TissGeneSummary for CAMK2A |
Gene summary |
Basic gene information | Gene symbol | CAMK2A |
Gene name | calcium/calmodulin-dependent protein kinase II alpha | |
Synonyms | CAMKA | |
Cytomap | UCSC genome browser: 5q32 | |
Type of gene | protein-coding | |
RefGenes | NM_015981.3, NM_171825.2, | |
Description | CaM kinase II alpha subunitCaM-kinase II alpha chainCaMK-II alpha subunitCaMKIINalphacaM kinase II subunit alphacaMK-II subunit alphacalcium/calmodulin-dependent protein kinase (CaM kinase) II alphacalcium/calmodulin-dependent protein kinase II alp | |
Modification date | 20141207 | |
dbXrefs | MIM : 114078 | |
HGNC : HGNC | ||
Ensembl : ENSG00000070808 | ||
HPRD : 06532 | ||
Vega : OTTHUMG00000134281 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CAMK2A | |
BioGPS: 815 | ||
Pathway | NCI Pathway Interaction Database: CAMK2A | |
KEGG: CAMK2A | ||
REACTOME: CAMK2A | ||
Pathway Commons: CAMK2A | ||
Context | iHOP: CAMK2A | |
ligand binding site mutation search in PubMed: CAMK2A | ||
UCL Cancer Institute: CAMK2A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of CAMK2A | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 17052756 | GO:0006468 | protein phosphorylation | 17052756 |
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TissGeneExp for CAMK2A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -2.462609577 | -0.429209577 | -2.0334 | 1.02E-08 | 8.98E-08 |
KICH | -4.111047885 | -0.793775885 | -3.317272 | 1.35E-08 | 7.00E-08 |
LUAD | -1.780665678 | 0.172384322 | -1.95305 | 3.18E-20 | 6.73E-19 |
BLCA | -2.026515042 | 1.409079694 | -3.435594737 | 1.74E-06 | 4.90E-05 |
KIRC | -3.259781051 | -0.35655744 | -2.903223611 | 5.47E-17 | 3.22E-16 |
PRAD | -2.117507654 | -0.588244192 | -1.529263462 | 3.96E-07 | 3.09E-06 |
LUSC | -1.645544041 | 0.469579488 | -2.115123529 | 2.73E-15 | 1.76E-14 |
KIRP | -3.78996126 | 0.243454365 | -4.033415625 | 7.81E-13 | 1.27E-11 |
STAD | -2.403051885 | -0.243345635 | -2.15970625 | 0.000387 | 0.002472622 |
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TissGene-miRNA for CAMK2A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CAMK2A |
TissGeneSNV for CAMK2A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V476I | THCA | 1 |
p.A472V | STAD | 1 |
p.D385N | STAD | 1 |
p.A390S | UCEC | 1 |
p.R220H | UCEC | 1 |
p.W214R | LIHC | 1 |
p.K331Q | KIRC | 1 |
p.H468N | LUAD | 1 |
p.A483V | STAD | 1 |
p.I430V | COAD | 1 |
p.R405Q | GBM | 1 |
p.S234L | SKCM | 1 |
p.S25L | CESC | 1 |
p.A447T | LGG | 1 |
p.R220C | STAD | 1 |
p.D90N | BRCA | 1 |
p.T381M | UCEC | 1 |
p.S234L | UCEC | 1 |
p.A174E | LUSC | 1 |
p.L75I | SARC | 1 |
p.V465I | THCA | 1 |
p.W473X | LIHC | 1 |
p.I119M | BRCA | 1 |
p.G130W | HNSC | 1 |
p.E105D | THCA | 1 |
p.F24L | UCEC | 1 |
p.S275Y | LIHC | 1 |
p.T286I | UCEC | 1 |
p.D325N | ESCA | 1 |
p.W462* | LIHC | 1 |
p.L304V | CESC | 1 |
p.D156E | THYM | 1 |
p.E58Q | KIRP | 1 |
p.R62H | CESC | 1 |
p.R74Q | ESCA | 1 |
p.P177T | LUAD | 1 |
p.R62C | SKCM | 1 |
p.D374N | STAD | 1 |
p.A483V | PRAD | 1 |
p.S331L | BLCA | 1 |
p.M339V | LGG | 1 |
p.K298R | SKCM | 1 |
p.A458T | LIHC | 1 |
p.I101T | LGG | 1 |
p.D325N | SKCM | 1 |
p.H418Y | SKCM | 1 |
p.R186W | UCEC | 1 |
p.S344R | ESCA | 1 |
p.E17K | UCEC | 1 |
p.F16L | BLCA | 1 |
p.A472V | PRAD | 1 |
p.E162* | UCEC | 1 |
p.V287M | HNSC | 1 |
p.G22E | SKCM | 1 |
p.K32E | LIHC | 1 |
p.E17Q | BLCA | 1 |
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TissGeneCNV for CAMK2A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CAMK2A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK098391 | CDC42BPA-CAMK2A | chr1:227262066 | chr5:149599055 | |
Chimerdb3.0 | ChiTaRs | NA | AW838949 | CAMK2A-GTF2B | chr5:149605906 | chr1:89341631 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A0B9-01A | KIAA1429-CAMK2A | Out-of-frame | Chr8:95541298 | Chr5:149602276 |
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TissGeneNet for CAMK2A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CAMK2A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CAMK2A |
TissGeneDrug for CAMK2A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CAMK2A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 2 | BeFree,LHGDN |
umls:C0005586 | Bipolar Disorder | 2 | BeFree,GAD |
umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | LHGDN |
umls:C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
umls:C0020429 | Hyperalgesia | 1 | CTD_human |
umls:C0021368 | Inflammation | 1 | RGD |
umls:C0028754 | Obesity | 1 | GWASCAT |
umls:C0029463 | Osteosarcoma | 1 | LHGDN |
umls:C0036341 | Schizophrenia | 1 | LHGDN |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0043094 | Weight Gain | 1 | GAD |
umls:C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
umls:C0242387 | Mandibulofacial Dysostosis | 1 | BeFree |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0600427 | Cocaine Dependence | 1 | BeFree |
umls:C0752347 | Lewy Body Disease | 1 | BeFree |
umls:C1270972 | Mild cognitive disorder | 1 | BeFree |
umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
umls:C3714756 | Intellectual Disability | 1 | BeFree |