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| TissGeneSummary for CASR |
 Gene summary |
| Basic gene information | Gene symbol | CASR |
| Gene name | calcium-sensing receptor | |
| Synonyms | CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|HYPOC1|NSHPT|PCAR1 | |
| Cytomap | UCSC genome browser: 3q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000388.3, NM_001178065.1, | |
| Description | extracellular calcium-sensing receptorparathyroid Ca(2+)-sensing receptor 1parathyroid cell calcium-sensing receptor 1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 601199 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000036828 | ||
| HPRD : 03122 | ||
| Vega : OTTHUMG00000159491 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CASR | |
| BioGPS: 846 | ||
| Pathway | NCI Pathway Interaction Database: CASR | |
| KEGG: CASR | ||
| REACTOME: CASR | ||
| Pathway Commons: CASR | ||
| Context | iHOP: CASR | |
| ligand binding site mutation search in PubMed: CASR | ||
| UCL Cancer Institute: CASR | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of CASR | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0070509 | calcium ion import | 20846291 | GO:0070509 | calcium ion import | 20846291 |
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| TissGeneExp for CASR |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 1.179347819 | 8.20265893 | -7.023311111 | 3.28E-36 | 9.42E-35 |
| KIRP | 1.616847472 | 8.363869347 | -6.747021875 | 2.38E-16 | 8.75E-15 |
| KICH | 2.532614597 | 8.336606597 | -5.803992 | 4.46E-10 | 3.07E-09 |
| COAD | -2.218014788 | 0.208096751 | -2.426111538 | 1.15E-10 | 1.63E-09 |
| LIHC | -1.594473403 | 1.426196597 | -3.02067 | 3.66E-15 | 1.10E-13 |
| STAD | -1.458593153 | -0.099677528 | -1.358915625 | 0.00926 | 0.032438847 |
| THCA | -2.374252793 | -1.311151098 | -1.063101695 | 0.00029 | 0.000742266 |
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| TissGene-miRNA for CASR |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-6838-5p | MIMAT0027578 | 0.016 | -0.29 | 78 |
| ACC | hsa-miR-6838-5p | MIMAT0027578 | 0.016 | -0.29 | 78 |
| LUAD | hsa-miR-429 | MIMAT0001536 | 0.0094 | -0.34 | 60 |
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| TissGeneMut for CASR |
| TissGeneSNV for CASR |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P39S | SKCM | 4 |
| p.R392* | STAD | 2 |
| p.S923F | SKCM | 2 |
| p.S122Y | UCEC | 2 |
| p.D500N | SKCM | 2 |
| p.G518E | SKCM | 2 |
| p.E582K | SKCM | 2 |
| p.E931K | SKCM | 2 |
| p.F629S | SKCM | 2 |
| p.R392Q | SKCM | 2 |
| p.F619S | SKCM | 2 |
| p.E353K | SKCM | 2 |
| p.S490F | SKCM | 2 |
| p.A86V | THYM | 1 |
| p.R227* | STAD | 1 |
| p.D585N | SKCM | 1 |
| p.P579L | SKCM | 1 |
| p.L360F | SKCM | 1 |
| p.L1025M | LGG | 1 |
| p.E241V | LIHC | 1 |
| p.E765* | LUAD | 1 |
| p.Q1027L | LUAD | 1 |
| p.G730R | SKCM | 1 |
| p.R886Q | BRCA | 1 |
| p.S296R | SKCM | 1 |
| p.E582V | SKCM | 1 |
| p.G290S | SKCM | 1 |
| p.L770I | LUAD | 1 |
| p.L912V | LUSC | 1 |
| p.V653I | PRAD | 1 |
| p.S913F | SKCM | 1 |
| p.E1039K | HNSC | 1 |
| p.R331Q | MESO | 1 |
| p.E332K | SKCM | 1 |
| p.T92K | KIRP | 1 |
| p.T972M | STAD | 1 |
| p.R392X | STAD | 1 |
| p.T406S | BLCA | 1 |
| p.G1029E | SKCM | 1 |
| p.R896C | COAD | 1 |
| p.P569L | SKCM | 1 |
| p.G979D | ACC | 1 |
| p.A880T | UCEC | 1 |
| p.A986S | COAD | 1 |
| p.L689M | UCEC | 1 |
| p.S1061N | LUAD | 1 |
| p.G94E | BLCA | 1 |
| p.R561K | SKCM | 1 |
| p.R896W | GBM | 1 |
| p.G971S | STAD | 1 |
| p.P692L | PAAD | 1 |
| p.R340S | OV | 1 |
| p.R688H | OV | 1 |
| p.E880V | THYM | 1 |
| p.I491V | LIHC | 1 |
| p.E564K | SKCM | 1 |
| p.G567E | SKCM | 1 |
| p.P163S | LUSC | 1 |
| p.I613T | LUSC | 1 |
| p.E297K | CESC | 1 |
| p.F128L | STAD | 1 |
| p.D1015N | SKCM | 1 |
| p.P89S | SKCM | 1 |
| p.G43E | SKCM | 1 |
| p.G21R | HNSC | 1 |
| p.P1015L | UCEC | 1 |
| p.E981K | LUAD | 1 |
| p.P757L | SKCM | 1 |
| p.E80K | BRCA | 1 |
| p.E614K | LGG | 1 |
| p.P935S | COAD | 1 |
| p.R701L | UCEC | 1 |
| p.R69C | UCEC | 1 |
| p.G1034E | SKCM | 1 |
| p.L1035M | LGG | 1 |
| p.R185X | SKCM | 1 |
| p.Y514C | STAD | 1 |
| p.W206X | SKCM | 1 |
| p.F615L | LIHC | 1 |
| p.N710K | LUAD | 1 |
| p.N583D | SKCM | 1 |
| p.E362K | SKCM | 1 |
| p.P711L | PAAD | 1 |
| p.A625T | PAAD | 1 |
| p.R711L | LUAD | 1 |
| p.R185* | SKCM | 1 |
| p.D1022N | SKCM | 1 |
| p.S342F | SKCM | 1 |
| p.R883C | SARC | 1 |
| p.R205C | UCEC | 1 |
| p.S830F | SKCM | 1 |
| p.G559R | SKCM | 1 |
| p.R227* | UCEC | 1 |
| p.P808L | GBM | 1 |
| p.G447S | LIHC | 1 |
| p.D31N | STAD | 1 |
| p.W685* | SKCM | 1 |
| p.Q1017L | LUAD | 1 |
| p.P439T | GBM | 1 |
| p.K803E | HNSC | 1 |
| p.R392Q | STAD | 1 |
| p.E991K | LUAD | 1 |
| p.F183Y | LUSC | 1 |
| p.Q764H | LUAD | 1 |
| p.K892Q | UCS | 1 |
| p.E456K | SKCM | 1 |
| p.P393S | SKCM | 1 |
| p.D1032N | SKCM | 1 |
| p.P569S | SKCM | 1 |
| p.E574K | SKCM | 1 |
| p.D23N | LUSC | 1 |
| p.G695D | SKCM | 1 |
| p.E127* | ACC | 1 |
| p.E777K | CESC | 1 |
| p.G917E | SKCM | 1 |
| p.G903R | SKCM | 1 |
| p.R205H | STAD | 1 |
| p.E350V | LUSC | 1 |
| p.P747L | SKCM | 1 |
| p.R906C | DLBC | 1 |
| p.H344L | BRCA | 1 |
| p.E809Q | ESCA | 1 |
| p.F76C | UCEC | 1 |
| p.E282D | CESC | 1 |
| p.A897G | LUAD | 1 |
| p.D1005N | BRCA | 1 |
| p.T186I | STAD | 1 |
| p.D575N | SKCM | 1 |
| p.R726H | DLBC | 1 |
| p.Q432X | STAD | 1 |
| p.E379K | SKCM | 1 |
| p.D23N | SKCM | 1 |
| p.V689M | COAD | 1 |
| p.G366R | SKCM | 1 |
| p.G913R | SKCM | 1 |
| p.C851G | SKCM | 1 |
| p.R415Q | LIHC | 1 |
| p.P163S | SKCM | 1 |
| p.L276F | SKCM | 1 |
| p.V894I | BRCA | 1 |
| p.A430V | READ | 1 |
| p.P22L | SKCM | 1 |
| p.V1066M | LUAD | 1 |
| p.N593D | SKCM | 1 |
| p.A693T | STAD | 1 |
| p.W728* | SKCM | 1 |
| p.G440R | HNSC | 1 |
| p.P923L | COAD | 1 |
| p.R648C | SKCM | 1 |
| p.F320L | ESCA | 1 |
| p.S171G | LUSC | 1 |
| p.M197I | SKCM | 1 |
| p.S388L | SKCM | 1 |
| p.R185Q | SKCM | 1 |
| p.P1062S | SKCM | 1 |
| p.I613F | SKCM | 1 |
| p.V1056M | LUAD | 1 |
| p.N639K | BRCA | 1 |
| p.W828L | PRAD | 1 |
| p.N700K | LUAD | 1 |
| p.R701C | SKCM | 1 |
| p.P748S | SKCM | 1 |
| p.E871K | SKCM | 1 |
| p.A194V | LUAD | 1 |
| p.R701L | LUAD | 1 |
| p.P758S | SKCM | 1 |
| p.D990H | LUSC | 1 |
| p.E1030K | SKCM | 1 |
| p.D248H | BLCA | 1 |
| p.G969D | ACC | 1 |
| p.F798Y | KIRC | 1 |
| p.D398N | LUAD | 1 |
| p.K28N | SKCM | 1 |
| p.R69H | LUSC | 1 |
| p.R535M | COAD | 1 |
| p.R205C | ESCA | 1 |
| p.R901P | LUSC | 1 |
| p.D217N | HNSC | 1 |
| p.N732I | LUAD | 1 |
| p.A824T | COAD | 1 |
| p.T151K | LUAD | 1 |
| p.R415W | THYM | 1 |
| p.P920T | UCEC | 1 |
| p.S1071N | LUAD | 1 |
| p.R726C | SARC | 1 |
| p.L780I | LUAD | 1 |
| p.S697G | STAD | 1 |
| p.V827I | GBM | 1 |
| p.S387N | SKCM | 1 |
| p.S687G | STAD | 1 |
| p.T722I | KIRC | 1 |
| p.S417F | SKCM | 1 |
| p.E604K | LGG | 1 |
| p.S490F | READ | 1 |
| p.L700F | STAD | 1 |
| p.G567R | SKCM | 1 |
| p.L10I | UCEC | 1 |
| p.G581R | SKCM | 1 |
| p.R795Q | UCEC | 1 |
| p.E1029K | HNSC | 1 |
| p.G30R | SKCM | 1 |
| p.R227X | STAD | 1 |
| p.R901G | LUSC | 1 |
| p.C585F | OV | 1 |
| p.P596Q | LUAD | 1 |
| p.V631M | PAAD | 1 |
| p.G768C | HNSC | 1 |
| p.T919S | LUAD | 1 |
| p.W206* | SKCM | 1 |
| p.P1045A | HNSC | 1 |
| p.D248N | BLCA | 1 |
| p.S303F | SKCM | 1 |
| p.E881K | SKCM | 1 |
| p.R901C | LIHC | 1 |
| p.E475D | OV | 1 |
| p.G685D | SKCM | 1 |
| p.A73V | SKCM | 1 |
| p.A589T | LUAD | 1 |
| p.Q968K | PRAD | 1 |
| p.P579S | SKCM | 1 |
| p.T92M | COAD | 1 |
| p.E232G | UCEC | 1 |
| p.R96K | SKCM | 1 |
| p.G778C | HNSC | 1 |
| p.T92M | LUAD | 1 |
| p.P833S | SKCM | 1 |
| p.L665F | SKCM | 1 |
| p.S497F | SKCM | 1 |
| p.R285W | UCEC | 1 |
| p.P393L | SKCM | 1 |
| p.L184F | SKCM | 1 |
| p.K719N | STAD | 1 |
| p.E1020K | SKCM | 1 |
| p.P721L | PAAD | 1 |
| p.W675X | SKCM | 1 |
| p.Q432* | STAD | 1 |
| p.L679M | UCEC | 1 |
| p.G1076R | BLCA | 1 |
| p.E777K | SKCM | 1 |
| p.R890H | STAD | 1 |
| p.E620K | SKCM | 1 |
| p.A794S | CESC | 1 |
| p.L628F | SKCM | 1 |
| p.I813V | UCEC | 1 |
| p.T732A | BRCA | 1 |
| p.R890H | PAAD | 1 |
| p.R638C | SKCM | 1 |
| p.E767K | UCEC | 1 |
| p.E1053K | HNSC | 1 |
| p.V1081D | LUAD | 1 |
| p.G1044E | SKCM | 1 |
| p.V846L | LUAD | 1 |
| p.G376D | LIHC | 1 |
| p.R415W | UCEC | 1 |
| p.G363C | LUAD | 1 |
| p.P935L | COAD | 1 |
| p.E681K | SKCM | 1 |
| p.F979S | UCEC | 1 |
| p.A579T | LUAD | 1 |
| p.G329S | SKCM | 1 |
| p.N1006T | UCEC | 1 |
| p.P910T | UCEC | 1 |
| p.S244F | SKCM | 1 |
| p.V846I | SKCM | 1 |
| p.I162M | COAD | 1 |
| p.R66H | OV | 1 |
| p.G1066R | BLCA | 1 |
| p.E809K | SKCM | 1 |
| p.R906H | BLCA | 1 |
| p.R891H | UCEC | 1 |
| p.R711C | SKCM | 1 |
| p.C861G | SKCM | 1 |
| p.T898M | PRAD | 1 |
| p.K709N | STAD | 1 |
| p.A430T | KIRC | 1 |
| p.E350K | SKCM | 1 |
| p.L618F | SKCM | 1 |
| p.K806* | SKCM | 1 |
| p.A295S | LUAD | 1 |
| p.Q260R | SKCM | 1 |
| p.P682L | COAD | 1 |
| p.E1009K | SKCM | 1 |
| p.G30E | SKCM | 1 |
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| TissGeneCNV for CASR |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CASR |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-91-8499-01A | FAM162A-CASR | Out-of-Frame | chr3:122103146 | chr3:121980374 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A27V-01A | SUCLA2-CASR | 5UTR-5UTR | Chr13:48611742 | Chr3:121972795 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-91-8499-01A | FAM162A-CASR | Out-of-frame | Chr3:122103146 | Chr3:121980375 |
| TCGAfusionPortal | PRADA | OV | TCGA-23-1120-01A | LPP-CASR | In-frame | Chr3:188202492 | Chr3:121980375 |
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| TissGeneNet for CASR |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| COAD (tumor) | COAD (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| KICH (tumor) | KICH (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (tumor) | CASR, UBC, PRKCG, PRKCA, VCP, FLNA, RNF19A, TMED2, PRKCB, CHD8, PI4K2B (normal) |
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| TissGeneProg for CASR |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CASR |
| TissGeneDrug for CASR |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB01012 | Cinacalcet | Agonist | Small molecule | Approved |
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| TissGeneDisease for CASR |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0342637 | Hypocalciuric hypercalcemia, familial, type 1 | 103 | BeFree,CLINVAR,CTD_human,GAD,MGD,ORPHANET,UNIPROT |
| umls:C0020437 | Hypercalcemia | 57 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0342345 | Hypoparathyroidism - autosomal dominant | 40 | BeFree,CLINVAR |
| umls:C0221002 | Hyperparathyroidism, Primary | 25 | BeFree,GAD,LHGDN |
| umls:C0020502 | Hyperparathyroidism | 24 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0020626 | Hypoparathyroidism | 23 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0020438 | Hypercalciuria | 20 | BeFree,GAD,LHGDN,RGD |
| umls:C0699790 | Colon Carcinoma | 19 | BeFree |
| umls:C3715128 | HYPOCALCEMIA, AUTOSOMAL DOMINANT 1 | 17 | BeFree,MGD,ORPHANET,UNIPROT |
| umls:C0020503 | Hyperparathyroidism, Secondary | 16 | BeFree,GAD |
| umls:C1527249 | Colorectal Cancer | 16 | BeFree,GAD |
| umls:C0007102 | Malignant tumor of colon | 15 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 13 | BeFree |
| umls:C0262587 | Parathyroid Adenoma | 13 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 12 | BeFree |
| umls:C0678222 | Breast Carcinoma | 12 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 10 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 10 | BeFree |
| umls:C0342342 | Idiopathic Hypoparathyroidism | 9 | BeFree |
| umls:C0596263 | Carcinogenesis | 9 | BeFree |
| umls:C0001430 | Adenoma | 8 | BeFree |
| umls:C0023418 | leukemia | 8 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 8 | BeFree,GAD,LHGDN |
| umls:C0022650 | Kidney Calculi | 7 | BeFree,GAD |
| umls:C0029456 | Osteoporosis | 7 | BeFree |
| umls:C0392525 | Nephrolithiasis | 7 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 6 | BeFree,GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 6 | BeFree,GAD |
| umls:C0178874 | Tumor Progression | 6 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 6 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | BeFree |
| umls:C0020598 | Hypocalcemia | 5 | CTD_human,GAD,LHGDN |
| umls:C0025517 | Metabolic Diseases | 5 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 5 | BeFree,LHGDN |
| umls:C0027819 | Neuroblastoma | 5 | BeFree |
| umls:C0030305 | Pancreatitis | 5 | BeFree,LHGDN |
| umls:C0030521 | Parathyroid Neoplasms | 5 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 5 | BeFree |
| umls:C0700095 | Central neuroblastoma | 5 | BeFree |
| umls:C1832615 | HYPERPARATHYROIDISM, NEONATAL SEVERE | 5 | CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C2239176 | Liver carcinoma | 5 | BeFree |
| umls:C0004775 | Bartter Disease | 4 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 4 | BeFree,LHGDN |
| umls:C0011849 | Diabetes Mellitus | 4 | BeFree |
| umls:C0020599 | Hypocalciuria | 4 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 4 | BeFree,GAD,LHGDN |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 4 | BeFree |
| umls:C0028754 | Obesity | 4 | BeFree |
| umls:C0280100 | Solid tumour | 4 | BeFree |
| umls:C0345406 | Neonatal hyperparathyroidism | 4 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 4 | BeFree |
| umls:C0403447 | Chronic Kidney Insufficiency | 4 | BeFree,GAD |
| umls:C0543800 | Idiopathic hypercalciuria | 4 | BeFree |
| umls:C0687150 | Parathyroid Gland Adenocarcinoma | 4 | BeFree |
| umls:C0004153 | Atherosclerosis | 3 | BeFree,RGD |
| umls:C0020538 | Hypertensive disease | 3 | BeFree,GAD |
| umls:C0027051 | Myocardial Infarction | 3 | BeFree,LHGDN,RGD |
| umls:C0027709 | Nephrocalcinosis | 3 | BeFree |
| umls:C0029463 | Osteosarcoma | 3 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 3 | BeFree |
| umls:C0035078 | Kidney Failure | 3 | BeFree |
| umls:C0042870 | Vitamin D Deficiency | 3 | BeFree,LHGDN |
| umls:C0085859 | Polyglandular Type I Autoimmune Syndrome | 3 | BeFree |
| umls:C0149911 | Humoral hypercalcemia of malignancy (disorder) | 3 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 3 | BeFree |
| umls:C0451641 | Urolithiasis | 3 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 3 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 3 | BeFree |
| umls:C1809471 | Familial benign hypercalcemia | 3 | BeFree,CLINVAR,ORPHANET |
| umls:C1833683 | NEPHROLITHIASIS, CALCIUM OXALATE | 3 | BeFree |
| umls:C1864729 | HYPERPARATHYROIDISM 3 | 3 | BeFree |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004114 | Astrocytoma | 2 | BeFree |
| umls:C0006705 | Calcium Metabolism Disorders | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree |
| umls:C0014130 | Endocrine System Diseases | 2 | BeFree,GAD |
| umls:C0014544 | Epilepsy | 2 | BeFree |
| umls:C0017150 | Gastrinoma | 2 | BeFree |
| umls:C0017178 | Gastrointestinal Diseases | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 2 | BeFree |
| umls:C0020507 | Hyperplasia | 2 | LHGDN |
| umls:C0021670 | insulinoma | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | BeFree,LHGDN |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0024299 | Lymphoma | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0030517 | Parathyroid Diseases | 2 | BeFree |
| umls:C0036572 | Seizures | 2 | BeFree |
| umls:C0085110 | Severe Combined Immunodeficiency | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree,GAD |
| umls:C0271846 | Familial hyperparathyroidism | 2 | BeFree |
| umls:C0391957 | idiopathic epilepsy | 2 | BeFree |
| umls:C1261473 | Sarcoma | 2 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 2 | BeFree |
| umls:C1832648 | Hypoparathyroidism familial isolated | 2 | BeFree,CLINVAR,CTD_human |
| umls:C2316810 | Chronic kidney disease stage 5 | 2 | BeFree |
| umls:C0001925 | Albuminuria | 1 | RGD |
| umls:C0002063 | Alkalosis | 1 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0003130 | Anoxia | 1 | RGD |
| umls:C0003507 | Aortic Valve Stenosis | 1 | GAD |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0006663 | Calcinosis | 1 | GAD |
| umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0007193 | Cardiomyopathy, Dilated | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | GAD,LHGDN |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0012242 | Digestive System Disorders | 1 | BeFree |
| umls:C0019034 | Hemoglobin SC Disease | 1 | BeFree |
| umls:C0020542 | Pulmonary Hypertension | 1 | RGD |
| umls:C0020676 | Hypothyroidism | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0022680 | Polycystic Kidney Diseases | 1 | BeFree |
| umls:C0022951 | Lactose Intolerance | 1 | BeFree |
| umls:C0023530 | Leukopenia | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0025267 | Multiple Endocrine Neoplasia Type 1 | 1 | BeFree |
| umls:C0026269 | Mitral Valve Stenosis | 1 | GAD |
| umls:C0027055 | Myocardial Reperfusion Injury | 1 | RGD |
| umls:C0027947 | Neutropenia | 1 | BeFree |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0042963 | Vomiting | 1 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0085207 | Gestational Diabetes | 1 | BeFree |
| umls:C0086543 | Cataract | 1 | BeFree |
| umls:C0149782 | Squamous cell carcinoma of lung | 1 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0220989 | Acquired partial lipodystrophy | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238461 | Anaplastic thyroid carcinoma | 1 | BeFree |
| umls:C0268450 | Gitelman Syndrome | 1 | BeFree |
| umls:C0268800 | Simple renal cyst | 1 | BeFree |
| umls:C0270850 | Idiopathic generalized epilepsy | 1 | BeFree,CTD_human |
| umls:C0282687 | Hemorrhagic Fever, Ebola | 1 | BeFree |
| umls:C0333186 | Restenosis | 1 | BeFree |
| umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
| umls:C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | BeFree |
| umls:C0342634 | Neonatal hypocalcemia | 1 | BeFree |
| umls:C0342639 | Familial idiopathic hypercalciuria | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0521707 | Bilateral cataracts (disorder) | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0598935 | Tumor Initiation | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0745106 | hyperparathyroid | 1 | BeFree |
| umls:C0751956 | Acute Cerebrovascular Accidents | 1 | BeFree |
| umls:C0853897 | Diabetic Cardiomyopathies | 1 | RGD |
| umls:C0854110 | Insulin resistant diabetes | 1 | BeFree |
| umls:C0854467 | Myelosuppression | 1 | BeFree |
| umls:C0860204 | Cholestatic liver disease | 1 | BeFree |
| umls:C0878544 | Cardiomyopathies | 1 | RGD |
| umls:C1290807 | Diarrheal disorder | 1 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1519689 | Tumor Promotion | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C1704436 | Peripheral Arterial Diseases | 1 | BeFree |
| umls:C1704981 | Hyperparathyroidism-Jaw Tumor Syndrome | 1 | BeFree |
| umls:C1833372 | HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE III | 1 | BeFree |
| umls:C1835171 | Hypomagnesemia 2, renal | 1 | BeFree |
| umls:C1865868 | ALZHEIMER DISEASE 5 | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree,LHGDN |
| umls:C2752062 | EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 8 | 1 | CLINVAR,UNIPROT |
| umls:C3163620 | Hypotension Adverse Event | 1 | GAD |
| umls:C3494489 | Autoimmune polyendocrinopathy syndrome, type 1 | 1 | BeFree |
| umls:C1832611 | Hypercalciuric Hypercalcemia | 0 | CLINVAR |
| umls:C1840402 | HYPERPARATHYROIDISM 1 | 0 | MGD |
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