TissGeneSummary for UCN2 |
Gene summary |
Basic gene information | Gene symbol | UCN2 |
Gene name | urocortin 2 | |
Synonyms | SRP|UCN-II|UCNI|UR|URP | |
Cytomap | UCSC genome browser: 3p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_033199.3, | |
Description | prepro-urocortin 2stresscopin-related peptideucn IIurocortin IIurocortin-2urocortin-related peptide | |
Modification date | 20141207 | |
dbXrefs | MIM : 605902 | |
HGNC : HGNC | ||
Ensembl : ENSG00000145040 | ||
HPRD : 16171 | ||
Vega : OTTHUMG00000133533 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UCN2 | |
BioGPS: 90226 | ||
Pathway | NCI Pathway Interaction Database: UCN2 | |
KEGG: UCN2 | ||
REACTOME: UCN2 | ||
Pathway Commons: UCN2 | ||
Context | iHOP: UCN2 | |
ligand binding site mutation search in PubMed: UCN2 | ||
UCL Cancer Institute: UCN2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of UCN2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for UCN2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -2.043053219 | -3.534644599 | 1.491591379 | 1.41E-09 | 7.34E-09 |
LUSC | 0.565364664 | -3.22527259 | 3.790637255 | 2.00E-24 | 4.06E-23 |
COAD | -0.980274174 | -3.709001097 | 2.728726923 | 1.56E-12 | 3.76E-11 |
HNSC | 2.037089243 | 0.269231103 | 1.76785814 | 1.15E-07 | 1.11E-06 |
ESCA | 1.396917784 | -2.12171858 | 3.518636364 | 0.000477 | 0.008952067 |
BLCA | 1.494992425 | -1.000928628 | 2.495921053 | 7.72E-05 | 0.000913134 |
STAD | -1.323501818 | -3.136479943 | 1.812978125 | 1.14E-05 | 0.000130809 |
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TissGene-miRNA for UCN2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for UCN2 |
TissGeneSNV for UCN2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E46X | ESCA | 1 |
p.R41* | LIHC | 1 |
p.R31C | LGG | 1 |
p.R66S | ESCA | 1 |
p.R66C | COAD | 1 |
p.A92V | COAD | 1 |
p.R41X | LIHC | 1 |
p.R41Q | COAD | 1 |
p.R31H | PAAD | 1 |
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TissGeneCNV for UCN2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for UCN2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for UCN2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for UCN2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for UCN2 |
TissGeneDrug for UCN2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for UCN2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0266929 | Chronic Periodontitis | 2 | BeFree |
umls:C0003123 | Anorexia | 1 | CTD_human |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0009319 | Colitis | 1 | RGD |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0011633 | Dermatomyositis | 1 | BeFree |
umls:C0014175 | Endometriosis | 1 | BeFree |
umls:C0018801 | Heart failure | 1 | CTD_human |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0036996 | Short Rib-Polydactyly Syndrome | 1 | BeFree |
umls:C0079541 | Holoprosencephaly | 1 | BeFree |
umls:C0085655 | Polymyositis | 1 | BeFree |
umls:C0221056 | Adult type dermatomyositis | 1 | BeFree |
umls:C0265633 | Congenital absence of tibia | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |