TissGeneSummary for SPZ1 |
Gene summary |
Basic gene information | Gene symbol | SPZ1 |
Gene name | spermatogenic leucine zipper 1 | |
Synonyms | NYD-TSP1|PPP1R148 | |
Cytomap | UCSC genome browser: 5q14.1 | |
Type of gene | protein-coding | |
RefGenes | NM_032567.3, | |
Description | protein phosphatase 1, regulatory subunit 148spermatogenic leucine zipper protein 1spermatogenic zip 1testis-specific protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000164299 | ||
HPRD : 15440 | ||
Vega : OTTHUMG00000162514 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPZ1 | |
BioGPS: 84654 | ||
Pathway | NCI Pathway Interaction Database: SPZ1 | |
KEGG: SPZ1 | ||
REACTOME: SPZ1 | ||
Pathway Commons: SPZ1 | ||
Context | iHOP: SPZ1 | |
ligand binding site mutation search in PubMed: SPZ1 | ||
UCL Cancer Institute: SPZ1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPZ1 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPZ1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SPZ1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPZ1 |
TissGeneSNV for SPZ1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R213C | SKCM | 2 |
p.Q191E | PRAD | 2 |
p.E75* | UCEC | 2 |
p.D78Y | ESCA | 1 |
p.E111D | READ | 1 |
p.H413N | LUAD | 1 |
p.K389R | UCEC | 1 |
p.G288S | HNSC | 1 |
p.L164V | HNSC | 1 |
p.K77N | SKCM | 1 |
p.Q346* | LUAD | 1 |
p.A8V | LUAD | 1 |
p.F410L | HNSC | 1 |
p.E75X | READ | 1 |
p.E351D | UCS | 1 |
p.Q333H | CESC | 1 |
p.Q227X | SKCM | 1 |
p.L341P | UCEC | 1 |
p.A180T | SKCM | 1 |
p.F86V | STAD | 1 |
p.K140N | UCEC | 1 |
p.D209Y | READ | 1 |
p.P21A | LUAD | 1 |
p.T291A | SKCM | 1 |
p.M122I | DLBC | 1 |
p.E121D | UCEC | 1 |
p.S425L | LUAD | 1 |
p.D209Y | CESC | 1 |
p.M423L | SKCM | 1 |
p.Q333H | BLCA | 1 |
p.P128S | LGG | 1 |
p.A415T | LIHC | 1 |
p.S4T | SKCM | 1 |
p.D391Y | PAAD | 1 |
p.E111* | UCEC | 1 |
p.S7P | LIHC | 1 |
p.E134K | KIRC | 1 |
p.D78Y | UCEC | 1 |
p.E87K | SKCM | 1 |
p.Q67H | UCEC | 1 |
p.I161M | BLCA | 1 |
p.E139X | COAD | 1 |
p.E296K | SKCM | 1 |
p.L419I | UCEC | 1 |
p.G288S | LGG | 1 |
p.D78E | LUAD | 1 |
p.T16N | LUAD | 1 |
p.E136X | COAD | 1 |
p.M383V | LGG | 1 |
p.I167T | UCEC | 1 |
p.W388* | SKCM | 1 |
p.A93S | LGG | 1 |
p.R233K | SKCM | 1 |
p.T148N | LUAD | 1 |
p.E111X | READ | 1 |
p.S4T | LUAD | 1 |
p.R213H | READ | 1 |
p.Q191X | ESCA | 1 |
p.S46F | HNSC | 1 |
p.Y358* | KIRC | 1 |
p.S311N | PAAD | 1 |
p.P44H | CESC | 1 |
p.Q227* | SKCM | 1 |
p.E136Q | KIRC | 1 |
p.E147K | SKCM | 1 |
p.E62K | SKCM | 1 |
p.E222K | UCEC | 1 |
p.E95* | BRCA | 1 |
p.L317* | LUAD | 1 |
p.W388X | SKCM | 1 |
p.E374* | UCEC | 1 |
p.C328F | ESCA | 1 |
p.S311N | STAD | 1 |
p.P44L | SKCM | 1 |
p.E95X | COAD | 1 |
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TissGeneCNV for SPZ1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPZ1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SPZ1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPZ1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPZ1 |
TissGeneDrug for SPZ1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPZ1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 5 | BeFree |
umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
umls:C0028754 | Obesity | 3 | BeFree |
umls:C0699790 | Colon Carcinoma | 3 | BeFree |
umls:C1519670 | Tumor Angiogenesis | 3 | BeFree |
umls:C0001430 | Adenoma | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0017601 | Glaucoma | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0018801 | Heart failure | 2 | BeFree |
umls:C0018802 | Congestive heart failure | 2 | BeFree |
umls:C0022116 | Ischemia | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0038356 | Stomach Neoplasms | 2 | BeFree,CTD_human |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 2 | BeFree |
umls:C0003857 | Congenital arteriovenous malformation | 1 | BeFree |
umls:C0003864 | Arthritis | 1 | BeFree |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0011644 | Scleroderma | 1 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0016057 | Fibrosarcoma | 1 | BeFree |
umls:C0017075 | Ganglioneuroma | 1 | BeFree |
umls:C0018889 | Helminthiasis | 1 | BeFree |
umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
umls:C0023652 | Lichen Sclerosus et Atrophicus | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0028945 | oligodendroglioma | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0029928 | Ovarian Diseases | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0034155 | Purpura, Thrombotic Thrombocytopenic | 1 | BeFree |
umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
umls:C0156259 | Hypertrophy of kidney | 1 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
umls:C0238190 | Inclusion Body Myositis (disorder) | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C0278883 | Metastatic melanoma | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0334590 | Anaplastic Oligodendroglioma | 1 | BeFree |
umls:C0595936 | Aqueous Humor Disorders | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
umls:C0751713 | Inclusion Body Myopathy, Sporadic | 1 | BeFree |
umls:C0812413 | Malignant Pleural Mesothelioma | 1 | BeFree |
umls:C1318485 | Liver regeneration disorder | 1 | BeFree |
umls:C1335110 | Oligodendroglial Neoplasm | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1510885 | Angiogenic Switch | 1 | BeFree |
umls:C1698581 | Rokitansky Kuster Hauser syndrome | 1 | BeFree |
umls:C1704436 | Peripheral Arterial Diseases | 1 | BeFree |
umls:C2584778 | Thrombotic thrombocytopenic purpura, acquired | 1 | BeFree |