TissGeneSummary for ADAM20 |
Gene summary |
Basic gene information | Gene symbol | ADAM20 |
Gene name | ADAM metallopeptidase domain 20 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 14q24.1 | |
Type of gene | protein-coding | |
RefGenes | NM_003814.4, | |
Description | ADAM 20a disintegrin and metalloproteinase domain 20disintegrin and metalloproteinase domain-containing protein 20 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603712 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134007 | ||
HPRD : 04754 | ||
Vega : OTTHUMG00000167548 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM20 | |
BioGPS: 8748 | ||
Pathway | NCI Pathway Interaction Database: ADAM20 | |
KEGG: ADAM20 | ||
REACTOME: ADAM20 | ||
Pathway Commons: ADAM20 | ||
Context | iHOP: ADAM20 | |
ligand binding site mutation search in PubMed: ADAM20 | ||
UCL Cancer Institute: ADAM20 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ADAM20 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAM20 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ADAM20 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAM20 |
TissGeneSNV for ADAM20 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P751S | SKCM | 2 |
p.P297L | SKCM | 2 |
p.N46T | KIRC | 1 |
p.G77V | LUAD | 1 |
p.N736T | STAD | 1 |
p.P197S | STAD | 1 |
p.V287I | UCEC | 1 |
p.G734R | CESC | 1 |
p.L40V | LUAD | 1 |
p.F758L | UCEC | 1 |
p.V284L | UCEC | 1 |
p.W252S | LIHC | 1 |
p.P666S | SKCM | 1 |
p.G494V | ACC | 1 |
p.L175F | LUSC | 1 |
p.P623L | SKCM | 1 |
p.R116W | PAAD | 1 |
p.I99L | PAAD | 1 |
p.P751S | HNSC | 1 |
p.S511* | HNSC | 1 |
p.P451S | SKCM | 1 |
p.N618I | PCPG | 1 |
p.H635Y | HNSC | 1 |
p.D323G | UCEC | 1 |
p.S112F | LUSC | 1 |
p.P10S | SKCM | 1 |
p.S248F | SKCM | 1 |
p.R340* | SKCM | 1 |
p.Q578E | BLCA | 1 |
p.C159Y | STAD | 1 |
p.L383* | LUAD | 1 |
p.P447L | READ | 1 |
p.P653L | HNSC | 1 |
p.A147T | COAD | 1 |
p.N529S | LGG | 1 |
p.H561N | BRCA | 1 |
p.F69Y | LUAD | 1 |
p.R121T | HNSC | 1 |
p.E466V | LIHC | 1 |
p.Q16X | SKCM | 1 |
p.R340X | SKCM | 1 |
p.E327* | UCEC | 1 |
p.I188M | UCEC | 1 |
p.S677N | LGG | 1 |
p.K106N | HNSC | 1 |
p.V300F | LUAD | 1 |
p.W708G | STAD | 1 |
p.R767C | COAD | 1 |
p.S273P | STAD | 1 |
p.A81S | ESCA | 1 |
p.S213I | LUSC | 1 |
p.Q85K | SKCM | 1 |
p.T475I | SKCM | 1 |
p.E469* | LUAD | 1 |
p.F117L | SKCM | 1 |
p.D308H | LUSC | 1 |
p.Y160C | KIRP | 1 |
p.C670G | KIRP | 1 |
p.Q518K | THYM | 1 |
p.W43* | PRAD | 1 |
p.A709S | BRCA | 1 |
p.D9Y | PRAD | 1 |
p.R672H | UCEC | 1 |
p.E466A | SKCM | 1 |
p.Q16* | SKCM | 1 |
p.C704S | GBM | 1 |
p.S330Y | UCEC | 1 |
p.C484Y | STAD | 1 |
p.P653H | LUSC | 1 |
p.E194A | UCEC | 1 |
p.Q433K | CHOL | 1 |
p.A39D | HNSC | 1 |
p.I584V | PCPG | 1 |
p.R672H | PRAD | 1 |
p.Q145H | LUAD | 1 |
p.K421N | ESCA | 1 |
p.F294I | SKCM | 1 |
p.L625V | PRAD | 1 |
p.K357E | BLCA | 1 |
p.R121I | HNSC | 1 |
p.A81T | UCEC | 1 |
p.P95S | SKCM | 1 |
p.R590L | HNSC | 1 |
p.T216S | STAD | 1 |
p.G620* | LUAD | 1 |
p.V549L | LUSC | 1 |
p.L183V | LUSC | 1 |
p.G468R | READ | 1 |
p.P751L | SKCM | 1 |
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TissGeneCNV for ADAM20 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAM20 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ADAM20 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAM20 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAM20 |
TissGeneDrug for ADAM20 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAM20 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |