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| TissGeneSummary for MEGF10 |
 Gene summary |
| Basic gene information | Gene symbol | MEGF10 |
| Gene name | multiple EGF-like-domains 10 | |
| Synonyms | EMARDD | |
| Cytomap | UCSC genome browser: 5q33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001256545.1, NM_032446.2, | |
| Description | multiple epidermal growth factor-like domains protein 10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612453 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000145794 | ||
| HPRD : 14384 | ||
| Vega : OTTHUMG00000128984 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MEGF10 | |
| BioGPS: 84466 | ||
| Pathway | NCI Pathway Interaction Database: MEGF10 | |
| KEGG: MEGF10 | ||
| REACTOME: MEGF10 | ||
| Pathway Commons: MEGF10 | ||
| Context | iHOP: MEGF10 | |
| ligand binding site mutation search in PubMed: MEGF10 | ||
| UCL Cancer Institute: MEGF10 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of MEGF10 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0034109 | homotypic cell-cell adhesion | 22407321 | GO:0034109 | homotypic cell-cell adhesion | 22407321 |
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| TissGeneExp for MEGF10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -3.635369079 | -1.587935079 | -2.047434 | 4.91E-11 | 6.65E-10 |
| COAD | -3.017326772 | -1.330849848 | -1.686476923 | 7.16E-08 | 5.19E-07 |
| KIRC | -3.711887135 | -2.389749635 | -1.3221375 | 3.90E-16 | 2.14E-15 |
| KIRP | -4.331400329 | -2.601053454 | -1.730346875 | 1.84E-10 | 1.99E-09 |
| LUSC | -0.266973981 | -3.357587707 | 3.090613725 | 4.80E-10 | 1.70E-09 |
| LUAD | -1.968162183 | -3.459763907 | 1.491601724 | 4.41E-07 | 1.54E-06 |
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| TissGene-miRNA for MEGF10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MEGF10 |
| TissGeneSNV for MEGF10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S1053L | UCEC | 3 |
| p.E1050K | SKCM | 2 |
| p.E38K | SKCM | 1 |
| p.Q530X | TGCT | 1 |
| p.W130* | SKCM | 1 |
| p.C34F | KIRC | 1 |
| p.A654T | COAD | 1 |
| p.K1012N | STAD | 1 |
| p.P747L | STAD | 1 |
| p.S377N | ESCA | 1 |
| p.R777H | KICH | 1 |
| p.Y794X | KIRC | 1 |
| p.D1127Y | LUAD | 1 |
| p.F996S | SKCM | 1 |
| p.K969Q | SKCM | 1 |
| p.P692L | SKCM | 1 |
| p.R799H | THYM | 1 |
| p.G479E | SKCM | 1 |
| p.W259L | LUSC | 1 |
| p.H931R | UCEC | 1 |
| p.W19L | LUAD | 1 |
| p.C615S | LUAD | 1 |
| p.D768N | KIRC | 1 |
| p.C118S | LUAD | 1 |
| p.A1062T | COAD | 1 |
| p.R71W | COAD | 1 |
| p.T847N | LGG | 1 |
| p.S1128T | OV | 1 |
| p.D803H | LUAD | 1 |
| p.P518S | SKCM | 1 |
| p.A506V | LUAD | 1 |
| p.L319F | SKCM | 1 |
| p.H1106P | SKCM | 1 |
| p.T778I | COAD | 1 |
| p.L740I | UCEC | 1 |
| p.A920T | LUAD | 1 |
| p.C718Y | STAD | 1 |
| p.S1067T | KIRC | 1 |
| p.E179D | THYM | 1 |
| p.W577* | LUAD | 1 |
| p.A756E | LUAD | 1 |
| p.T70A | PAAD | 1 |
| p.A848T | SKCM | 1 |
| p.P162S | SARC | 1 |
| p.G671E | SKCM | 1 |
| p.G997E | SKCM | 1 |
| p.E322D | UCEC | 1 |
| p.Q530* | TGCT | 1 |
| p.R455C | BLCA | 1 |
| p.A722D | LUAD | 1 |
| p.Y741H | KIRC | 1 |
| p.G165R | UCEC | 1 |
| p.C268F | LUAD | 1 |
| p.M948L | STAD | 1 |
| p.P552L | LIHC | 1 |
| p.P389Q | LGG | 1 |
| p.K459E | HNSC | 1 |
| p.W176X | COAD | 1 |
| p.S1120L | SKCM | 1 |
| p.P444R | STAD | 1 |
| p.P928R | LUAD | 1 |
| p.P107_splice | UCEC | 1 |
| p.G994S | HNSC | 1 |
| p.D728N | LUAD | 1 |
| p.G131E | SKCM | 1 |
| p.E103K | SKCM | 1 |
| p.S625R | LUAD | 1 |
| p.G1004R | BLCA | 1 |
| p.Q198H | ESCA | 1 |
| p.S1135N | ESCA | 1 |
| p.P981L | COAD | 1 |
| p.G663D | SARC | 1 |
| p.F959L | BLCA | 1 |
| p.R349G | KIRC | 1 |
| p.G532D | STAD | 1 |
| p.L28F | LUAD | 1 |
| p.P940S | SKCM | 1 |
| p.M1003I | KIRP | 1 |
| p.P972S | SKCM | 1 |
| p.P51T | LGG | 1 |
| p.D596Y | LUSC | 1 |
| p.L5W | LUAD | 1 |
| p.S401Y | UCEC | 1 |
| p.T441I | PCPG | 1 |
| p.R349C | UCEC | 1 |
| p.D1112N | SKCM | 1 |
| p.G917S | LUAD | 1 |
| p.R77Q | UCEC | 1 |
| p.W130X | SKCM | 1 |
| p.G1047S | PRAD | 1 |
| p.R799C | SKCM | 1 |
| p.P1036L | LIHC | 1 |
| p.V249I | UCEC | 1 |
| p.C182S | UCEC | 1 |
| p.R521C | STAD | 1 |
| p.G522E | SKCM | 1 |
| p.P466S | SKCM | 1 |
| p.G857R | STAD | 1 |
| p.P256H | PRAD | 1 |
| p.K969E | STAD | 1 |
| p.G228C | LUAD | 1 |
| p.P121R | KIRP | 1 |
| p.G857R | PRAD | 1 |
| p.W144C | BLCA | 1 |
| p.P584S | STAD | 1 |
| p.P604A | ACC | 1 |
| p.Y794N | KIRC | 1 |
| p.C430W | LUAD | 1 |
| p.H1110N | KIRC | 1 |
| p.G696V | UCEC | 1 |
| p.C1021R | LUAD | 1 |
| p.C191S | OV | 1 |
| p.A826S | SARC | 1 |
| p.W66L | LAML | 1 |
| p.A408S | LUAD | 1 |
| p.R1072G | THYM | 1 |
| p.N678D | OV | 1 |
| p.L870F | UCEC | 1 |
| p.V106G | UCEC | 1 |
| p.H284N | SKCM | 1 |
| p.W391C | HNSC | 1 |
| p.P1098S | SKCM | 1 |
| p.A603V | STAD | 1 |
| p.M104I | LUAD | 1 |
| p.T78K | LUAD | 1 |
| p.S687Y | THYM | 1 |
| p.P96H | SKCM | 1 |
| p.G752R | SKCM | 1 |
| p.C298Y | LUAD | 1 |
| p.C624S | LUAD | 1 |
| p.D1009N | LGG | 1 |
| p.R844L | BLCA | 1 |
| p.S4Y | UCEC | 1 |
| p.D142N | SKCM | 1 |
| p.E357D | THYM | 1 |
| p.G590V | ESCA | 1 |
| p.A338E | CESC | 1 |
| p.G650D | STAD | 1 |
| p.A874E | LUAD | 1 |
| p.H478Q | ACC | 1 |
| p.H248Q | LIHC | 1 |
| p.R686I | LUAD | 1 |
| p.R90H | PRAD | 1 |
| p.R1093H | COAD | 1 |
| p.C253F | THYM | 1 |
| p.R151Q | BLCA | 1 |
| p.R844Q | PAAD | 1 |
| p.R844Q | SKCM | 1 |
| p.R306W | HNSC | 1 |
| p.Q236H | BLCA | 1 |
| p.G403R | KIRP | 1 |
| p.A110V | STAD | 1 |
| p.S1121F | SKCM | 1 |
| p.G304W | ESCA | 1 |
| p.P466L | SKCM | 1 |
| p.G562R | LGG | 1 |
| p.S687F | PAAD | 1 |
| p.R558C | PAAD | 1 |
| p.S545I | TGCT | 1 |
| p.S401Y | READ | 1 |
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| TissGeneCNV for MEGF10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MEGF10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for MEGF10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, ITSN2, RACGAP1, DHX16, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, ARHGAP32, HDAC4, ITSN2, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (normal) |
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| COAD (tumor) | COAD (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, AP2M1, SNRNP200, BAHD1, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, CEP57, ZNFX1, AARS2, SCAPER, MCF2L2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, CUL7, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ALMS1, AARS2, MCF2L2 (normal) |
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| KICH (tumor) | KICH (normal) |
| MEGF10, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, GRB10, SART3, RANBP10, AP2M1, SNRNP200, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER (normal) |
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| KIRC (tumor) | KIRC (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, GRB10, RANBP10, AP2M1, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, MCF2L2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, HSPA12A, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, HSPA12A, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, DHX16, GRB10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, ITSN2, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MEGF10, CADPS2, ARHGAP32, HDAC4, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, ZNFX1, AARS2, SCAPER, MCF2L2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, ITSN2, RACGAP1, DHX16, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, CUL7, HSPA12A, ZNFX1, ALMS1, SCAPER, MCF2L2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| MEGF10, CADPS2, KIAA1598, HDAC4, ITSN2, RACGAP1, DHX16, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, BAHD1, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, SNRNP200, BAHD1, CUL7, TMEM132A, HSPA12A, ZNFX1, ALMS1, AARS2, SCAPER (normal) |
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| STAD (tumor) | STAD (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, GRB10, SART3, RANBP10, SNRNP200, TAOK2, BAHD1, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, ITSN2, RACGAP1, DHX16, GRB10, SART3, RANBP10, AP2M1, TAOK2, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (normal) |
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| THCA (tumor) | THCA (normal) |
| MEGF10, CADPS2, KIAA1598, ARHGAP32, ITSN2, RACGAP1, DHX16, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (tumor) | MEGF10, CADPS2, KIAA1598, ARHGAP32, HDAC4, RACGAP1, GRB10, SART3, RANBP10, AP2M1, SNRNP200, TAOK2, CUL7, TMEM132A, HSPA12A, CEP57, ZNFX1, ALMS1, AARS2, SCAPER, MCF2L2 (normal) |
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| TissGeneProg for MEGF10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MEGF10 |
| TissGeneDrug for MEGF10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MEGF10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0026848 | Myopathy | 3 | BeFree,CTD_human |
| umls:C0011168 | Deglutition Disorders | 2 | BeFree,CTD_human |
| umls:C0036341 | Schizophrenia | 2 | BeFree,GAD |
| umls:C0476273 | Respiratory distress | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GWASCAT |
| umls:C0014175 | Endometriosis | 1 | GAD |
| umls:C0035220 | Respiratory Distress Syndrome, Newborn | 1 | CTD_human |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0270960 | Congenital myopathy (disorder) | 1 | BeFree |
| umls:C0518014 | Hematocrit level | 1 | GAD |
| umls:C0521532 | Diaphragmatic paresis | 1 | BeFree |
| umls:C3280679 | MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET | 1 | CLINVAR,UNIPROT |
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