TissGeneSummary for ADAM18 |
Gene summary |
Basic gene information | Gene symbol | ADAM18 |
Gene name | ADAM metallopeptidase domain 18 | |
Synonyms | ADAM27|tMDCIII | |
Cytomap | UCSC genome browser: 8p11.22 | |
Type of gene | protein-coding | |
RefGenes | NM_001190956.1, NM_014237.2, | |
Description | a disintegrin and metalloproteinase domain 18disintegrin and metalloproteinase domain-containing protein 18putative ADAM18 gene producttransmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000168619 | ||
HPRD : 07469 | ||
Vega : OTTHUMG00000164040 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM18 | |
BioGPS: 8749 | ||
Pathway | NCI Pathway Interaction Database: ADAM18 | |
KEGG: ADAM18 | ||
REACTOME: ADAM18 | ||
Pathway Commons: ADAM18 | ||
Context | iHOP: ADAM18 | |
ligand binding site mutation search in PubMed: ADAM18 | ||
UCL Cancer Institute: ADAM18 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ADAM18 | ||
Description by TissGene annotations | Cancer gene Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAM18 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.093263742 | -2.091306797 | 1.998043056 | 1.54E-10 | 5.32E-10 |
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TissGene-miRNA for ADAM18 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAM18 |
TissGeneSNV for ADAM18 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M143I | SKCM | 5 |
p.G667E | SKCM | 4 |
p.G549E | SKCM | 4 |
p.E678K | SKCM | 3 |
p.S244F | SKCM | 3 |
p.G96E | SKCM | 3 |
p.G312E | SKCM | 3 |
p.S536L | SKCM | 3 |
p.P102S | SKCM | 3 |
p.P170S | SKCM | 3 |
p.P540S | SKCM | 2 |
p.D198N | SKCM | 2 |
p.R255K | SKCM | 2 |
p.E240K | SKCM | 2 |
p.G22E | SKCM | 2 |
p.Q390* | SKCM | 2 |
p.S659F | SKCM | 2 |
p.P289S | SKCM | 2 |
p.H618Y | SKCM | 2 |
p.P30S | SKCM | 2 |
p.G116E | SKCM | 2 |
p.M587I | SKCM | 2 |
p.W161C | STAD | 1 |
p.A272S | STAD | 1 |
p.L3F | SKCM | 1 |
p.H280Y | BLCA | 1 |
p.A513V | READ | 1 |
p.R261W | UCEC | 1 |
p.G591R | SKCM | 1 |
p.Q390X | SKCM | 1 |
p.E529K | SKCM | 1 |
p.F222C | UCEC | 1 |
p.G486E | SKCM | 1 |
p.A722T | PAAD | 1 |
p.H82N | ESCA | 1 |
p.E526K | SKCM | 1 |
p.P698L | SKCM | 1 |
p.R366T | LIHC | 1 |
p.S104L | SKCM | 1 |
p.P651T | LUAD | 1 |
p.P514Q | LUAD | 1 |
p.I316T | BLCA | 1 |
p.E373Q | CESC | 1 |
p.Q142* | SKCM | 1 |
p.S112F | SKCM | 1 |
p.C335Y | UCEC | 1 |
p.E678A | ESCA | 1 |
p.K504E | PRAD | 1 |
p.L264R | SKCM | 1 |
p.P281H | LUSC | 1 |
p.D364N | SKCM | 1 |
p.E77K | SKCM | 1 |
p.S233F | SKCM | 1 |
p.M303_splice | LUSC | 1 |
p.P129S | SKCM | 1 |
p.X740Y | SKCM | 1 |
p.S728* | UCEC | 1 |
p.T176A | READ | 1 |
p.P170L | SKCM | 1 |
p.G326V | UCEC | 1 |
p.W685* | SKCM | 1 |
p.S589* | LUSC | 1 |
p.Y420S | LUSC | 1 |
p.S246R | SKCM | 1 |
p.G480S | SKCM | 1 |
p.Q670* | SKCM | 1 |
p.E100K | UCEC | 1 |
p.K176Q | UCEC | 1 |
p.W259C | BRCA | 1 |
p.F222L | SKCM | 1 |
p.C335* | SKCM | 1 |
p.D590Y | LUAD | 1 |
p.F460V | READ | 1 |
p.W259* | PRAD | 1 |
p.S523Y | COAD | 1 |
p.G285E | SKCM | 1 |
p.P86S | SKCM | 1 |
p.A348P | ESCA | 1 |
p.D298Y | READ | 1 |
p.L231P | LUSC | 1 |
p.C335X | SKCM | 1 |
p.G312R | SKCM | 1 |
p.G12E | SKCM | 1 |
p.P435S | THYM | 1 |
p.A206V | SKCM | 1 |
p.K32N | HNSC | 1 |
p.S80Y | UCEC | 1 |
p.T438I | LUSC | 1 |
p.F372C | UCEC | 1 |
p.P449S | SKCM | 1 |
p.G480V | PRAD | 1 |
p.E100K | SKCM | 1 |
p.F657C | SKCM | 1 |
p.S64* | STAD | 1 |
p.K144E | LIHC | 1 |
p.D735N | SKCM | 1 |
p.T568K | LUAD | 1 |
p.S729F | COAD | 1 |
p.T287A | ESCA | 1 |
p.E193K | SKCM | 1 |
p.K671N | SKCM | 1 |
p.C406S | LIHC | 1 |
p.S64X | STAD | 1 |
p.V192L | LUAD | 1 |
p.Y94F | LUAD | 1 |
p.L60I | UCEC | 1 |
p.R366I | LGG | 1 |
p.F70V | ESCA | 1 |
p.C517W | PAAD | 1 |
p.H346Y | SKCM | 1 |
p.T333S | SARC | 1 |
p.E402X | ESCA | 1 |
p.G647E | SKCM | 1 |
p.M221I | SKCM | 1 |
p.S352R | OV | 1 |
p.I230T | LIHC | 1 |
p.K715E | STAD | 1 |
p.G22R | SKCM | 1 |
p.E723G | DLBC | 1 |
p.M344I | SKCM | 1 |
p.N345I | LUSC | 1 |
p.E733* | THYM | 1 |
p.D147H | KIRP | 1 |
p.E402K | SKCM | 1 |
p.G466E | SKCM | 1 |
p.G247W | KIRC | 1 |
p.I123L | DLBC | 1 |
p.S133L | SKCM | 1 |
p.Q413R | UCEC | 1 |
p.Y463F | STAD | 1 |
p.E18K | SKCM | 1 |
p.E733X | THYM | 1 |
p.R481C | STAD | 1 |
p.A195T | SKCM | 1 |
p.P305S | SKCM | 1 |
p.F655I | READ | 1 |
p.G634V | STAD | 1 |
p.L547I | UCS | 1 |
p.E121K | SKCM | 1 |
p.I243F | STAD | 1 |
p.P289L | LUSC | 1 |
p.A626T | LGG | 1 |
p.A560D | LUSC | 1 |
p.D652N | SKCM | 1 |
p.S523Y | UCEC | 1 |
p.G61E | SKCM | 1 |
p.P651S | SKCM | 1 |
p.V276L | BLCA | 1 |
p.Q566* | BLCA | 1 |
p.S716T | DLBC | 1 |
p.A249V | READ | 1 |
p.V730I | UCEC | 1 |
p.P473A | LUSC | 1 |
p.G396E | SKCM | 1 |
p.Q670X | SKCM | 1 |
p.T50K | THCA | 1 |
p.E39K | SKCM | 1 |
p.P289S | LUSC | 1 |
p.D735N | COAD | 1 |
p.G285* | HNSC | 1 |
p.D590N | SKCM | 1 |
p.G591E | SKCM | 1 |
p.T176N | READ | 1 |
p.K416M | SKCM | 1 |
p.W237L | COAD | 1 |
p.G634W | LGG | 1 |
p.P289L | SKCM | 1 |
p.W685X | SKCM | 1 |
p.G634R | LUAD | 1 |
p.P646S | SKCM | 1 |
p.Q142L | DLBC | 1 |
p.R135K | SKCM | 1 |
p.C578F | LIHC | 1 |
p.K375N | LUAD | 1 |
p.S151Y | COAD | 1 |
p.E193Q | BLCA | 1 |
p.S732L | SKCM | 1 |
p.K295I | ESCA | 1 |
p.R649K | LUAD | 1 |
p.D198Y | LUAD | 1 |
p.F639I | SKCM | 1 |
p.G591E | READ | 1 |
p.M200I | SKCM | 1 |
p.P148S | SKCM | 1 |
p.M587V | LUAD | 1 |
p.A318T | SKCM | 1 |
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TissGeneCNV for ADAM18 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAM18 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI206708 | ADAM18-PPAPDC1B | chr8:39587582 | chr8:38123659 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A105-01A | ADAM18-LSM1 | Out-of-Frame | chr8:39581426 | chr8:38029551 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A105-01A | ADAM18-LSM1 | Out-of-frame | Chr8:39581426 | Chr8:38029551 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A574-01A | FGFR1-ADAM18 | Out-of-frame | Chr8:38314874 | Chr8:39463826 |
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TissGeneNet for ADAM18 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAM18 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAM18 |
TissGeneDrug for ADAM18 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAM18 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |