TissGeneSummary for FAM181A |
Gene summary |
Basic gene information | Gene symbol | FAM181A |
Gene name | family with sequence similarity 181, member A | |
Synonyms | C14orf152 | |
Cytomap | UCSC genome browser: 14q32.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001207071.1, NM_001207072.1,NM_001207073.1,NM_001207074.1,NM_138344.4, | |
Description | protein FAM181A | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000140067 | ||
HPRD : 12636 | ||
Vega : OTTHUMG00000171297 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM181A | |
BioGPS: 90050 | ||
Pathway | NCI Pathway Interaction Database: FAM181A | |
KEGG: FAM181A | ||
REACTOME: FAM181A | ||
Pathway Commons: FAM181A | ||
Context | iHOP: FAM181A | |
ligand binding site mutation search in PubMed: FAM181A | ||
UCL Cancer Institute: FAM181A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM181A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM181A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.517091285 | 2.501579405 | -3.01867069 | 7.15E-16 | 7.90E-15 |
BRCA | -2.504648212 | -1.395237685 | -1.109410526 | 6.77E-22 | 5.57E-21 |
LUSC | -0.583631751 | 2.405754523 | -2.989386275 | 5.65E-14 | 3.01E-13 |
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TissGene-miRNA for FAM181A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM181A |
TissGeneSNV for FAM181A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L239Q | LIHC | 1 |
p.R119W | SARC | 1 |
p.E97K | SKCM | 1 |
p.H316R | PRAD | 1 |
p.R132K | SKCM | 1 |
p.R38C | SKCM | 1 |
p.A199T | ESCA | 1 |
p.S96F | SKCM | 1 |
p.D320N | SKCM | 1 |
p.Y166C | STAD | 1 |
p.V270I | LUAD | 1 |
p.H281Y | SKCM | 1 |
p.D148N | LUAD | 1 |
p.S9Y | HNSC | 1 |
p.R119W | BLCA | 1 |
p.P205S | STAD | 1 |
p.T244A | STAD | 1 |
p.E242K | HNSC | 1 |
p.Q326H | CESC | 1 |
p.Q221X | COAD | 1 |
p.R139K | SKCM | 1 |
p.A199T | LUSC | 1 |
p.S56L | COAD | 1 |
p.S34F | SKCM | 1 |
p.R77K | SKCM | 1 |
p.Q283* | BLCA | 1 |
p.A79T | COAD | 1 |
p.G59S | SKCM | 1 |
p.R116W | STAD | 1 |
p.D136E | CESC | 1 |
p.G323S | SKCM | 1 |
p.D144N | SKCM | 1 |
p.P262A | PRAD | 1 |
p.E228Q | LUAD | 1 |
p.R100H | ESCA | 1 |
p.E174K | SKCM | 1 |
p.G268S | HNSC | 1 |
p.L253Q | LUAD | 1 |
p.P2S | UCEC | 1 |
p.E159K | SKCM | 1 |
p.F75V | PAAD | 1 |
p.R100C | SKCM | 1 |
p.R119L | LUAD | 1 |
p.D258N | SKCM | 1 |
p.H219Y | SKCM | 1 |
p.R132G | TGCT | 1 |
p.E223K | LUAD | 1 |
p.P346L | SKCM | 1 |
p.P38L | SKCM | 1 |
p.P284L | SKCM | 1 |
p.N19H | UCEC | 1 |
p.E112K | SKCM | 1 |
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TissGeneCNV for FAM181A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM181A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM181A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM181A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM181A |
TissGeneDrug for FAM181A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM181A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |