TissGeneSummary for RGS8 |
Gene summary |
Basic gene information | Gene symbol | RGS8 |
Gene name | regulator of G-protein signaling 8 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1q25 | |
Type of gene | protein-coding | |
RefGenes | NM_001102450.1, NM_033345.2, | |
Description | regulator of G-protein signalling 8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607189 | |
HGNC : HGNC | ||
Ensembl : ENSG00000135824 | ||
HPRD : 06221 | ||
Vega : OTTHUMG00000035219 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RGS8 | |
BioGPS: 85397 | ||
Pathway | NCI Pathway Interaction Database: RGS8 | |
KEGG: RGS8 | ||
REACTOME: RGS8 | ||
Pathway Commons: RGS8 | ||
Context | iHOP: RGS8 | |
ligand binding site mutation search in PubMed: RGS8 | ||
UCL Cancer Institute: RGS8 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGTGCT | |
Reference showing the relevant tissue of RGS8 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RGS8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.129889752 | 4.024400078 | -4.154289831 | 2.86E-27 | 9.05E-25 |
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TissGene-miRNA for RGS8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RGS8 |
TissGeneSNV for RGS8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S56F | SKCM | 4 |
p.S157F | SKCM | 2 |
p.S139F | SKCM | 2 |
p.W53C | LUAD | 1 |
p.T76M | ESCA | 1 |
p.A54V | PAAD | 1 |
p.T76M | SKCM | 1 |
p.E99K | SKCM | 1 |
p.T149S | BRCA | 1 |
p.R71C | SKCM | 1 |
p.L153I | UCEC | 1 |
p.R26I | DLBC | 1 |
p.S74F | SKCM | 1 |
p.G12E | LUSC | 1 |
p.D157H | LUAD | 1 |
p.P53S | SKCM | 1 |
p.G166E | SKCM | 1 |
p.E137K | SKCM | 1 |
p.E138K | SKCM | 1 |
p.E138G | SKCM | 1 |
p.E155V | SKCM | 1 |
p.P35S | SKCM | 1 |
p.K122E | STAD | 1 |
p.L119V | OV | 1 |
p.E173V | SKCM | 1 |
p.D17E | BRCA | 1 |
p.E81K | SKCM | 1 |
p.F78S | LIHC | 1 |
p.K104E | STAD | 1 |
p.A146D | LUAD | 1 |
p.L34V | LUAD | 1 |
p.A72T | ESCA | 1 |
p.G148E | SKCM | 1 |
p.R177S | LUAD | 1 |
p.P118L | KIRC | 1 |
p.R34X | READ | 1 |
p.A2V | STAD | 1 |
p.F96S | LIHC | 1 |
p.D29N | SKCM | 1 |
p.R161M | LUSC | 1 |
p.E120K | SKCM | 1 |
p.C107S | BRCA | 1 |
p.Q19H | CHOL | 1 |
p.S139Y | LUAD | 1 |
p.R58H | UCEC | 1 |
p.R8C | COAD | 1 |
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TissGeneCNV for RGS8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RGS8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A243-01A | ADIPOR1-RGS8 | In-frame | Chr1:202912886 | Chr1:182617438 |
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TissGeneNet for RGS8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RGS8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RGS8 |
TissGeneDrug for RGS8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RGS8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007137 | Squamous cell carcinoma | 1 | GAD |
umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
umls:C0036341 | Schizophrenia | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
umls:C2931456 | Prostate cancer, familial | 1 | BeFree |