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| TissGeneSummary for C3orf20 |
 Gene summary |
| Basic gene information | Gene symbol | C3orf20 |
| Gene name | chromosome 3 open reading frame 20 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 3p25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001184957.1, NM_001184958.1,NM_032137.4, | |
| Description | uncharacterized protein C3orf20 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000131379 | ||
| HPRD : 12821 | ||
| Vega : OTTHUMG00000155545 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C3orf20 | |
| BioGPS: 84077 | ||
| Pathway | NCI Pathway Interaction Database: C3orf20 | |
| KEGG: C3orf20 | ||
| REACTOME: C3orf20 | ||
| Pathway Commons: C3orf20 | ||
| Context | iHOP: C3orf20 | |
| ligand binding site mutation search in PubMed: C3orf20 | ||
| UCL Cancer Institute: C3orf20 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of C3orf20 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C3orf20 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for C3orf20 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C3orf20 |
| TissGeneSNV for C3orf20 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P63S | SKCM | 2 |
| p.F379L | BLCA | 2 |
| p.E82K | SKCM | 2 |
| p.E576K | SKCM | 2 |
| p.P63L | STAD | 1 |
| p.Y223D | SKCM | 1 |
| p.P826L | STAD | 1 |
| p.P656L | LUSC | 1 |
| p.R312Q | UCS | 1 |
| p.R577C | COAD | 1 |
| p.E274* | LUSC | 1 |
| p.G789R | SKCM | 1 |
| p.P138L | COAD | 1 |
| p.R699H | GBM | 1 |
| p.R768K | SKCM | 1 |
| p.R24H | STAD | 1 |
| p.K546R | SKCM | 1 |
| p.S839R | PAAD | 1 |
| p.R511W | COAD | 1 |
| p.Q364E | BLCA | 1 |
| p.G667R | SKCM | 1 |
| p.P100A | COAD | 1 |
| p.R484Q | COAD | 1 |
| p.W178X | SKCM | 1 |
| p.V797I | BRCA | 1 |
| p.Q608E | BLCA | 1 |
| p.G197E | SKCM | 1 |
| p.M537I | LUAD | 1 |
| p.K195N | READ | 1 |
| p.K242N | STAD | 1 |
| p.L730M | LUAD | 1 |
| p.A388T | COAD | 1 |
| p.R291H | STAD | 1 |
| p.R671W | CESC | 1 |
| p.P269L | SKCM | 1 |
| p.R740L | LUAD | 1 |
| p.R547W | UCEC | 1 |
| p.R558H | COAD | 1 |
| p.E476K | SKCM | 1 |
| p.P63L | SKCM | 1 |
| p.D762Y | LUSC | 1 |
| p.H321Y | SKCM | 1 |
| p.C279F | LUAD | 1 |
| p.R3H | KICH | 1 |
| p.R128H | STAD | 1 |
| p.R796H | ESCA | 1 |
| p.P147L | SKCM | 1 |
| p.P765L | SKCM | 1 |
| p.Q811H | LUAD | 1 |
| p.A421V | SKCM | 1 |
| p.E174K | SKCM | 1 |
| p.S622F | SKCM | 1 |
| p.Q364E | ESCA | 1 |
| p.R312L | SARC | 1 |
| p.S832N | KIRP | 1 |
| p.E470K | SKCM | 1 |
| p.G218R | BLCA | 1 |
| p.G856E | SARC | 1 |
| p.K574N | OV | 1 |
| p.P887L | SKCM | 1 |
| p.A114T | SKCM | 1 |
| p.K367E | UCEC | 1 |
| p.R814Q | STAD | 1 |
| p.Y101D | SKCM | 1 |
| p.G75E | SKCM | 1 |
| p.T332A | LIHC | 1 |
| p.L888F | SKCM | 1 |
| p.E274Q | BLCA | 1 |
| p.G794W | OV | 1 |
| p.R169C | SKCM | 1 |
| p.A563T | UCEC | 1 |
| p.R522L | OV | 1 |
| p.E728K | COAD | 1 |
| p.K595N | ESCA | 1 |
| p.E578K | HNSC | 1 |
| p.K374T | UCEC | 1 |
| p.R796C | SKCM | 1 |
| p.R291C | SKCM | 1 |
| p.Q12* | BLCA | 1 |
| p.D706A | STAD | 1 |
| p.L289F | SKCM | 1 |
| p.A155D | UCEC | 1 |
| p.R671W | HNSC | 1 |
| p.P338S | SKCM | 1 |
| p.V837A | LIHC | 1 |
| p.S892N | BLCA | 1 |
| p.T425A | ACC | 1 |
| p.K536N | LUAD | 1 |
| p.V88A | STAD | 1 |
| p.P147S | SKCM | 1 |
| p.A216V | SKCM | 1 |
| p.F373L | CESC | 1 |
| p.V487I | SKCM | 1 |
| p.N480K | SKCM | 1 |
| p.G163C | UCEC | 1 |
| p.S115Y | READ | 1 |
| p.D532N | PRAD | 1 |
| p.R283Q | CESC | 1 |
| p.F555L | UCEC | 1 |
| p.D277E | THYM | 1 |
| p.D65N | COAD | 1 |
| p.R312Q | SARC | 1 |
| p.R526I | UCEC | 1 |
| p.V883M | LUAD | 1 |
| p.R403C | READ | 1 |
| p.D827N | SKCM | 1 |
| p.R116H | COAD | 1 |
| p.E543K | BLCA | 1 |
| p.R890K | SKCM | 1 |
| p.A316V | HNSC | 1 |
| p.R125H | KICH | 1 |
| p.L167F | SKCM | 1 |
| p.A212T | STAD | 1 |
| p.P834S | SKCM | 1 |
| p.S258I | BRCA | 1 |
| p.P269S | SKCM | 1 |
| p.A90T | COAD | 1 |
| p.R592W | STAD | 1 |
| p.H432Q | LUAD | 1 |
| p.G42C | UCS | 1 |
| p.L765M | UCEC | 1 |
| p.C290R | LUAD | 1 |
| p.W463* | LUAD | 1 |
| p.W300* | SKCM | 1 |
| p.M160T | LIHC | 1 |
| p.V687G | UCEC | 1 |
| p.P712S | SKCM | 1 |
| p.S744F | SKCM | 1 |
| p.R705* | SKCM | 1 |
| p.R312Q | BLCA | 1 |
| p.W463* | BLCA | 1 |
| p.S558P | STAD | 1 |
| p.L668R | LUAD | 1 |
| p.L313P | SKCM | 1 |
| p.T303A | ACC | 1 |
| p.E481K | SKCM | 1 |
| p.P704L | COAD | 1 |
| p.Y751H | UCEC | 1 |
| p.R583X | SKCM | 1 |
| p.E296K | SKCM | 1 |
| p.D694A | GBM | 1 |
| p.E454K | SKCM | 1 |
| p.K317T | SKCM | 1 |
| p.A16T | UCEC | 1 |
| p.G489* | LUAD | 1 |
| p.R674C | SKCM | 1 |
| p.L766F | SKCM | 1 |
| p.E480X | COAD | 1 |
| p.P105Q | UCEC | 1 |
| p.H199Y | SKCM | 1 |
| p.F786I | GBM | 1 |
| p.E147G | LIHC | 1 |
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| TissGeneCNV for C3orf20 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C3orf20 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for C3orf20 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C3orf20 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C3orf20 |
| TissGeneDrug for C3orf20 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C3orf20 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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