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| TissGeneSummary for COIL |
 Gene summary |
| Basic gene information | Gene symbol | COIL |
| Gene name | coilin | |
| Synonyms | CLN80|p80-coilin | |
| Cytomap | UCSC genome browser: 17q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004645.2, | |
| Description | coilin p80p80 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600272 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000121058 | ||
| HPRD : 02605 | ||
| Vega : OTTHUMG00000178126 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_COIL | |
| BioGPS: 8161 | ||
| Pathway | NCI Pathway Interaction Database: COIL | |
| KEGG: COIL | ||
| REACTOME: COIL | ||
| Pathway Commons: COIL | ||
| Context | iHOP: COIL | |
| ligand binding site mutation search in PubMed: COIL | ||
| UCL Cancer Institute: COIL | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of COIL | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for COIL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for COIL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-let-7f-5p | MIMAT0000067 | 0.0053 | -0.37 | 56 |
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| TissGeneMut for COIL |
| TissGeneSNV for COIL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R413W | PRAD | 1 |
| p.E273D | HNSC | 1 |
| p.G371D | UCEC | 1 |
| p.Y15S | LUAD | 1 |
| p.L66F | LGG | 1 |
| p.V427L | SKCM | 1 |
| p.K108I | KIRC | 1 |
| p.E249* | LUAD | 1 |
| p.T448A | LUSC | 1 |
| p.C191Y | LUAD | 1 |
| p.S285C | LUAD | 1 |
| p.E62G | LUAD | 1 |
| p.K555E | THCA | 1 |
| p.D155E | PRAD | 1 |
| p.S566T | STAD | 1 |
| p.S447C | HNSC | 1 |
| p.P355L | LIHC | 1 |
| p.Q214E | SKCM | 1 |
| p.R410W | ESCA | 1 |
| p.K186T | READ | 1 |
| p.S248L | BLCA | 1 |
| p.A537V | STAD | 1 |
| p.E534K | BLCA | 1 |
| p.V423I | SKCM | 1 |
| p.L515V | BLCA | 1 |
| p.S247F | SKCM | 1 |
| p.L66F | PRAD | 1 |
| p.V540A | STAD | 1 |
| p.L515I | UCEC | 1 |
| p.D155N | KIRC | 1 |
| p.L32F | HNSC | 1 |
| p.Q214K | GBM | 1 |
| p.P18S | UCEC | 1 |
| p.L515F | BLCA | 1 |
| p.K555E | SARC | 1 |
| p.L328F | CESC | 1 |
| p.W395R | UCEC | 1 |
| p.L106F | PRAD | 1 |
| p.D14Y | STAD | 1 |
| p.L66F | PAAD | 1 |
| p.L401F | SKCM | 1 |
| p.P388S | SKCM | 1 |
| p.N213S | STAD | 1 |
| p.E398G | LUSC | 1 |
| p.Q12* | BRCA | 1 |
| p.R419* | BLCA | 1 |
| p.S424F | HNSC | 1 |
| p.D125H | CESC | 1 |
| p.L66F | HNSC | 1 |
| p.R419Q | CESC | 1 |
| p.R164I | UCEC | 1 |
| p.R112L | KIRP | 1 |
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| TissGeneCNV for COIL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for COIL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF990573 | INPPL1-COIL | chr11:71940796 | chr17:55016435 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A15H-01A | COIL-CDR2L | Out-of-Frame | chr17:55038135 | chr17:72995598 |
