TissGeneSummary for SLC22A16 |
Gene summary |
Basic gene information | Gene symbol | SLC22A16 |
Gene name | solute carrier family 22 (organic cation/carnitine transporter), member 16 | |
Synonyms | CT2|FLIPT2|OAT6|OCT6|OKB1|dJ261K5.1 | |
Cytomap | UCSC genome browser: 6q22.1|6q21-q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_033125.3, | |
Description | WUGSC:RG331P03.1carnitine transporter 2flipt 2fly-like putative organic ion transporter 2fly-like putative transporter 2organic cation transporter 6organic cation transporter OKB1organic cation/carnitine transporter 6solute carrier family 22 (orga | |
Modification date | 20141207 | |
dbXrefs | MIM : 608276 | |
HGNC : HGNC | ||
Ensembl : ENSG00000004809 | ||
HPRD : 12202 | ||
Vega : OTTHUMG00000016171 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC22A16 | |
BioGPS: 85413 | ||
Pathway | NCI Pathway Interaction Database: SLC22A16 | |
KEGG: SLC22A16 | ||
REACTOME: SLC22A16 | ||
Pathway Commons: SLC22A16 | ||
Context | iHOP: SLC22A16 | |
ligand binding site mutation search in PubMed: SLC22A16 | ||
UCL Cancer Institute: SLC22A16 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SLC22A16 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0015695 | organic cation transport | 12089149 | GO:0015837 | amine transport | 15963465 | GO:0015879 | carnitine transport | 12089149 | GO:0046717 | acid secretion | 12089149 | GO:1902603 | carnitine transmembrane transport | 12089149 | GO:0015695 | organic cation transport | 12089149 | GO:0015837 | amine transport | 15963465 | GO:0015879 | carnitine transport | 12089149 | GO:0046717 | acid secretion | 12089149 | GO:1902603 | carnitine transmembrane transport | 12089149 |
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TissGeneExp for SLC22A16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.90342427 | -1.995782604 | 1.092358333 | 3.43E-08 | 9.91E-08 |
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TissGene-miRNA for SLC22A16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC22A16 |
TissGeneSNV for SLC22A16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S377F | SKCM | 3 |
p.A514T | STAD | 2 |
p.S375L | SKCM | 1 |
p.A567G | THCA | 1 |
p.V478A | STAD | 1 |
p.A457V | KIRP | 1 |
p.V252A | COAD | 1 |
p.R300Q | SKCM | 1 |
p.L295F | ESCA | 1 |
p.A514D | LUAD | 1 |
p.A199V | SARC | 1 |
p.A492T | UCEC | 1 |
p.S110W | BLCA | 1 |
p.T87M | BRCA | 1 |
p.L295I | KIRC | 1 |
p.E526* | KIRP | 1 |
p.L185F | PRAD | 1 |
p.S548I | COAD | 1 |
p.G118D | STAD | 1 |
p.E232G | DLBC | 1 |
p.F509C | READ | 1 |
p.N57H | BRCA | 1 |
p.P159L | SKCM | 1 |
p.L528I | COAD | 1 |
p.E526X | KIRP | 1 |
p.V184I | BLCA | 1 |
p.G450R | SKCM | 1 |
p.P400S | SKCM | 1 |
p.S354I | UCEC | 1 |
p.D177H | LUAD | 1 |
p.Q82H | HNSC | 1 |
p.S323L | BRCA | 1 |
p.S275Y | COAD | 1 |
p.H37Y | SKCM | 1 |
p.S573F | SKCM | 1 |
p.G385S | KIRC | 1 |
p.N104I | SKCM | 1 |
p.R486H | UCEC | 1 |
p.A304T | LUSC | 1 |
p.R182W | UCEC | 1 |
p.G332V | BRCA | 1 |
p.M311T | COAD | 1 |
p.G455R | UCEC | 1 |
p.F29L | LUAD | 1 |
p.S248F | SKCM | 1 |
p.H245N | LUAD | 1 |
p.G450E | SKCM | 1 |
p.Y402C | STAD | 1 |
p.M44I | HNSC | 1 |
p.V362I | READ | 1 |
p.G261V | LIHC | 1 |
p.G180E | SKCM | 1 |
p.R181C | LUAD | 1 |
p.S421F | SKCM | 1 |
p.R150Q | SKCM | 1 |
p.P470T | LUAD | 1 |
p.Q305H | READ | 1 |
p.P525L | SKCM | 1 |
p.I310T | STAD | 1 |
p.A408T | COAD | 1 |
p.P493L | SKCM | 1 |
p.G93D | BLCA | 1 |
p.W152R | LUAD | 1 |
p.H50Y | SKCM | 1 |
p.F249V | HNSC | 1 |
p.A514T | HNSC | 1 |
p.P570H | PRAD | 1 |
p.E94D | COAD | 1 |
p.P333S | SKCM | 1 |
p.R212P | LUAD | 1 |
p.R100M | LUAD | 1 |
p.E97K | SKCM | 1 |
p.P124S | SKCM | 1 |
p.T565M | COAD | 1 |
p.G45A | LUAD | 1 |
p.W241L | LUAD | 1 |
p.H49R | COAD | 1 |
p.D127N | HNSC | 1 |
p.L322V | MESO | 1 |
p.S480R | LIHC | 1 |
p.S176Y | LUAD | 1 |
p.W241* | UCEC | 1 |
p.P525S | UCEC | 1 |
p.R571S | SKCM | 1 |
p.L516R | STAD | 1 |
p.N104T | STAD | 1 |
p.Q133K | LUSC | 1 |
p.T356K | LUAD | 1 |
p.V362F | ESCA | 1 |
p.P280L | SKCM | 1 |
p.D84G | HNSC | 1 |
p.L295I | THYM | 1 |
p.Y464H | UCEC | 1 |
p.P292L | SKCM | 1 |
p.A202S | BLCA | 1 |
p.I454V | LUAD | 1 |
p.L274V | HNSC | 1 |
p.G511E | SKCM | 1 |
p.W69R | STAD | 1 |
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TissGeneCNV for SLC22A16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC22A16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | LUSC | TCGA-43-A475-01A | TAF8-SLC22A16 | Out-of-Frame | chr6:42023752 | chr6:110763978 |
Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-43-A475-01A | TAF8-SLC22A16 | Out-of-Frame | chr6:42023751 | chr6:110763977 |
Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-43-A475-01A | TAF8-SLC22A16 | In-Frame | chr6:42023769 | chr6:110763979 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A04V-01A | PRDM1-SLC22A16 | In-frame | Chr6:106554374 | Chr6:110763978 |
TCGAfusionPortal | PRADA | LUAD | TCGA-38-4630-01A | C6orf186-SLC22A16 | Out-of-frame | Chr6:110620125 | Chr6:110778220 |
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TissGeneNet for SLC22A16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC22A16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC22A16 |
TissGeneDrug for SLC22A16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC22A16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree,GAD |
umls:C0014170 | Endometrial Neoplasms | 1 | LHGDN |
umls:C0023418 | leukemia | 1 | BeFree,LHGDN |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0853193 | Bipolar I disorder | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C3495559 | Juvenile arthritis | 1 | CTD_human |