TissGeneSummary for C2orf16 |
Gene summary |
Basic gene information | Gene symbol | C2orf16 |
Gene name | chromosome 2 open reading frame 16 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_032266.3, | |
Description | P-S-E-R-S-H-H-S repeats containinguncharacterized protein C2orf16 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000221843 | ||
HPRD : 09849 | ||
Vega : OTTHUMG00000159099 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C2orf16 | |
BioGPS: 84226 | ||
Pathway | NCI Pathway Interaction Database: C2orf16 | |
KEGG: C2orf16 | ||
REACTOME: C2orf16 | ||
Pathway Commons: C2orf16 | ||
Context | iHOP: C2orf16 | |
ligand binding site mutation search in PubMed: C2orf16 | ||
UCL Cancer Institute: C2orf16 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C2orf16 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C2orf16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for C2orf16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C2orf16 |
TissGeneSNV for C2orf16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E1317K | SKCM | 3 |
p.R1453* | UCEC | 3 |
p.G466E | SKCM | 2 |
p.R1775H | COAD | 2 |
p.R1727C | LGG | 2 |
p.E268K | BLCA | 2 |
p.R976K | SKCM | 2 |
p.M831I | SKCM | 2 |
p.R1476T | UCS | 1 |
p.D1055N | SKCM | 1 |
p.S1054R | LUSC | 1 |
p.G171C | CHOL | 1 |
p.S1666A | UCEC | 1 |
p.E1499Q | HNSC | 1 |
p.S1592R | STAD | 1 |
p.V697I | PAAD | 1 |
p.T451R | BLCA | 1 |
p.H1638Y | SKCM | 1 |
p.E268K | SARC | 1 |
p.E226* | HNSC | 1 |
p.P1016S | COAD | 1 |
p.A1075T | ESCA | 1 |
p.R1839C | SKCM | 1 |
p.R849Q | SKCM | 1 |
p.R1645S | COAD | 1 |
p.R1296Q | SKCM | 1 |
p.P109A | HNSC | 1 |
p.P551H | COAD | 1 |
p.E581A | STAD | 1 |
p.Q202R | LUAD | 1 |
p.R1861S | ESCA | 1 |
p.H1751R | DLBC | 1 |
p.R1708S | SKCM | 1 |
p.S1033F | PRAD | 1 |
p.S1674F | UCEC | 1 |
p.D1408Y | UCEC | 1 |
p.P1888S | SKCM | 1 |
p.Q1229H | STAD | 1 |
p.G11D | UCEC | 1 |
p.R1775C | LIHC | 1 |
p.R1823H | LGG | 1 |
p.R1839H | CESC | 1 |
p.S1030* | BRCA | 1 |
p.Q1635H | OV | 1 |
p.F1490L | UCEC | 1 |
p.A1020T | UCEC | 1 |
p.Q383* | SKCM | 1 |
p.R849Q | LUAD | 1 |
p.S348L | HNSC | 1 |
p.V1230F | UCEC | 1 |
p.A157T | UCS | 1 |
p.Q383X | SKCM | 1 |
p.G1507E | SKCM | 1 |
p.V645A | GBM | 1 |
p.P1856S | SKCM | 1 |
p.R1154H | PAAD | 1 |
p.R1359W | UCEC | 1 |
p.R1237H | PAAD | 1 |
p.P420S | LUAD | 1 |
p.V501E | LUAD | 1 |
p.R1453* | STAD | 1 |
p.R490K | UCEC | 1 |
p.T1214I | UCS | 1 |
p.S1792I | UCEC | 1 |
p.S416F | HNSC | 1 |
p.R1567C | UCEC | 1 |
p.L889V | BLCA | 1 |
p.R1476K | STAD | 1 |
