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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HSD17B6
check button Gene summary
Basic gene informationGene symbolHSD17B6
Gene namehydroxysteroid (17-beta) dehydrogenase 6
SynonymsHSE|RODH|SDR9C6
CytomapUCSC genome browser: 12q13
Type of geneprotein-coding
RefGenesNM_003725.3,
Description17-beta-HSD 617-beta-hydroxysteroid dehydrogenase type 63(alpha->beta)-hydroxysteroid epimerase3(alpha->beta)-hydroxysteroid epimerasel3-alpha->beta-HSE3-alpha->beta-hydroxysteroid epimerase3-hydroxysteroid epimeraseNAD+ -dependent 3 alpha-hydroxys
Modification date20141207
dbXrefs MIM : 606623
HGNC : HGNC
Ensembl : ENSG00000025423
HPRD : 09431
Vega : OTTHUMG00000170854
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HSD17B6
BioGPS: 8630
PathwayNCI Pathway Interaction Database: HSD17B6
KEGG: HSD17B6
REACTOME: HSD17B6
Pathway Commons: HSD17B6
ContextiHOP: HSD17B6
ligand binding site mutation search in PubMed: HSD17B6
UCL Cancer Institute: HSD17B6
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of HSD17B6
Description by TissGene annotationsFused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for HSD17B6

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD0.4541851451.887073606-1.4328884621.86E-058.01E-05
KICH-3.769392548-0.623408548-3.1459843.61E-157.58E-14
BRCA1.561722189-1.5779067583.1396289471.22E-605.30E-58
THCA3.2836427064.974934232-1.6912915258.99E-105.27E-09
LUSC1.2347411785.554476472-4.3197352943.74E-354.95E-33
LUAD2.8139688326.0442309-3.2302620691.19E-233.98E-22
STAD-0.2552631731.161586827-1.416852.71E-063.85E-05
BLCA0.9377327153.677616926-2.7398842111.11E-063.61E-05
KIRC-1.952104492-0.305115603-1.6469888893.08E-161.71E-15
LIHC7.7266394529.771041452-2.0444023.42E-061.64E-05
HNSC0.331157685-1.9186678972.2498255812.29E-181.03E-15
ESCA-0.9580270930.782336543-1.7403636360.001840.02200086
KIRP-2.119181923-0.605900673-1.513281250.0002820.000878117


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TissGene-miRNA for HSD17B6

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for HSD17B6
TissGeneSNV for HSD17B6

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.F209LLUAD2
p.P118LBLCA1
p.R280QUCEC1
p.R104KSKCM1
p.D286YHNSC1
p.M216TSKCM1
p.A58TUCEC1
p.E63*SARC1
p.N256TSTAD1
p.L116FSKCM1
p.E63KSKCM1
p.S295CLUAD1
p.Q68HSARC1
p.E229KSKCM1
p.A59TACC1
p.M250VLIHC1
p.R52*CESC1
p.K98ECOAD1
p.E123QCOAD1
p.G182ESKCM1
p.R222*UCEC1
p.S163CBLCA1
p.R278QUCEC1
p.A92TSARC1
p.L82VBRCA1
p.M223ICESC1
p.A59VLUAD1
p.T273PLIHC1


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TissGeneCNV for HSD17B6

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for HSD17B6

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanPRADTCGA-G9-6494-01AHSD17B6-PATZ15'UTR-CDSchr12:57157198chr22:31738946


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TissGeneNet for HSD17B6

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for HSD17B6

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for HSD17B6
TissGeneDrug for HSD17B6

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for HSD17B6

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0001627Congenital adrenal hyperplasia9BeFree
umls:C2936791Antley-Bixler Syndrome, Autosomal Dominant8BeFree
umls:C0268596Multiple Acyl Coenzyme A Dehydrogenase Deficiency7BeFree
umls:C0032460Polycystic Ovary Syndrome6BeFree,GAD
umls:C0342776Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency5BeFree
umls:C0000768Congenital Abnormality4BeFree
umls:C0001125Acidosis, Lactic3BeFree
umls:C0023264Leigh Disease3BeFree
umls:C0025517Metabolic Diseases3BeFree
umls:C0029928Ovarian Diseases3BeFree
umls:C0266362Ambiguous Genitalia3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C085265421-hydroxylase deficiency3BeFree
umls:C0917796Optic Atrophy, Hereditary, Leber3BeFree
umls:C2936858Congenital adrenal hyperplasia due to 21 hydroxylase deficiency3BeFree
umls:C0001916Albinism2BeFree
umls:C0005586Bipolar Disorder2BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0025521Inborn Errors of Metabolism2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0030421Paraganglioma2BeFree
umls:C0036341Schizophrenia2BeFree
umls:C0037231Sjogren-Larsson Syndrome2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site2BeFree
umls:C0520463Chronic active hepatitis2BeFree
umls:C0524851Neurodegenerative Disorders2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0684249Carcinoma of lung2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0949857Mitochondrial Respiratory Chain Deficiencies2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C0004096Asthma1BeFree
umls:C0004352Autistic Disorder1BeFree
umls:C0006118Brain Neoplasms1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0010674Cystic Fibrosis1BeFree
umls:C0011570Mental Depression1BeFree
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0013080Down Syndrome1BeFree
umls:C0020615Hypoglycemia1BeFree
umls:C0020757Ichthyoses1BeFree
umls:C0020758Congenital ichthyosis1BeFree
umls:C0022661Kidney Failure, Chronic1BeFree
umls:C0023893Liver Cirrhosis, Experimental1CTD_human
umls:C0023895Liver diseases1BeFree
umls:C0024121Lung Neoplasms1BeFree
umls:C0025637Methemoglobinemia1BeFree
umls:C0026848Myopathy1BeFree
umls:C0027868Neuromuscular Diseases1BeFree
umls:C0030552Paresis1BeFree
umls:C0035334Retinitis Pigmentosa1BeFree
umls:C0037772Spastic Paraplegia1BeFree
umls:C0039984Thoracic Outlet Syndrome1BeFree
umls:C0085584Encephalopathies1BeFree
umls:C0151786Muscle Weakness1BeFree
umls:C0152115Lingual-Facial-Buccal Dyskinesia1BeFree
umls:C0162666Mitochondrial Encephalomyopathies1BeFree
umls:C0162671MELAS Syndrome1BeFree
umls:C0220766Congenital hypoplasia of adrenal gland1BeFree
umls:C0264716Chronic heart failure1BeFree
umls:C0265234Branchio-Oto-Renal Syndrome1BeFree
umls:C0268312Progressive intrahepatic cholestasis (disorder)1BeFree
umls:C0278488Carcinoma breast stage IV1BeFree
umls:C0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0346255Oncocytoma, renal1BeFree
umls:C0403447Chronic Kidney Insufficiency1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0559758Multisystem disorder1BeFree
umls:C0567312Menopause present (finding)1GWASCAT
umls:C0686347Tardive Dyskinesia1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0854723Retinal Dystrophies1BeFree
umls:C1708371Histiocytoid Cardiomyopathy1BeFree
umls:C1852373Mitochondrial encephalopathy1BeFree
umls:C1862939AMYOTROPHIC LATERAL SCLEROSIS 11BeFree
umls:C1862941Amyotrophic Lateral Sclerosis, Sporadic1BeFree
umls:C1865349Ethylmalonic encephalopathy1BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C1955741Glucocorticoid deficiency1BeFree