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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ARHGAP24
check button Gene summary
Basic gene informationGene symbolARHGAP24
Gene nameRho GTPase activating protein 24
SynonymsFILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAP
CytomapUCSC genome browser: 4q22.1
Type of geneprotein-coding
RefGenesNM_001025616.2,
NM_001042669.1,NM_001287805.1,NM_031305.2,
DescriptionRAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrho GTPase-activating protein 24rho-type GTPase-activating protein 24rhoGAP of 73 kDasarcoma antigen NY-SAR-88
Modification date20141207
dbXrefs MIM : 610586
HGNC : HGNC
Ensembl : ENSG00000138639
HPRD : 09804
Vega : OTTHUMG00000130427
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ARHGAP24
BioGPS: 83478
PathwayNCI Pathway Interaction Database: ARHGAP24
KEGG: ARHGAP24
REACTOME: ARHGAP24
Pathway Commons: ARHGAP24
ContextiHOP: ARHGAP24
ligand binding site mutation search in PubMed: ARHGAP24
UCL Cancer Institute: ARHGAP24
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of ARHGAP24
Description by TissGene annotationsProtective TissGene in OS
Protective TissGene in RFS
Have significant anti-correlated miRNA
TissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for ARHGAP24

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH2.1991349983.816578998-1.6174441.33E-109.90E-10
KIRP2.5114162483.716209998-1.204793759.65E-097.41E-08
LUAD0.0511867221.437172929-1.3859862074.23E-185.89E-17
BRCA-0.6259851770.66837184-1.2943570184.84E-285.62E-27
THCA-0.1505005952.327860422-2.4783610175.31E-212.67E-19
KIRC2.3199308313.844066942-1.5241361111.16E-302.32E-29
LUSC0.0058506841.451636959-1.4457862753.36E-121.49E-11
ESCA-0.2636650021.364034998-1.62770.0005850.010120062
BLCA-1.4139755280.298534998-1.7125105260.0001350.001383594
STAD-0.3284431270.700253748-1.0286968751.34E-050.000147728


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TissGene-miRNA for ARHGAP24

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-302b-3pMIMAT00007150.019-0.2778
ACChsa-miR-302b-3pMIMAT00007150.019-0.2778
ACChsa-miR-130b-3pMIMAT00006910.015-0.2878
ACChsa-miR-130b-3pMIMAT00006910.015-0.2878
LUADhsa-miR-205-5pMIMAT00002660.023-0.360
ACChsa-miR-4295MIMAT00168440.0039-0.3578
ACChsa-miR-4295MIMAT00168440.0039-0.3578


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TissGeneMut for ARHGAP24
TissGeneSNV for ARHGAP24

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D92NUCEC1
p.R150LLUAD1
p.V156APAAD1
p.G586EKIRP1
p.D606VUCEC1
p.S502CLIHC1
p.R499*PAAD1
p.M542IBLCA1
p.T35ATGCT1
p.R414GBLCA1
p.L288SSTAD1
p.L325FSKCM1
p.D92NUCS1
p.E51DKICH1
p.T728MUCEC1
p.S602FSKCM1
p.D612HSTAD1
p.T8MKIRP1
p.D161VSTAD1
p.R499QBLCA1
p.R36QBRCA1
p.M283VLIHC1
p.R702*STAD1
p.W125*SKCM1
p.R702XSTAD1
p.L104FCESC1
p.G485DSTAD1
p.R216*BLCA1
p.R142CSKCM1
p.S71YUCEC1
p.K227TKIRC1
p.M655TSKCM1
p.P597QGBM1
p.Q110KSKCM1
p.R146IUCEC1
p.F270LUCEC1
p.G336DREAD1
p.P11SSKCM1
p.D688GKIRP1
p.R702*UCEC1
p.E589KHNSC1
p.E580KLUAD1
p.L105FLUAD1
p.R461KSKCM1
p.N188SCOAD1
p.F51LBLCA1
p.Q15*SKCM1
p.S391FSKCM1
p.K82MLIHC1
p.I296TPAAD1
p.T290MBRCA1
p.D533NESCA1
p.P89LSKCM1
p.E677KLUAD1
p.Q525PKIRP1
p.G30XSTAD1
p.L48FLUAD1
p.S570FSKCM1
p.G585WSTAD1
p.G30*STAD1
p.L544HLIHC1
p.G45WLUAD1
p.R499*UCEC1
p.R298HSTAD1
p.R121HHNSC1
p.E425XCOAD1
p.R122QUCEC1
p.K352ESTAD1
p.L418FSKCM1
p.G130XCOAD1
p.Q548HHNSC1
p.Q15XSKCM1
p.G16VUCEC1
p.H100YBRCA1
p.M701TUCEC1
p.S298FSKCM1
p.R368KSKCM1
p.K324RUCEC1
p.K351NUCEC1
p.S509FSKCM1
p.R702QSKCM1
p.K404NUCEC1
p.K422NUCEC1
p.D161NLGG1
p.R499XPAAD1
p.K195NSTAD1
p.A711VCHOL1
p.G24WLUAD1


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TissGeneCNV for ARHGAP24

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ARHGAP24

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNADA819158ARHGAP24-BANK1chr4:86491874chr4:102942670
Chimerdb3.0ChiTaRsNAAK130576ARHGAP24-ARHGAP24chr4:86646342chr4:86396528
Chimerdb3.0ChiTaRsNAAW749210FGD6-ARHGAP24chr12:95491543chr4:86915995
Chimerdb3.0FusionScanSARCTCGA-DX-A1KY-01AARHGAP24-STAC5'UTR-CDSchr4:86396712chr3:36570187
TCGAfusionPortalPRADABRCATCGA-E2-A1IO-01AARHGAP24-C4orf14In-frameChr4:86643125Chr4:57840188


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TissGeneNet for ARHGAP24

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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COAD (tumor)COAD (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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HNSC (tumor)HNSC (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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KICH (tumor)KICH (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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KIRC (tumor)KIRC (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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KIRP (tumor)KIRP (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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LIHC (tumor)LIHC (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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LUAD (tumor)LUAD (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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LUSC (tumor)LUSC (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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PRAD (tumor)PRAD (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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STAD (tumor)STAD (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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THCA (tumor)THCA (normal)
ARHGAP24, FLNA, ROCK1 (tumor)ARHGAP24, FLNA, ROCK1 (normal)
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TissGeneProg for ARHGAP24

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ARHGAP24
TissGeneDrug for ARHGAP24

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ARHGAP24

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0596263Carcinogenesis53BeFree
umls:C0027819Neuroblastoma33BeFree
umls:C0700095Central neuroblastoma30BeFree
umls:C0006142Malignant neoplasm of breast19BeFree
umls:C0678222Breast Carcinoma18BeFree
umls:C2239176Liver carcinoma18BeFree
umls:C0009402Colorectal Carcinoma17BeFree
umls:C0242379Malignant neoplasm of lung16BeFree
umls:C0024299Lymphoma14BeFree
umls:C0029925Ovarian Carcinoma14BeFree
umls:C0684249Carcinoma of lung14BeFree
umls:C0027627Neoplasm Metastasis13BeFree
umls:C1527249Colorectal Cancer13BeFree
umls:C0007137Squamous cell carcinoma11BeFree
umls:C1140680Malignant neoplasm of ovary11BeFree
umls:C0023467Leukemia, Myelocytic, Acute10BeFree
umls:C0025202melanoma9BeFree
umls:C0023449Acute lymphocytic leukemia7BeFree
umls:C0178874Tumor Progression7BeFree
umls:C0600139Prostate carcinoma7BeFree
umls:C0005684Malignant neoplasm of urinary bladder6BeFree
umls:C0007131Non-Small Cell Lung Carcinoma6BeFree
umls:C0023434Chronic Lymphocytic Leukemia6BeFree
umls:C0376545Hematologic Neoplasms6BeFree
umls:C0699791Stomach Carcinoma6BeFree
umls:C0699885Carcinoma of bladder6BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma6BeFree,GAD
umls:C0001418Adenocarcinoma5BeFree
umls:C0007115Malignant neoplasm of thyroid5BeFree
umls:C0025286Meningioma5BeFree
umls:C0026764Multiple Myeloma5BeFree
umls:C0376358Malignant neoplasm of prostate5BeFree
umls:C0549473Thyroid carcinoma5BeFree
umls:C0686619Secondary malignant neoplasm of lymph node5BeFree
umls:C1168401Squamous cell carcinoma of the head and neck5BeFree
umls:C0007847Malignant tumor of cervix4BeFree
umls:C0023418leukemia4BeFree
umls:C0024623Malignant neoplasm of stomach4BeFree
umls:C0220641Lip and Oral Cavity Carcinoma4BeFree
umls:C0302592Cervix carcinoma4BeFree
umls:C0546837Malignant neoplasm of esophagus4BeFree
umls:C0677886Epithelial ovarian cancer4BeFree
umls:C0001430Adenoma3BeFree
umls:C0004114Astrocytoma3BeFree
umls:C0014859Esophageal Neoplasms3BeFree
umls:C0017638Glioma3BeFree
umls:C0023470Myeloid Leukemia3BeFree
umls:C0028945oligodendroglioma3BeFree
umls:C0152013Adenocarcinoma of lung (disorder)3BeFree
umls:C0152018Esophageal carcinoma3BeFree
umls:C0153381Malignant neoplasm of mouth3BeFree
umls:C0206698Cholangiocarcinoma3BeFree
umls:C0279626Squamous cell carcinoma of esophagus3BeFree
umls:C0280100Solid tumour3BeFree
umls:C0751396Well Differentiated Oligodendroglioma3BeFree
umls:C0919267ovarian neoplasm3BeFree
umls:C1519670Tumor Angiogenesis3BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype3BeFree
umls:C0006118Brain Neoplasms2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0014474Ependymoma2BeFree
umls:C0017152Gastritis2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0023473Myeloid Leukemia, Chronic2BeFree
umls:C0023487Acute Promyelocytic Leukemia2BeFree
umls:C0027430Nasal Polyps2BeFree
umls:C0027962Melanocytic nevus2BeFree
umls:C0029463Osteosarcoma2BeFree
umls:C0079772T-Cell Lymphoma2BeFree
umls:C0153382Malignant neoplasm of oropharynx2BeFree
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0278701Gastric Adenocarcinoma2BeFree
umls:C0343641Human papilloma virus infection2BeFree
umls:C0346647Malignant neoplasm of pancreas2BeFree
umls:C0376544Hematopoietic Neoplasms2BeFree
umls:C0429087Electrocardiogram: P-R interval2GWASCAT
umls:C0585442Osteosarcoma of bone2BeFree
umls:C0598766Leukemogenesis2BeFree
umls:C2349952Oropharyngeal Carcinoma2BeFree
umls:C3539878Triple Negative Breast Neoplasms2BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0003850Arteriosclerosis1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0005699Blast Phase1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007113Rectal Carcinoma1BeFree
umls:C0007121Bronchogenic Carcinoma1BeFree
umls:C0007129Merkel cell carcinoma1BeFree
umls:C0009404Colorectal Neoplasms1BeFree
umls:C0010606Adenoid Cystic Carcinoma1BeFree
umls:C0015625Fanconi Anemia1BeFree
umls:C0017185Gastrointestinal Neoplasms1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0017668Focal glomerulosclerosis1BeFree
umls:C0018133Graft-vs-Host Disease1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0020175Hunger1BeFree
umls:C0022658Kidney Diseases1BeFree
umls:C0023448Lymphoid leukemia1BeFree
umls:C0023474Leukemia, Myeloid, Chronic-Phase1BeFree
umls:C0023531Leukoplakia1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0024305Lymphoma, Non-Hodgkin1BeFree
umls:C0024314Lymphoproliferative Disorders1BeFree
umls:C0025149Medulloblastoma1BeFree
umls:C0026269Mitral Valve Stenosis1BeFree
umls:C0026277Mixed Salivary Gland Tumor1BeFree
umls:C0026769Multiple Sclerosis1BeFree
umls:C0030521Parathyroid Neoplasms1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0033027Preleukemia1BeFree
umls:C0035335Retinoblastoma1BeFree
umls:C0038356Stomach Neoplasms1BeFree
umls:C0040136Thyroid Neoplasm1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0042373Vascular Diseases1BeFree
umls:C0079731B-Cell Lymphomas1BeFree
umls:C0079744Diffuse Large B-Cell Lymphoma1BeFree
umls:C0079745Lymphoma, Large-Cell, Follicular1BeFree
umls:C0079773Lymphoma, T-Cell, Cutaneous1BeFree
umls:C0085669Acute leukemia1BeFree
umls:C0149678Epstein-Barr Virus Infections1BeFree
umls:C0151546Oral Cavity Carcinoma1BeFree
umls:C0153452Malignant neoplasm of gallbladder1BeFree
umls:C0178468Autoimmune thyroid disease1BeFree
umls:C0235782Gallbladder Carcinoma1BeFree
umls:C0238448Testicular embryonal carcinoma1BeFree
umls:C0262587Parathyroid Adenoma1BeFree
umls:C0278601Inflammatory Breast Carcinoma1BeFree
umls:C0278687Ovarian epithelial cancer stage III1BeFree
umls:C0278883Metastatic melanoma1BeFree
umls:C0278996Cancer of Head and Neck1BeFree
umls:C0280313Squamous cell carcinoma of oropharynx1BeFree
umls:C0333497Segmental glomerulosclerosis1BeFree
umls:C0334583Pilocytic Astrocytoma1BeFree
umls:C0334590Anaplastic Oligodendroglioma1BeFree
umls:C0346957Disseminated Malignant Neoplasm1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0549379Recurrent Carcinoma1BeFree
umls:C0553723Squamous cell carcinoma of skin1BeFree
umls:C0585362Squamous cell carcinoma of mouth1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0740457Malignant neoplasm of kidney1BeFree
umls:C0751688Malignant Squamous Cell Neoplasm1BeFree
umls:C0850666Helicobacter pylori infection1BeFree
umls:C0860207Drug-Induced Liver Injury1GAD
umls:C0862506Borderline ovarian tumour1BeFree
umls:C0878500Intraepithelial Neoplasia1BeFree
umls:C0948216Ovarian adenocarcinoma1BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia1BeFree
umls:C1336076Sporadic Breast Carcinoma1BeFree
umls:C1337013Differentiated Thyroid Gland Carcinoma1BeFree
umls:C1378703Renal carcinoma1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1510586Autism Spectrum Disorders1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1623038Cirrhosis1BeFree
umls:C1654637androgen independent prostate cancer1BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C2752147XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C3150911GASTRIC CANCER, INTESTINAL1BeFree
umls:C3463824MYELODYSPLASTIC SYNDROME1BeFree
umls:C3469521FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)1BeFree
umls:C3539909Allergic disposition1BeFree