TissGeneSummary for SPATA16 |
Gene summary |
Basic gene information | Gene symbol | SPATA16 |
Gene name | spermatogenesis associated 16 | |
Synonyms | NYD-SP12|SPGF6 | |
Cytomap | UCSC genome browser: 3q26.31 | |
Type of gene | protein-coding | |
RefGenes | NM_031955.5, | |
Description | spermatogenesis-associated protein 16testis development protein NYD-SP12testis-specific Golgi protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 609856 | |
HGNC : HGNC | ||
Ensembl : ENSG00000144962 | ||
HPRD : 11408 | ||
Vega : OTTHUMG00000156865 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPATA16 | |
BioGPS: 83893 | ||
Pathway | NCI Pathway Interaction Database: SPATA16 | |
KEGG: SPATA16 | ||
REACTOME: SPATA16 | ||
Pathway Commons: SPATA16 | ||
Context | iHOP: SPATA16 | |
ligand binding site mutation search in PubMed: SPATA16 | ||
UCL Cancer Institute: SPATA16 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPATA16 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPATA16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.020456746 | -1.004712746 | -1.015744 | 5.69E-07 | 2.24E-06 |
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TissGene-miRNA for SPATA16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPATA16 |
TissGeneSNV for SPATA16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E42K | SKCM | 2 |
p.W175* | SKCM | 2 |
p.M1I | SKCM | 2 |
p.R136C | SKCM | 2 |
p.P450S | SKCM | 2 |
p.G447E | STAD | 1 |
p.R554Q | BRCA | 1 |
p.R554Q | STAD | 1 |
p.S5R | LUAD | 1 |
p.E214K | SKCM | 1 |
p.G197X | SKCM | 1 |
p.H164D | GBM | 1 |
p.K431E | STAD | 1 |
p.P219T | CESC | 1 |
p.A195S | LIHC | 1 |
p.W524C | HNSC | 1 |
p.D182N | SKCM | 1 |
p.M429I | HNSC | 1 |
p.R136C | HNSC | 1 |
p.R298K | SKCM | 1 |
p.Q198K | LUAD | 1 |
p.P414L | SKCM | 1 |
p.K95N | LUAD | 1 |
p.S145F | SKCM | 1 |
p.Q476H | COAD | 1 |
p.T428A | LUSC | 1 |
p.K118N | CESC | 1 |
p.E71X | ESCA | 1 |
p.T360I | LUSC | 1 |
p.L485I | LUSC | 1 |
p.Q97H | LUAD | 1 |
p.R136L | LUAD | 1 |
p.A224V | HNSC | 1 |
p.P244L | SKCM | 1 |
p.R432* | UCEC | 1 |
p.E473K | SKCM | 1 |
p.K395N | PAAD | 1 |
p.T232A | OV | 1 |
p.N518S | HNSC | 1 |
p.I340L | HNSC | 1 |
p.H18R | DLBC | 1 |
p.K48E | SKCM | 1 |
p.H18Y | SKCM | 1 |
p.R84W | KIRC | 1 |
p.E87K | STAD | 1 |
p.Y17C | HNSC | 1 |
p.A288T | UCEC | 1 |
p.K67E | LIHC | 1 |
p.E124K | SKCM | 1 |
p.K190N | LUSC | 1 |
p.E410K | SKCM | 1 |
p.E71D | UCS | 1 |
p.G197R | SKCM | 1 |
p.D438N | SKCM | 1 |
p.W374C | HNSC | 1 |
p.M560I | SKCM | 1 |
p.I440V | LUSC | 1 |
p.E316K | SKCM | 1 |
p.V22G | LIHC | 1 |
p.K190R | LIHC | 1 |
p.G394R | SKCM | 1 |
p.E138A | STAD | 1 |
p.L383I | UCEC | 1 |
p.R554Q | SKCM | 1 |
p.G53V | LUAD | 1 |
p.L513F | SKCM | 1 |
p.S185F | SKCM | 1 |
p.R200K | SKCM | 1 |
p.G197* | SKCM | 1 |
p.V256A | STAD | 1 |
p.D361E | LIHC | 1 |
p.A332V | STAD | 1 |
p.A332V | UCEC | 1 |
p.D19N | SKCM | 1 |
p.R84P | LUSC | 1 |
p.P352H | UCEC | 1 |
p.D421H | HNSC | 1 |
p.R554L | LUAD | 1 |
p.E78D | LUSC | 1 |
p.A227V | STAD | 1 |
p.P330S | SKCM | 1 |
p.G297E | SKCM | 1 |
p.Q363E | BLCA | 1 |
p.V178I | SKCM | 1 |
p.F408Y | LIHC | 1 |
p.E473K | LUAD | 1 |
p.A499E | MESO | 1 |
p.E315Q | UCEC | 1 |
p.H411R | LUAD | 1 |
p.A183V | COAD | 1 |
p.R62I | KIRP | 1 |
p.L537I | UCEC | 1 |
p.A353T | STAD | 1 |
p.I335K | HNSC | 1 |
p.R62K | SKCM | 1 |
p.M560I | BLCA | 1 |
p.E71* | ESCA | 1 |
p.F536C | UCEC | 1 |
p.N26S | PRAD | 1 |
p.H265R | COAD | 1 |
p.E61Q | LUAD | 1 |
p.W175X | SKCM | 1 |
p.P378S | SKCM | 1 |
p.M426I | SKCM | 1 |
p.G213E | SKCM | 1 |
p.L194F | LIHC | 1 |
p.K64E | LUAD | 1 |
p.D493N | SKCM | 1 |
p.G4E | SKCM | 1 |
p.A507E | HNSC | 1 |
p.P113T | HNSC | 1 |
p.R277K | SKCM | 1 |
p.S325L | UCEC | 1 |
p.L239V | HNSC | 1 |
p.Q480E | CESC | 1 |
p.M125I | SKCM | 1 |
p.P116L | KIRC | 1 |
p.L513R | SKCM | 1 |
p.H114Y | SKCM | 1 |
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TissGeneCNV for SPATA16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPATA16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AQ-A04L-01B | LPP-SPATA16 | In-frame | Chr3:188584166 | Chr3:172737365 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7430-01A | NCEH1-SPATA16 | In-frame | Chr3:172428637 | Chr3:172674614 |
TCGAfusionPortal | PRADA | LUAD | TCGA-05-4417-01A | TMEM131-SPATA16 | In-frame | Chr2:98543889 | Chr3:172766884 |
TCGAfusionPortal | PRADA | LUSC | TCGA-46-6025-01A | FNDC3B-SPATA16 | 5UTR-CDS | Chr3:171757561 | Chr3:172607482 |
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TissGeneNet for SPATA16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPATA16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPATA16 |
TissGeneDrug for SPATA16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPATA16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002690 | Amputation Stumps | 1 | BeFree |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0403825 | Globozoospermia | 1 | CLINVAR,CTD_human,UNIPROT |