p.S837L | CESC | 1 |
p.S1661R | UVM | 1 |
p.Q1271E | LUAD | 1 |
p.E814D | PAAD | 1 |
p.R1551H | UCEC | 1 |
p.E1691* | HNSC | 1 |
p.R849* | LUAD | 1 |
p.E401* | UCEC | 1 |
p.S1797R | HNSC | 1 |
p.R1524T | CESC | 1 |
p.K177Q | LUSC | 1 |
p.K219N | THYM | 1 |
p.R1296* | HNSC | 1 |
p.G1472V | STAD | 1 |
p.M277I | HNSC | 1 |
p.C631Y | LUSC | 1 |
p.P1769S | ESCA | 1 |
p.S552L | BRCA | 1 |
p.E1619K | LGG | 1 |
p.P1972S | BLCA | 1 |
p.R1275Q | THYM | 1 |
p.F290L | BLCA | 1 |
p.G1940R | SKCM | 1 |
p.G249R | LGG | 1 |
p.Q258K | LUAD | 1 |
p.Q1675K | SKCM | 1 |
p.G968S | HNSC | 1 |
p.R1655H | PAAD | 1 |
p.S890F | SKCM | 1 |
p.R1708K | BLCA | 1 |
p.M1891T | STAD | 1 |
p.R1126Q | BLCA | 1 |
p.R1564T | BLCA | 1 |
p.I950V | STAD | 1 |
p.Q683H | LGG | 1 |
p.M27I | SKCM | 1 |
p.R284M | COAD | 1 |
p.S1599F | SKCM | 1 |
p.G11D | SKCM | 1 |
p.M1290V | LUAD | 1 |
p.S308C | LUSC | 1 |
p.E282K | BLCA | 1 |
p.C1622F | UCEC | 1 |
p.R1724K | SKCM | 1 |
p.E1579K | SKCM | 1 |
p.P1109H | UCEC | 1 |
p.S1140L | LUAD | 1 |
p.G625E | SKCM | 1 |
p.T464S | SKCM | 1 |
p.S1637R | SKCM | 1 |
p.I12M | SKCM | 1 |
p.S425C | TGCT | 1 |
p.L1067H | LUSC | 1 |
p.T1212I | HNSC | 1 |
p.S1752R | SKCM | 1 |
p.H1758N | LUSC | 1 |
p.H1133Y | SKCM | 1 |
p.S1688N | UCEC | 1 |
p.Q1643E | COAD | 1 |
p.N1502S | SKCM | 1 |
p.R1934H | UCEC | 1 |
p.S447L | SKCM | 1 |
p.S488F | BLCA | 1 |
p.Q1675* | SKCM | 1 |
p.L1428S | UCEC | 1 |
p.R1775C | UCEC | 1 |
p.G303R | SKCM | 1 |
p.H1711Y | CESC | 1 |
p.G771E | SKCM | 1 |
p.E1795D | PAAD | 1 |
p.Y14F | PRAD | 1 |
p.T583I | STAD | 1 |
p.Q710H | BLCA | 1 |
p.K140N | UCEC | 1 |
p.E1811K | SKCM | 1 |
p.S1061C | BLCA | 1 |
p.P938H | LGG | 1 |
p.K1973N | READ | 1 |
p.Y1445C | STAD | 1 |
p.E263K | SKCM | 1 |
p.S1744C | TGCT | 1 |
p.R1453X | COAD | 1 |
p.A1444S | SARC | 1 |
p.D247N | SKCM | 1 |
p.K1291N | BRCA | 1 |
p.S498Y | UCEC | 1 |
p.P295S | UCEC | 1 |
p.H1598Y | SKCM | 1 |
p.L1072P | LIHC | 1 |
p.D483N | SKCM | 1 |
p.Q398X | SKCM | 1 |
p.E623D | SKCM | 1 |
p.N1597H | STAD | 1 |
p.R490S | LUSC | 1 |
p.S668F | BLCA | 1 |
p.T1000I | LUAD | 1 |
p.H1822R | SKCM | 1 |
p.R124K | SKCM | 1 |
p.G968D | HNSC | 1 |
p.R1556I | UCEC | 1 |
p.S178Y | UCEC | 1 |
p.R1772K | STAD | 1 |
p.E538K | STAD | 1 |
p.H1751Y | DLBC | 1 |
p.Q314K | SARC | 1 |
p.Q142H | UCEC | 1 |
p.D345H | LUAD | 1 |
p.R357Q | READ | 1 |
p.P1569L | SKCM | 1 |
p.R1639C | BLCA | 1 |
p.R1703H | DLBC | 1 |
p.Q22K | LUAD | 1 |
p.T738I | LUAD | 1 |
p.Q398* | SKCM | 1 |
p.T4P | LUSC | 1 |
p.P608T | LUSC | 1 |
p.E778V | KIRP | 1 |
p.Y141F | PRAD | 1 |
