TissGeneSummary for KIAA1683 |
Gene summary |
Basic gene information | Gene symbol | KIAA1683 |
Gene name | KIAA1683 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001145304.1, NM_001145305.1,NM_025249.3, | |
Description | uncharacterized protein KIAA1683 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000130518 | ||
HPRD : 13882 | ||
Vega : OTTHUMG00000183354 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KIAA1683 | |
BioGPS: 80726 | ||
Pathway | NCI Pathway Interaction Database: KIAA1683 | |
KEGG: KIAA1683 | ||
REACTOME: KIAA1683 | ||
Pathway Commons: KIAA1683 | ||
Context | iHOP: KIAA1683 | |
ligand binding site mutation search in PubMed: KIAA1683 | ||
UCL Cancer Institute: KIAA1683 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KIAA1683 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KIAA1683 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.423207647 | 3.232513529 | -2.809305882 | 5.04E-18 | 4.61E-17 |
LUAD | 0.649743009 | 3.530384388 | -2.880641379 | 1.92E-18 | 2.78E-17 |
KIRP | 0.322026091 | 1.949907341 | -1.62788125 | 4.61E-07 | 2.52E-06 |
BRCA | 0.71923711 | 2.874317812 | -2.155080702 | 1.62E-28 | 1.96E-27 |
HNSC | -1.417542877 | 0.489343169 | -1.906886047 | 1.50E-08 | 1.76E-07 |
COAD | -0.26322463 | 1.803840754 | -2.067065385 | 1.35E-08 | 1.17E-07 |
STAD | 0.896507341 | 2.022291716 | -1.125784375 | 0.000104 | 0.00079828 |
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TissGene-miRNA for KIAA1683 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KIAA1683 |
TissGeneSNV for KIAA1683 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A425T | LGG | 1 |
p.A1116T | DLBC | 1 |
p.R1125C | LUSC | 1 |
p.E177K | BLCA | 1 |
p.L82F | SKCM | 1 |
p.H646D | KIRC | 1 |
p.A136D | CHOL | 1 |
p.P344S | SKCM | 1 |
p.P1095H | BRCA | 1 |
p.A759V | UCEC | 1 |
p.P205L | BLCA | 1 |
p.R952L | LIHC | 1 |
p.S481F | SKCM | 1 |
p.V1143F | SKCM | 1 |
p.R139H | CESC | 1 |
p.Q864* | SKCM | 1 |
p.E71K | UCEC | 1 |
p.R83Q | CESC | 1 |
p.W1311R | UCEC | 1 |
p.S480L | SKCM | 1 |
p.E295K | SKCM | 1 |
p.M1141I | LUAD | 1 |
p.D764N | BLCA | 1 |
p.T479I | UCEC | 1 |
p.P908H | COAD | 1 |
p.P1253L | SKCM | 1 |
p.K190R | COAD | 1 |
p.E870D | LUAD | 1 |
p.R944H | STAD | 1 |
p.E627K | STAD | 1 |
p.G810R | UCEC | 1 |
p.R1254H | ESCA | 1 |
p.D1030N | HNSC | 1 |
p.P835L | COAD | 1 |
p.A892S | PAAD | 1 |
p.R1130C | HNSC | 1 |
p.R172H | UCEC | 1 |
p.R1151H | STAD | 1 |
p.W1177* | STAD | 1 |
p.V346A | SKCM | 1 |
p.T358M | UCEC | 1 |
p.H56Y | HNSC | 1 |
p.V79I | STAD | 1 |
p.E48V | SKCM | 1 |
p.P209S | SKCM | 1 |
p.P51S | SKCM | 1 |
p.S1285C | BLCA | 1 |
p.E71K | ESCA | 1 |
p.R1130L | LUAD | 1 |
p.A733V | STAD | 1 |
p.P415L | SKCM | 1 |
p.V558M | UCEC | 1 |
p.L123P | LIHC | 1 |
p.Q1121* | SKCM | 1 |
p.G545C | LUSC | 1 |
p.H1361Q | LIHC | 1 |
p.M932T | UCEC | 1 |
p.P1016H | SARC | 1 |
p.G609D | STAD | 1 |
p.P485S | SKCM | 1 |
p.Q170H | BRCA | 1 |
p.A1303V | PRAD | 1 |
p.H1338Y | SKCM | 1 |
p.I329M | PRAD | 1 |
p.P867S | SKCM | 1 |
p.H1151Y | SKCM | 1 |
p.P317L | SKCM | 1 |
p.P407L | UCEC | 1 |
p.P326L | SKCM | 1 |
p.M954I | LUAD | 1 |
p.Y354H | OV | 1 |
p.R416Q | COAD | 1 |
p.R943L | LUAD | 1 |
p.P66L | BLCA | 1 |
p.G1081D | LGG | 1 |
p.M1I | CESC | 1 |
p.R1219C | HNSC | 1 |
p.Q730P | BLCA | 1 |
p.F1314L | THYM | 1 |
p.A1198P | HNSC | 1 |
p.P195S | SKCM | 1 |
p.P813S | SKCM | 1 |
p.K282Q | UCEC | 1 |
p.T219A | LUSC | 1 |
p.A614V | DLBC | 1 |
p.P823R | COAD | 1 |
p.K478E | LAML | 1 |
p.N466S | COAD | 1 |
p.T108M | UCEC | 1 |
p.W1088* | LUAD | 1 |
p.G1123A | KIRP | 1 |
p.R1006W | UCEC | 1 |
p.T524A | DLBC | 1 |
p.A707V | OV | 1 |
p.A104T | COAD | 1 |
p.F1314C | LUAD | 1 |
p.F1127C | LUAD | 1 |
p.M716I | SKCM | 1 |
p.S432F | SKCM | 1 |
p.E1276X | ESCA | 1 |
p.P1066L | SKCM | 1 |
p.R943C | HNSC | 1 |
p.F620V | LGG | 1 |
p.V727M | UCEC | 1 |
p.D1217N | HNSC | 1 |
p.C1220S | LUAD | 1 |
p.Q53X | STAD | 1 |
p.A379V | SKCM | 1 |
p.N289K | STAD | 1 |
p.P209L | SKCM | 1 |
p.A1140T | COAD | 1 |
p.E87K | STAD | 1 |
p.T358A | LUSC | 1 |
p.Q53* | STAD | 1 |
p.V525M | UCEC | 1 |
p.S571F | SARC | 1 |
p.P383S | SKCM | 1 |
p.L713M | LGG | 1 |
p.V1330F | SKCM | 1 |
p.Q482K | UCEC | 1 |
p.P748L | STAD | 1 |
p.R1138W | SKCM | 1 |
p.P813T | ESCA | 1 |
p.I423T | STAD | 1 |
p.R509C | STAD | 1 |
p.A305T | LGG | 1 |
p.L339V | HNSC | 1 |
p.H1182P | SKCM | 1 |
p.S148F | SKCM | 1 |
p.I245M | BLCA | 1 |
p.R787C | LUAD | 1 |
p.V812M | BLCA | 1 |
p.A614V | COAD | 1 |
p.T362N | UCEC | 1 |
p.R6T | BLCA | 1 |
p.R1176H | LIHC | 1 |
p.S792R | BRCA | 1 |
p.R964H | STAD | 1 |
p.R77H | READ | 1 |
p.A1310T | ESCA | 1 |
p.W1364X | STAD | 1 |
p.M716L | HNSC | 1 |
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TissGeneCNV for KIAA1683 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KIAA1683 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KIAA1683 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KIAA1683 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KIAA1683 |
TissGeneDrug for KIAA1683 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KIAA1683 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |