TissGeneSummary for AKAP4 |
Gene summary |
Basic gene information | Gene symbol | AKAP4 |
Gene name | A kinase (PRKA) anchor protein 4 | |
Synonyms | AKAP 82|AKAP-4|AKAP82|CT99|FSC1|HI|PRKA4|hAKAP82|p82 | |
Cytomap | UCSC genome browser: Xp11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_003886.2, NM_139289.1, | |
Description | A-kinase anchor protein 4A-kinase anchor protein 82 kDacancer/testis antigen 99major sperm fibrous sheath proteinprotein kinase A anchoring protein 4protein kinase A-anchoring protein 4testis-specific gene HI | |
Modification date | 20141207 | |
dbXrefs | MIM : 300185 | |
HGNC : HGNC | ||
Ensembl : ENSG00000147081 | ||
HPRD : 02173 | ||
Vega : OTTHUMG00000021517 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AKAP4 | |
BioGPS: 8852 | ||
Pathway | NCI Pathway Interaction Database: AKAP4 | |
KEGG: AKAP4 | ||
REACTOME: AKAP4 | ||
Pathway Commons: AKAP4 | ||
Context | iHOP: AKAP4 | |
ligand binding site mutation search in PubMed: AKAP4 | ||
UCL Cancer Institute: AKAP4 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of AKAP4 | Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome. Silva JV, Yoon S, De Bock PJ, Goltsev AV, Gevaert K, Mendes JF, Fardilha M. Biochim Biophys Acta. 2017 Feb;1861(2):375-385. doi: 10.1016/j.bbagen.2016.11.041. Epub 2016 Nov 30. (pmid:27913189) go to article | |
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for AKAP4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.606821846 | 0.502504543 | -1.109326389 | 6.10E-18 | 3.96E-17 |
KIRP | -0.729694415 | 0.451061835 | -1.18075625 | 1.54E-08 | 1.15E-07 |
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TissGene-miRNA for AKAP4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AKAP4 |
TissGeneSNV for AKAP4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E226K | SKCM | 3 |
p.S209F | SKCM | 3 |
p.S218F | SKCM | 2 |
p.E235K | SKCM | 2 |
p.S538F | SKCM | 1 |
p.H148N | COAD | 1 |
p.E235K | UCEC | 1 |
p.N754T | PAAD | 1 |
p.S721L | SKCM | 1 |
p.Q823K | LUAD | 1 |
p.R167C | UCS | 1 |
p.G839E | SKCM | 1 |
p.H595Y | HNSC | 1 |
p.D161Y | CESC | 1 |
p.G688E | SKCM | 1 |
p.T491N | LUSC | 1 |
p.L65Q | LUAD | 1 |
p.S757C | HNSC | 1 |
p.V759I | UCEC | 1 |
p.D200E | SKCM | 1 |
p.A406T | STAD | 1 |
p.L41M | LUAD | 1 |
p.C386W | ESCA | 1 |
p.S207F | SKCM | 1 |
p.E377K | STAD | 1 |
p.A52V | LUAD | 1 |
p.K713X | KIRC | 1 |
p.D12N | UCEC | 1 |
p.R9H | SARC | 1 |
p.G830E | SKCM | 1 |
p.D314E | COAD | 1 |
p.L638R | COAD | 1 |
p.S703F | STAD | 1 |
p.L421F | PRAD | 1 |
p.R176H | LGG | 1 |
p.S5C | HNSC | 1 |
p.G67S | DLBC | 1 |
p.Q740H | LUAD | 1 |
p.M578R | BLCA | 1 |
p.T491N | THYM | 1 |
p.Y714H | SKCM | 1 |
p.S468F | SKCM | 1 |
p.G820C | LUSC | 1 |
p.Q718H | ESCA | 1 |
p.S547F | SKCM | 1 |
p.M286I | UCEC | 1 |
p.H604Y | HNSC | 1 |
p.E641* | LUAD | 1 |
p.D209E | SKCM | 1 |
p.G504R | SKCM | 1 |
p.C386X | COAD | 1 |
p.P107S | SKCM | 1 |
p.M286T | HNSC | 1 |
p.E424D | STAD | 1 |
p.G745A | DLBC | 1 |
p.R167C | CESC | 1 |
p.G513R | SKCM | 1 |
p.S443Y | UCEC | 1 |
p.Q510L | CESC | 1 |
p.G736C | LUAD | 1 |
p.G679E | SKCM | 1 |
p.E522* | HNSC | 1 |
p.K368N | CESC | 1 |
p.E568K | BRCA | 1 |
p.L115I | READ | 1 |
p.Y705H | SKCM | 1 |
p.D538E | BRCA | 1 |
p.P255S | COAD | 1 |
p.L362F | LUAD | 1 |
p.D343E | LUSC | 1 |
p.R728M | LUAD | 1 |
p.Y29C | LIHC | 1 |
p.Q193H | HNSC | 1 |
p.V798A | LUAD | 1 |
p.N188D | STAD | 1 |
p.L50M | LUAD | 1 |
p.Q762R | ACC | 1 |
p.V32M | SKCM | 1 |
p.D698N | SKCM | 1 |
p.E324* | UCEC | 1 |
p.S610T | STAD | 1 |
p.Q501K | LGG | 1 |
p.P477Q | LIHC | 1 |
p.E277G | LIHC | 1 |
p.S459F | SKCM | 1 |
p.R287C | STAD | 1 |
p.Q727H | ESCA | 1 |
p.S450Y | LUSC | 1 |
p.L531M | LUAD | 1 |
p.S808R | LIHC | 1 |
p.T411K | LUAD | 1 |
p.S54C | HNSC | 1 |
p.N759Y | SARC | 1 |
p.I426L | LUAD | 1 |
p.M689K | BRCA | 1 |
p.C43Y | STAD | 1 |
p.Q202H | KIRC | 1 |
p.A731T | GBM | 1 |
p.M277T | HNSC | 1 |
p.D478N | STAD | 1 |
p.L715F | LUAD | 1 |
p.W406* | SKCM | 1 |
p.K87N | COAD | 1 |
p.G67C | COAD | 1 |
p.V370A | LIHC | 1 |
p.Y48F | LUAD | 1 |
p.P191H | THYM | 1 |
p.M389I | LUAD | 1 |
p.R167H | LGG | 1 |
p.Q501K | ACC | 1 |
p.D4N | SKCM | 1 |
p.K130E | SKCM | 1 |
p.A663S | HNSC | 1 |
p.H671N | LUAD | 1 |
p.R409I | UCS | 1 |
p.M569R | BLCA | 1 |
p.R176C | UCS | 1 |
p.P609Q | UCEC | 1 |
p.E146* | HNSC | 1 |
p.A654S | HNSC | 1 |
p.R264Q | UCEC | 1 |
p.S225F | UCEC | 1 |
p.W415X | SKCM | 1 |
p.S10R | LGG | 1 |
p.L707F | GBM | 1 |
p.R400I | UCS | 1 |
p.A842S | LUSC | 1 |
p.L490P | UCEC | 1 |
p.E640Q | BRCA | 1 |
p.K419R | LGG | 1 |
p.S63C | HNSC | 1 |
p.M344I | SKCM | 1 |
p.N248K | BLCA | 1 |
p.G685E | SKCM | 1 |
p.G67D | ESCA | 1 |
p.Q785P | UCEC | 1 |
p.R429C | BRCA | 1 |
p.K724E | HNSC | 1 |
p.D616N | SKCM | 1 |
p.L302I | UCEC | 1 |
p.V221I | UCEC | 1 |
p.S130R | UCEC | 1 |
p.M474I | CESC | 1 |
p.D689N | SKCM | 1 |
p.A728E | KIRP | 1 |
p.D108N | HNSC | 1 |
p.K428R | LGG | 1 |
p.G694E | SKCM | 1 |
p.D611E | LGG | 1 |
p.C15Y | PCPG | 1 |
p.Q771R | ACC | 1 |
p.K541E | SARC | 1 |
p.I697R | LUSC | 1 |
p.P266A | STAD | 1 |
p.L333F | UCEC | 1 |
p.V41M | SKCM | 1 |
p.E137* | HNSC | 1 |
p.A141S | STAD | 1 |
p.N763T | PAAD | 1 |
p.S198F | SKCM | 1 |
p.E291A | OV | 1 |
p.M465I | SKCM | 1 |
p.A595T | SKCM | 1 |
p.M335I | SKCM | 1 |
p.D457V | BRCA | 1 |
p.L638F | STAD | 1 |
p.D485Y | BRCA | 1 |
p.A586T | SKCM | 1 |
p.V807A | LUAD | 1 |
p.Q814K | LUAD | 1 |
p.A150S | STAD | 1 |
p.S730L | SKCM | 1 |
p.D80G | LGG | 1 |
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TissGeneCNV for AKAP4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AKAP4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for AKAP4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AKAP4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AKAP4 |
TissGeneDrug for AKAP4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AKAP4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002690 | Amputation Stumps | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0206692 | Carcinoma, Lobular | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0555971 | Oral infection | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1520166 | Xenograft Model | 1 | BeFree |