TissGeneSummary for C11orf70 |
Gene summary |
Basic gene information | Gene symbol | C11orf70 |
Gene name | chromosome 11 open reading frame 70 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001195005.1, NM_032930.2, | |
Description | uncharacterized protein C11orf70 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000137691 | ||
HPRD : 14433 | ||
Vega : OTTHUMG00000167320 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C11orf70 | |
BioGPS: 85016 | ||
Pathway | NCI Pathway Interaction Database: C11orf70 | |
KEGG: C11orf70 | ||
REACTOME: C11orf70 | ||
Pathway Commons: C11orf70 | ||
Context | iHOP: C11orf70 | |
ligand binding site mutation search in PubMed: C11orf70 | ||
UCL Cancer Institute: C11orf70 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C11orf70 | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C11orf70 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.535803697 | 1.007533558 | -1.543337255 | 3.63E-07 | 9.53E-07 |
PRAD | -0.804489029 | 0.725614817 | -1.530103846 | 1.26E-12 | 6.57E-11 |
KICH | -2.675568952 | 0.738743048 | -3.414312 | 9.61E-10 | 6.02E-09 |
KIRC | -0.947071508 | 0.293272937 | -1.240344444 | 6.23E-07 | 1.62E-06 |
KIRP | -1.167325327 | -0.007340952 | -1.159984375 | 0.00366 | 0.008880649 |
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TissGene-miRNA for C11orf70 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C11orf70 |
TissGeneSNV for C11orf70 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E156K | SKCM | 2 |
p.R167* | UCEC | 2 |
p.E239* | SKCM | 1 |
p.D265H | SKCM | 1 |
p.V222I | LIHC | 1 |
p.R144Q | SKCM | 1 |
p.E156X | PRAD | 1 |
p.V181I | BRCA | 1 |
p.K199Q | MESO | 1 |
p.D200Y | LUSC | 1 |
p.E97K | BLCA | 1 |
p.R205* | SKCM | 1 |
p.L96F | PRAD | 1 |
p.W48L | UCEC | 1 |
p.R205Q | SKCM | 1 |
p.R121Q | SKCM | 1 |
p.R205X | SKCM | 1 |
p.M230I | PAAD | 1 |
p.Y57N | LIHC | 1 |
p.L136I | UCEC | 1 |
p.R214C | UCEC | 1 |
p.E156* | PRAD | 1 |
p.S217Y | PAAD | 1 |
p.D151H | LUSC | 1 |
p.H112D | KIRP | 1 |
p.E239K | LGG | 1 |
p.R252H | LUAD | 1 |
p.E165* | LUAD | 1 |
p.D185N | SKCM | 1 |
p.G224D | LAML | 1 |
p.C175Y | ESCA | 1 |
p.K221T | THCA | 1 |
p.A197T | UCEC | 1 |
p.P249S | SKCM | 1 |
p.E92G | STAD | 1 |
p.M108I | LGG | 1 |
p.S82F | LGG | 1 |
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TissGeneCNV for C11orf70 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C11orf70 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A3I8-01A | ST3GAL4-C11orf70 | In-Frame | chr11:126279306 | chr11:101929610 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A3I8-01A | ST3GAL4-C11orf70 | In-Frame | chr11:126283543 | chr11:101929610 |
TCGAfusionPortal | PRADA | BLCA | TCGA-C4-A0F0-01A | DYNC2H1-C11orf70 | Out-of-frame | Chr11:102999734 | Chr11:101918546 |
TCGAfusionPortal | PRADA | LUAD | TCGA-62-A46O-01A | YAP1-C11orf70 | In-frame | Chr11:101985125 | Chr11:101951946 |
TCGAfusionPortal | PRADA | LUAD | TCGA-69-7979-01A | YAP1-C11orf70 | In-frame | Chr11:101985125 | Chr11:101918546 |
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TissGeneNet for C11orf70 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C11orf70 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C11orf70 |
TissGeneDrug for C11orf70 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C11orf70 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |