TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TP63

Gene summary

Basic gene information	Gene symbol	TP63
	Gene name	tumor protein p63
	Synonyms	AIS\|B(p51A)\|B(p51B)\|EEC3\|KET\|LMS\|NBP\|OFC8\|RHS\|SHFM4\|TP53CP\|TP53L\|TP73L\|p40\|p51\|p53CP\|p63\|p73H\|p73L
	Cytomap	UCSC genome browser: 3q28
	Type of gene	protein-coding
	RefGenes	NM_001114978.1, NM_001114979.1,NM_001114980.1,NM_001114981.1,NM_001114982.1, NM_003722.4,
	Description	CUSPamplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein 63tumor protein p53-competing proteintumor protein p63 deltaN isoform delta
	Modification date	20141222
dbXrefs	MIM : 603273
	HGNC : HGNC
	Ensembl : ENSG00000073282
	HPRD : 04469
	Vega : OTTHUMG00000156313
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_TP63
	BioGPS: 8626
Pathway	NCI Pathway Interaction Database: TP63
	KEGG: TP63
	REACTOME: TP63
	Pathway Commons: TP63
Context	iHOP: TP63
	ligand binding site mutation search in PubMed: TP63
	UCL Cancer Institute: TP63
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	BladderSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	BLCASKCM
Reference showing the relevant tissue of TP63
Description by TissGene annotations	Cancer gene Have significant anti-correlated miRNA Fused withTSGene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006974	cellular response to DNA damage stimulus	19451233
GO:0045747	positive regulation of Notch signaling pathway	11641404
GO:0045892	negative regulation of transcription, DNA-templated	12446784
GO:0045893	positive regulation of transcription, DNA-templated	12446784
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	20123734
GO:2000271	positive regulation of fibroblast apoptotic process	9774969
GO:0006974	cellular response to DNA damage stimulus	19451233
GO:0045747	positive regulation of Notch signaling pathway	11641404
GO:0045892	negative regulation of transcription, DNA-templated	12446784
GO:0045893	positive regulation of transcription, DNA-templated	12446784
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	20123734
GO:2000271	positive regulation of fibroblast apoptotic process	9774969

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TissGeneExp for TP63

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
THCA	-1.765700818	-3.104849971	1.339149153	3.32E-05	9.93E-05
PRAD	1.746098693	3.705289077	-1.959190385	6.96E-08	6.78E-07
BRCA	0.188683139	3.253504192	-3.064821053	5.92E-20	4.20E-19
KIRC	-3.731729726	-2.633904726	-1.097825	1.31E-06	3.32E-06
HNSC	6.674245339	5.413654641	1.260590698	2.75E-08	2.97E-07
KIRP	-4.76084674	-2.79482799	-1.96601875	3.33E-08	2.28E-07
LUSC	5.109600013	0.459398052	4.650201961	2.97E-14	1.64E-13
COAD	-4.777987846	-3.597164769	-1.180823077	2.46E-05	0.000102469

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TissGene-miRNA for TP63

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type	miRNA id	miRNA accession	P-val.	Coeff.	# samples
LUAD	hsa-miR-454-3p	MIMAT0003885	0.038	-0.27	60
LUAD	hsa-miR-301a-3p	MIMAT0000688	0.0076	-0.34	60
LUAD	hsa-miR-130b-3p	MIMAT0000691	0.0011	-0.41	60

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TissGeneMut for TP63

TissGeneSNV for TP63

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.R379C	SKCM	9
p.E609K	SKCM	7
p.R285C	SKCM	5
p.E515K	SKCM	4
p.D60N	SKCM	3
p.R393Q	SKCM	3
p.R594*	SKCM	3
p.R643Q	SKCM	3
p.S458L	SKCM	3
p.R549Q	SKCM	2
p.D398N	SKCM	2
p.S365L	SKCM	2
p.R594*	UCEC	2
p.P163L	SKCM	2
p.M216I	SKCM	2
p.S271L	SKCM	2
p.S535F	SKCM	2
p.R500X	SKCM	2
p.A139T	STAD	2
p.R266Q	SKCM	1
p.P152H	LUAD	1
p.P527L	STAD	1
p.M122I	SKCM	1
p.F458L	READ	1
p.E583K	SKCM	1
p.D76N	SKCM	1
p.D582N	SKCM	1
p.P456L	SKCM	1
p.P464L	BLCA	1
p.S478C	TGCT	1
p.P219L	CESC	1
p.R266*	UCEC	1
p.N389S	SKCM	1
p.D583_splice	UCEC	1
p.R338H	UCEC	1
p.Q575E	BLCA	1
p.R243X	SKCM	1
p.R226H	GBM	1
p.Q20H	PAAD	1
p.H615Y	SKCM	1
p.M387I	SKCM	1
p.I58T	BLCA	1
p.E5K	SKCM	1
p.Q204K	LUAD	1
p.E409D	LUSC	1
p.R594X	STAD	1
p.Q575*	CESC	1
p.Q575H	BLCA	1
p.S365*	TGCT	1
p.M469I	BLCA	1
p.M293I	SKCM	1
p.L553I	STAD	1
p.H521Y	SKCM	1
p.I213M	STAD	1
p.G314A	PRAD	1
p.M472T	STAD	1
p.R249L	LGG	1
p.R668S	PAAD	1
p.S142C	LUAD	1
p.S160C	LUAD	1
p.S189L	BLCA	1
p.S365L	KIRC	1
p.E632*	CESC	1
p.K324R	COAD	1
p.S189L	STAD	1
p.M107L	OV	1
p.S129L	SKCM	1
p.Y194_splice	GBM	1
p.P39L	SKCM	1
p.M1I	SKCM	1
p.R266Q	STAD	1
p.T5I	LUAD	1
p.R637C	UCEC	1
p.K369N	CESC	1
p.P532S	SKCM	1
p.R226H	SKCM	1
p.R594*	STAD	1
p.E48X	READ	1
p.E399X	ESCA	1
p.R319L	LUAD	1
p.R643*	PRAD	1
p.A150T	UCEC	1
p.R337Q	BLCA	1
p.S295F	SKCM	1
p.A9V	THYM	1
p.M316I	SKCM	1
p.T434M	SKCM	1
p.R330K	ESCA	1
p.S92I	STAD	1
p.S119N	SKCM	1
p.E53Q	LUAD	1
p.K588I	SKCM	1
p.R555K	SKCM	1
p.G332V	ESCA	1
p.N483S	SKCM	1
p.R393*	GBM	1
p.D16N	BLCA	1
p.G269E	SKCM	1
p.Q182*	SKCM	1
p.M581I	SKCM	1
p.R172X	COAD	1
p.Q122*	SKCM	1
p.R483Q	PAAD	1
p.E48K	BLCA	1
p.R376H	LGG	1
p.L481P	SKCM	1
p.S35L	SKCM	1
p.D157Y	UCEC	1
p.L552V	SKCM	1
p.S533F	SKCM	1
p.P69L	SKCM	1
p.P528T	MESO	1
p.E33K	SKCM	1
p.E90Q	BLCA	1
p.L584R	HNSC	1
p.R393C	LGG	1
p.N662S	SKCM	1
p.A554S	BLCA	1
p.A164V	PRAD	1
p.G635V	HNSC	1
p.R7W	LIHC	1
p.S364L	SKCM	1
p.A489T	UCEC	1
p.S630F	SKCM	1
p.A139V	LIHC	1
p.Y134C	HNSC	1
p.L646V	SKCM	1
p.D355N	BLCA	1
p.R376H	STAD	1
p.R172Q	SKCM	1
p.D488N	SKCM	1
p.P527L	SKCM	1
p.E459K	SKCM	1
p.A596V	UCEC	1
p.G629C	LUAD	1
p.A227T	PAAD	1
p.G349E	BLCA	1
p.N467S	SARC	1
p.Q88X	SKCM	1
p.S439F	SKCM	1
p.G255E	SKCM	1
p.G349E	SKCM	1
p.A51V	READ	1
p.E183X	READ	1
p.S536F	SKCM	1
p.S389F	SKCM	1
p.R337*	SKCM	1
p.A164V	SKCM	1
p.R343L	LGG	1
p.D398N	SARC	1
p.R352M	BLCA	1
p.K369N	KIRC	1
p.G128E	SKCM	1
p.K188M	CESC	1
p.R674H	SKCM	1
p.R337L	UCEC	1
p.P492A	BLCA	1
p.T193M	STAD	1
p.G175E	SKCM	1
p.D73N	SKCM	1
p.E328K	SKCM	1
p.T388I	LUSC	1
p.D137N	SKCM	1
p.G222E	SKCM	1
p.L525H	SKCM	1
p.P532L	SKCM	1
p.R487C	LGG	1
p.T144M	UCEC	1
p.T340M	SKCM	1
p.S484L	SKCM	1
p.P396T	LUAD	1
p.D660N	STAD	1
p.D546N	SKCM	1
p.K391N	UCEC	1
p.A45T	COAD	1
p.P133L	SKCM	1
p.A227T	GBM	1
p.A227T	PCPG	1
p.P80L	COAD	1
p.P496S	SKCM	1
p.T238M	STAD	1
p.E248K	HNSC	1
p.T434M	LIHC	1
p.R376H	KIRP	1
p.A96V	COAD	1
p.R643Q	OV	1
p.S68L	GBM	1
p.D170N	SKCM	1
p.A70T	KICH	1
p.M1I	BLCA	1
p.S365X	TGCT	1
p.S184L	HNSC	1
p.E677K	SKCM	1
p.D43N	SKCM	1
p.R461K	SKCM	1
p.G33S	COAD	1
p.D100N	SKCM	1
p.P260S	SKCM	1
p.T112M	UCEC	1
p.D489N	SKCM	1
p.S184W	LUSC	1
p.S38F	SKCM	1
p.F3L	HNSC	1
p.T281R	BLCA	1
p.R376L	CHOL	1
p.R266Q	HNSC	1
p.R37Q	SKCM	1
p.E657D	LUAD	1
p.D583V	UCEC	1
p.D397G	SKCM	1
p.A164T	KICH	1
p.T329P	OV	1
p.W658*	SKCM	1
p.G349A	CESC	1
p.M487I	SKCM	1
p.R37Q	UCEC	1
p.P492S	GBM	1
p.M222I	SKCM	1

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TissGeneCNV for TP63

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for TP63

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	BG698692	TP63-MVK		chr3:189598181	chr12:110034441
Chimerdb3.0	ChiTaRs	NA	BQ331863	MAN2B2-TP63		chr4:6595070	chr3:189578930
Chimerdb3.0	ChiTaRs	NA	BE843564	GABARAPL2-TP63		chr16:75611449	chr3:189614740
Chimerdb3.0	ChiTaRs	NA	AW852777	TNRC6B-TP63		chr22:40685643	chr3:189449012
Chimerdb3.0	FusionScan	ESCA	TCGA-IG-A6QS-01A	TP63-PINX1	In-Frame	chr3:189526315	chr8:10623426
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-55-A493-01A	TP63-P3H2	Out-of-Frame	chr3:189604182	chr3:189682767
TCGAfusionPortal	PRADA	BRCA	TCGA-E9-A1RH-01A	LPP-TP63	5UTR-CDS	Chr3:188059507	Chr3:189526061
TCGAfusionPortal	PRADA	LGG	TCGA-CS-4942-01A	LEPREL1-TP63	In-frame	Chr3:189838041	Chr3:189526061
TCGAfusionPortal	PRADA	LUSC	TCGA-39-5035-01A	IL1RAP-TP63	5UTR-CDS	Chr3:190232008	Chr3:189526061
TCGAfusionPortal	PRADA	SKCM	TCGA-GF-A769-01A	ZMAT3-TP63	Out-of-frame	Chr3:178785271	Chr3:189455529

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TissGeneNet for TP63

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
TP63, TP53, TP53BP2, PPP1R13L, IKBKB, BTRC, TP73, PPP2R5A, DAB2IP, SFN, DPH1, JPH1, BRD8, KRT14, KRT5, AGBL2, KRT6C, ADH5, IRF6, COL17A1, HPX (tumor)	TP63, UACA, HSP90AB1, YAP1, SACS, TCF4, DAB2IP, A2M, CDT1, JAG1, MYL9, FLNC, KRT14, PLS3, KRT5, CENPE, KRT6C, CCT8, COL17A1, S1PR5, TDRD9 (normal)

COAD (tumor)	COAD (normal)
TP63, FUS, RELA, HNRNPK, UPF2, SACS, TCF4, UBE2I, PPP2R5A, BECN1, HSPA5, FBXW7, JAG1, SYNCRIP, KRT14, KRT6C, HNRNPR, HNRNPA3, EMX1, S1PR5, SLC35A3 (tumor)	TP63, HNRNPAB, MAP1A, SMAD2, SACS, TCF4, NONO, A2M, SMARCD2, CARM1, CDT1, JAG1, FLNC, PIK3C3, HP, KRT14, KRT5, ITIH4, KRT6C, TDRD9, ZBTB4 (normal)

HNSC (tumor)	HNSC (normal)
TP63, PPP1R13L, HNRNPAB, TUBA1C, CPSF6, FASN, SFN, A2M, TOP2A, CAD, CDT1, JAG1, MYL9, SYNCRIP, PLS3, KRT5, CENPE, KRT6C, IRF6, HNRNPA3, ASPM (tumor)	TP63, RPL13A, RPL3, PIN1, PPP2R5A, EP300, RPSA, DHX9, GNB2L1, WWP1, JAG1, SYNCRIP, N4BP2, KRT14, PLS3, KRT5, KRT6C, SNRPA, IRF6, COL17A1, SLC35A3 (normal)

KICH (tumor)	KICH (normal)
TP63, UACA, PIN1, TP73, PPP2R5A, FBXW7, CARM1, ITCH, DPH1, CDT1, JPH1, MYL9, FLNC, WT1, RNF38, KRT5, CENPE, HIST1H1D, COL17A1, S1PR5, TDRD9 (tumor)	TP63, TUBA1C, CPSF6, FASN, DAXX, RPSA, HSPA5, PSMD2, GNB2L1, RPLP0, WWP1, TMBIM6, KRT14, KRT5, IGF2BP1, AGBL2, SATB2, DDX23, IRF6, HIST1H1D, TRMT11 (normal)

KIRC (tumor)	KIRC (normal)
TP63, FUS, COPS6, UACA, SACS, INPP5E, FBXW7, CARM1, DPH1, ATP5A1, JPH1, JAG1, FLNC, WT1, SYNCRIP, BRD8, KRT5, CENPE, HNRNPL, EMX1, TRMT11 (tumor)	TP63, UACA, IKBKB, TCF4, MYL12A, SOX2, FBXW7, TOP2A, PIWIL1, MYL9, FLNC, TMBIM6, KRT14, KRT5, CENPE, KRT6C, ADH5, HNRNPA3, ASPM, HIST1H1D, GAS8 (normal)

KIRP (tumor)	KIRP (normal)
TP63, PPP1R13L, HNRNPK, VCP, TP73, DNAJB6, A2M, EEF1A1, GNB2L1, DPH1, JAG1, FLNC, WT1, RPL12, KRT5, CABLES1, HIST1H1D, S1PR5, GCGR, ZBTB4, SLC35A3 (tumor)	TP63, FASN, TP73, TCF4, SOX2, A2M, TOP2A, FLNC, KRT14, KRT5, CENPE, IGF2BP1, CABLES1, KRT6C, SATB2, HNRNPA3, ASPM, EMX1, HIST1H1D, GAS8, S1PR5 (normal)

LIHC (tumor)	LIHC (normal)
TP63, UACA, UPF2, CPSF6, IKBKB, PIN1, SACS, BTRC, EP300, FBXW7, RPLP0, RNF38, MDM4, PIK3C3, KRT14, GOLGA4, KRT5, AGBL2, KRT6C, ASPM, SLC35A3 (tumor)	TP63, COPS6, RPL13A, HIPK2, YAP1, TCF4, RPSA, RPL24, GNB2L1, RPLP0, UBE4B, RNF38, PIK3C3, KRT14, PLS3, GOLGA4, KRT5, SNRPA, NIPSNAP3A, HNRNPR, COL17A1 (normal)

LUAD (tumor)	LUAD (normal)
TP63, HSP90AB1, MAP1A, BTRC, TP73, CHUK, PINX1, SOX2, DHX9, HSPA5, CAD, FLNC, KRT5, ITIH4, AGBL2, SEC24C, IRF6, COL17A1, GAS8, NPRL3, SLC35A3 (tumor)	TP63, PPP1R13L, CDKN1A, MAP1A, FASN, TP73, TCF4, CHUK, A2M, ATP5A1, JAG1, KRT14, PLS3, KRT5, AGBL2, KRT6C, HNRNPL, IRF6, COL17A1, S1PR5, HPX (normal)

LUSC (tumor)	LUSC (normal)
TP63, SAFB, MAP1A, FASN, TP73, INPP5E, SOX2, JAG1, WT1, KRT14, PLS3, KRT5, AGBL2, KRT6C, SATB2, ADH5, NIPSNAP3A, IRF6, MTHFSD, GAS8, ZBTB4 (tumor)	TP63, TUBA1C, TP73, PPP2R5A, SOX2, SFN, A2M, PSMD2, CARM1, JAG1, BRD8, KRT14, PLS3, KRT5, CABLES1, KRT6C, SEC24C, IRF6, EMX1, COL17A1, S1PR5 (normal)

PRAD (tumor)	PRAD (normal)
TP63, PPP1R13L, HNRNPK, CDKN2A, SMAD2, TP73, NONO, JAG1, KRT5, CENPE, AGBL2, DDX23, HNRNPL, NIPSNAP3A, HNRNPR, IRF6, HNRNPA3, CCT8, MTHFSD, COL17A1, S1PR5 (tumor)	TP63, PPP1R13L, HNRNPAB, YAP1, MAP1A, TP73, TCF4, DAB2IP, SOX2, SFN, MYL9, FLNC, KRT14, PLS3, KRT5, AGBL2, KRT6C, HNRNPL, COL17A1, S1PR5, ZBTB4 (normal)

STAD (tumor)	STAD (normal)
TP63, TP53BP2, PPP1R13L, MDM2, YAP1, FASN, BTRC, PPP2R5A, SOX2, BECN1, PPP1R13B, ITCH, JAG1, SYNCRIP, N4BP2, KRT14, PLS3, KRT5, KRT6C, SEC24C, S1PR5 (tumor)	TP63, PPP1R13L, RPL3, UBC, MDM2, HSP90AB1, SAFB, NONO, SFN, DHX9, FBXW7, JAG1, KRT14, PLS3, KRT5, KRT6C, SATB2, HNRNPR, COL17A1, S1PR5, ZBTB4 (normal)

THCA (tumor)	THCA (normal)
TP63, GRB2, CDKN2A, IKBKB, SACS, TP73, TCF4, SFN, A2M, FBXW7, TOP2A, CDT1, MDM4, TMBIM6, KRT14, KRT5, CENPE, IGF2BP1, SATB2, ASPM, S1PR5 (tumor)	TP63, CCNC, UACA, PPP1R13L, RELA, MYL12A, DAB2IP, PPP1R13B, SFN, HSPA5, CAD, ATP5A1, JAG1, KRT14, PLS3, KRT5, KRT6C, ASPM, COL17A1, GAS8, NPRL3 (normal)

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TissGeneProg for TP63

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for TP63

TissGeneDrug for TP63

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for TP63

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0007137	Squamous cell carcinoma	58	BeFree,CTD_human,LHGDN
umls:C0596263	Carcinogenesis	51	BeFree
umls:C0013575	Ectodermal Dysplasia	39	BeFree,GAD,LHGDN
umls:C2699510	Split-Hand/Foot Malformation	29	BeFree
umls:C0406709	Hay-Wells syndrome	28	BeFree,CLINVAR,CTD_human,MGD,UNIPROT
umls:C0406704	Rudiger syndrome 1	25	BeFree,CTD_human,ORPHANET
umls:C0265554	Ectrodactyly	22	BeFree,ORPHANET
umls:C2931019	Split hand foot deformity 1	22	BeFree
umls:C0001418	Adenocarcinoma	18	BeFree,CTD_human,GAD,LHGDN
umls:C1168401	Squamous cell carcinoma of the head and neck	17	BeFree
umls:C1785148	RAPP-HODGKIN SYNDROME	17	BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0027627	Neoplasm Metastasis	16	BeFree,CTD_human
umls:C0242379	Malignant neoplasm of lung	14	BeFree,GAD,GWASCAT
umls:C0678222	Breast Carcinoma	13	BeFree
umls:C1863204	ADULT SYNDROME	12	BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0006142	Malignant neoplasm of breast	11	BeFree
umls:C0158646	Cleft palate with cleft lip	11	BeFree
umls:C0339182	Ankyloblepharon	11	BeFree
umls:C0684249	Carcinoma of lung	11	BeFree
umls:C0005684	Malignant neoplasm of urinary bladder	10	BeFree,GAD
umls:C0152013	Adenocarcinoma of lung (disorder)	10	BeFree,CTD_human,GWASCAT
umls:C0600139	Prostate carcinoma	9	BeFree
umls:C0178874	Tumor Progression	8	BeFree
umls:C0376358	Malignant neoplasm of prostate	8	BeFree
umls:C0005695	Bladder Neoplasm	7	BeFree,GAD,LHGDN
umls:C0007131	Non-Small Cell Lung Carcinoma	7	BeFree
umls:C0008925	Cleft Palate	7	BeFree,CTD_human,GAD
umls:C0019693	HIV Infections	7	BeFree
umls:C0699885	Carcinoma of bladder	7	BeFree
umls:C0000768	Congenital Abnormality	6	BeFree
umls:C0029925	Ovarian Carcinoma	6	BeFree
umls:C0008924	Cleft Lip	5	BeFree,CTD_human,GAD,LHGDN
umls:C0024299	Lymphoma	5	BeFree
umls:C0079731	B-Cell Lymphomas	5	BeFree
umls:C0206139	Lichen Planus, Oral	5	BeFree
umls:C0206762	Limb Deformities, Congenital	5	BeFree,CTD_human
umls:C0302592	Cervix carcinoma	5	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	5	BeFree
umls:C1140680	Malignant neoplasm of ovary	5	BeFree
umls:C1261473	Sarcoma	5	BeFree
umls:C0010606	Adenoid Cystic Carcinoma	4	BeFree,LHGDN
umls:C0016508	Congenital Foot Deformity	4	BeFree,CTD_human
umls:C0027819	Neuroblastoma	4	BeFree
umls:C0206694	Mucoepidermoid Carcinoma	4	BeFree,LHGDN
umls:C0238198	Gastrointestinal Stromal Tumors	4	BeFree
umls:C0700095	Central neuroblastoma	4	BeFree
umls:C0919267	ovarian neoplasm	4	BeFree,CTD_human,LHGDN
umls:C1858562	ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 3	4	CLINVAR,CTD_human,MGD,UNIPROT
umls:C1863753	LIMB-MAMMARY SYNDROME	4	BeFree,CLINVAR,CTD_human,ORPHANET
umls:C0005689	Bladder Exstrophy	3	BeFree,MGD,ORPHANET
umls:C0007129	Merkel cell carcinoma	3	BeFree,LHGDN
umls:C0007133	Carcinoma, Papillary	3	BeFree,LHGDN
umls:C0008073	Developmental Disabilities	3	BeFree
umls:C0009402	Colorectal Carcinoma	3	BeFree
umls:C0010346	Crohn Disease	3	BeFree
umls:C0014859	Esophageal Neoplasms	3	BeFree
umls:C0025202	melanoma	3	BeFree
umls:C0029463	Osteosarcoma	3	BeFree
umls:C0033578	Prostatic Neoplasms	3	BeFree,CTD_mouse,LHGDN
umls:C0033860	Psoriasis	3	BeFree,LHGDN
umls:C0037579	Soft Tissue Neoplasms	3	BeFree
umls:C0038363	Aphthous Stomatitis	3	BeFree
umls:C0038367	Ulcerative stomatitis	3	BeFree
umls:C0152018	Esophageal carcinoma	3	BeFree
umls:C0206623	Adenosquamous carcinoma	3	BeFree
umls:C0235974	Pancreatic carcinoma	3	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	3	BeFree
umls:C0279671	Cervical Squamous Cell Carcinoma	3	BeFree
umls:C0585213	Minor oral aphthous ulceration	3	BeFree
umls:C0585442	Osteosarcoma of bone	3	BeFree
umls:C1176475	Ductal Carcinoma	3	BeFree,LHGDN
umls:C1527249	Colorectal Cancer	3	BeFree
umls:C1800706	Idiopathic Pulmonary Fibrosis	3	BeFree,LHGDN
umls:C1851710	LATERAL MENINGOCELE SYNDROME	3	BeFree
umls:C1851841	ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1	3	BeFree
umls:C3539878	Triple Negative Breast Neoplasms	3	BeFree
umls:C3811653	Experimental Organism Basal Cell Carcinoma	3	BeFree
umls:C0002452	Amelogenesis Imperfecta	2	BeFree
umls:C0003873	Rheumatoid Arthritis	2	BeFree
umls:C0004096	Asthma	2	BeFree
umls:C0004763	Barrett Esophagus	2	BeFree,LHGDN
umls:C0007114	Malignant neoplasm of skin	2	BeFree
umls:C0007138	Carcinoma, Transitional Cell	2	LHGDN
umls:C0008626	Congenital chromosomal disease	2	BeFree
umls:C0009404	Colorectal Neoplasms	2	CTD_human,LHGDN
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	2	BeFree
umls:C0014072	Experimental Autoimmune Encephalomyelitis	2	BeFree
umls:C0018566	Congenital Hand Deformities	2	BeFree,CTD_human
umls:C0021390	Inflammatory Bowel Diseases	2	BeFree
umls:C0022548	Keloid	2	BeFree,LHGDN
umls:C0022568	Keratitis	2	BeFree
umls:C0023269	leiomyosarcoma	2	BeFree
umls:C0023434	Chronic Lymphocytic Leukemia	2	BeFree
umls:C0024121	Lung Neoplasms	2	CTD_human,GAD
umls:C0024141	Lupus Erythematosus, Systemic	2	BeFree
umls:C0024530	Malaria	2	BeFree
umls:C0026769	Multiple Sclerosis	2	BeFree
umls:C0028754	Obesity	2	BeFree
umls:C0036095	Salivary Gland Neoplasms	2	BeFree
umls:C0037274	Dermatologic disorders	2	BeFree
umls:C0042133	Uterine Fibroids	2	BeFree
umls:C0079774	Peripheral T-Cell Lymphoma	2	BeFree
umls:C0085106	Familial benign pemphigus	2	BeFree
umls:C0149678	Epstein-Barr Virus Infections	2	BeFree
umls:C0149925	Small cell carcinoma of lung	2	BeFree
umls:C0151514	Atrophic condition of skin	2	BeFree
umls:C0153594	Malignant neoplasm of testis	2	BeFree
umls:C0205698	Undifferentiated carcinoma	2	BeFree
umls:C0206638	Giant Cell Tumor of Bone	2	BeFree,LHGDN
umls:C0206650	Fibroadenoma	2	BeFree
umls:C0206664	Teratocarcinoma	2	BeFree
umls:C0206720	Squamous Cell Neoplasms	2	CTD_human,LHGDN
umls:C0206754	Neuroendocrine Tumors	2	BeFree
umls:C0238463	Papillary thyroid carcinoma	2	BeFree
umls:C0241069	Superficial ulcer of skin (disorder)	2	BeFree
umls:C0333875	High-Grade Squamous Intraepithelial Lesions	2	BeFree
umls:C0346647	Malignant neoplasm of pancreas	2	BeFree
umls:C0374997	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	2	BeFree
umls:C0375023	Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site	2	BeFree
umls:C0376545	Hematologic Neoplasms	2	BeFree
umls:C0376634	Craniofacial Abnormalities	2	BeFree,CTD_human
umls:C0410702	Adolescent idiopathic scoliosis	2	BeFree
umls:C0432028	Split foot	2	BeFree
umls:C0546837	Malignant neoplasm of esophagus	2	BeFree
umls:C0595989	Carcinoma of larynx	2	BeFree
umls:C0685787	Cleft face	2	BeFree
umls:C0855197	Testicular malignant germ cell tumor	2	BeFree
umls:C1458155	Mammary Neoplasms	2	BeFree
umls:C1709246	Non-Neoplastic Disorder	2	BeFree
umls:C1854442	SPLIT-HAND/FOOT MALFORMATION 4	2	CLINVAR,CTD_human,UNIPROT
umls:C2239176	Liver carcinoma	2	BeFree
umls:C0001080	Achondroplasia	1	BeFree
umls:C0004134	Ataxia	1	BeFree
umls:C0004779	Basal Cell Nevus Syndrome	1	BeFree
umls:C0006145	Breast Diseases	1	CTD_human
umls:C0007115	Malignant neoplasm of thyroid	1	BeFree
umls:C0007117	Basal cell carcinoma	1	LHGDN
umls:C0007120	Bronchioloalveolar Adenocarcinoma	1	LHGDN
umls:C0007124	Noninfiltrating Intraductal Carcinoma	1	BeFree
umls:C0007621	Neoplastic Cell Transformation	1	CTD_human
umls:C0007873	Uterine Cervical Neoplasm	1	BeFree
umls:C0008441	Chondroblastoma	1	BeFree
umls:C0008497	Choriocarcinoma	1	LHGDN
umls:C0011615	Dermatitis, Atopic	1	BeFree
umls:C0013502	Echinococcosis	1	BeFree
umls:C0013595	Eczema	1	BeFree
umls:C0014145	Yolk Sac Tumor	1	LHGDN
umls:C0014457	Eosinophilia	1	LHGDN
umls:C0014544	Epilepsy	1	BeFree
umls:C0017525	Giant Cell Tumors	1	BeFree
umls:C0018194	Giant Cell Granuloma	1	LHGDN
umls:C0018418	Gynecomastia	1	BeFree
umls:C0020507	Hyperplasia	1	LHGDN
umls:C0021364	Male infertility	1	BeFree
umls:C0021400	Influenza	1	BeFree
umls:C0022575	Keratoconjunctivitis Sicca	1	BeFree
umls:C0022602	Actinic keratosis	1	BeFree
umls:C0022603	Seborrheic keratosis	1	BeFree
umls:C0023267	Fibroid Tumor	1	BeFree
umls:C0023452	Leukemia, Lymphocytic, Acute, L1	1	GWASCAT
umls:C0024117	Chronic Obstructive Airway Disease	1	GAD
umls:C0024301	Lymphoma, Follicular	1	BeFree
umls:C0025286	Meningioma	1	LHGDN
umls:C0025500	Mesothelioma	1	LHGDN
umls:C0026269	Mitral Valve Stenosis	1	BeFree
umls:C0026918	Mycobacterium Infections	1	BeFree
umls:C0026948	Mycosis Fungoides	1	BeFree
umls:C0027070	Myoepithelioma	1	BeFree
umls:C0027708	Nephroblastoma	1	BeFree
umls:C0029417	Osteoblastoma	1	BeFree
umls:C0030297	Pancreatic Neoplasm	1	CTD_human,GAD
umls:C0032019	Pituitary Neoplasms	1	BeFree
umls:C0036631	Seminoma	1	LHGDN
umls:C0037268	Skin Abnormalities	1	CTD_human
umls:C0038987	Sweat Gland Neoplasms	1	CTD_human
umls:C0039075	Syndactyly	1	BeFree
umls:C0039538	Teratoma	1	BeFree
umls:C0040100	Thymoma	1	LHGDN
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0041296	Tuberculosis	1	BeFree
umls:C0042755	Virilism	1	BeFree
umls:C0079773	Lymphoma, T-Cell, Cutaneous	1	BeFree
umls:C0080032	Pleural Effusion, Malignant	1	BeFree
umls:C0085750	Adenosis of Breast	1	BeFree
umls:C0149782	Squamous cell carcinoma of lung	1	BeFree
umls:C0151860	Acquired porencephaly	1	BeFree
umls:C0152244	Bone Cysts, Aneurysmal	1	BeFree
umls:C0153381	Malignant neoplasm of mouth	1	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	1	BeFree
umls:C0155877	Allergic asthma	1	BeFree
umls:C0162361	Hidrotic Ectodermal Dysplasia	1	BeFree
umls:C0162810	Cicatrix, Hypertrophic	1	BeFree,LHGDN
umls:C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	1	BeFree
umls:C0206658	Smooth Muscle Tumor	1	BeFree
umls:C0206659	Embryonal Carcinoma	1	LHGDN
umls:C0206666	Trophoblastic Tumor, Placental Site	1	BeFree
umls:C0206674	Adenoma, Villous	1	LHGDN
umls:C0206704	Carcinoma, Large Cell	1	LHGDN
umls:C0206706	Verrucous carcinoma	1	BeFree
umls:C0220641	Lip and Oral Cavity Carcinoma	1	BeFree
umls:C0221228	Comedone	1	BeFree
umls:C0221269	Pseudolymphoma	1	BeFree
umls:C0233794	Memory impairment	1	BeFree
umls:C0239337	Deformity of limb	1	BeFree
umls:C0263361	Psoriasis vulgaris	1	BeFree
umls:C0276262	Verruca plana	1	BeFree
umls:C0278601	Inflammatory Breast Carcinoma	1	BeFree
umls:C0279651	Gallbladder adenocarcinoma	1	BeFree
umls:C0280324	Laryngeal Squamous Cell Carcinoma	1	BeFree
umls:C0282612	Prostatic Intraepithelial Neoplasias	1	CTD_mouse
umls:C0349788	Arrhythmogenic Right Ventricular Dysplasia	1	BeFree,LHGDN
umls:C0392077	Cardiac sarcoidosis	1	BeFree
umls:C0406557	Poikiloderma of Kindler	1	BeFree
umls:C0494165	Secondary malignant neoplasm of liver	1	BeFree
umls:C0549379	Recurrent Carcinoma	1	BeFree
umls:C0549473	Thyroid carcinoma	1	BeFree
umls:C0553723	Squamous cell carcinoma of skin	1	BeFree
umls:C0559260	Congenital scoliosis	1	BeFree
umls:C0585362	Squamous cell carcinoma of mouth	1	BeFree
umls:C0677898	invasive cancer	1	BeFree
umls:C0936016	Testicular Feminization	1	BeFree
umls:C1265996	Large cell neuroendocrine carcinoma	1	BeFree
umls:C1266089	Metaplastic carcinoma	1	BeFree
umls:C1319315	Adenocarcinoma of large intestine	1	BeFree
umls:C1333878	B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma	1	BeFree
umls:C1334455	Pulmonary Sclerosing Hemangioma	1	BeFree
umls:C1368683	Epithelioma	1	BeFree
umls:C1512409	Hepatocarcinogenesis	1	BeFree
umls:C1518171	Malignant Conversion	1	BeFree
umls:C1519346	Skin Carcinogenesis	1	BeFree
umls:C1561549	Glomerular filtration rate finding	1	GAD
umls:C1561989	Limbal stem cell deficiency	1	BeFree
umls:C1707291	NUT Midline Carcinoma	1	BeFree
umls:C1720887	Female Urogenital Diseases	1	CTD_human
umls:C1837217	Cleft lip, isolated	1	BeFree
umls:C1867983	PORENCEPHALY, FAMILIAL	1	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	GAD
umls:C2931822	Nasopharyngeal carcinoma	1	BeFree
umls:C2986622	Cervical Intraepithelial Neoplasia Grade 2/3	1	BeFree
umls:C3273239	Proliferative Inflammatory Atrophy	1	BeFree
umls:C0017168	Gastroesophageal reflux disease	0	MGD
umls:C1851878	OROFACIAL CLEFT 8	0	CLINVAR