TissGeneSummary for LIPF |
Gene summary |
Basic gene information | Gene symbol | LIPF |
Gene name | lipase, gastric | |
Synonyms | GL|HGL|HLAL | |
Cytomap | UCSC genome browser: 10q23.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001198828.1, NM_001198829.1,NM_001198830.1,NM_004190.3, | |
Description | gastric lipasegastric triacylglycerol lipase | |
Modification date | 20141207 | |
dbXrefs | MIM : 601980 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182333 | ||
HPRD : 09063 | ||
Vega : OTTHUMG00000018695 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LIPF | |
BioGPS: 8513 | ||
Pathway | NCI Pathway Interaction Database: LIPF | |
KEGG: LIPF | ||
REACTOME: LIPF | ||
Pathway Commons: LIPF | ||
Context | iHOP: LIPF | |
ligand binding site mutation search in PubMed: LIPF | ||
UCL Cancer Institute: LIPF | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
Reference showing the relevant tissue of LIPF | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for LIPF |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for LIPF |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for LIPF |
TissGeneSNV for LIPF |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E47K | SKCM | 2 |
p.E57K | SKCM | 2 |
p.H181L | LUAD | 1 |
p.E58K | BLCA | 1 |
p.L363F | BLCA | 1 |
p.L353P | UCEC | 1 |
p.K159N | UCEC | 1 |
p.D360Y | BLCA | 1 |
p.D149N | SKCM | 1 |
p.G72V | LUAD | 1 |
p.Q47H | BLCA | 1 |
p.P161S | SKCM | 1 |
p.R284C | SKCM | 1 |
p.Q86H | THYM | 1 |
p.G77E | SKCM | 1 |
p.G319E | BLCA | 1 |
p.N127T | UCEC | 1 |
p.K408T | SKCM | 1 |
p.A149V | SKCM | 1 |
p.G180V | CHOL | 1 |
p.G25E | SKCM | 1 |
p.G350C | ESCA | 1 |
p.F237V | PAAD | 1 |
p.G340D | SKCM | 1 |
p.H177R | STAD | 1 |
p.S310Y | LIHC | 1 |
p.S391Y | UCEC | 1 |
p.L251F | SKCM | 1 |
p.D149G | PAAD | 1 |
p.D398N | KIRC | 1 |
p.G82V | LUAD | 1 |
p.K10N | UCEC | 1 |
p.G350D | SKCM | 1 |
p.D118Y | LUAD | 1 |
p.L241F | SKCM | 1 |
p.G22E | STAD | 1 |
p.E60Q | LUAD | 1 |
p.T186A | LUAD | 1 |
p.S193F | SKCM | 1 |
p.P75L | SKCM | 1 |
p.P382S | SKCM | 1 |
p.G15E | SKCM | 1 |
p.D159N | SKCM | 1 |
p.I393M | SKCM | 1 |
p.F91Y | LUAD | 1 |
p.E376D | LUAD | 1 |
p.G32E | STAD | 1 |
p.P151S | SKCM | 1 |
p.E64K | BLCA | 1 |
p.G67E | SKCM | 1 |
p.E376K | SKCM | 1 |
p.H171L | LUAD | 1 |
p.Y66C | BRCA | 1 |
p.A109V | READ | 1 |
p.I403M | SKCM | 1 |
p.D159G | PAAD | 1 |
p.D384H | SARC | 1 |
p.R77I | UCEC | 1 |
p.K407X | LIHC | 1 |
p.W348X | KIRC | 1 |
p.V80E | GBM | 1 |
p.K69T | UCEC | 1 |
p.R274C | SKCM | 1 |
p.P348H | LUSC | 1 |
p.P65L | SKCM | 1 |
p.F247V | PAAD | 1 |
p.P392S | SKCM | 1 |
p.K69I | SKCM | 1 |
p.V135D | STAD | 1 |
p.Q47* | CESC | 1 |
p.K79I | SKCM | 1 |
p.F179C | READ | 1 |
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TissGeneCNV for LIPF |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for LIPF |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA967267 | LIPF-PGA3 | chr10:90428486 | chr11:60974027 | |
Chimerdb3.0 | ChiTaRs | NA | BP341172 | LIPF-LIPF | chr10:90433488 | chr10:90424203 | |
Chimerdb3.0 | ChiTaRs | NA | BP341542 | YWHAE-LIPF | chr17:1303511 | chr10:90424200 | |
Chimerdb3.0 | ChiTaRs | NA | AW867927 | FBRSL1-LIPF | chr12:133073669 | chr10:90435973 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OJ-11A | LIPF-PGA3 | Out-of-Frame | chr10:90436037 | chr11:60974968 |
Chimerdb3.0 | FusionScan | LGG | TCGA-E1-A7YN-01A | ATAD1-LIPF | In-Frame | chr10:89550066 | chr10:90427043 |
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TissGeneNet for LIPF |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for LIPF |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for LIPF |
TissGeneDrug for LIPF |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB01083 | Orlistat | Inhibitor | Small molecule | Approved|Investigational |
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TissGeneDisease for LIPF |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0008384 | Cholesterol Ester Storage Disease | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | GAD |
umls:C0043208 | Wolman Disease | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |