TissGeneSummary for CDKL2 |
Gene summary |
Basic gene information | Gene symbol | CDKL2 |
Gene name | cyclin-dependent kinase-like 2 (CDC2-related kinase) | |
Synonyms | KKIAMRE|P56 | |
Cytomap | UCSC genome browser: 4q21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_003948.3, | |
Description | CDC2-related kinasecyclin-dependent kinase-like 2p56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREserine/threonine-protein kinase KKIAMRE | |
Modification date | 20141207 | |
dbXrefs | MIM : 603442 | |
HGNC : HGNC | ||
HPRD : 16021 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDKL2 | |
BioGPS: 8999 | ||
Pathway | NCI Pathway Interaction Database: CDKL2 | |
KEGG: CDKL2 | ||
REACTOME: CDKL2 | ||
Pathway Commons: CDKL2 | ||
Context | iHOP: CDKL2 | |
ligand binding site mutation search in PubMed: CDKL2 | ||
UCL Cancer Institute: CDKL2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CDKL2 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CDKL2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -2.076697627 | 0.477717758 | -2.554415385 | 1.39E-12 | 3.50E-11 |
PRAD | -1.329645704 | -0.027297627 | -1.302348077 | 2.07E-08 | 2.34E-07 |
KIRC | 2.462042224 | 3.954574168 | -1.492531944 | 3.49E-18 | 2.33E-17 |
LUSC | 0.278691815 | 3.708407502 | -3.429715686 | 1.44E-22 | 2.32E-21 |
LUAD | 2.528761525 | 3.987339111 | -1.458577586 | 2.58E-09 | 1.27E-08 |
BRCA | -1.831407411 | 0.250775923 | -2.082183333 | 1.92E-17 | 1.15E-16 |
STAD | -1.268115415 | 0.42077521 | -1.688890625 | 0.00176 | 0.008280837 |
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TissGene-miRNA for CDKL2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CDKL2 |
TissGeneSNV for CDKL2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R251I | UCEC | 1 |
p.L55P | COAD | 1 |
p.I243M | BLCA | 1 |
p.E12X | STAD | 1 |
p.D327G | LUAD | 1 |
p.R149Q | ESCA | 1 |
p.K181R | STAD | 1 |
p.R149* | SARC | 1 |
p.M43T | LIHC | 1 |
p.A169P | BLCA | 1 |
p.E490D | DLBC | 1 |
p.S420F | CESC | 1 |
p.V402M | PRAD | 1 |
p.Y4C | SKCM | 1 |
p.G358C | ESCA | 1 |
p.S329P | PRAD | 1 |
p.I412V | LUSC | 1 |
p.E299* | UCEC | 1 |
p.R252H | UCEC | 1 |
p.Q226* | BRCA | 1 |
p.V157A | OV | 1 |
p.K316N | BLCA | 1 |
p.S14G | STAD | 1 |
p.P461T | PRAD | 1 |
p.S329F | SKCM | 1 |
p.N374S | GBM | 1 |
p.S317F | SKCM | 1 |
p.S329F | CESC | 1 |
p.E5K | LUSC | 1 |
p.H213Y | SKCM | 1 |
p.E12* | STAD | 1 |
p.K231E | BLCA | 1 |
p.K231X | KIRP | 1 |
p.R50Q | HNSC | 1 |
p.P477S | PRAD | 1 |
p.P408T | ESCA | 1 |
p.V102L | GBM | 1 |
p.Q136L | LUAD | 1 |
p.S462X | KIRP | 1 |
p.G358C | UCEC | 1 |
p.F35L | COAD | 1 |
p.K231* | KIRP | 1 |
p.E130D | UCEC | 1 |
p.V177I | PRAD | 1 |
p.I110M | STAD | 1 |
p.T159I | KIRP | 1 |
p.G13R | COAD | 1 |
p.D273E | UCEC | 1 |
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TissGeneCNV for CDKL2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CDKL2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI223964 | CDKL2-ULK4 | chr4:76540566 | chr3:41704257 | |
TCGAfusionPortal | PRADA | LUAD | TCGA-38-4632-01A | CDKL2-G3BP2 | In-frame | Chr4:76551005 | Chr4:76573925 |
TCGAfusionPortal | PRADA | LUAD | TCGA-55-7914-01A | CDKL2-CXCL11 | CDS-5UTR | Chr4:76551005 | Chr4:76957217 |
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TissGeneNet for CDKL2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CDKL2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CDKL2 |
TissGeneDrug for CDKL2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CDKL2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027092 | Myopia | 1 | BeFree |
umls:C0206633 | Angiomyolipoma | 1 | BeFree |