUBN | chrX:153585863 | chr10:16955945 |
| Top |
| TissGeneNet for CUBN |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (tumor) | CUBN, LGALS3, ALB, GC, TF, LRP2, RRP1B, SCGB1A1, GIF (normal) |
 |  |
| Top |
| TissGeneProg for CUBN |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for CUBN |
| TissGeneDrug for CUBN |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00200 | Hydroxocobalamin | Other | Small molecule | Approved |
| Top |
| TissGeneDisease for CUBN |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1306856 | Megaloblastic anemia due to inborn errors of metabolism | 10 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0002888 | Anemia, Megaloblastic | 8 | BeFree |
| umls:C0024523 | Malabsorption Syndrome | 6 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree,GAD |
| umls:C0035078 | Kidney Failure | 2 | BeFree |
| umls:C0730345 | Microalbuminuria | 2 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 2 | BeFree |
| umls:C0001925 | Albuminuria | 1 | GAD |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GAD |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree,GAD |
| umls:C0011881 | Diabetic Nephropathy | 1 | RGD |
| umls:C0021368 | Inflammation | 1 | GAD |
| umls:C0021655 | Insulin Resistance | 1 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | CTD_human |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042847 | Vitamin B 12 Deficiency | 1 | BeFree |
| umls:C0080178 | Spina Bifida | 1 | BeFree,GAD |
| umls:C0235031 | Neurologic Symptoms | 1 | BeFree |
| umls:C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0340952 | Secondary anemia NOS | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | GAD |
| umls:C0456844 | Light chain myeloma | 1 | BeFree |
| umls:C0497552 | Congenital neurologic anomalies | 1 | LHGDN |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0810364 | Cleft Lip with or without Cleft Palate | 1 | BeFree |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1394891 | Intrinsic Factor Deficiency | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | GAD |
| umls:C1562585 | Leprosy, Multibacillary | 1 | BeFree |
| umls:C2316810 | Chronic kidney disease stage 5 | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |