TissGeneSummary for SLC25A31 |
Gene summary |
Basic gene information | Gene symbol | SLC25A31 |
Gene name | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 | |
Synonyms | AAC4|ANT4|SFEC35kDa | |
Cytomap | UCSC genome browser: 4q28.1 | |
Type of gene | protein-coding | |
RefGenes | NM_031291.2, | |
Description | ADP,ATP carrier protein 4ADP/ATP translocase 4ANT 4adenine nucleotide translocase 4adenine nucleotide translocator 4solute carrier family 25 member 31sperm flagellar energy carrier protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 610796 | |
HGNC : HGNC | ||
Ensembl : ENSG00000151475 | ||
HPRD : 13160 | ||
Vega : OTTHUMG00000133300 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC25A31 | |
BioGPS: 83447 | ||
Pathway | NCI Pathway Interaction Database: SLC25A31 | |
KEGG: SLC25A31 | ||
REACTOME: SLC25A31 | ||
Pathway Commons: SLC25A31 | ||
Context | iHOP: SLC25A31 | |
ligand binding site mutation search in PubMed: SLC25A31 | ||
UCL Cancer Institute: SLC25A31 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SLC25A31 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC25A31 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SLC25A31 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC25A31 |
TissGeneSNV for SLC25A31 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G28R | LUAD | 1 |
p.P145S | SKCM | 1 |
p.A37V | STAD | 1 |
p.R259L | STAD | 1 |
p.S19F | SKCM | 1 |
p.G158R | SKCM | 1 |
p.L265S | BLCA | 1 |
p.E118K | SARC | 1 |
p.L87F | COAD | 1 |
p.D311N | SKCM | 1 |
p.R92Q | STAD | 1 |
p.E306D | STAD | 1 |
p.V198L | LUAD | 1 |
p.R43L | LUAD | 1 |
p.H274L | LUAD | 1 |
p.R152Q | SKCM | 1 |
p.G276E | SKCM | 1 |
p.D302Y | UCEC | 1 |
p.R164* | UCEC | 1 |
p.R13W | HNSC | 1 |
p.D180E | LUSC | 1 |
p.Y93C | COAD | 1 |
p.R282C | SKCM | 1 |
p.V232L | LUSC | 1 |
p.R150Q | SKCM | 1 |
p.D147H | BLCA | 1 |
p.A30T | STAD | 1 |
p.R152Q | HNSC | 1 |
p.A284T | THYM | 1 |
p.A134S | LUSC | 1 |
p.G65V | BLCA | 1 |
p.V90G | SKCM | 1 |
p.E60K | LUAD | 1 |
p.P242L | SKCM | 1 |
p.A30T | LIHC | 1 |
p.A39V | COAD | 1 |
p.L87F | STAD | 1 |
p.A39V | READ | 1 |
p.L223F | SKCM | 1 |
p.L223I | READ | 1 |
p.M174I | SKCM | 1 |
p.G85V | BLCA | 1 |
p.K167E | STAD | 1 |
p.R75C | UCEC | 1 |
p.R200* | PRAD | 1 |
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TissGeneCNV for SLC25A31 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC25A31 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-J9-A8CL-01A | C4orf29-SLC25A31 | Out-of-Frame | chr4:128910976 | chr4:128694540 |
TCGAfusionPortal | PRADA | LUAD | TCGA-55-1592-01A | BMP2K-SLC25A31 | Out-of-frame | Chr4:79786874 | Chr4:128694541 |
TCGAfusionPortal | PRADA | PRAD | TCGA-J9-A8CL-01A | C4orf29-SLC25A31 | Out-of-frame | Chr4:128910976 | Chr4:128694541 |
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TissGeneNet for SLC25A31 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC25A31 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC25A31 |
TissGeneDrug for SLC25A31 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC25A31 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 2 | BeFree |