TissGeneSummary for WDR87 |
Gene summary |
Basic gene information | Gene symbol | WDR87 |
Gene name | WD repeat domain 87 | |
Synonyms | NYD-SP11 | |
Cytomap | UCSC genome browser: 19q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_001291088.1, NM_031951.4, | |
Description | WD repeat-containing protein 87testis development protein NYD-SP11 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000171804 | ||
Vega : OTTHUMG00000048187 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WDR87 | |
BioGPS: 83889 | ||
Pathway | NCI Pathway Interaction Database: WDR87 | |
KEGG: WDR87 | ||
REACTOME: WDR87 | ||
Pathway Commons: WDR87 | ||
Context | iHOP: WDR87 | |
ligand binding site mutation search in PubMed: WDR87 | ||
UCL Cancer Institute: WDR87 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of WDR87 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for WDR87 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.265484903 | 1.637833741 | -1.903318644 | 2.69E-09 | 1.47E-08 |
LUAD | -0.828663687 | -1.880249894 | 1.051586207 | 0.000635 | 0.001422882 |
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TissGene-miRNA for WDR87 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for WDR87 |
TissGeneSNV for WDR87 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E2264K | COAD | 5 |
p.V2262E | PRAD | 4 |
p.K141N | UCEC | 3 |
p.E2264K | READ | 2 |
p.S2629G | ESCA | 2 |
p.Q1897H | LIHC | 2 |
p.K2270E | KIRC | 2 |
p.E1677D | COAD | 2 |
p.H826L | KIRC | 1 |
p.K1746N | UCEC | 1 |
p.E1727* | UCEC | 1 |
p.M1276T | COAD | 1 |
p.R2427S | UCEC | 1 |
p.E1898X | LIHC | 1 |
p.R2737W | READ | 1 |
p.R867Q | COAD | 1 |
p.D2746Y | READ | 1 |
p.E1775* | UCEC | 1 |
p.E2166K | CESC | 1 |
p.A1889T | READ | 1 |
p.Q1491K | BRCA | 1 |
p.G362C | ESCA | 1 |
p.K1667N | UCEC | 1 |
p.D64Y | UCEC | 1 |
p.K637N | UCEC | 1 |
p.S985C | ESCA | 1 |
p.L842Q | LIHC | 1 |
p.R2269G | COAD | 1 |
p.E2662D | COAD | 1 |
p.L900F | SARC | 1 |
p.R658W | UCEC | 1 |
p.V1310I | LIHC | 1 |
p.K1408R | SARC | 1 |
p.K1299T | ESCA | 1 |
p.E2223X | COAD | 1 |
p.S2359I | UCEC | 1 |
p.R1058W | UCEC | 1 |
p.Q687H | UCEC | 1 |
p.P2668T | THYM | 1 |
p.R619W | UCEC | 1 |
p.R471Q | LIHC | 1 |
p.S240N | UCEC | 1 |
p.M2499V | READ | 1 |
p.L2599P | UCEC | 1 |
p.E1668K | SARC | 1 |
p.L2912F | ACC | 1 |
p.K32N | READ | 1 |
p.P419T | UCEC | 1 |
p.E1792V | LIHC | 1 |
p.Q1086H | ESCA | 1 |
p.Q1125H | ESCA | 1 |
p.K1090N | COAD | 1 |
p.R2511G | UCEC | 1 |
p.R1019W | UCEC | 1 |
p.A1603V | UCEC | 1 |
p.A1127T | BRCA | 1 |
p.T1207A | UCEC | 1 |
p.I1115M | CESC | 1 |
p.E1641D | UCEC | 1 |
p.K1894T | LIHC | 1 |
p.M192L | LIHC | 1 |
p.A1889D | UCEC | 1 |
p.R432Q | LIHC | 1 |
p.R320Q | CESC | 1 |
p.T896I | LIHC | 1 |
p.Q53* | ESCA | 1 |
p.T1206A | LIHC | 1 |
p.A1666S | READ | 1 |
p.S2590G | ESCA | 1 |
p.I2175M | UCEC | 1 |
p.L1909R | ESCA | 1 |
p.R2035K | SARC | 1 |
p.K2770Q | UCEC | 1 |
p.E2436* | UCEC | 1 |
p.E2018* | LIHC | 1 |
p.I2076M | LIHC | 1 |
p.Q367K | KIRP | 1 |
p.E1753V | LIHC | 1 |
p.Q1927K | THYM | 1 |
p.L2638P | UCEC | 1 |
p.L1934M | SARC | 1 |
p.E80* | UCEC | 1 |
p.E2342* | UCEC | 1 |
p.E980D | COAD | 1 |
p.L1376F | ESCA | 1 |
p.S49Y | CESC | 1 |
p.E2438D | LIHC | 1 |
p.S1027C | BRCA | 1 |
p.E2064D | UCEC | 1 |
p.V505I | UCEC | 1 |
p.Q913K | COAD | 1 |
p.E1699* | UCEC | 1 |
p.T2464A | DLBC | 1 |
p.E1695K | SARC | 1 |
p.R768Q | UCEC | 1 |
p.L2873F | ACC | 1 |
p.L675S | LIHC | 1 |
p.R99W | UCEC | 1 |
p.K1828N | UCEC | 1 |
p.R2050I | UCEC | 1 |
p.M2037V | SARC | 1 |
p.L1948R | ESCA | 1 |
p.K32N | UCEC | 1 |
p.E1598K | UCEC | 1 |
p.E1313D | UCEC | 1 |
p.E1600D | UCEC | 1 |
p.F46L | UCEC | 1 |
p.D1177E | COAD | 1 |
p.S1257Y | LIHC | 1 |
p.E1928D | READ | 1 |
p.V2262E | LGG | 1 |
p.M153L | LIHC | 1 |
p.V2520I | LIHC | 1 |
p.T857I | LIHC | 1 |
p.M2663I | UCEC | 1 |
p.M462T | COAD | 1 |
p.E1677D | UCEC | 1 |
p.E1555D | BRCA | 1 |
p.K1338T | ESCA | 1 |
p.Q1604K | SARC | 1 |
p.S1024C | ESCA | 1 |
p.E435D | UCEC | 1 |
p.Y328* | UCEC | 1 |
p.Q328K | KIRP | 1 |
p.M889I | LIHC | 1 |
p.E2662K | UCEC | 1 |
p.E1907D | UCEC | 1 |
p.P2865T | SARC | 1 |
p.R947H | DLBC | 1 |
p.M1396L | SARC | 1 |
p.P935L | COAD | 1 |
p.H953R | KIRC | 1 |
p.R2843Q | COAD | 1 |
p.P1078L | LIHC | 1 |
p.K2289E | KIRP | 1 |
p.E1656D | UCEC | 1 |
p.E1494D | COAD | 1 |
p.L636S | LIHC | 1 |
p.E2211X | COAD | 1 |
p.Y289* | UCEC | 1 |
p.R2141W | COAD | 1 |
p.S1296Y | LIHC | 1 |
p.E2069K | SARC | 1 |
p.K1844N | ACC | 1 |
p.V710M | COAD | 1 |
p.S1194F | CESC | 1 |
p.D1152Y | READ | 1 |
p.K966E | UCEC | 1 |
p.R1137W | SARC | 1 |
p.P1117L | LIHC | 1 |
p.G2423E | SARC | 1 |
p.P380T | UCEC | 1 |
p.E2185G | LIHC | 1 |
p.K1883N | ACC | 1 |
p.S201N | UCEC | 1 |
p.L184P | TGCT | 1 |
p.P2428H | LIHC | 1 |
p.R331W | UCEC | 1 |
p.H746N | ESCA | 1 |
p.E1825X | COAD | 1 |
p.L2861V | COAD | 1 |
p.G2378D | UCEC | 1 |
p.K1961N | COAD | 1 |
p.Y533H | LUAD | 1 |
p.L630F | UCEC | 1 |
p.K2089N | COAD | 1 |
p.T2492R | SARC | 1 |
p.S1096C | CESC | 1 |
p.M850I | LIHC | 1 |
p.E2785* | UCEC | 1 |
p.W2750X | COAD | 1 |
p.I1186T | UCEC | 1 |
p.L145P | TGCT | 1 |
p.L1955F | LUAD | 1 |
p.K2334N | CESC | 1 |
p.R1588X | COAD | 1 |
p.L1415F | ESCA | 1 |
p.E2264K | DLBC | 1 |
p.R2263M | COAD | 1 |
p.E1612Q | LIHC | 1 |
p.Q913K | THYM | 1 |
p.L803Q | LIHC | 1 |
p.E1979X | LIHC | 1 |
p.K1371N | UCEC | 1 |
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TissGeneCNV for WDR87 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for WDR87 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for WDR87 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for WDR87 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for WDR87 |
TissGeneDrug for WDR87 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for WDR87 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |