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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for WISP3
check button Gene summary
Basic gene informationGene symbolWISP3
Gene nameWNT1 inducible signaling pathway protein 3
SynonymsCCN6|LIBC|PPAC|PPD
CytomapUCSC genome browser: 6q21
Type of geneprotein-coding
RefGenesNM_003880.3,
NM_198239.1,NR_125353.1,NR_125354.1,NM_130396.1,
DescriptionCCN family member 6WISP-3WNT1-inducible-signaling pathway protein 3
Modification date20141207
dbXrefs MIM : 603400
HGNC : HGNC
Ensembl : ENSG00000112761
HPRD : 04550
Vega : OTTHUMG00000185101
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_WISP3
BioGPS: 8838
PathwayNCI Pathway Interaction Database: WISP3
KEGG: WISP3
REACTOME: WISP3
Pathway Commons: WISP3
ContextiHOP: WISP3
ligand binding site mutation search in PubMed: WISP3
UCL Cancer Institute: WISP3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCATGCT
Reference showing the relevant tissue of WISP3
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for WISP3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC-0.4056193422.556608436-2.9622277781.08E-198.23E-19
KIRP-0.126178372.784774755-2.9109531257.31E-084.53E-07
KICH-1.286444622.71634738-4.0027927.15E-172.52E-15
BRCA0.1550206442.802630293-2.6476096492.96E-222.48E-21
PRAD-0.4685192350.913842303-1.3823615382.01E-071.72E-06
LUSC0.91243891-1.2669120712.179350984.75E-071.24E-06
HNSC1.9245711940.4576107291.4669604650.005270.014183612
COAD0.343373073-1.3791692351.7225423080.004450.010833278
STAD2.108699755-0.0779439952.186643750.0001640.00117839


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TissGene-miRNA for WISP3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for WISP3
TissGeneSNV for WISP3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E55*UCEC2
p.D271NCOAD1
p.S195*LUAD1
p.A179STHYM1
p.K98NLUSC1
p.G23DSTAD1
p.L27VBLCA1
p.V86MBRCA1
p.Q194RPRAD1
p.W223XCHOL1
p.W234*SKCM1
p.K58NPAAD1
p.K76NPAAD1
p.G21VACC1
p.G180DUCEC1
p.E128KLIHC1
p.K233TCOAD1
p.R87KLUSC1
p.R245KSTAD1
p.C183FSKCM1
p.G41DSTAD1
p.C337*STAD1
p.W349*SKCM1
p.S293YHNSC1
p.R357IUCEC1
p.L7PHNSC1
p.H14YSKCM1
p.E102DCOAD1
p.Q154*SKCM1
p.R357IREAD1
p.C359YLGG1
p.C337*LUAD1
p.G283ESKCM1
p.P172LLUAD1
p.C227SLUSC1
p.R263KSTAD1
p.K98NBLCA1
p.L264PLUSC1
p.E141GGBM1
p.K80NBLCA1
p.C337XSTAD1
p.G189RSKCM1


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TissGeneCNV for WISP3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for WISP3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0TopHat-FusionBRCATCGA-E2-A1LE-01AWISP3-PSMB1Out-of-Framechr6:112389527chr6:170852688


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TissGeneNet for WISP3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for WISP3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for WISP3
TissGeneDrug for WISP3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for WISP3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0432215Progressive pseudorheumatoid dysplasia15BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0278601Inflammatory Breast Carcinoma9BeFree
umls:C0006142Malignant neoplasm of breast7BeFree
umls:C0678222Breast Carcinoma7BeFree
umls:C0041296Tuberculosis4BeFree
umls:C0263661Disorder of skeletal system4BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0020445Hypercholesterolemia, Familial2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0041327Tuberculosis, Pulmonary2BeFree
umls:C0265220Pallister-Hall syndrome2BeFree
umls:C0345354Radial polydactyly2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C1458155Mammary Neoplasms2BeFree,LHGDN
umls:C1527249Colorectal Cancer2BeFree,GAD
umls:C0003864Arthritis1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree,LHGDN
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0008479Chondrosarcoma1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0013336Dwarfism1BeFree
umls:C0017563Gingival Diseases1BeFree
umls:C0017668Focal glomerulosclerosis1BeFree
umls:C0019348Herpes Simplex Infections1BeFree
umls:C0024121Lung Neoplasms1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0029408Degenerative polyarthritis1BeFree,LHGDN
umls:C0029422Osteochondrodysplasias1LHGDN
umls:C0031090Periodontal Diseases1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0039075Syndactyly1BeFree
umls:C0041309Tuberculosis, Cutaneous1BeFree
umls:C0041318Tuberculosis, Meningeal1BeFree
umls:C0085568Buruli Ulcer1BeFree
umls:C0151332Active tuberculosis1BeFree
umls:C0152427Polydactyly1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0220697POLYDACTYLY, POSTAXIAL1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0278134Absence of sensation1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0525045Mood Disorders1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C1334274Invasive Carcinoma1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C1609538Latent Tuberculosis1BeFree
umls:C1654637androgen independent prostate cancer1BeFree
umls:C2239176Liver carcinoma1LHGDN
umls:C3495559Juvenile arthritis1BeFree
umls:C3714757Juvenile rheumatoid arthritis1BeFree