| TCGAfusionPortal | PRADA | BLCA | TCGA-DK-A1A5-01A | COIL-CA4 | Out-of-frame | Chr17:55038136 | Chr17:58232675 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A15H-01A | COIL-CDR2L | Out-of-frame | Chr17:55038136 | Chr17:72995599 |
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| TissGeneNet for COIL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| COIL, XRCC5, UBC, NOLC1, NUDT18, CDK2, TFCP2, CEP70, SART3, CYB5R2, TGS1, ANKS1B, NIF3L1, VRK1, MYO5B, HABP4, SCYL1, USPL1, ZNF277, CEP76, PLEKHG4 (tumor) | COIL, XRCC5, SMN1, SUMO2, NOLC1, NUDT18, CDK2, PICK1, SNX6, SART3, PSME3, MAD1L1, TGS1, ANKS1B, NIF3L1, HABP4, SCYL1, CEP76, FAM115A, PREPL, KLHL8 (normal) |
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| COAD (tumor) | COAD (normal) |
| COIL, SUMO2, PSMA1, CDK2, C1QBP, TAF9, DHX16, SNX6, SNRPB, ACTN4, PRMT1, TGS1, WDYHV1, VRK2, DNAJA3, NIF3L1, XRCC6, VRK1, MYO5B, USPL1, GCC1 (tumor) | COIL, XRCC5, SMN1, SUMO2, PSMA1, NUDT18, CCNE1, TAF9, FXR2, PRMT1, PSME3, TGS1, ACTN1, DNAJA3, NIF3L1, SCYL1, USPL1, BYSL, KPNA3, PREPL, KLHL8 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| COIL, KLC2, XRCC5, CDK2, ACTN2, FXR2, SNX6, ACTN4, PRMT1, LNX1, TGS1, VRK2, NIF3L1, VRK1, MYO5B, HABP4, CCDC136, TSPYL2, SCYL1, ZNF277, CEP76 (tumor) | COIL, UBC, SUMO2, TCEB3B, CDK2, TFCP2, CEP70, SART3, LNX1, PSME3, TGS1, ACTN1, VRK2, DNAJA3, NIF3L1, HABP4, SCYL1, CEP76, PREPL, KLHL8, PLEKHG4 (normal) |
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| KICH (tumor) | KICH (normal) |
| COIL, KLC2, UBC, SUMO2, PSMA1, NOLC1, PICK1, FXR2, SNX6, MYBBP1A, ACTN4, PRMT1, PSME3, MAD1L1, ZBTB25, NIF3L1, XRCC6, VRK1, MYO5B, FHL5, CEP76 (tumor) | COIL, XRCC5, SUMO2, NOLC1, TCEB3B, CDK2, C1QBP, PICK1, DHX16, SNX6, PSME3, ACTN1, VRK2, NIF3L1, CCDC136, SCYL1, BYSL, KPNA3, PRMT8, PREPL, WRAP53 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| COIL, XRCC5, CCDC159, SUMO2, NOLC1, PIAS4, CSNK2B, SNX6, CEP70, ACTN4, PSME3, TGS1, VRK2, ZBTB25, NIF3L1, VRK1, KLC4, USPL1, CEP76, PREPL, KLHL8 (tumor) | COIL, KLC2, XRCC5, CCDC159, SUMO2, NOLC1, NUDT18, CDK2, PICK1, SNX6, SNRPB, ACTN4, MAD1L1, TGS1, VRK2, VRK1, SCYL1, USPL1, KPNA3, PRMT8, PREPL (normal) |
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| KIRP (tumor) | KIRP (normal) |
| COIL, XRCC5, SUMO2, PSMA1, PIAS4, CCNE1, TAF9, SNX6, CEP70, ACTN4, TGS1, WDYHV1, VRK2, NIF3L1, XRCC6, VRK1, CCDC136, KLC4, USPL1, ZNF277, CEP76 (tumor) | COIL, XRCC5, SUMO2, NOLC1, NUDT18, CDK2, CCNE1, PRMT1, PSME3, TGS1, VRK2, ZBTB25, NIF3L1, VRK1, HABP4, KLC4, TSPYL2, SCYL1, USPL1, CEP76, FAM115A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| COIL, CCDC159, CDK2, CSNK2B, PICK1, TFCP2, SNX6, SART3, LNX1, MAD1L1, TGS1, VRK2, NIF3L1, VRK1, SCYL1, USPL1, ZNF277, FAM115A, KPNA3, PREPL, KLHL8 (tumor) | COIL, SIRT7, CCDC159, SUMO2, NOLC1, NUDT18, CDK2, CCNE1, TAF9, DHX16, SNRPB, SART3, PSME3, TGS1, VRK2, NIF3L1, XRCC6, VRK1, SCYL1, CEP76, PLEKHG4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| COIL, KLC2, XRCC5, SUMO2, PIAS4, C1QBP, TAF9, PICK1, FXR2, DHX16, SNX6, MYBBP1A, LNX1, MAD1L1, ACTN1, VRK1, SCYL1, ZNF277, KPNA3, PREPL, PLEKHG4 (tumor) | COIL, XRCC5, SUMO2, PSMA1, NUDT18, CDK2, CCNE1, C1QBP, TAF9, SNX6, SNRPB, PSME3, TGS1, WDYHV1, VRK2, NIF3L1, VRK1, TSPYL2, FHL5, CEP76, BYSL (normal) |
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| LUSC (tumor) | LUSC (normal) |
| COIL, KLC2, XRCC5, UBC, SUMO2, PSMA1, PIAS4, TAF9, PICK1, DHX16, SNX6, MYBBP1A, MAD1L1, NIF3L1, XRCC6, VRK1, SCYL1, USPL1, ZNF277, CEP76, KPNA3 (tumor) | COIL, SUMO2, CDK2, C1QBP, TAF9, ATXN1, CEP70, SNRPB, PSME3, MAD1L1, TGS1, ACTN1, VRK2, NIF3L1, XRCC6, VRK1, HABP4, SCYL1, CEP76, PREPL, KLHL8 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| COIL, KLC2, XRCC5, SUMO2, PSMA1, C1QBP, TAF9, FXR2, DHX16, SNX6, MYBBP1A, SNRPB, ACTN4, MAD1L1, ACTN1, NIF3L1, XRCC6, VRK1, USPL1, ZNF277, CEP76 (tumor) | COIL, XRCC5, UBC, NUDT18, CDK2, PICK1, FXR2, TFCP2, SNX6, CYB5R2, MAD1L1, TGS1, VRK2, NIF3L1, CCDC136, USPL1, CEP76, FAM115A, PREPL, WRAP53, KLHL8 (normal) |
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| STAD (tumor) | STAD (normal) |
| COIL, KLC2, XRCC5, SUMO2, PSMA1, PIAS4, C1QBP, TAF9, FXR2, DHX16, SNX6, ACTN4, VRK2, DNAJA3, KALRN, NIF3L1, XRCC6, VRK1, ZNF277, CEP76, FAM115A (tumor) | COIL, XRCC5, SUMO2, PSMA1, NUDT18, CDK2, CCNE1, CSNK2B, TAF9, SNRPB, SART3, PRMT1, PSME3, ACTN1, NIF3L1, XRCC6, VRK1, FHL5, CEP76, BYSL, PLEKHG4 (normal) |
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| THCA (tumor) | THCA (normal) |
| COIL, SIRT7, CCDC159, NUDT18, CSNK2B, TFCP2, SNRPB, SART3, LNX1, MAD1L1, TGS1, ANKS1B, NIF3L1, XRCC6, USPL1, CEP76, FAM115A, BYSL, PREPL, WRAP53, KLHL8 (tumor) | COIL, KLC2, UBC, NOLC1, CSNK2B, TFCP2, CEP70, SNRPB, ACTN4, SART3, LNX1, MAD1L1, TGS1, WDYHV1, ACTN1, ANKS1B, SCYL1, USPL1, FAM115A, PREPL, KLHL8 (normal) |
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| TissGeneProg for COIL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for COIL |
| TissGeneDrug for COIL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for COIL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 6 | BeFree |
| umls:C0334121 | Inflammatory Myofibroblastic Tumor | 2 | BeFree |
| umls:C0008497 | Choriocarcinoma | 1 | BeFree |
| umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | BeFree |
| umls:C0015230 | Exanthema | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | LHGDN |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0026847 | Spinal Muscular Atrophy | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0221023 | Cyclic neutropenia | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0848332 | Spots on skin | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1301362 | Lymphoma, Primary Cutaneous Anaplastic Large Cell | 1 | BeFree |
| umls:C2936904 | Opitz GBBB Syndrome, X-Linked | 1 | BeFree |
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