TissGeneSummary for USP6 |
Gene summary |
Basic gene information | Gene symbol | USP6 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_USP6 | |
BioGPS: 84669 | ||
Pathway | NCI Pathway Interaction Database: USP6 | |
KEGG: USP6 | ||
REACTOME: USP6 | ||
Pathway Commons: USP6 | ||
Context | iHOP: USP6 | |
ligand binding site mutation search in PubMed: USP6 | ||
UCL Cancer Institute: USP6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of USP6 | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for USP6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for USP6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for USP6 |
TissGeneSNV for USP6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K1223N | UCEC | 2 |
p.D335N | SKCM | 2 |
p.R1208W | SKCM | 2 |
p.D769A | THYM | 2 |
p.G498E | HNSC | 1 |
p.F170L | BLCA | 1 |
p.S91T | COAD | 1 |
p.R398Q | HNSC | 1 |
p.R1113Q | UCEC | 1 |
p.T300I | LIHC | 1 |
p.G125R | PAAD | 1 |
p.E1045* | UCEC | 1 |
p.L319P | CESC | 1 |
p.M577I | SKCM | 1 |
p.R1249W | UCEC | 1 |
p.R136M | PRAD | 1 |
p.L830I | LUAD | 1 |
p.K519T | STAD | 1 |
p.P614L | LUAD | 1 |
p.V39I | COAD | 1 |
p.R1024W | COAD | 1 |
p.W467R | GBM | 1 |
p.R23H | BLCA | 1 |
p.M717T | STAD | 1 |
p.S675L | HNSC | 1 |
p.V25A | CESC | 1 |
p.L1136R | LUSC | 1 |
p.V1264I | COAD | 1 |
p.Q117E | CESC | 1 |
p.R96* | SKCM | 1 |
p.T337S | LUAD | 1 |
p.Q783* | GBM | 1 |
p.Y567D | BLCA | 1 |
p.V97A | CESC | 1 |
p.D961Y | UCEC | 1 |
p.R1082Q | ESCA | 1 |
p.Q1007H | COAD | 1 |
p.E1029D | LUAD | 1 |
p.K692N | LGG | 1 |
p.L342I | UCEC | 1 |
p.V797I | HNSC | 1 |
p.S1148L | COAD | 1 |
p.G962E | SKCM | 1 |
p.E132* | CESC | 1 |
p.W475X | LIHC | 1 |
p.D1088H | CESC | 1 |
p.S1107T | SARC | 1 |
p.E79K | SKCM | 1 |
p.W77C | STAD | 1 |
p.Y1366* | THCA | 1 |
p.L757V | DLBC | 1 |
p.S345A | STAD | 1 |
p.A662T | SKCM | 1 |
p.G1232E | SKCM | 1 |
p.H682Y | SKCM | 1 |
p.P796S | SKCM | 1 |
p.A1165T | UCEC | 1 |
p.E1102K | SKCM | 1 |
p.V231I | SKCM | 1 |
p.R456W | LUAD | 1 |
p.W1090C | LUAD | 1 |
p.R1245Q | LUSC | 1 |
p.R456W | THCA | 1 |
p.Q934P | SKCM | 1 |
p.I101M | CESC | 1 |
p.G563R | SKCM | 1 |
p.G788R | SKCM | 1 |
p.D980N | SKCM | 1 |
p.D1398N | SKCM | 1 |
p.R700Q | BLCA | 1 |
p.Q688* | BRCA | 1 |
p.R73Q | UCEC | 1 |
p.W451* | SKCM | 1 |
p.W77L | BRCA | 1 |
p.V148M | THYM | 1 |
p.W926X | READ | 1 |
p.P469S | SKCM | 1 |
p.T72R | COAD | 1 |
p.P357S | SARC | 1 |
p.S1195I | UCEC | 1 |
p.T490P | KIRP | 1 |
p.T74A | HNSC | 1 |
p.M882I | BLCA | 1 |
p.C1277Y | PCPG | 1 |
p.R27X | PRAD | 1 |
p.P247S | SKCM | 1 |
p.Q308X | STAD | 1 |
p.Q688E | LUSC | 1 |
p.G134D | GBM | 1 |
p.L1117I | UCEC | 1 |
p.A205T | THYM | 1 |
p.G163E | SKCM | 1 |
p.D1359N | HNSC | 1 |
p.E1129K | BRCA | 1 |
p.R161* | SKCM | 1 |
p.D521Y | UCEC | 1 |
p.Y1053C | STAD | 1 |
p.R398W | GBM | 1 |
p.G1322E | SKCM | 1 |
p.P243R | LUSC | 1 |
p.R1038C | UCEC | 1 |
p.A1028V | KIRP | 1 |
p.W666X | SKCM | 1 |
p.D1354H | CESC | 1 |
p.R149S | PAAD | 1 |
p.R1198L | STAD | 1 |
p.G17E | SKCM | 1 |
p.R153Q | GBM | 1 |
p.M713V | SKCM | 1 |
p.V338E | LUSC | 1 |
p.G839R | SKCM | 1 |
p.V287M | PAAD | 1 |
p.H939N | BLCA | 1 |
p.D1359N | SKCM | 1 |
p.C691Y | LGG | 1 |
p.L790F | LUAD | 1 |
p.S815L | LUAD | 1 |
p.S18L | SKCM | 1 |
p.R410C | SKCM | 1 |
p.P15S | SARC | 1 |
p.R1113X | LGG | 1 |
p.R985K | ESCA | 1 |
p.P390A | BLCA | 1 |
p.W666* | SKCM | 1 |
p.E935K | SKCM | 1 |
p.R674I | UCEC | 1 |
p.D1354N | SKCM | 1 |
p.R310C | STAD | 1 |
p.G440R | LGG | 1 |
p.A175V | SKCM | 1 |
p.E1029K | SKCM | 1 |
p.R23L | LUAD | 1 |
p.K1158* | UCEC | 1 |
p.K255Q | LUAD | 1 |
p.R1249W | HNSC | 1 |
p.D1114G | LIHC | 1 |
p.Q430H | LUAD | 1 |
p.S476N | PAAD | 1 |
p.P712Q | PRAD | 1 |
p.R1113* | LGG | 1 |
p.R943C | SKCM | 1 |
p.P710T | THYM | 1 |
p.P221L | LUSC | 1 |
p.G579R | LUAD | 1 |
p.E649K | SKCM | 1 |
p.V924L | COAD | 1 |
p.T911I | SKCM | 1 |
p.G820R | SKCM | 1 |
p.R686K | HNSC | 1 |
p.R895C | SKCM | 1 |
p.S190R | LUAD | 1 |
p.P952L | SKCM | 1 |
p.P837L | SKCM | 1 |
p.V338M | PRAD | 1 |
p.K347N | UCEC | 1 |
p.R322P | LUAD | 1 |
p.D944N | LAML | 1 |
p.E1304K | SKCM | 1 |
p.T193A | CESC | 1 |
p.A208T | SKCM | 1 |
p.S803L | SKCM | 1 |
p.I1371T | LGG | 1 |
p.E1029K | BLCA | 1 |
p.P776S | SKCM | 1 |
p.T346M | STAD | 1 |
p.E626* | UCEC | 1 |
p.G530V | CESC | 1 |
p.S1298R | LUSC | 1 |
p.D81V | OV | 1 |
p.D1392N | SKCM | 1 |
p.T330I | STAD | 1 |
p.K749Q | UCEC | 1 |
p.E168K | SKCM | 1 |
p.R956Q | UCS | 1 |
p.E1400K | SKCM | 1 |
p.F789L | SKCM | 1 |
p.R376L | LUAD | 1 |
p.Y1366X | THCA | 1 |
p.R456W | STAD | 1 |
p.R956Q | SKCM | 1 |
p.R27* | PRAD | 1 |
p.R912W | SARC | 1 |
p.L639R | STAD | 1 |
p.R1249L | THYM | 1 |
p.V338M | LUAD | 1 |
p.G900R | SKCM | 1 |
p.P1125T | HNSC | 1 |
p.H89N | COAD | 1 |
p.P807A | UCEC | 1 |
p.Q308* | STAD | 1 |
p.T193I | SKCM | 1 |
p.L304V | BLCA | 1 |
p.D33Y | LUSC | 1 |
p.I609M | UCEC | 1 |
p.G530E | SKCM | 1 |
p.P102S | COAD | 1 |
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TissGeneCNV for USP6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for USP6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AY624557 | CNBP-USP6 | chr3:128902727 | chr17:5033229 | |
Chimerdb3.0 | ChiTaRs | NA | AY380226 | CDH11-USP6 | chr16:65155882 | chr17:5033229 | |
Chimerdb3.0 | ChiTaRs | NA | AY380225 | CDH11-USP6 | chr16:65155882 | chr17:5033659 | |
Chimerdb3.0 | ChiTaRs | NA | AY380222 | CDH11-USP6 | chr16:65155882 | chr17:5028508 | |
Chimerdb3.0 | ChiTaRs | NA | AY380224 | CDH11-USP6 | chr16:65155882 | chr17:5033660 | |
Chimerdb3.0 | ChiTaRs | NA | X78261 | LOC100130950-USP6 | chr17:5104846 | chr17:5026755 | |
Chimerdb3.0 | ChiTaRs | NA | HQ326701 | MYH9-USP6 | chr22:36783984 | chr17:5033659 | |
Chimerdb3.0 | ChiTaRs | aneurysmal bone cyst | AY624559 | THRAP3-USP6 | chr1:36690107 | chr17:5033229 | |
Chimerdb3.0 | ChiTaRs | aneurysmal bone cyst | AY624556 | CNBP-USP6 | chr3:128902727 | chr17:5033660 | |
Chimerdb3.0 | ChiTaRs | aneurysmal bone cyst | AY624558 | COL1A1-USP6 | chr17:48278911 | chr17:5033231 | |
Chimerdb3.0 | ChiTaRs | aneurysmal bone cyst | AY624560 | CENPP-USP6 | chr9:95186587 | chr17:5033229 | |
Chimerdb3.0 | ChiTaRs | fasciitis | HQ326700 | MYH9-USP6 | chr22:36783984 | chr17:5033229 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-EW-A2FV-01A | USP6-STXBP4 | Out-of-Frame | chr17:5052062 | chr17:53218670 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A1-A0SN-01A | USP6-CLTC | In-Frame | chr17:5052062 | chr17:57728563 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A18J-01A | RPAIN-USP6 | Out-of-Frame | chr17:5326149 | chr17:5064822 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AN-A04A-01A | ATP5G1-USP6 | 5'UTR-CDS | chr17:46970202 | chr17:5048699 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-EW-A1J1-01A | USP6-ELOF1 | CDS-5'UTR | chr17:5052062 | chr19:11665180 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A2-A3XZ-01A | USP6-PTRH2 | CDS-5'UTR | chr17:5052062 | chr17:57775339 |
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TissGeneNet for USP6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for USP6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for USP6 |
TissGeneDrug for USP6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for USP6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0152244 | Bone Cysts, Aneurysmal | 12 | BeFree,LHGDN |
umls:C0005967 | Bone neoplasms | 2 | BeFree |
umls:C0410005 | Nodular fasciitis | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0010674 | Cystic Fibrosis | 1 | BeFree |
umls:C0017525 | Giant Cell Tumors | 1 | BeFree |
umls:C0020502 | Hyperparathyroidism | 1 | BeFree |
umls:C0027122 | Myositis Ossificans | 1 | BeFree,LHGDN |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0242383 | Age related macular degeneration | 1 | BeFree |
umls:C0259779 | Fibrous Dysplasia | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |