TissGeneSummary for TSSK1B |
Gene summary |
Basic gene information | Gene symbol | TSSK1B |
Gene name | testis-specific serine kinase 1B | |
Synonyms | SPOGA4|STK22D|TSK1|TSSK1 | |
Cytomap | UCSC genome browser: 5q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_032028.3, | |
Description | TSK-1TSSK-1serine/threonine kinase 22D (spermiogenesis associated)serine/threonine kinase FKSG81serine/threonine-protein kinase 22Aspermiogenesis associated 4testis-specific kinase 1testis-specific serine kinase 1testis-specific serine/threonine-p | |
Modification date | 20141207 | |
dbXrefs | MIM : 610709 | |
HGNC : HGNC | ||
Ensembl : ENSG00000212122 | ||
HPRD : 11610 | ||
Vega : OTTHUMG00000128835 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSSK1B | |
BioGPS: 83942 | ||
Pathway | NCI Pathway Interaction Database: TSSK1B | |
KEGG: TSSK1B | ||
REACTOME: TSSK1B | ||
Pathway Commons: TSSK1B | ||
Context | iHOP: TSSK1B | |
ligand binding site mutation search in PubMed: TSSK1B | ||
UCL Cancer Institute: TSSK1B | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TSSK1B | Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. Andrology. 2013 Jan;1(1):160-8. (pmid:23258646) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 15733851 | GO:0006468 | protein phosphorylation | 15733851 |
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TissGeneExp for TSSK1B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TSSK1B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TSSK1B |
TissGeneSNV for TSSK1B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E301K | UCEC | 3 |
p.S291F | SKCM | 3 |
p.D129N | SKCM | 2 |
p.E329K | SKCM | 2 |
p.E301K | SARC | 1 |
p.R160C | UCEC | 1 |
p.R232H | OV | 1 |
p.P191S | SKCM | 1 |
p.T310S | LUAD | 1 |
p.G278E | SKCM | 1 |
p.E363D | STAD | 1 |
p.R45L | STAD | 1 |
p.A50T | PRAD | 1 |
p.A50T | UCEC | 1 |
p.V132I | THYM | 1 |
p.V94I | BLCA | 1 |
p.S178L | BLCA | 1 |
p.S121F | SKCM | 1 |
p.A180V | COAD | 1 |
p.M351V | BRCA | 1 |
p.E185G | UCEC | 1 |
p.D247N | COAD | 1 |
p.D145H | BLCA | 1 |
p.T310I | SKCM | 1 |
p.R292W | PAAD | 1 |
p.G15W | COAD | 1 |
p.G293E | COAD | 1 |
p.N234D | SKCM | 1 |
p.P348Q | UCEC | 1 |
p.R105W | SKCM | 1 |
p.G212S | COAD | 1 |
p.Q119H | COAD | 1 |
p.E112K | COAD | 1 |
p.S22F | SKCM | 1 |
p.E363K | SKCM | 1 |
p.Q95H | LUAD | 1 |
p.V133I | HNSC | 1 |
p.K195E | UCEC | 1 |
p.W271X | SKCM | 1 |
p.P300S | SKCM | 1 |
p.E301K | BLCA | 1 |
p.G356R | LUAD | 1 |
p.R105Q | CESC | 1 |
p.P215S | COAD | 1 |
p.D3E | SKCM | 1 |
p.R9Q | SKCM | 1 |
p.E100* | UCEC | 1 |
p.E265K | SKCM | 1 |
p.E60K | SKCM | 1 |
p.D217N | SKCM | 1 |
p.D111V | COAD | 1 |
p.D247N | SKCM | 1 |
p.R168* | SKCM | 1 |
p.R260Q | COAD | 1 |
p.R135W | STAD | 1 |
p.I43V | SKCM | 1 |
p.E77K | STAD | 1 |
p.V86F | LUAD | 1 |
p.R163W | LGG | 1 |
p.G106E | SKCM | 1 |
p.W271* | SKCM | 1 |
p.R232L | LUAD | 1 |
p.P215S | ESCA | 1 |
p.L144F | SKCM | 1 |
p.R237C | READ | 1 |
p.R9Q | STAD | 1 |
p.L241P | COAD | 1 |
p.E301K | GBM | 1 |
p.F56S | UCEC | 1 |
p.A39V | COAD | 1 |
p.R168X | SKCM | 1 |
p.D247H | SKCM | 1 |
p.K246M | LUAD | 1 |
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TissGeneCNV for TSSK1B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TSSK1B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TSSK1B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TSSK1B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TSSK1B |
TissGeneDrug for TSSK1B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TSSK1B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036421 | Systemic Scleroderma | 5 | BeFree |
umls:C0004364 | Autoimmune Diseases | 1 | CTD_mouse |
umls:C0011644 | Scleroderma | 1 | BeFree |
umls:C0018133 | Graft-vs-Host Disease | 1 | BeFree |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0867389 | Chronic graft-versus-host disease | 1 | BeFree |
umls:C0878544 | Cardiomyopathies | 1 | BeFree |