TissGeneSummary for FSCB |
Gene summary |
Basic gene information | Gene symbol | FSCB |
Gene name | fibrous sheath CABYR binding protein | |
Synonyms | C14orf155 | |
Cytomap | UCSC genome browser: 14q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_032135.3, | |
Description | fibrous sheath CABYR-binding protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 611779 | |
HGNC : HGNC | ||
Ensembl : ENSG00000189139 | ||
HPRD : 12638 | ||
Vega : OTTHUMG00000140262 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FSCB | |
BioGPS: 84075 | ||
Pathway | NCI Pathway Interaction Database: FSCB | |
KEGG: FSCB | ||
REACTOME: FSCB | ||
Pathway Commons: FSCB | ||
Context | iHOP: FSCB | |
ligand binding site mutation search in PubMed: FSCB | ||
UCL Cancer Institute: FSCB | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FSCB | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FSCB |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FSCB |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FSCB |
TissGeneSNV for FSCB |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S22L | SKCM | 2 |
p.A632S | LUAD | 2 |
p.A521S | LUSC | 1 |
p.P387L | HNSC | 1 |
p.E621K | SKCM | 1 |
p.S24I | HNSC | 1 |
p.L346P | ESCA | 1 |
p.V314F | LUAD | 1 |
p.E759* | UCEC | 1 |
p.E418K | SKCM | 1 |
p.E447V | OV | 1 |
p.R215K | COAD | 1 |
p.E570* | LUSC | 1 |
p.P409Q | LUAD | 1 |
p.E67K | LUSC | 1 |
p.E537K | SKCM | 1 |
p.A281E | SARC | 1 |
p.S354L | LUAD | 1 |
p.Q764P | COAD | 1 |
p.A277V | UCEC | 1 |
p.E640Q | ESCA | 1 |
p.S684Y | PAAD | 1 |
p.A644S | LUAD | 1 |
p.E524K | HNSC | 1 |
p.A709E | LUAD | 1 |
p.A644S | ESCA | 1 |
p.R385Q | HNSC | 1 |
p.A644S | HNSC | 1 |
p.P720L | HNSC | 1 |
p.V776D | LUSC | 1 |
p.P769L | UCEC | 1 |
p.E179K | SKCM | 1 |
p.S160I | HNSC | 1 |
p.E824K | BLCA | 1 |
p.A306D | KIRC | 1 |
p.K63N | LUAD | 1 |
p.P573H | LUSC | 1 |
p.R136C | SKCM | 1 |
p.A281V | DLBC | 1 |
p.E245D | LUAD | 1 |
p.A281V | UCEC | 1 |
p.V151L | LUAD | 1 |
p.S37N | LUSC | 1 |
p.E633D | ESCA | 1 |
p.A523S | LUAD | 1 |
p.A668D | LUAD | 1 |
p.P483H | HNSC | 1 |
p.P398S | THCA | 1 |
p.N120S | STAD | 1 |
p.E349K | LUSC | 1 |
p.E532D | ACC | 1 |
p.P672T | LIHC | 1 |
p.P109A | LUAD | 1 |
p.D100N | LUSC | 1 |
p.A504D | UCEC | 1 |
p.P109T | HNSC | 1 |
p.N144S | HNSC | 1 |
p.E154* | LUAD | 1 |
p.A324S | LUAD | 1 |
p.P769S | LUAD | 1 |
p.A644S | SARC | 1 |
p.K4E | UCEC | 1 |
p.M446I | LUAD | 1 |
p.E541G | LUAD | 1 |
p.L528I | UCEC | 1 |
p.A310V | STAD | 1 |
p.E616D | LUAD | 1 |
p.E245G | LUAD | 1 |
p.R821H | THCA | 1 |
p.D722V | LUSC | 1 |
p.P147T | ESCA | 1 |
p.L440R | ESCA | 1 |
p.S204C | LUAD | 1 |
p.Q317* | BLCA | 1 |
p.A751S | HNSC | 1 |
p.S40I | LUAD | 1 |
p.L229V | LUAD | 1 |
p.P196L | LUAD | 1 |
p.A751P | KIRC | 1 |
p.H16Q | SARC | 1 |
p.G138E | SKCM | 1 |
p.L351P | STAD | 1 |
p.A410T | PAAD | 1 |
p.E84X | UCS | 1 |
p.T141I | READ | 1 |
p.S162* | CESC | 1 |
p.E452D | LUAD | 1 |
p.D796N | PAAD | 1 |
p.R492W | COAD | 1 |
p.T69N | LUAD | 1 |
p.A281V | PAAD | 1 |
p.S217L | HNSC | 1 |
p.E84K | SKCM | 1 |
p.Q560H | UCEC | 1 |
p.P330L | SKCM | 1 |
p.P763L | LGG | 1 |
p.E669D | ESCA | 1 |
p.T141P | READ | 1 |
p.P226S | SKCM | 1 |
p.E311D | UCEC | 1 |
p.P320S | LUSC | 1 |
p.P376S | HNSC | 1 |
p.E339K | SKCM | 1 |
p.M143T | STAD | 1 |
p.A766S | LUAD | 1 |
p.E676K | LUAD | 1 |
p.E383G | LUAD | 1 |
p.A668S | BRCA | 1 |
p.E332V | HNSC | 1 |
p.E282D | LUSC | 1 |
p.D423E | BRCA | 1 |
p.E710Q | OV | 1 |
p.R492W | STAD | 1 |
p.R235S | LGG | 1 |
p.R385W | SKCM | 1 |
p.E469* | UCEC | 1 |
p.P433H | LUAD | 1 |
p.S193I | LUAD | 1 |
p.I350V | LIHC | 1 |
p.N212Y | HNSC | 1 |
p.A253V | COAD | 1 |
p.S214I | COAD | 1 |
p.E571K | SKCM | 1 |
p.P147S | LUSC | 1 |
p.K211I | COAD | 1 |
p.S52P | HNSC | 1 |
p.S217L | CESC | 1 |
p.P661S | SARC | 1 |
p.E95K | KIRC | 1 |
p.N212Y | SKCM | 1 |
p.I117M | LUAD | 1 |
p.E54* | LUAD | 1 |
p.E727D | LUAD | 1 |
p.H29N | BLCA | 1 |
p.S37R | LUAD | 1 |
p.E582D | STAD | 1 |
p.P409S | COAD | 1 |
p.S775L | READ | 1 |
p.E339K | LGG | 1 |
p.T28I | SARC | 1 |
p.A542S | GBM | 1 |
p.A618T | PAAD | 1 |
p.K153N | LUAD | 1 |
p.R30H | UCS | 1 |
p.P241S | LUAD | 1 |
p.Q292K | LUSC | 1 |
p.A618P | STAD | 1 |
p.E357K | UCEC | 1 |
p.E681K | HNSC | 1 |
p.E110* | BLCA | 1 |
p.G3V | PRAD | 1 |
p.T455N | LUAD | 1 |
p.P387L | LUSC | 1 |
p.T175K | PRAD | 1 |
p.G581C | UCEC | 1 |
p.P330S | SKCM | 1 |
p.P686S | HNSC | 1 |
p.E339K | STAD | 1 |
p.S48Y | COAD | 1 |
p.Q156H | UCEC | 1 |
p.H290Y | LUSC | 1 |
p.Q804K | LUAD | 1 |
p.Q113E | BLCA | 1 |
p.L347M | LUSC | 1 |
p.E84* | UCS | 1 |
p.D76N | SKCM | 1 |
p.P631S | SKCM | 1 |
p.H195Q | COAD | 1 |
p.A453S | LUAD | 1 |
p.G767E | UCEC | 1 |
p.L380P | COAD | 1 |
p.A591T | PRAD | 1 |
p.S798F | DLBC | 1 |
p.A277V | ESCA | 1 |
p.E541* | LUAD | 1 |
p.K189N | UCS | 1 |
p.Q113H | LUSC | 1 |
p.V115I | LUAD | 1 |
p.A281V | STAD | 1 |
p.E811* | UCEC | 1 |
p.S812I | UCEC | 1 |
p.E356K | BRCA | 1 |
p.Q509* | SKCM | 1 |
p.P511L | LIHC | 1 |
p.P763Q | LUAD | 1 |
p.A630T | GBM | 1 |
p.K189N | UCEC | 1 |
p.A632S | STAD | 1 |
p.S186L | SKCM | 1 |
p.G65V | LUSC | 1 |
p.W140R | HNSC | 1 |
p.S214N | READ | 1 |
p.V622F | STAD | 1 |
p.I164T | LUSC | 1 |
p.Q133* | UCEC | 1 |
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TissGeneCNV for FSCB |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FSCB |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FSCB |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FSCB |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FSCB |
TissGeneDrug for FSCB |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FSCB |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004096 | Asthma | 1 | GAD |