p.R1719H | COAD | 1 |
p.R1934C | LUAD | 1 |
p.H1559Y | DLBC | 1 |
p.E1273K | SKCM | 1 |
p.D483H | LUAD | 1 |
p.R1639C | UCEC | 1 |
p.N13H | COAD | 1 |
p.E604D | LGG | 1 |
p.R1708K | SKCM | 1 |
p.I767T | DLBC | 1 |
p.I1516M | BLCA | 1 |
p.E937* | UCEC | 1 |
p.H1670Q | UCEC | 1 |
p.K454N | UCEC | 1 |
p.V1106A | UCEC | 1 |
p.S402Y | UCEC | 1 |
p.T259A | STAD | 1 |
p.K367E | LUSC | 1 |
p.Q1053H | LUSC | 1 |
p.S241L | SKCM | 1 |
p.N13H | UCEC | 1 |
p.H1735Y | BLCA | 1 |
p.E331* | UCEC | 1 |
p.E1795K | UCEC | 1 |
p.L1145F | SKCM | 1 |
p.C1759R | LIHC | 1 |
p.I774V | COAD | 1 |
p.P1856L | SKCM | 1 |
p.V1188I | CESC | 1 |
p.D1105N | SKCM | 1 |
p.G757E | HNSC | 1 |
p.S652N | SKCM | 1 |
p.G303E | SKCM | 1 |
p.G725E | SKCM | 1 |
p.R476K | SKCM | 1 |
p.E289* | UCEC | 1 |
p.M1046I | SKCM | 1 |
p.R1773S | LIHC | 1 |
p.P943S | ESCA | 1 |
p.D173N | LGG | 1 |
p.K1325N | BRCA | 1 |
p.D1408G | BLCA | 1 |
p.E236K | SKCM | 1 |
p.R1820S | HNSC | 1 |
p.H1783Y | STAD | 1 |
p.I782T | LUAD | 1 |
p.P467S | BRCA | 1 |
p.T298A | SKCM | 1 |
p.P267L | STAD | 1 |
p.R1373W | STAD | 1 |
p.L411Q | LUSC | 1 |
p.P183L | SKCM | 1 |
p.V1162F | THYM | 1 |
p.R1655S | SARC | 1 |
p.D1039N | CESC | 1 |
p.R1700K | HNSC | 1 |
p.E1047K | SKCM | 1 |
p.R1184K | SKCM | 1 |
p.M116I | SKCM | 1 |
p.R1655H | UCEC | 1 |
p.D1039N | SKCM | 1 |
p.K1501Q | READ | 1 |
p.P1609L | UCEC | 1 |
p.E1683Q | BLCA | 1 |
p.P400L | BLCA | 1 |
p.H554R | LUSC | 1 |
p.E64K | LGG | 1 |
p.P1697T | BLCA | 1 |
p.R1663H | STAD | 1 |
p.W880R | LUAD | 1 |
p.P1769L | SKCM | 1 |
p.Q1473R | LIHC | 1 |
p.D1377E | LUAD | 1 |
p.R1190Q | SKCM | 1 |
p.A1226D | BRCA | 1 |
p.M1915I | BLCA | 1 |
p.A1075S | COAD | 1 |
p.C1400Y | BLCA | 1 |
p.V563G | STAD | 1 |
p.F206C | UCEC | 1 |
p.L17F | BLCA | 1 |
p.E439Q | BLCA | 1 |
p.C631Y | UCEC | 1 |
p.S866C | LUSC | 1 |
p.E671Q | LUSC | 1 |
p.Q656K | KIRC | 1 |
p.P69T | BLCA | 1 |
p.R1732K | LUAD | 1 |
p.S146Y | HNSC | 1 |
p.R1323G | KIRC | 1 |
p.K1537E | LUAD | 1 |
p.R1814C | SKCM | 1 |
p.E117K | SKCM | 1 |
p.V213I | READ | 1 |
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TissGeneCNV for C2orf16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C2orf16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for C2orf16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C2orf16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C2orf16 |
TissGeneDrug for C2orf16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C2orf16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0524620 | Metabolic Syndrome X | 1 | GAD |