TissGeneSummary for ACSBG2 |
Gene summary |
Basic gene information | Gene symbol | ACSBG2 |
Gene name | acyl-CoA synthetase bubblegum family member 2 | |
Synonyms | BGR|BRGL|PRTD-NY3|PRTDNY3 | |
Cytomap | UCSC genome browser: 19p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001289177.1, NM_001289178.1,NM_001289179.1,NM_001289180.1,NM_030924.4, | |
Description | bubblegum-related proteinlong-chain-fatty-acid--CoA ligase ACSBG2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 614363 | |
HGNC : HGNC | ||
Ensembl : ENSG00000130377 | ||
HPRD : 09824 | ||
Vega : OTTHUMG00000180754 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACSBG2 | |
BioGPS: 81616 | ||
Pathway | NCI Pathway Interaction Database: ACSBG2 | |
KEGG: ACSBG2 | ||
REACTOME: ACSBG2 | ||
Pathway Commons: ACSBG2 | ||
Context | iHOP: ACSBG2 | |
ligand binding site mutation search in PubMed: ACSBG2 | ||
UCL Cancer Institute: ACSBG2 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ACSBG2 | The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase. Pei Z, Jia Z, Watkins PA. J Biol Chem. 2006 Mar 10;281(10):6632-41. Epub 2005 Dec 21. (pmid:16371355 ) go to article | |
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0001676 | long-chain fatty acid metabolic process | 16371355 | GO:0006631 | fatty acid metabolic process | 16371355 | GO:0001676 | long-chain fatty acid metabolic process | 16371355 | GO:0006631 | fatty acid metabolic process | 16371355 |
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TissGeneExp for ACSBG2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.444386042 | -0.363154463 | -1.081231579 | 1.28E-20 | 9.65E-20 |
KIRC | -0.959900223 | 0.629677554 | -1.589577778 | 1.75E-08 | 5.17E-08 |
KIRP | -1.521004737 | 1.303814013 | -2.82481875 | 3.35E-12 | 5.04E-11 |
KICH | -1.052720112 | 0.414299888 | -1.46702 | 0.00207 | 0.0042361 |
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TissGene-miRNA for ACSBG2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ACSBG2 |
TissGeneSNV for ACSBG2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.I250M | KIRP | 4 |
p.I200M | KIRP | 3 |
p.E29K | SKCM | 3 |
p.I250M | UCEC | 2 |
p.T376A | UCEC | 2 |
p.K259Q | UCEC | 2 |
p.R350K | SKCM | 1 |
p.I181V | LIHC | 1 |
p.H392P | COAD | 1 |
p.Q434H | UCEC | 1 |
p.P525S | LGG | 1 |
p.R91Q | BRCA | 1 |
p.P475S | LGG | 1 |
p.E632D | UCEC | 1 |
p.G398E | PAAD | 1 |
p.S376L | SKCM | 1 |
p.D111N | SKCM | 1 |
p.E368K | LGG | 1 |
p.Q8E | HNSC | 1 |
p.R91Q | KIRP | 1 |
p.R300K | SKCM | 1 |
p.P478T | LUAD | 1 |
p.F267L | BLCA | 1 |
p.A618V | COAD | 1 |
p.I395M | BRCA | 1 |
p.W28* | SKCM | 1 |
p.N84K | LIHC | 1 |
p.N316H | KIRC | 1 |
p.E261K | BLCA | 1 |
p.S494F | HNSC | 1 |
p.P271L | SKCM | 1 |
p.R104C | ESCA | 1 |
p.C415S | HNSC | 1 |
p.D17N | STAD | 1 |
p.A125S | THYM | 1 |
p.Y86N | SKCM | 1 |
p.A227S | BLCA | 1 |
p.F150L | SKCM | 1 |
p.P528T | LUAD | 1 |
p.K209Q | CESC | 1 |
p.S169L | CESC | 1 |
p.Y36N | SKCM | 1 |
p.R54C | ESCA | 1 |
p.E427* | CESC | 1 |
p.P538S | SKCM | 1 |
p.N366H | KIRC | 1 |
p.G107* | LUSC | 1 |
p.I489M | HNSC | 1 |
p.T430M | BRCA | 1 |
p.G44E | SKCM | 1 |
p.E632D | CHOL | 1 |
p.E407K | COAD | 1 |
p.P488S | SKCM | 1 |
p.K355E | SKCM | 1 |
p.I233M | BLCA | 1 |
p.R63Q | READ | 1 |
p.T255A | UCEC | 1 |
p.Q623* | HNSC | 1 |
p.A399V | READ | 1 |
p.T255A | KIRP | 1 |
p.F408L | UCEC | 1 |
p.L47F | SARC | 1 |
p.Q608P | STAD | 1 |
p.F63L | SKCM | 1 |
p.L351I | LUAD | 1 |
p.D13E | COAD | 1 |
p.G534S | SKCM | 1 |
p.M1I | COAD | 1 |
p.F56L | COAD | 1 |
p.E265D | UCEC | 1 |
p.D17G | SKCM | 1 |
p.I237M | STAD | 1 |
p.D161N | SKCM | 1 |
p.Q297* | BLCA | 1 |
p.Q573* | HNSC | 1 |
p.N34K | LIHC | 1 |
p.D149N | SKCM | 1 |
p.V153A | PAAD | 1 |
p.E472K | SKCM | 1 |
p.L81I | LUAD | 1 |
p.E514* | UCEC | 1 |
p.S115Y | ESCA | 1 |
p.K360N | READ | 1 |
p.W274L | SKCM | 1 |
p.L111M | READ | 1 |
p.D487N | READ | 1 |
p.L118F | SKCM | 1 |
p.I250M | KIRC | 1 |
p.V103A | PAAD | 1 |
p.G448E | PAAD | 1 |
p.L412F | THYM | 1 |
p.L456R | SKCM | 1 |
p.R63Q | UCEC | 1 |
p.I323F | SKCM | 1 |
p.S444F | HNSC | 1 |
p.G10A | BLCA | 1 |
p.L20I | LGG | 1 |
p.Q247* | BLCA | 1 |
p.I273F | SKCM | 1 |
p.F113L | SKCM | 1 |
p.P428S | STAD | 1 |
p.K305E | SKCM | 1 |
p.I352T | STAD | 1 |
p.E79K | SKCM | 1 |
p.V143I | UCEC | 1 |
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TissGeneCNV for ACSBG2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ACSBG2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA868830 | ACSBG2-SLC14A2 | chr19:6193105 | chr18:43063380 | |
Chimerdb3.0 | ChiTaRs | NA | AI939380 | ACSBG2-IGFBP5 | chr19:6138285 | chr2:217539795 | |
Chimerdb3.0 | FusionScan | LUAD | TCGA-75-5125-01A | NCLN-ACSBG2 | In-Frame | chr19:3193426 | chr19:6187293 |
TCGAfusionPortal | PRADA | LUAD | TCGA-75-5125-01A | NCLN-ACSBG2 | In-frame | Chr19:3193426 | Chr19:6187294 |
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TissGeneNet for ACSBG2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ACSBG2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ACSBG2 |
TissGeneDrug for ACSBG2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ACSBG2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0041296 | Tuberculosis | 1 | BeFree |
umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree,LHGDN |