TissGeneSummary for MFSD7 |
Gene summary |
Basic gene information | Gene symbol | MFSD7 |
Gene name | major facilitator superfamily domain containing 7 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4p16.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001294341.1, NM_001294342.1,NM_032219.3, | |
Description | MYL5major facilitator superfamily domain-containing protein 7myosin light polypeptide 5 regulatory protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000169026 | ||
HPRD : 08650 | ||
Vega : OTTHUMG00000119001 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MFSD7 | |
BioGPS: 84179 | ||
Pathway | NCI Pathway Interaction Database: MFSD7 | |
KEGG: MFSD7 | ||
REACTOME: MFSD7 | ||
Pathway Commons: MFSD7 | ||
Context | iHOP: MFSD7 | |
ligand binding site mutation search in PubMed: MFSD7 | ||
UCL Cancer Institute: MFSD7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
Reference showing the relevant tissue of MFSD7 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MFSD7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 0.033614691 | 1.352910845 | -1.319296154 | 1.49E-05 | 6.57E-05 |
LUSC | 0.440902474 | 2.50306718 | -2.062164706 | 2.29E-18 | 2.18E-17 |
KICH | 4.100897768 | 2.423873768 | 1.677024 | 5.37E-05 | 0.0001485 |
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TissGene-miRNA for MFSD7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MFSD7 |
TissGeneSNV for MFSD7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R459C | SKCM | 1 |
p.A428T | PAAD | 1 |
p.L270P | STAD | 1 |
p.A493V | ACC | 1 |
p.E59D | UCEC | 1 |
p.I57V | STAD | 1 |
p.S92F | SKCM | 1 |
p.A108V | GBM | 1 |
p.I259M | PAAD | 1 |
p.T162M | COAD | 1 |
p.G109R | KIRC | 1 |
p.E59G | GBM | 1 |
p.R402Q | BLCA | 1 |
p.A98_splice | LUSC | 1 |
p.E271* | LUAD | 1 |
p.A523V | SKCM | 1 |
p.E362Q | BLCA | 1 |
p.V327M | STAD | 1 |
p.P193L | SKCM | 1 |
p.R401Q | BLCA | 1 |
p.I260M | PAAD | 1 |
p.A97V | LUAD | 1 |
p.A27T | COAD | 1 |
p.Q242E | OV | 1 |
p.H550Y | BLCA | 1 |
p.Q337K | LUSC | 1 |
p.G535D | THCA | 1 |
p.R113H | PRAD | 1 |
p.T443P | LIHC | 1 |
p.A85V | HNSC | 1 |
p.A167T | UCEC | 1 |
p.A546S | LUAD | 1 |
p.A547S | LUAD | 1 |
p.A228T | STAD | 1 |
p.A275T | LIHC | 1 |
p.H549Y | BLCA | 1 |
p.E270* | LUAD | 1 |
p.Y75* | STAD | 1 |
p.V93I | HNSC | 1 |
p.A427T | PAAD | 1 |
p.E363Q | BLCA | 1 |
p.A19V | COAD | 1 |
p.L269P | STAD | 1 |
p.R160Q | UCEC | 1 |
p.E216D | BLCA | 1 |
p.Y75X | STAD | 1 |
p.A288T | COAD | 1 |
p.A493V | COAD | 1 |
p.A127T | COAD | 1 |
p.G350R | STAD | 1 |
p.A325T | KIRC | 1 |
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TissGeneCNV for MFSD7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MFSD7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MFSD7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MFSD7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MFSD7 |
TissGeneDrug for MFSD7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MFSD7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |