TissGeneSummary for GKAP1 |
Gene summary |
Basic gene information | Gene symbol | GKAP1 |
Gene name | G kinase anchoring protein 1 | |
Synonyms | GKAP42 | |
Cytomap | UCSC genome browser: 9q21.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001135953.1, NM_025211.3, | |
Description | G kinase-anchoring protein 1cGMP-dependent protein kinase anchoring protein 42kDacGMP-dependent protein kinase-anchoring protein of 42 kDaprotein kinase anchoring protein GKAP42 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611356 | |
HGNC : HGNC | ||
Ensembl : ENSG00000165113 | ||
HPRD : 17042 | ||
Vega : OTTHUMG00000020106 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GKAP1 | |
BioGPS: 80318 | ||
Pathway | NCI Pathway Interaction Database: GKAP1 | |
KEGG: GKAP1 | ||
REACTOME: GKAP1 | ||
Pathway Commons: GKAP1 | ||
Context | iHOP: GKAP1 | |
ligand binding site mutation search in PubMed: GKAP1 | ||
UCL Cancer Institute: GKAP1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of GKAP1 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GKAP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.720614524 | -0.63495374 | -1.085660784 | 1.09E-05 | 2.46E-05 |
HNSC | -2.71249291 | -1.094106863 | -1.618386047 | 1.51E-07 | 1.42E-06 |
BLCA | -1.400060964 | -0.153282016 | -1.246778947 | 0.00326 | 0.019079579 |
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TissGene-miRNA for GKAP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GKAP1 |
TissGeneSNV for GKAP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q66K | CESC | 1 |
p.T323A | UCEC | 1 |
p.D363N | SARC | 1 |
p.T323A | STAD | 1 |
p.E346Q | HNSC | 1 |
p.R226Q | UCEC | 1 |
p.S14F | LUSC | 1 |
p.D215N | SKCM | 1 |
p.H144R | LIHC | 1 |
p.I269M | BLCA | 1 |
p.T178A | LGG | 1 |
p.Q157H | LUAD | 1 |
p.Q66R | CESC | 1 |
p.S328L | SKCM | 1 |
p.L309F | SKCM | 1 |
p.E143Q | BLCA | 1 |
p.Q278P | LUAD | 1 |
p.K61Q | COAD | 1 |
p.S123F | SKCM | 1 |
p.K192N | LIHC | 1 |
p.P176L | SKCM | 1 |
p.D206N | LUAD | 1 |
p.E268K | BLCA | 1 |
p.H330Y | SKCM | 1 |
p.Q364* | SKCM | 1 |
p.K305N | UCEC | 1 |
p.S137I | LUSC | 1 |
p.D188G | BLCA | 1 |
p.Q270K | PRAD | 1 |
p.N100K | HNSC | 1 |
p.P176S | SKCM | 1 |
p.R115I | THYM | 1 |
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TissGeneCNV for GKAP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GKAP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF361491 | GKAP1-MECP2 | chr9:86382697 | chrX:153321732 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A25B-01A | UBQLN1-GKAP1 | CDS-5UTR | Chr9:86322415 | Chr9:86421475 |
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TissGeneNet for GKAP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GKAP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GKAP1 |
TissGeneDrug for GKAP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GKAP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |