TissGeneSummary for QRICH2 |
Gene summary |
Basic gene information | Gene symbol | QRICH2 |
Gene name | glutamine rich 2 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17q25.1 | |
Type of gene | protein-coding | |
RefGenes | NM_032134.1, | |
Description | glutamine-rich protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000129646 | ||
HPRD : 10891 | ||
Vega : OTTHUMG00000167578 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_QRICH2 | |
BioGPS: 84074 | ||
Pathway | NCI Pathway Interaction Database: QRICH2 | |
KEGG: QRICH2 | ||
REACTOME: QRICH2 | ||
Pathway Commons: QRICH2 | ||
Context | iHOP: QRICH2 | |
ligand binding site mutation search in PubMed: QRICH2 | ||
UCL Cancer Institute: QRICH2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of QRICH2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for QRICH2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 1.928358249 | 0.782734249 | 1.145624 | 2.20E-07 | 9.40E-07 |
LIHC | 1.441762249 | 0.102630249 | 1.339132 | 8.06E-10 | 8.95E-09 |
THCA | 1.292147808 | 2.5298173 | -1.237669492 | 5.72E-13 | 5.46E-12 |
HNSC | -0.033868077 | 1.141320295 | -1.175188372 | 3.58E-06 | 2.33E-05 |
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TissGene-miRNA for QRICH2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for QRICH2 |
TissGeneSNV for QRICH2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A449T | UCEC | 2 |
p.A449G | UCEC | 2 |
p.A191T | PRAD | 1 |
p.R264Q | COAD | 1 |
p.V876A | COAD | 1 |
p.V776A | COAD | 1 |
p.H80L | LIHC | 1 |
p.R1229Q | BRCA | 1 |
p.L1450I | COAD | 1 |
p.Q909* | HNSC | 1 |
p.D403E | BRCA | 1 |
p.R117W | LUAD | 1 |
p.R723C | ESCA | 1 |
p.G959D | STAD | 1 |
p.D1052H | HNSC | 1 |
p.H1635Q | SKCM | 1 |
p.Q657* | SKCM | 1 |
p.Q759X | KIRP | 1 |
p.L524* | SARC | 1 |
p.D440Y | BLCA | 1 |
p.V710M | KIRC | 1 |
p.E1463* | UCEC | 1 |
p.E1372A | LUSC | 1 |
p.G1117A | PAAD | 1 |
p.P848T | LUSC | 1 |
p.P1565L | SKCM | 1 |
p.D938E | SARC | 1 |
p.P150L | PAAD | 1 |
p.S1641G | LUAD | 1 |
p.D611G | LIHC | 1 |
p.T1188M | COAD | 1 |
p.Q759* | KIRP | 1 |
p.R973X | STAD | 1 |
p.T1581A | HNSC | 1 |
p.S1191F | SKCM | 1 |
p.D540Y | PAAD | 1 |
p.L1366M | THYM | 1 |
p.R793H | BLCA | 1 |
p.A465V | PAAD | 1 |
p.S1656L | HNSC | 1 |
p.R160X | COAD | 1 |
p.M1588I | BLCA | 1 |
p.R452C | PRAD | 1 |
p.P598H | CESC | 1 |
p.Q597P | KIRC | 1 |
p.L424F | LUAD | 1 |
p.P1204H | BLCA | 1 |
p.P1214S | SKCM | 1 |
p.R583H | PRAD | 1 |
p.R327H | LGG | 1 |
p.L875S | COAD | 1 |
p.R117Q | SKCM | 1 |
p.R1289Q | KIRC | 1 |
p.R1663K | SKCM | 1 |
p.A933V | UCEC | 1 |
p.D996V | SKCM | 1 |
p.A4V | SKCM | 1 |
p.R1525H | BRCA | 1 |
p.Y781N | SKCM | 1 |
p.D784N | LIHC | 1 |
p.A59V | UCEC | 1 |
p.S1535F | SKCM | 1 |
p.D315N | BLCA | 1 |
p.G1057D | GBM | 1 |
p.P537L | SKCM | 1 |
p.G634S | CESC | 1 |
p.Q657X | SKCM | 1 |
p.Q727* | SKCM | 1 |
p.G779C | LUSC | 1 |
p.A11P | KIRP | 1 |
p.E1318K | SKCM | 1 |
p.L936F | HNSC | 1 |
p.R1403C | UCEC | 1 |
p.V1634M | COAD | 1 |
p.P965R | BLCA | 1 |
p.G769V | OV | 1 |
p.A616V | UCEC | 1 |
p.H581D | KIRC | 1 |
p.R593H | KIRP | 1 |
p.R28W | SKCM | 1 |
p.R1245* | BRCA | 1 |
p.L351F | PAAD | 1 |
p.P878S | SKCM | 1 |
p.A640V | LIHC | 1 |
p.Y1231N | SKCM | 1 |
p.I1655S | LIHC | 1 |
p.D295N | PAAD | 1 |
p.P840L | SKCM | 1 |
p.S97F | SKCM | 1 |
p.H906Y | COAD | 1 |
p.R1606Q | STAD | 1 |
p.M1048I | HNSC | 1 |
p.R1289Q | SKCM | 1 |
p.A1266V | LGG | 1 |
p.H974R | COAD | 1 |
p.E29A | COAD | 1 |
p.V1443M | THYM | 1 |
p.Q787* | SKCM | 1 |
p.R578C | LUAD | 1 |
p.E1029Q | LUAD | 1 |
p.G225R | HNSC | 1 |
p.P1536S | ESCA | 1 |
p.F934L | ESCA | 1 |
p.R153H | HNSC | 1 |
p.M276I | READ | 1 |
p.Y944C | UCEC | 1 |
p.R703C | STAD | 1 |
p.P982S | READ | 1 |
p.V766I | TGCT | 1 |
p.R1245Q | SKCM | 1 |
p.R653H | SKCM | 1 |
p.R643C | LUSC | 1 |
p.P925Q | THYM | 1 |
p.R417C | UCEC | 1 |
p.K1088N | LUAD | 1 |
p.G634S | COAD | 1 |
p.R1262C | STAD | 1 |
p.R973* | STAD | 1 |
p.A555T | LGG | 1 |
p.F1423L | UCEC | 1 |
p.A640T | LIHC | 1 |
p.R1379H | GBM | 1 |
p.R850K | SKCM | 1 |
p.D591V | KIRP | 1 |
p.R28W | READ | 1 |
p.R317H | STAD | 1 |
p.P141L | SKCM | 1 |
p.L299V | CESC | 1 |
p.Q717* | SKCM | 1 |
p.V686I | COAD | 1 |
p.A913V | STAD | 1 |
p.G1261C | KIRP | 1 |
p.G734A | BRCA | 1 |
p.P238S | COAD | 1 |
p.L615* | LUAD | 1 |
p.L202S | COAD | 1 |
p.R1245Q | BRCA | 1 |
p.E1306K | UCEC | 1 |
p.Q566* | SKCM | 1 |
p.H1601Q | PRAD | 1 |
p.R1392W | SKCM | 1 |
p.E1402K | HNSC | 1 |
p.D1484V | LAML | 1 |
p.Q566X | SKCM | 1 |
p.A445V | PAAD | 1 |
p.R153H | LUAD | 1 |
p.P1637L | UCEC | 1 |
p.L1068M | COAD | 1 |
p.R872Q | BLCA | 1 |
p.R633C | COAD | 1 |
p.E20G | COAD | 1 |
p.P1025L | SKCM | 1 |
p.R1403C | PAAD | 1 |
p.A445V | KIRP | 1 |
p.S1656L | BLCA | 1 |
p.S1165P | READ | 1 |
p.R693H | BLCA | 1 |
p.Q1531E | BLCA | 1 |
p.A11V | DLBC | 1 |
p.R572S | THYM | 1 |
p.A449T | PAAD | 1 |
p.Q1150L | KIRP | 1 |
p.L1426I | UCEC | 1 |
p.Q692* | BLCA | 1 |
p.Q30K | SARC | 1 |
p.S122F | SKCM | 1 |
p.A445V | PRAD | 1 |
p.Q1105* | SARC | 1 |
p.E1308K | SKCM | 1 |
p.D530N | BLCA | 1 |
p.E1079K | ESCA | 1 |
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TissGeneCNV for QRICH2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for QRICH2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE061270 | QRICH2-QRICH2 | chr17:74278410 | chr17:74278435 | |
TCGAfusionPortal | PRADA | KIRC | TCGA-BP-4983-01A | CASKIN2-QRICH2 | In-frame | Chr17:73509792 | Chr17:74286158 |
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TissGeneNet for QRICH2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for QRICH2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for QRICH2 |
TissGeneDrug for QRICH2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for QRICH2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |