TissGeneSummary for CABS1 |
Gene summary |
Basic gene information | Gene symbol | CABS1 |
Gene name | calcium-binding protein, spermatid-specific 1 | |
Synonyms | C4orf35|CLPH|NYD-SP26 | |
Cytomap | UCSC genome browser: 4q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_033122.3, | |
Description | calcium-binding and spermatid-specific protein 1calcium-binding protein, sperm-specific 1casein-like phosphoproteintestis development protein NYD-SP26 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000145309 | ||
HPRD : 14865 | ||
Vega : OTTHUMG00000129405 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CABS1 | |
BioGPS: 85438 | ||
Pathway | NCI Pathway Interaction Database: CABS1 | |
KEGG: CABS1 | ||
REACTOME: CABS1 | ||
Pathway Commons: CABS1 | ||
Context | iHOP: CABS1 | |
ligand binding site mutation search in PubMed: CABS1 | ||
UCL Cancer Institute: CABS1 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CABS1 | Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif. St Laurent CD, St Laurent KE, Mathison RD, Befus AD. Am J Physiol Regul Integr Comp Physiol. 2015 Apr 1;308(7):R569-75. doi: 10.1152/ajpregu.00153.2014. Epub 2015 Jan 28. (pmid:25632019) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CABS1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for CABS1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CABS1 |
TissGeneSNV for CABS1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S131Y | UCEC | 2 |
p.E241K | COAD | 2 |
p.T90A | LUAD | 1 |
p.E237D | COAD | 1 |
p.A30T | READ | 1 |
p.E78K | SKCM | 1 |
p.D288Y | LUAD | 1 |
p.P35S | SKCM | 1 |
p.S210Y | LUAD | 1 |
p.D187G | STAD | 1 |
p.G294E | SKCM | 1 |
p.D109H | BLCA | 1 |
p.S194F | LUSC | 1 |
p.E306K | SKCM | 1 |
p.T380M | STAD | 1 |
p.G294R | SKCM | 1 |
p.S189I | PAAD | 1 |
p.E379V | HNSC | 1 |
p.G82V | LUAD | 1 |
p.K19* | STAD | 1 |
p.S136F | SKCM | 1 |
p.Q206H | ACC | 1 |
p.E262K | ESCA | 1 |
p.W298G | COAD | 1 |
p.D80H | BLCA | 1 |
p.E335V | LUAD | 1 |
p.L285P | HNSC | 1 |
p.L244V | TGCT | 1 |
p.D4N | COAD | 1 |
p.K19X | STAD | 1 |
p.L333P | LUAD | 1 |
p.A174T | UCEC | 1 |
p.K74N | STAD | 1 |
p.E142A | SKCM | 1 |
p.D59N | SKCM | 1 |
p.E16K | SKCM | 1 |
p.P218S | SKCM | 1 |
p.S189R | LUAD | 1 |
p.E73K | SKCM | 1 |
p.S157L | BLCA | 1 |
p.L234V | ESCA | 1 |
p.S245R | UCS | 1 |
p.E248K | BLCA | 1 |
p.Y54* | LUAD | 1 |
p.M394I | COAD | 1 |
p.D84N | GBM | 1 |
p.E95X | READ | 1 |
p.R301T | HNSC | 1 |
p.E95D | SKCM | 1 |
p.K76N | SKCM | 1 |
p.I212V | BLCA | 1 |
p.A178V | HNSC | 1 |
p.V324I | LGG | 1 |
p.K72M | LUAD | 1 |
p.E155K | LUAD | 1 |
p.G294X | COAD | 1 |
p.A255V | LUAD | 1 |
p.E155D | UCEC | 1 |
p.E293* | LUAD | 1 |
p.K71* | BLCA | 1 |
p.V324I | GBM | 1 |
p.D84N | UCEC | 1 |
p.D84N | COAD | 1 |
p.V162I | GBM | 1 |
p.G101A | LUAD | 1 |
p.D277H | BLCA | 1 |
p.S337L | SKCM | 1 |
p.V48I | COAD | 1 |
p.T97A | LUAD | 1 |
p.I106V | OV | 1 |
p.S110Y | KIRC | 1 |
p.S124L | SKCM | 1 |
p.E241K | STAD | 1 |
p.A327V | LUAD | 1 |
Top |
TissGeneCNV for CABS1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CABS1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CABS1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CABS1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CABS1 |
TissGeneDrug for CABS1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CABS1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0850803 | Anaphylaxis (non medication) | 1 | BeFree |
umls:C3665444 | Neutrophilia (disorder) | 1 | BeFree |