TissGeneSummary for TTC29 |
Gene summary |
Basic gene information | Gene symbol | TTC29 |
Gene name | tetratricopeptide repeat domain 29 | |
Synonyms | NYD-SP14|TBPP2A | |
Cytomap | UCSC genome browser: 4q31.22 | |
Type of gene | protein-coding | |
RefGenes | NM_001300761.1, NM_031956.2, | |
Description | TPR repeat protein 29testis development protein NYD-SP14tetratricopeptide repeat protein 29 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000137473 | ||
HPRD : 14866 | ||
Vega : OTTHUMG00000162047 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TTC29 | |
BioGPS: 83894 | ||
Pathway | NCI Pathway Interaction Database: TTC29 | |
KEGG: TTC29 | ||
REACTOME: TTC29 | ||
Pathway Commons: TTC29 | ||
Context | iHOP: TTC29 | |
ligand binding site mutation search in PubMed: TTC29 | ||
UCL Cancer Institute: TTC29 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TTC29 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for TTC29 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -2.086086119 | -0.860982729 | -1.22510339 | 6.80E-13 | 6.33E-12 |
KICH | -2.402720899 | -1.137704899 | -1.265016 | 1.53E-06 | 5.63E-06 |
KIRC | -1.970960955 | -0.670701232 | -1.300259722 | 7.72E-11 | 2.78E-10 |
LUAD | -0.133223933 | 2.508024342 | -2.641248276 | 4.78E-08 | 1.95E-07 |
LUSC | -1.22974584 | 2.514173768 | -3.743919608 | 2.79E-14 | 1.54E-13 |
Top |
TissGene-miRNA for TTC29 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for TTC29 |
TissGeneSNV for TTC29 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E392K | SKCM | 2 |
p.E26K | SKCM | 2 |
p.E226K | SKCM | 2 |
p.I329F | LUAD | 1 |
p.L211F | BRCA | 1 |
p.E137K | SKCM | 1 |
p.K17E | MESO | 1 |
p.E154Q | CESC | 1 |
p.A276T | COAD | 1 |
p.C177Y | STAD | 1 |
p.G240R | SKCM | 1 |
p.K339N | UCEC | 1 |
p.E157D | LUAD | 1 |
p.M419I | SKCM | 1 |
p.D118N | KIRC | 1 |
p.D118A | ACC | 1 |
p.P38L | SKCM | 1 |
p.D92N | KIRC | 1 |
p.I289L | SKCM | 1 |
p.F377L | STAD | 1 |
p.N273H | SKCM | 1 |
p.E272K | SKCM | 1 |
p.P12L | SKCM | 1 |
p.S423I | COAD | 1 |
p.E488K | SKCM | 1 |
p.A44P | LUAD | 1 |
p.Q375* | SKCM | 1 |
p.A274V | LGG | 1 |
p.G214R | SKCM | 1 |
p.D115N | SKCM | 1 |
p.L216I | LUAD | 1 |
p.D176N | ESCA | 1 |
p.E332Q | HNSC | 1 |
p.R53* | LUAD | 1 |
p.Y119S | UCS | 1 |
p.E109K | SKCM | 1 |
p.E200K | SKCM | 1 |
p.V70M | UCEC | 1 |
p.E366K | SKCM | 1 |
p.M434I | SKCM | 1 |
p.K200E | HNSC | 1 |
p.L132M | ACC | 1 |
p.R100Q | SKCM | 1 |
p.V341A | LUAD | 1 |
p.A370V | HNSC | 1 |
p.V96M | UCEC | 1 |
p.R37C | LUAD | 1 |
p.E181* | UCEC | 1 |
p.S383N | LGG | 1 |
p.E131D | LUAD | 1 |
p.D141N | SKCM | 1 |
p.A344V | HNSC | 1 |
p.E232K | HNSC | 1 |
p.E137K | UCEC | 1 |
p.F381I | STAD | 1 |
p.K156N | LUAD | 1 |
p.E164X | COAD | 1 |
p.Q236* | BLCA | 1 |
p.E249K | SKCM | 1 |
p.K182N | LUAD | 1 |
p.E232K | LUAD | 1 |
p.N440K | LUAD | 1 |
p.E275K | SKCM | 1 |
p.L217P | LUAD | 1 |
p.E206* | LUAD | 1 |
p.V367A | LUAD | 1 |
p.K397N | UCEC | 1 |
p.Y145S | UCS | 1 |
p.K21X | LIHC | 1 |
p.K76N | UCEC | 1 |
p.E83K | SKCM | 1 |
p.A293T | UCEC | 1 |
p.K270E | THYM | 1 |
p.E190V | LGG | 1 |
p.A229T | UCEC | 1 |
p.G435R | BRCA | 1 |
p.R241Q | BLCA | 1 |
p.E111K | SKCM | 1 |
p.E206K | LUAD | 1 |
p.H140Y | COAD | 1 |
p.K365N | UCEC | 1 |
p.R191Q | SKCM | 1 |
p.R165Q | SKCM | 1 |
p.K339N | BRCA | 1 |
p.G240E | SKCM | 1 |
p.L106M | ACC | 1 |
p.K50N | UCEC | 1 |
p.D66G | BLCA | 1 |
p.E131K | UCEC | 1 |
p.R241L | LUAD | 1 |
p.R238I | UCEC | 1 |
p.K47* | LIHC | 1 |
p.L191P | LUAD | 1 |
p.Y426H | BLCA | 1 |
p.D202N | ESCA | 1 |
p.E232* | LUAD | 1 |
p.L285* | STAD | 1 |
p.A264T | COAD | 1 |
p.E358Q | HNSC | 1 |
p.R249L | LUAD | 1 |
p.E489K | SARC | 1 |
p.D92A | ACC | 1 |
Top |
TissGeneCNV for TTC29 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for TTC29 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE068017 | HLA-H-TTC29 | chr6:29952494 | chr4:147661868 | |
TCGAfusionPortal | PRADA | OV | TCGA-13-0760-01A | SLC10A7-TTC29 | Out-of-frame | Chr4:147438190 | Chr4:147628703 |
Top |
TissGeneNet for TTC29 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for TTC29 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for TTC29 |
TissGeneDrug for TTC29 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for TTC29 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |