TissGeneSummary for TSSK6 |
Gene summary |
Basic gene information | Gene symbol | TSSK6 |
Gene name | testis-specific serine kinase 6 | |
Synonyms | CT72|SSTK|TSSK4 | |
Cytomap | UCSC genome browser: 19p13.11 | |
Type of gene | protein-coding | |
RefGenes | NM_032037.3, | |
Description | TSK-6cancer/testis antigen 72serine/threonine protein kinase SSTKsmall serine/threonine kinasetestis-specific serine/threonine-protein kinase 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610712 | |
HGNC : HGNC | ||
Ensembl : ENSG00000178093 | ||
HPRD : 15441 | ||
Vega : OTTHUMG00000182146 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSSK6 | |
BioGPS: 83983 | ||
Pathway | NCI Pathway Interaction Database: TSSK6 | |
KEGG: TSSK6 | ||
REACTOME: TSSK6 | ||
Pathway Commons: TSSK6 | ||
Context | iHOP: TSSK6 | |
ligand binding site mutation search in PubMed: TSSK6 | ||
UCL Cancer Institute: TSSK6 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TSSK6 | Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family. Genet Mol Res. 2015 Nov 23;14(4):14908-19. doi: 10.4238/2015.October.18.56. (pmid:) go to article | |
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 15870294 | GO:0006468 | protein phosphorylation | 15870294 |
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TissGeneExp for TSSK6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -0.017029984 | -1.117223984 | 1.100194 | 2.79E-07 | 1.72E-06 |
BLCA | -0.051273669 | -1.282778932 | 1.231505263 | 4.04E-05 | 0.000547239 |
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TissGene-miRNA for TSSK6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-363-3p | MIMAT0000707 | 0.041 | -0.28 | 56 |
UCS | hsa-miR-92a-3p | MIMAT0000092 | 0.0081 | -0.35 | 56 |
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TissGeneMut for TSSK6 |
TissGeneSNV for TSSK6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G227C | SKCM | 1 |
p.E20Q | LUSC | 1 |
p.D114N | HNSC | 1 |
p.D51N | LUSC | 1 |
p.E77K | UCEC | 1 |
p.E20D | BLCA | 1 |
p.E20K | OV | 1 |
p.P252L | COAD | 1 |
p.D96Y | PAAD | 1 |
p.R59X | STAD | 1 |
p.R65W | STAD | 1 |
p.R47Q | CESC | 1 |
p.R59* | STAD | 1 |
p.D216H | BLCA | 1 |
p.P70S | SARC | 1 |
p.S174A | LUSC | 1 |
p.D135N | UCEC | 1 |
p.P50S | SKCM | 1 |
p.E80K | KIRC | 1 |
p.G109R | LUSC | 1 |
p.P50L | SKCM | 1 |
p.Q111E | CESC | 1 |
p.R149H | COAD | 1 |
p.G156D | UCEC | 1 |
p.V38M | UCEC | 1 |
p.L236V | LUAD | 1 |
p.R124H | STAD | 1 |
p.G199S | STAD | 1 |
p.S257F | SKCM | 1 |
p.A48V | STAD | 1 |
p.P58L | PAAD | 1 |
p.V53I | STAD | 1 |
p.P231L | SKCM | 1 |
p.D146N | SKCM | 1 |
p.D114N | LUSC | 1 |
p.R103H | HNSC | 1 |
p.R106C | UCEC | 1 |
p.R16H | ESCA | 1 |
p.F250L | BLCA | 1 |
p.E235K | SKCM | 1 |
p.F76L | HNSC | 1 |
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TissGeneCNV for TSSK6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TSSK6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TSSK6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TSSK6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TSSK6 |
TissGeneDrug for TSSK6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TSSK6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |